4NKFA

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
343
structure length
339
Chain Sequence
DVYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Farnesyl pyrophosphate synthase
publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 129
structure length 339
sequence length 343
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4nkfA00
4KQUA 3ICNA 4NFKF 3KRCB 3N5HF 5ILZA 5EROA 2Z4YA 4DI5A 1JFAA 3MZVA 5A0JA 1YHKA 5E8KA 2OPNA 4FJQA 3TFNA 3OYRA 2Z78A 4RXDA 4XQSF 4P0WA 5AYPA 1KIZA 4LTZA 4OMGA 4MC3A 4PVXF 5A0KA 3AQBB 5H9DA 5DHKA 2Z7HA 4KQ5A 5AFXA 4NG6A 1WKZA 2E8VA 4KFAA 5B0MA 3LG5A 3ZCDA 3VJEA 2P1CA 4KK2A 1YJ4A 3ICZA 3ZOUA 3SAEA 4KPDA 4OKMA 2I19A 4PVYF 5E8HA 5DJVF 4NFJF 1RTRA 3WCAA 1WL3A 3WEJA 3WE9A 2ZEUA 4LOBA 4L2XF 1VG2A 3OACB 3LSNA 1WMWA 5B0IA 5ILYA 1HX9A 3ZL6A 5AELA 4KKMA 4LZ0A 2Z50A 2E8UA 3Q1OA 2E94A 3N46F 4E1EA 3WEIA 5ILJA 3N0FA 4HD1A 5IMPA 1WL2A 5JV1F 4P0VA 3M02A 3KRFA 1YYTA 2E4OA 2E8TA 5DW7A 2ZCOA 5IK6A 2OA6A 2J5CA 4DWBA 4LZCA 3N3DA 3VJ9A 2E93A 3P5PA 5KSXF 3ID0A 4RYPA 2Z4WA 5EAUA 2ZCRA 4H5EF 5IK0A 5E8LA 4JZXA 5IMIA 1N23A 2Q80A 5ERNA 4LA5A 4QXSF 5B03A 2OPMA 3KRFB 4LXWA 4NKFA 3W7FA 3KB9A 1YYRA 3P8LA 3TC1A 3WCDA 4XQTF 2DH4A 1VG3A 3PDEA 3WCGA 1YHMA 3LLWA 3M00A 3G4DA 4ZQ8A 2ONGA 3WJNA 4LFVF 2AEKA 3PYBA 4K10A 3M9UA 4LLTA 4KVYA 4KQSA 2QISA 2F8ZF 3AQCB 3BNXA 2Z7IA 5ILDA 1UBXA 3V1XA 1YV5A 3WEKA 4H5CF 4LFEA 4XQRF 4JYXA 3Q2ZA 5B00A 3WCLA 1RQJA 5DGMF 2ONHA 4MC0A 5AHUB 1N22A 3WJKA 3RMGA 4GA3A 2E8XA 1HXCA 3ZMBA 3OACA 4KPJA 1HM4A 1YYQA 4H5DF 2F9KF 3N6KF 5B0KA 3DYGA 4DHDA 2PS8A 3RYWA 3SDQA 3SDRA 2AETA 4OKZA 4KUXA 2F89F 4LPHF 5DJPF 3CP6A 3ACXA 3WCCA 3ZMCA 4JZBA 1V4HA 5JA0F 2Q58A 3CKEA 3KRAA 1HM7A 3V1VA 3WC9A 5ER8A 3WCFA 1EZFA 2FTZA 4GP1A 3VJCA 1UBWA 3N3LF 5EATA 2AELA 5IM1A 2ZCSA 2E92A 5JUZF 4RXCA 1UBVA 1N1BA 4GP2A 3KRAB 3TFVA 4EA0A 3DYFA 5A0IA 4JVJF 4EA1A 4KVWA 4WK5A 2Q9YA 3WCEA 4NFIF 5EASA 3IBAA 2ZY1A 3RBMA 4E9ZA 3MAVA 2J1PA 2AZJA 5DZ2A 1VG7A 3TS7A 2PS5A 3OABA 4N1ZF 1HXGA 1FPSA 3EZ3A 4LTVA 3G4FA 3WCMA 5ILKA 2Z4VA 2Z4ZA 2PS6A 1V4KA 3N49F 3SDUA 3UCAA 2F94F 1WY0A 3QQVA 5DGSF 3WEHA 3OABB 4LIXA 4P0XA 2Z4XA 3N0GA 3NF2A 3VJBA 2FORA 3LK5A 3Q2QA 3WSBA 4Q23A 5ILHA 2AZLA 1YHLA 3ICMA 5DHIA 1DGPA 3LVSA 3EGTA 5HNAA 5HN8A 5HN9A 3LGZB 2Q9ZA 5IVGA 3NRIA 4NKEA 3N5JF 1N1ZA 3SDVA 1UBYA 1V4IA 3AE0A 2EWGA 3KRPA 4RNQA 3WEGA 3EFQA 4N9UA 5DJRF 1YYSA 1V4JA 5I1UA 3LGKA 4LZ3A 5IKAA 2Z52A 4LUUA 5HN7A 1VG4A 4KVDA 5ERMA 2PS4A 3LMDA 3V66A 4DXJA 3PH7A 5DIQF 3M0GA 5DGNF 4E9UA 4RXEA 3KRPB 2E90A 4LLSA 4JXYA 2H8OA 3SDTA 4F6VA 1JFGA 2F8CF 3APZA 2E8WA 3WJOA 4LFGA 3KBKA 3WEFA 5JV2F 1PS1A 5B0LA 1DI1A 2F92F 3LEEA 1N21A 3AQ0A 1V4EA 5IK9A 4LA6A 3QKCA 2VF6A 3WCHA 3WCIA 4DZWA 5IL3A 4KVIA 5IKHA 3M01A 3WCJA 3DYHA 3NPRA 3WCBA 3S9VA 5JV0F 2PS7A 4QPFA 4FP4A 3P8RA 1HXAA 2O1OA 2J1OA 1N20A 1N24A 