4NGFA

Structure of human dicer platform-paz-connector helix cassette in complex with 17-mer sirna having 5'-p and uu-3' ends (3.1 angstrom resolution)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
298
structure length
260
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRYCVLPLNVVSTLDIDFKFMEDIEKSETKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 50
structure length 260
sequence length 298
chains with identical sequence B, C, D
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngfA02
3QIRA 4Z4EA 1SI3A 4NH3A 4OLBA 4NH6A 2L5CA 3O6EX 4OLAA 3MJ0A 4KRFA 4NGDA 2QVWA 4W5RA 4NGFA 4NHAA 5JS1A 5KI6A 4Z4IA 3O7VX 3O7XA 1VYNA 4Z4CA 4F3TA 4W5QA 4NGCA 4NH5A 5T7BA 1T2SA 1R6ZA 4KREA 4W5TA 2FFLA 1R4KA 1SI2A 2XFMA 5JS2A 2L5DA 1T2RA 4NGGA 4Z4GA 4W5NA 4W5OA 3O3IX 4Z4HA 4NGBA 4Z4FA
chains in the Genus database with same CATH superfamily
3QIRA 4Z4EA 1SI3A 3HM9A 4NH3A 3F73A 4OLBA 3DLHA 4NH6A 2L5CA 3O6EX 3DA5A 4OLAA 3MJ0A 1U04A 4KRFA 3U1UA 3DLBA 3HJFA 4NGDA 4L1UA 1Z26A 3HVRA 2QVWA 4W5RA 4NGFA 4NHAA 5JS1A 5KI6A 4Z4IA 3O7VX 3O7XA 1VYNA 4Z4CA 4NGBA 4F3TA 4W5QA 4NGCA 4NH5A 5T7BA 1T2SA 2DB9A 3HK2A 1R6ZA 4KREA 2FFLA 2BZEA 1R4KA 4W5TA 1SI2A 2XFMA 5JS2A 2L5DA 3HO1A 1T2RA 4NGGA 4Z4GA 1Z25A 4W5NA 4W5OA 3O3IX 4Z4HA 4L1PA 4Z4FA
chains in the Genus database with same CATH topology
3QIRA 4Z4EA 1SI3A 3HM9A 4NH3A 3F73A 4OLBA 3DLHA 4NH6A 2L5CA 3O6EX 3DA5A 4OLAA 3MJ0A 1U04A 4KRFA 3U1UA 3DLBA 3HJFA 4NGDA 4L1UA 1Z26A 3HVRA 2QVWA 4W5RA 4NGFA 4NHAA 5JS1A 5KI6A 4Z4IA 3O7VX 3O7XA 1VYNA 4Z4CA 4NGBA 4F3TA 4W5QA 4NGCA 4NH5A 5T7BA 1T2SA 2DB9A 3HK2A 1R6ZA 4KREA 2FFLA 2BZEA 1R4KA 4W5TA 1SI2A 2XFMA 5JS2A 2L5DA 3HO1A 1T2RA 4NGGA 4Z4GA 1Z25A 4W5NA 4W5OA 3O3IX 4Z4HA 4L1PA 4Z4FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QIR A;  4Z4E A;  1SI3 A;  4NH3 A;  4OLB A;  4NH6 A;  2L5C A;  3O6E X;  4OLA A;  3MJ0 A;  4KRF A;  4NGD A;  2QVW A;  4W5R A;  4NGF A;  4NHA A;  5JS1 A;  5KI6 A;  4Z4I A;  3O7V X;  3O7X A;  1VYN A;  4Z4C A;  4F3T A;  4W5Q A;  4NGC A;  4NH5 A;  5T7B A;  1T2S A;  1R6Z A;  4KRE A;  4W5T A;  2FFL A;  1R4K A;  1SI2 A;  2XFM A;  5JS2 A;  2L5D A;  1T2R A;  4NGG A;  4Z4G A;  4W5N A;  4W5O A;  3O3I X;  4Z4H A;  4NGB A;  4Z4F A; 
#chains in the Genus database with same CATH topology
 3QIR A;  4Z4E A;  1SI3 A;  3HM9 A;  4NH3 A;  3F73 A;  4OLB A;  3DLH A;  4NH6 A;  2L5C A;  3O6E X;  3DA5 A;  4OLA A;  3MJ0 A;  1U04 A;  4KRF A;  3U1U A;  3DLB A;  3HJF A;  4NGD A;  4L1U A;  1Z26 A;  3HVR A;  2QVW A;  4W5R A;  4NGF A;  4NHA A;  5JS1 A;  5KI6 A;  4Z4I A;  3O7V X;  3O7X A;  1VYN A;  4Z4C A;  4NGB A;  4F3T A;  4W5Q A;  4NGC A;  4NH5 A;  5T7B A;  1T2S A;  2DB9 A;  3HK2 A;  1R6Z A;  4KRE A;  2FFL A;  2BZE A;  1R4K A;  4W5T A;  1SI2 A;  2XFM A;  5JS2 A;  2L5D A;  3HO1 A;  1T2R A;  4NGG A;  4Z4G A;  1Z25 A;  4W5N A;  4W5O A;  3O3I X;  4Z4H A;  4L1P A;  4Z4F A; 
#chains in the Genus database with same CATH homology
 3QIR A;  4Z4E A;  1SI3 A;  3HM9 A;  4NH3 A;  3F73 A;  4OLB A;  3DLH A;  4NH6 A;  2L5C A;  3O6E X;  3DA5 A;  4OLA A;  3MJ0 A;  1U04 A;  4KRF A;  3U1U A;  3DLB A;  3HJF A;  4NGD A;  4L1U A;  1Z26 A;  3HVR A;  2QVW A;  4W5R A;  4NGF A;  4NHA A;  5JS1 A;  5KI6 A;  4Z4I A;  3O7V X;  3O7X A;  1VYN A;  4Z4C A;  4NGB A;  4F3T A;  4W5Q A;  4NGC A;  4NH5 A;  5T7B A;  1T2S A;  2DB9 A;  3HK2 A;  1R6Z A;  4KRE A;  2FFL A;  2BZE A;  1R4K A;  4W5T A;  1SI2 A;  2XFM A;  5JS2 A;  2L5D A;  3HO1 A;  1T2R A;  4NGG A;  4Z4G A;  1Z25 A;  4W5N A;  4W5O A;  3O3I X;  4Z4H A;  4L1P A;  4Z4F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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