3N45F 1RQIA 3ICKA 3CC9A 1WL0A 3N1VF 3WSAA 5B01A 3P5RA 3VJAA 3ACYA 3P41A 2ZEVA 3KROA 4OMHA 3BNYA 3ASXA 5B02A 4EA2A 1KIYA 3ADZA 5CG6A 4GAXA 4KWDA 3RYEA 4MC8A 3TFPA 3IPIA 4LPGF 4F6XA 3PYAA 2ZCQA 2AZKA 3KROB 4RXAA 3VJDA 1VG6A 3ACWA 3B7LA 1ZW5A 3LZ9A 4DEMF 4UMJA 2E95A 1YYUA 2F7MF 2RAHA 3Q30A 3LDWA 3LJIA 1YQ7A 2E91A 2OGDA 5B0JA 3KRCA 3LOMA 5CG5A 3N1WF 4F62A 5C05A 1WL1A 5IL8A 4DWGA 5IN8A 4NUAA 5ILIA 4OGUA 3VJ8A 5IMNA 4JXNA 3PKOA 3NPKA 3S4JA
chains in the Genus database with same CATH superfamily
4KQUA 3ICNA 4NFKF 3KRCB 3N5HF 5ILZA 5EROA 2Z4YA 4DI5A 1JFAA 3MZVA 5A0JA 1YHKA 5E8KA 2OPNA 4FJQA 3TFNA 3OYRA 2Z78A 4RXDA 4XQSF 4P0WA 5AYPA 1KIZA 4LTZA 4OMGA 4MC3A 4PVXF 5A0KA 3AQBB 5H9DA 5DHKA 2Z7HA 4KQ5A 5AFXA 4NG6A 1WKZA 2E8VA 4KFAA 5B0MA 3LG5A 3ZCDA 3VJEA 2P1CA 4KK2A 1YJ4A 3ICZA 3ZOUA 3SAEA 4KPDA 4OKMA 2I19A 4PVYF 5E8HA 5DJVF 4NFJF 1RTRA 3WCAA 1WL3A 3WEJA 3WE9A 2ZEUA 4LOBA 4L2XF 1VG2A 3OACB 3LSNA 1WMWA 5B0IA 5ILYA 1HX9A 3ZL6A 5AELA 4KKMA 4LZ0A 2Z50A 2E8UA 3Q1OA 2E94A 3N46F 4E1EA 3WEIA 5ILJA 3N0FA 4HD1A 5IMPA 1WL2A 5JV1F 4P0VA 3M02A 3KRFA 1YYTA 2E4OA 2E8TA 5DW7A 2ZCOA 5IK6A 2OA6A 2J5CA 4DWBA 4LZCA 3N3DA 3VJ9A 2E93A 3P5PA 5KSXF 3ID0A 4RYPA 2Z4WA 5EAUA 2ZCRA 4H5EF 5IK0A 5E8LA 4JZXA 5IMIA 1N23A 2Q80A 5ERNA 4LA5A 4QXSF 5B03A 2OPMA 3KRFB 4LXWA 4NKFA 3W7FA 3KB9A 1YYRA 3P8LA 3TC1A 3WCDA 4XQTF 2DH4A 1VG3A 3PDEA 3WCGA 1YHMA 3LLWA 3M00A 3G4DA 4ZQ8A 2ONGA 3WJNA 4LFVF 2AEKA 3PYBA 4K10A 3M9UA 4LLTA 4KVYA 4KQSA 2QISA 2F8ZF 3AQCB 3BNXA 2Z7IA 5ILDA 1UBXA 3V1XA 1YV5A 3WEKA 4H5CF 4LFEA 4XQRF 4JYXA 3Q2ZA 5B00A 3WCLA 1RQJA 5DGMF 2ONHA 4MC0A 5AHUB 1N22A 3WJKA 3RMGA 4GA3A 2E8XA 1HXCA 3ZMBA 3OACA 4KPJA 1HM4A 1YYQA 4H5DF 2F9KF 3N6KF 5B0KA 3DYGA 4DHDA 2PS8A 3RYWA 3SDQA 3SDRA 2AETA 4OKZA 4KUXA 2F89F 4LPHF 5DJPF 3CP6A 3ACXA 3WCCA 3ZMCA 4JZBA 1V4HA 5JA0F 2Q58A 3CKEA 3KRAA 1HM7A 3V1VA 3WC9A 5ER8A 3WCFA 1EZFA 2FTZA 4GP1A 3VJCA 1UBWA 3N3LF 5EATA 2AELA 5IM1A 2ZCSA 2E92A 5JUZF 4RXCA 1UBVA 1N1BA 4GP2A 3KRAB 3TFVA 4EA0A 3DYFA 5A0IA 4JVJF 4EA1A 4KVWA 4WK5A 2Q9YA 3WCEA 4NFIF 5EASA 3IBAA 2ZY1A 3RBMA 4E9ZA 3MAVA 2J1PA 2AZJA 5DZ2A 1VG7A 3TS7A 2PS5A 3OABA 4N1ZF 1HXGA 1FPSA 3EZ3A 4LTVA 3G4FA 3WCMA 5ILKA 2Z4VA 2Z4ZA 2PS6A 1V4KA 3N49F 3SDUA 3UCAA 2F94F 1WY0A 3QQVA 5DGSF 3WEHA 3OABB 4LIXA 4P0XA 2Z4XA 3N0GA 3NF2A 3VJBA 2FORA 3LK5A 3Q2QA 3WSBA 4Q23A 5ILHA 2AZLA 1YHLA 3ICMA 5DHIA 1DGPA 3LVSA 3EGTA 5HNAA 5HN8A 5HN9A 3LGZB 2Q9ZA 5IVGA 3NRIA 4NKEA 3N5JF 1N1ZA 3SDVA 1UBYA 1V4IA 3AE0A 2EWGA 3KRPA 4RNQA 3WEGA 3EFQA 4N9UA 5DJRF 1YYSA 1V4JA 5I1UA 3LGKA 4LZ3A 5IKAA 2Z52A 4LUUA 5HN7A 1VG4A 4KVDA 5ERMA 2PS4A 3LMDA 3V66A 4DXJA 3PH7A 5DIQF 3M0GA 5DGNF 4E9UA 4RXEA 3KRPB 2E90A 4LLSA 4JXYA 2H8OA 3SDTA 4F6VA 1JFGA 2F8CF 3APZA 2E8WA 3WJOA 4LFGA 3KBKA 3WEFA 5JV2F 1PS1A 5B0LA 1DI1A 2F92F 3LEEA 1N21A 3AQ0A 1V4EA 5IK9A 4LA6A 3QKCA 2VF6A 3WCHA 3WCIA 4DZWA 5IL3A 4KVIA 5IKHA 3M01A 3WCJA 3DYHA 3NPRA 3WCBA 3S9VA 5JV0F 2PS7A 4QPFA 4FP4A 3P8RA 1HXAA 2O1OA 2J1OA 1N20A 1N24A 3N45F 1RQIA 3ICKA 3CC9A 1WL0A 3N1VF 3WSAA 5B01A 3P5RA 3VJAA 3ACYA 3P41A 2ZEVA 3KROA 4OMHA 3BNYA 3ASXA 5B02A 4EA2A 1KIYA 3ADZA 5CG6A 4GAXA 4KWDA 3RYEA 4MC8A 3TFPA 3IPIA 4LPGF 4F6XA 3PYAA 2ZCQA 2AZKA 3KROB 4RXAA 3VJDA 1VG6A 3ACWA 3B7LA 1ZW5A 3LZ9A 4DEMF 4UMJA 2E95A 1YYUA 2F7MF 2RAHA 3Q30A 3LDWA 3LJIA 1YQ7A 2E91A 2OGDA 5B0JA 3KRCA 3LOMA 5CG5A 3N1WF 4F62A 5C05A 1WL1A 5IL8A 4DWGA 5IN8A 4NUAA 5ILIA 4OGUA 3VJ8A 5IMNA 4JXNA 3PKOA 3NPKA 3S4JA
chains in the Genus database with same CATH topology
4KQUA 3ICNA 4NFKF 3KRCB 3N5HF 5ILZA 5EROA 2Z4YA 4DI5A 1JFAA 3MZVA 5A0JA 1YHKA 5E8KA 2OPNA 4FJQA 3TFNA 3OYRA 2Z78A 4RXDA 4XQSF 4P0WA 5AYPA 1KIZA 4LTZA 4OMGA 4MC3A 4PVXF 5A0KA 3AQBB 5H9DA 5DHKA 2Z7HA 4KQ5A 5AFXA 4NG6A 1WKZA 2E8VA 4KFAA 5B0MA 3LG5A 3ZCDA 3VJEA 2P1CA 4KK2A 1YJ4A 3ICZA 3ZOUA 3SAEA 4KPDA 4OKMA 2I19A 4PVYF 5E8HA 5DJVF 4NFJF 1RTRA 3WCAA 1WL3A 3WEJA 3WE9A 2ZEUA 4LOBA 4L2XF 1VG2A 3OACB 3LSNA 1WMWA 5B0IA 5ILYA 1HX9A 3ZL6A 5AELA 4KKMA 4LZ0A 2Z50A 2E8UA 3Q1OA 2E94A 3N46F 4E1EA 3WEIA 5ILJA 3N0FA 4HD1A 5IMPA 1WL2A 5JV1F 4P0VA 3M02A 3KRFA 1YYTA 2E4OA 2E8TA 5DW7A 2ZCOA 5IK6A 2OA6A 2J5CA 4DWBA 4LZCA 3N3DA 3VJ9A 2E93A 3P5PA 5KSXF 3ID0A 4RYPA 2Z4WA 5EAUA 2ZCRA 4H5EF 5IK0A 5E8LA 4JZXA 5IMIA 1N23A 2Q80A 5ERNA 4LA5A 4QXSF 5B03A 2OPMA 3KRFB 4LXWA 4NKFA 3W7FA 3KB9A 1YYRA 3P8LA 3TC1A 3WCDA 4XQTF 2DH4A 1VG3A 3PDEA 3WCGA 1YHMA 3LLWA 3M00A 3G4DA 4ZQ8A 2ONGA 3WJNA 4LFVF 2AEKA 3PYBA 4K10A 3M9UA 4LLTA 4KVYA 4KQSA 2QISA 2F8ZF 3AQCB 3BNXA 2Z7IA 5ILDA 1UBXA 3V1XA 1YV5A 3WEKA 4H5CF 4LFEA 4XQRF 4JYXA 3Q2ZA 5B00A 3WCLA 1RQJA 5DGMF 2ONHA 4MC0A 5AHUB 1N22A 3WJKA 3RMGA 4GA3A 2E8XA 1HXCA 3ZMBA 3OACA 4KPJA 1HM4A 1YYQA 4H5DF 2F9KF 3N6KF 5B0KA 3DYGA 4DHDA 2PS8A 3RYWA 3SDQA 3SDRA 2AETA 4OKZA 4KUXA 2F89F 4LPHF 5DJPF 3CP6A 3ACXA 3WCCA 3ZMCA 4JZBA 1V4HA 5JA0F 2Q58A 3CKEA 3KRAA 1HM7A 3V1VA 3WC9A 5ER8A 3WCFA 1EZFA 2FTZA 4GP1A 3VJCA 1UBWA 3N3LF 5EATA 2AELA 5IM1A 2ZCSA 2E92A 5JUZF 4RXCA 1UBVA 1N1BA 4GP2A 3KRAB 3TFVA 4EA0A 3DYFA 5A0IA 4JVJF 4EA1A 4KVWA 4WK5A 2Q9YA 3WCEA 4NFIF 5EASA 3IBAA 2ZY1A 3RBMA 4E9ZA 3MAVA 2J1PA 2AZJA 5DZ2A 1VG7A 3TS7A 2PS5A 3OABA 4N1ZF 1HXGA 1FPSA 3EZ3A 4LTVA 3G4FA 3WCMA 5ILKA 2Z4VA 2Z4ZA 2PS6A 1V4KA 3N49F 3SDUA 3UCAA 2F94F 1WY0A 3QQVA 5DGSF 3WEHA 3OABB 4LIXA 4P0XA 2Z4XA 3N0GA 3NF2A 3VJBA 2FORA 3LK5A 3Q2QA 3WSBA 4Q23A 5ILHA 2AZLA 1YHLA 3ICMA 5DHIA 1DGPA 3LVSA 3EGTA 5HNAA 5HN8A 5HN9A 3LGZB 2Q9ZA 5IVGA 3NRIA 4NKEA 3N5JF 1N1ZA 3SDVA 1UBYA 1V4IA 3AE0A 2EWGA 3KRPA 4RNQA 3WEGA 3EFQA 4N9UA 5DJRF 1YYSA 1V4JA 5I1UA 3LGKA 4LZ3A 5IKAA 2Z52A 4LUUA 5HN7A 1VG4A 4KVDA 5ERMA 2PS4A 3LMDA 3V66A 4DXJA 3PH7A 5DIQF 3M0GA 5DGNF 4E9UA 4RXEA 3KRPB 2E90A 4LLSA 4JXYA 2H8OA 3SDTA 4F6VA 1JFGA 2F8CF 3APZA 2E8WA 3WJOA 4LFGA 3KBKA 3WEFA 5JV2F 1PS1A 5B0LA 1DI1A 2F92F 3LEEA 1N21A 3AQ0A 1V4EA 5IK9A 4LA6A 3QKCA 2VF6A 3WCHA 3WCIA 4DZWA 5IL3A 4KVIA 5IKHA 3M01A 3WCJA 3DYHA 3NPRA 3WCBA 3S9VA 5JV0F 2PS7A 4QPFA 4FP4A 3P8RA 1HXAA 2O1OA 2J1OA 1N20A 1N24A 3N45F 1RQIA 3ICKA 3CC9A 1WL0A 3N1VF 3WSAA 5B01A 3P5RA 3VJAA 3ACYA 3P41A 2ZEVA 3KROA 4OMHA 3BNYA 3ASXA 5B02A 4EA2A 1KIYA 3ADZA 5CG6A 4GAXA 4KWDA 3RYEA 4MC8A 3TFPA 3IPIA 4LPGF 4F6XA 3PYAA 2ZCQA 2AZKA 3KROB 4RXAA 3VJDA 1VG6A 3ACWA 3B7LA 1ZW5A 3LZ9A 4DEMF 4UMJA 2E95A 1YYUA 2F7MF 2RAHA 3Q30A 3LDWA 3LJIA 1YQ7A 2E91A 2OGDA 5B0JA 3KRCA 3LOMA 5CG5A 3N1WF 4F62A 5C05A 1WL1A 5IL8A 4DWGA 5IN8A 4NUAA 5ILIA 4OGUA 3VJ8A 5IMNA 4JXNA 3PKOA 3NPKA 3S4JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KQU A;  3ICN A;  4NFK F;  3KRC B;  3N5H F;  5ILZ A;  5ERO A;  2Z4Y A;  4DI5 A;  1JFA A;  3MZV A;  5A0J A;  1YHK A;  5E8K A;  2OPN A;  4FJQ A;  3TFN A;  3OYR A;  2Z78 A;  4RXD A;  4XQS F;  4P0W A;  5AYP A;  1KIZ A;  4LTZ A;  4OMG A;  4MC3 A;  4PVX F;  5A0K A;  3AQB B;  5H9D A;  5DHK A;  2Z7H A;  4KQ5 A;  5AFX A;  4NG6 A;  1WKZ A;  2E8V A;  4KFA A;  5B0M A;  3LG5 A;  3ZCD A;  3VJE A;  2P1C A;  4KK2 A;  1YJ4 A;  3ICZ A;  3ZOU A;  3SAE A;  4KPD A;  4OKM A;  2I19 A;  4PVY F;  5E8H A;  5DJV F;  4NFJ F;  1RTR A;  3WCA A;  1WL3 A;  3WEJ A;  3WE9 A;  2ZEU A;  4LOB A;  4L2X F;  1VG2 A;  3OAC B;  3LSN A;  1WMW A;  5B0I A;  5ILY A;  1HX9 A;  3ZL6 A;  5AEL A;  4KKM A;  4LZ0 A;  2Z50 A;  2E8U A;  3Q1O A;  2E94 A;  3N46 F;  4E1E A;  3WEI A;  5ILJ A;  3N0F A;  4HD1 A;  5IMP A;  1WL2 A;  5JV1 F;  4P0V A;  3M02 A;  3KRF A;  1YYT A;  2E4O A;  2E8T A;  5DW7 A;  2ZCO A;  5IK6 A;  2OA6 A;  2J5C A;  4DWB A;  4LZC A;  3N3D A;  3VJ9 A;  2E93 A;  3P5P A;  5KSX F;  3ID0 A;  4RYP A;  2Z4W A;  5EAU A;  2ZCR A;  4H5E F;  5IK0 A;  5E8L A;  4JZX A;  5IMI A;  1N23 A;  2Q80 A;  5ERN A;  4LA5 A;  4QXS F;  5B03 A;  2OPM A;  3KRF B;  4LXW A;  4NKF A;  3W7F A;  3KB9 A;  1YYR A;  3P8L A;  3TC1 A;  3WCD A;  4XQT F;  2DH4 A;  1VG3 A;  3PDE A;  3WCG A;  1YHM A;  3LLW A;  3M00 A;  3G4D A;  4ZQ8 A;  2ONG A;  3WJN A;  4LFV F;  2AEK A;  3PYB A;  4K10 A;  3M9U A;  4LLT A;  4KVY A;  4KQS A;  2QIS A;  2F8Z F;  3AQC B;  3BNX A;  2Z7I A;  5ILD A;  1UBX A;  3V1X A;  1YV5 A;  3WEK A;  4H5C F;  4LFE A;  4XQR F;  4JYX A;  3Q2Z A;  5B00 A;  3WCL A;  1RQJ A;  5DGM F;  2ONH A;  4MC0 A;  5AHU B;  1N22 A;  3WJK A;  3RMG A;  4GA3 A;  2E8X A;  1HXC A;  3ZMB A;  3OAC A;  4KPJ A;  1HM4 A;  1YYQ A;  4H5D F;  2F9K F;  3N6K F;  5B0K A;  3DYG A;  4DHD A;  2PS8 A;  3RYW A;  3SDQ A;  3SDR A;  2AET A;  4OKZ A;  4KUX A;  2F89 F;  4LPH F;  5DJP F;  3CP6 A;  3ACX A;  3WCC A;  3ZMC A;  4JZB A;  1V4H A;  5JA0 F;  2Q58 A;  3CKE A;  3KRA A;  1HM7 A;  3V1V A;  3WC9 A;  5ER8 A;  3WCF A;  1EZF A;  2FTZ A;  4GP1 A;  3VJC A;  1UBW A;  3N3L F;  5EAT A;  2AEL A;  5IM1 A;  2ZCS A;  2E92 A;  5JUZ F;  4RXC A;  1UBV A;  1N1B A;  4GP2 A;  3KRA B;  3TFV A;  4EA0 A;  3DYF A;  5A0I A;  4JVJ F;  4EA1 A;  4KVW A;  4WK5 A;  2Q9Y A;  3WCE A;  4NFI F;  5EAS A;  3IBA A;  2ZY1 A;  3RBM A;  4E9Z A;  3MAV A;  2J1P A;  2AZJ A;  5DZ2 A;  1VG7 A;  3TS7 A;  2PS5 A;  3OAB A;  4N1Z F;  1HXG A;  1FPS A;  3EZ3 A;  4LTV A;  3G4F A;  3WCM A;  5ILK A;  2Z4V A;  2Z4Z A;  2PS6 A;  1V4K A;  3N49 F;  3SDU A;  3UCA A;  2F94 F;  1WY0 A;  3QQV A;  5DGS F;  3WEH A;  3OAB B;  4LIX A;  4P0X A;  2Z4X A;  3N0G A;  3NF2 A;  3VJB A;  2FOR A;  3LK5 A;  3Q2Q A;  3WSB A;  4Q23 A;  5ILH A;  2AZL A;  1YHL A;  3ICM A;  5DHI A;  1DGP A;  3LVS A;  3EGT A;  5HNA A;  5HN8 A;  5HN9 A;  3LGZ B;  2Q9Z A;  5IVG A;  3NRI A;  4NKE A;  3N5J F;  1N1Z A;  3SDV A;  1UBY A;  1V4I A;  3AE0 A;  2EWG A;  3KRP A;  4RNQ A;  3WEG A;  3EFQ A;  4N9U A;  5DJR F;  1YYS A;  1V4J A;  5I1U A;  3LGK A;  4LZ3 A;  5IKA A;  2Z52 A;  4LUU A;  5HN7 A;  1VG4 A;  4KVD A;  5ERM A;  2PS4 A;  3LMD A;  3V66 A;  4DXJ A;  3PH7 A;  5DIQ F;  3M0G A;  5DGN F;  4E9U A;  4RXE A;  3KRP B;  2E90 A;  4LLS A;  4JXY A;  2H8O A;  3SDT A;  4F6V A;  1JFG A;  2F8C F;  3APZ A;  2E8W A;  3WJO A;  4LFG A;  3KBK A;  3WEF A;  5JV2 F;  1PS1 A;  5B0L A;  1DI1 A;  2F92 F;  3LEE A;  1N21 A;  3AQ0 A;  1V4E A;  5IK9 A;  4LA6 A;  3QKC A;  2VF6 A;  3WCH A;  3WCI A;  4DZW A;  5IL3 A;  4KVI A;  5IKH A;  3M01 A;  3WCJ A;  3DYH A;  3NPR A;  3WCB A;  3S9V A;  5JV0 F;  2PS7 A;  4QPF A;  4FP4 A;  3P8R A;  1HXA A;  2O1O A;  2J1O A;  1N20 A;  1N24 A;  3N45 F;  1RQI A;  3ICK A;  3CC9 A;  1WL0 A;  3N1V F;  3WSA A;  5B01 A;  3P5R A;  3VJA A;  3ACY A;  3P41 A;  2ZEV A;  3KRO A;  4OMH A;  3BNY A;  3ASX A;  5B02 A;  4EA2 A;  1KIY A;  3ADZ A;  5CG6 A;  4GAX A;  4KWD A;  3RYE A;  4MC8 A;  3TFP A;  3IPI A;  4LPG F;  4F6X A;  3PYA A;  2ZCQ A;  2AZK A;  3KRO B;  4RXA A;  3VJD A;  1VG6 A;  3ACW A;  3B7L A;  1ZW5 A;  3LZ9 A;  4DEM F;  4UMJ A;  2E95 A;  1YYU A;  2F7M F;  2RAH A;  3Q30 A;  3LDW A;  3LJI A;  1YQ7 A;  2E91 A;  2OGD A;  5B0J A;  3KRC A;  3LOM A;  5CG5 A;  3N1W F;  4F62 A;  5C05 A;  1WL1 A;  5IL8 A;  4DWG A;  5IN8 A;  4NUA A;  5ILI A;  4OGU A;  3VJ8 A;  5IMN A;  4JXN A;  3PKO A;  3NPK A;  3S4J A; 
#chains in the Genus database with same CATH topology
 4KQU A;  3ICN A;  4NFK F;  3KRC B;  3N5H F;  5ILZ A;  5ERO A;  2Z4Y A;  4DI5 A;  1JFA A;  3MZV A;  5A0J A;  1YHK A;  5E8K A;  2OPN A;  4FJQ A;  3TFN A;  3OYR A;  2Z78 A;  4RXD A;  4XQS F;  4P0W A;  5AYP A;  1KIZ A;  4LTZ A;  4OMG A;  4MC3 A;  4PVX F;  5A0K A;  3AQB B;  5H9D A;  5DHK A;  2Z7H A;  4KQ5 A;  5AFX A;  4NG6 A;  1WKZ A;  2E8V A;  4KFA A;  5B0M A;  3LG5 A;  3ZCD A;  3VJE A;  2P1C A;  4KK2 A;  1YJ4 A;  3ICZ A;  3ZOU A;  3SAE A;  4KPD A;  4OKM A;  2I19 A;  4PVY F;  5E8H A;  5DJV F;  4NFJ F;  1RTR A;  3WCA A;  1WL3 A;  3WEJ A;  3WE9 A;  2ZEU A;  4LOB A;  4L2X F;  1VG2 A;  3OAC B;  3LSN A;  1WMW A;  5B0I A;  5ILY A;  1HX9 A;  3ZL6 A;  5AEL A;  4KKM A;  4LZ0 A;  2Z50 A;  2E8U A;  3Q1O A;  2E94 A;  3N46 F;  4E1E A;  3WEI A;  5ILJ A;  3N0F A;  4HD1 A;  5IMP A;  1WL2 A;  5JV1 F;  4P0V A;  3M02 A;  3KRF A;  1YYT A;  2E4O A;  2E8T A;  5DW7 A;  2ZCO A;  5IK6 A;  2OA6 A;  2J5C A;  4DWB A;  4LZC A;  3N3D A;  3VJ9 A;  2E93 A;  3P5P A;  5KSX F;  3ID0 A;  4RYP A;  2Z4W A;  5EAU A;  2ZCR A;  4H5E F;  5IK0 A;  5E8L A;  4JZX A;  5IMI A;  1N23 A;  2Q80 A;  5ERN A;  4LA5 A;  4QXS F;  5B03 A;  2OPM A;  3KRF B;  4LXW A;  4NKF A;  3W7F A;  3KB9 A;  1YYR A;  3P8L A;  3TC1 A;  3WCD A;  4XQT F;  2DH4 A;  1VG3 A;  3PDE A;  3WCG A;  1YHM A;  3LLW A;  3M00 A;  3G4D A;  4ZQ8 A;  2ONG A;  3WJN A;  4LFV F;  2AEK A;  3PYB A;  4K10 A;  3M9U A;  4LLT A;  4KVY A;  4KQS A;  2QIS A;  2F8Z F;  3AQC B;  3BNX A;  2Z7I A;  5ILD A;  1UBX A;  3V1X A;  1YV5 A;  3WEK A;  4H5C F;  4LFE A;  4XQR F;  4JYX A;  3Q2Z A;  5B00 A;  3WCL A;  1RQJ A;  5DGM F;  2ONH A;  4MC0 A;  5AHU B;  1N22 A;  3WJK A;  3RMG A;  4GA3 A;  2E8X A;  1HXC A;  3ZMB A;  3OAC A;  4KPJ A;  1HM4 A;  1YYQ A;  4H5D F;  2F9K F;  3N6K F;  5B0K A;  3DYG A;  4DHD A;  2PS8 A;  3RYW A;  3SDQ A;  3SDR A;  2AET A;  4OKZ A;  4KUX A;  2F89 F;  4LPH F;  5DJP F;  3CP6 A;  3ACX A;  3WCC A;  3ZMC A;  4JZB A;  1V4H A;  5JA0 F;  2Q58 A;  3CKE A;  3KRA A;  1HM7 A;  3V1V A;  3WC9 A;  5ER8 A;  3WCF A;  1EZF A;  2FTZ A;  4GP1 A;  3VJC A;  1UBW A;  3N3L F;  5EAT A;  2AEL A;  5IM1 A;  2ZCS A;  2E92 A;  5JUZ F;  4RXC A;  1UBV A;  1N1B A;  4GP2 A;  3KRA B;  3TFV A;  4EA0 A;  3DYF A;  5A0I A;  4JVJ F;  4EA1 A;  4KVW A;  4WK5 A;  2Q9Y A;  3WCE A;  4NFI F;  5EAS A;  3IBA A;  2ZY1 A;  3RBM A;  4E9Z A;  3MAV A;  2J1P A;  2AZJ A;  5DZ2 A;  1VG7 A;  3TS7 A;  2PS5 A;  3OAB A;  4N1Z F;  1HXG A;  1FPS A;  3EZ3 A;  4LTV A;  3G4F A;  3WCM A;  5ILK A;  2Z4V A;  2Z4Z A;  2PS6 A;  1V4K A;  3N49 F;  3SDU A;  3UCA A;  2F94 F;  1WY0 A;  3QQV A;  5DGS F;  3WEH A;  3OAB B;  4LIX A;  4P0X A;  2Z4X A;  3N0G A;  3NF2 A;  3VJB A;  2FOR A;  3LK5 A;  3Q2Q A;  3WSB A;  4Q23 A;  5ILH A;  2AZL A;  1YHL A;  3ICM A;  5DHI A;  1DGP A;  3LVS A;  3EGT A;  5HNA A;  5HN8 A;  5HN9 A;  3LGZ B;  2Q9Z A;  5IVG A;  3NRI A;  4NKE A;  3N5J F;  1N1Z A;  3SDV A;  1UBY A;  1V4I A;  3AE0 A;  2EWG A;  3KRP A;  4RNQ A;  3WEG A;  3EFQ A;  4N9U A;  5DJR F;  1YYS A;  1V4J A;  5I1U A;  3LGK A;  4LZ3 A;  5IKA A;  2Z52 A;  4LUU A;  5HN7 A;  1VG4 A;  4KVD A;  5ERM A;  2PS4 A;  3LMD A;  3V66 A;  4DXJ A;  3PH7 A;  5DIQ F;  3M0G A;  5DGN F;  4E9U A;  4RXE A;  3KRP B;  2E90 A;  4LLS A;  4JXY A;  2H8O A;  3SDT A;  4F6V A;  1JFG A;  2F8C F;  3APZ A;  2E8W A;  3WJO A;  4LFG A;  3KBK A;  3WEF A;  5JV2 F;  1PS1 A;  5B0L A;  1DI1 A;  2F92 F;  3LEE A;  1N21 A;  3AQ0 A;  1V4E A;  5IK9 A;  4LA6 A;  3QKC A;  2VF6 A;  3WCH A;  3WCI A;  4DZW A;  5IL3 A;  4KVI A;  5IKH A;  3M01 A;  3WCJ A;  3DYH A;  3NPR A;  3WCB A;  3S9V A;  5JV0 F;  2PS7 A;  4QPF A;  4FP4 A;  3P8R A;  1HXA A;  2O1O A;  2J1O A;  1N20 A;  1N24 A;  3N45 F;  1RQI A;  3ICK A;  3CC9 A;  1WL0 A;  3N1V F;  3WSA A;  5B01 A;  3P5R A;  3VJA A;  3ACY A;  3P41 A;  2ZEV A;  3KRO A;  4OMH A;  3BNY A;  3ASX A;  5B02 A;  4EA2 A;  1KIY A;  3ADZ A;  5CG6 A;  4GAX A;  4KWD A;  3RYE A;  4MC8 A;  3TFP A;  3IPI A;  4LPG F;  4F6X A;  3PYA A;  2ZCQ A;  2AZK A;  3KRO B;  4RXA A;  3VJD A;  1VG6 A;  3ACW A;  3B7L A;  1ZW5 A;  3LZ9 A;  4DEM F;  4UMJ A;  2E95 A;  1YYU A;  2F7M F;  2RAH A;  3Q30 A;  3LDW A;  3LJI A;  1YQ7 A;  2E91 A;  2OGD A;  5B0J A;  3KRC A;  3LOM A;  5CG5 A;  3N1W F;  4F62 A;  5C05 A;  1WL1 A;  5IL8 A;  4DWG A;  5IN8 A;  4NUA A;  5ILI A;  4OGU A;  3VJ8 A;  5IMN A;  4JXN A;  3PKO A;  3NPK A;  3S4J A; 
#chains in the Genus database with same CATH homology
 4KQU A;  3ICN A;  4NFK F;  3KRC B;  3N5H F;  5ILZ A;  5ERO A;  2Z4Y A;  4DI5 A;  1JFA A;  3MZV A;  5A0J A;  1YHK A;  5E8K A;  2OPN A;  4FJQ A;  3TFN A;  3OYR A;  2Z78 A;  4RXD A;  4XQS F;  4P0W A;  5AYP A;  1KIZ A;  4LTZ A;  4OMG A;  4MC3 A;  4PVX F;  5A0K A;  3AQB B;  5H9D A;  5DHK A;  2Z7H A;  4KQ5 A;  5AFX A;  4NG6 A;  1WKZ A;  2E8V A;  4KFA A;  5B0M A;  3LG5 A;  3ZCD A;  3VJE A;  2P1C A;  4KK2 A;  1YJ4 A;  3ICZ A;  3ZOU A;  3SAE A;  4KPD A;  4OKM A;  2I19 A;  4PVY F;  5E8H A;  5DJV F;  4NFJ F;  1RTR A;  3WCA A;  1WL3 A;  3WEJ A;  3WE9 A;  2ZEU A;  4LOB A;  4L2X F;  1VG2 A;  3OAC B;  3LSN A;  1WMW A;  5B0I A;  5ILY A;  1HX9 A;  3ZL6 A;  5AEL A;  4KKM A;  4LZ0 A;  2Z50 A;  2E8U A;  3Q1O A;  2E94 A;  3N46 F;  4E1E A;  3WEI A;  5ILJ A;  3N0F A;  4HD1 A;  5IMP A;  1WL2 A;  5JV1 F;  4P0V A;  3M02 A;  3KRF A;  1YYT A;  2E4O A;  2E8T A;  5DW7 A;  2ZCO A;  5IK6 A;  2OA6 A;  2J5C A;  4DWB A;  4LZC A;  3N3D A;  3VJ9 A;  2E93 A;  3P5P A;  5KSX F;  3ID0 A;  4RYP A;  2Z4W A;  5EAU A;  2ZCR A;  4H5E F;  5IK0 A;  5E8L A;  4JZX A;  5IMI A;  1N23 A;  2Q80 A;  5ERN A;  4LA5 A;  4QXS F;  5B03 A;  2OPM A;  3KRF B;  4LXW A;  4NKF A;  3W7F A;  3KB9 A;  1YYR A;  3P8L A;  3TC1 A;  3WCD A;  4XQT F;  2DH4 A;  1VG3 A;  3PDE A;  3WCG A;  1YHM A;  3LLW A;  3M00 A;  3G4D A;  4ZQ8 A;  2ONG A;  3WJN A;  4LFV F;  2AEK A;  3PYB A;  4K10 A;  3M9U A;  4LLT A;  4KVY A;  4KQS A;  2QIS A;  2F8Z F;  3AQC B;  3BNX A;  2Z7I A;  5ILD A;  1UBX A;  3V1X A;  1YV5 A;  3WEK A;  4H5C F;  4LFE A;  4XQR F;  4JYX A;  3Q2Z A;  5B00 A;  3WCL A;  1RQJ A;  5DGM F;  2ONH A;  4MC0 A;  5AHU B;  1N22 A;  3WJK A;  3RMG A;  4GA3 A;  2E8X A;  1HXC A;  3ZMB A;  3OAC A;  4KPJ A;  1HM4 A;  1YYQ A;  4H5D F;  2F9K F;  3N6K F;  5B0K A;  3DYG A;  4DHD A;  2PS8 A;  3RYW A;  3SDQ A;  3SDR A;  2AET A;  4OKZ A;  4KUX A;  2F89 F;  4LPH F;  5DJP F;  3CP6 A;  3ACX A;  3WCC A;  3ZMC A;  4JZB A;  1V4H A;  5JA0 F;  2Q58 A;  3CKE A;  3KRA A;  1HM7 A;  3V1V A;  3WC9 A;  5ER8 A;  3WCF A;  1EZF A;  2FTZ A;  4GP1 A;  3VJC A;  1UBW A;  3N3L F;  5EAT A;  2AEL A;  5IM1 A;  2ZCS A;  2E92 A;  5JUZ F;  4RXC A;  1UBV A;  1N1B A;  4GP2 A;  3KRA B;  3TFV A;  4EA0 A;  3DYF A;  5A0I A;  4JVJ F;  4EA1 A;  4KVW A;  4WK5 A;  2Q9Y A;  3WCE A;  4NFI F;  5EAS A;  3IBA A;  2ZY1 A;  3RBM A;  4E9Z A;  3MAV A;  2J1P A;  2AZJ A;  5DZ2 A;  1VG7 A;  3TS7 A;  2PS5 A;  3OAB A;  4N1Z F;  1HXG A;  1FPS A;  3EZ3 A;  4LTV A;  3G4F A;  3WCM A;  5ILK A;  2Z4V A;  2Z4Z A;  2PS6 A;  1V4K A;  3N49 F;  3SDU A;  3UCA A;  2F94 F;  1WY0 A;  3QQV A;  5DGS F;  3WEH A;  3OAB B;  4LIX A;  4P0X A;  2Z4X A;  3N0G A;  3NF2 A;  3VJB A;  2FOR A;  3LK5 A;  3Q2Q A;  3WSB A;  4Q23 A;  5ILH A;  2AZL A;  1YHL A;  3ICM A;  5DHI A;  1DGP A;  3LVS A;  3EGT A;  5HNA A;  5HN8 A;  5HN9 A;  3LGZ B;  2Q9Z A;  5IVG A;  3NRI A;  4NKE A;  3N5J F;  1N1Z A;  3SDV A;  1UBY A;  1V4I A;  3AE0 A;  2EWG A;  3KRP A;  4RNQ A;  3WEG A;  3EFQ A;  4N9U A;  5DJR F;  1YYS A;  1V4J A;  5I1U A;  3LGK A;  4LZ3 A;  5IKA A;  2Z52 A;  4LUU A;  5HN7 A;  1VG4 A;  4KVD A;  5ERM A;  2PS4 A;  3LMD A;  3V66 A;  4DXJ A;  3PH7 A;  5DIQ F;  3M0G A;  5DGN F;  4E9U A;  4RXE A;  3KRP B;  2E90 A;  4LLS A;  4JXY A;  2H8O A;  3SDT A;  4F6V A;  1JFG A;  2F8C F;  3APZ A;  2E8W A;  3WJO A;  4LFG A;  3KBK A;  3WEF A;  5JV2 F;  1PS1 A;  5B0L A;  1DI1 A;  2F92 F;  3LEE A;  1N21 A;  3AQ0 A;  1V4E A;  5IK9 A;  4LA6 A;  3QKC A;  2VF6 A;  3WCH A;  3WCI A;  4DZW A;  5IL3 A;  4KVI A;  5IKH A;  3M01 A;  3WCJ A;  3DYH A;  3NPR A;  3WCB A;  3S9V A;  5JV0 F;  2PS7 A;  4QPF A;  4FP4 A;  3P8R A;  1HXA A;  2O1O A;  2J1O A;  1N20 A;  1N24 A;  3N45 F;  1RQI A;  3ICK A;  3CC9 A;  1WL0 A;  3N1V F;  3WSA A;  5B01 A;  3P5R A;  3VJA A;  3ACY A;  3P41 A;  2ZEV A;  3KRO A;  4OMH A;  3BNY A;  3ASX A;  5B02 A;  4EA2 A;  1KIY A;  3ADZ A;  5CG6 A;  4GAX A;  4KWD A;  3RYE A;  4MC8 A;  3TFP A;  3IPI A;  4LPG F;  4F6X A;  3PYA A;  2ZCQ A;  2AZK A;  3KRO B;  4RXA A;  3VJD A;  1VG6 A;  3ACW A;  3B7L A;  1ZW5 A;  3LZ9 A;  4DEM F;  4UMJ A;  2E95 A;  1YYU A;  2F7M F;  2RAH A;  3Q30 A;  3LDW A;  3LJI A;  1YQ7 A;  2E91 A;  2OGD A;  5B0J A;  3KRC A;  3LOM A;  5CG5 A;  3N1W F;  4F62 A;  5C05 A;  1WL1 A;  5IL8 A;  4DWG A;  5IN8 A;  4NUA A;  5ILI A;  4OGU A;  3VJ8 A;  5IMN A;  4JXN A;  3PKO A;  3NPK A;  3S4J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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