4NKFA

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 129
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
343
structure length
339
Chain Sequence
b'DVYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
molecule keywords Farnesyl pyrophosphate synthase
source organism Homo sapiens
molecule tags Transferase
total genus 129
structure length 339
sequence length 343
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4nkfA00
4JZXA 3ICKA 5IM1A 3LDWA 4QPFA 4DEMF 1JFAA 3VJ9A 5DIQF 1FPSA 2E8XA 1HXCA 1KIYA 4KFAA 2F8ZF 1UBYA 1RQJA 3WCJA 1YYUA 1N24A 3WJOA 3Q30A 3V1VA 2E94A 3Q1OA 5EATA 5IMPA 3APZA 3KRFB 5CG5A 4LFEA 3G4FA 3CP6A 4NUAA 3NF2A 4LFGA 1ZW5A 4NKEA 3NRIA 3VJ8A 5I1UA 2Q80A 4OGUA 5DZ2A 3TFNA 2DH4A 1EZFA 3PYBA 2VF6A 4LIXA 2J1OA 3M01A 4NFIF 4WK5A 5ILZA 3ACWA 1VG6A 3LMDA 5IVGA 1VG2A 5IKHA 3B7LA 1YYRA 3QQVA 3SAEA 3TFPA 2E8VA 2Z4VA 4LZCA 5IK6A 1WMWA 1RTRA 1JFGA 3N1WF 3ZL6A 5IMNA 2E8UA 2RAHA 3WSAA 3RYWA 1HM4A 2EWGA 3ZOUA 4E9UA 3CKEA 5AYPA 3V66A 1YJ4A 3QKCA 4OKMA 1DGPA 3LLWA 4LFVF 2P1CA 3DYFA 3RYEA 3S9VA 1V4IA 2Z78A 4KK2A 3WJNA 2Q9YA 4K10A 5IL3A 4LPGF 2PS5A 5ILYA 4NFKF 4RXAA 2AEKA 2E8TA 1YQ7A 1UBVA 3LGZB 4KVDA 3KROB 2ZCQA 4KQSA 3OABB 5DJVF 2OPNA 1N23A 4EA1A 5DJPF 3TFVA 2Z7IA 1V4JA 2E91A 1V4HA 2Z4YA 4RYPA 3ADZA 5EROA 3BNYA 4NKFA 3SDRA 3WEJA 3WCBA 4OMGA 4F6VA 2E8WA 5B00A 3KRPB 3WE9A 1VG4A 2F89F 5DJRF 4KPDA 5ILDA 3MAVA 4ZQ8A 3N5JF 3WEKA 3WCHA 3N0GA 3Q2QA 4KPJA 2PS7A 5H9DA 3PDEA 3KRFA 4LXWA 3ZMBA 1YV5A 4RXDA 4JVJF 3VJAA 4EA0A 2Z4ZA 3ASXA 3AQBB 3WC9A 1YYTA 2ZEVA 3SDVA 4GP1A 2E93A 3EZ3A 3EFQA 5DGNF 3IBAA 3WCAA 4DZWA 1HM7A 3KBKA 4OKZA 2E90A 3N45F 5B0JA 3P5PA 4XQTF 4KVWA 4RXCA 5DHIA 2Q58A 4FJQA 4KKMA 5B0IA 5EAUA 4OMHA 2ZCRA 4KUXA 3WEFA 5E8HA 4KQ5A 4LA5A 3LSNA 3VJDA 3OACB 1UBXA 3N1VF 3LJIA 3P8LA 5DGMF 4P0WA 5JA0F 3WSBA 3V1XA 2F8CF 4LOBA 1YHMA 1N21A 3N49F 4LZ0A 2ZY1A 3SDUA 4FP4A 5B0LA 3EGTA 3TS7A 1YHLA 3M02A 2Z50A 5ILKA 3KRAA 5HN8A 5ERMA 3M00A 4KVIA 2Z7HA 2I19A 3KROA 4N9UA 3P8RA 2E95A 3OABA 5JUZF 4LZ3A 4HD1A 3ZMCA 5B01A 4P0VA 1HX9A 3LZ9A 4H5CF 4KVYA 3KRCB 2AZJA 2E4OA 3CC9A 4PVXF 2FORA 1KIZA 3OYRA 2ONHA 3ICNA 3N46F 2J1PA 3KRPA 3WCCA 5IL8A 5DGSF 4JXNA 1N22A 2OPMA 1VG3A 3ACXA 1WL0A 4H5DF 3WCMA 3N5HF 3WCFA 5IMIA 2Z4XA 2AZKA 4UMJA 3LG5A 1N20A 2O1OA 2OGDA 4E1EA 5JV0F 5IK0A 4RNQA 5A0JA 4XQRF 1UBWA 4GAXA 3W7FA 2Z4WA 4XQSF 3LEEA 2OA6A 2ZCOA 4LTZA 1N1BA 2F9KF 4QXSF 4GP2A 3P41A 1YYSA 5AELA 3M0GA 3S4JA 1HXGA 3Q2ZA 4LTVA 5ILHA 4KWDA 1WKZA 3SDQA 4DWBA 5B03A 2F92F 3IPIA 3WCLA 5HNAA 3N0FA 4NG6A 3WCEA 2AELA 4P0XA 3SDTA 3OACA 4MC3A 1PS1A 2PS4A 3P5RA 4LA6A 1HXAA 4JZBA 3ACYA 3KB9A 4MC0A 5AFXA 3WEHA 4DI5A 3M9UA 3RMGA 4KQUA 1WL3A 4DWGA 3N3LF 3BNXA 5EASA 5B02A 3VJEA 3N3DA 4LLSA 3ICMA 3LOMA 3MZVA 4MC8A 3RBMA 5JV2F 5DW7A 1V4KA 5DHKA 4JYXA 5E8KA 5B0KA 1WL1A 3ID0A 2PS6A 1VG7A 3AQ0A 5AHUB 4JXYA 5ER8A 3NPRA 5C05A 3UCAA 5IN8A 5E8LA 2Z52A 1WY0A 3AE0A 1V4EA 2F94F 3ICZA 3WEIA 3KRCA 2J5CA 4LUUA 3TC1A 4DHDA 2E92A 4PVYF 3PH7A 1RQIA 4N1ZF 5HN7A 3WJKA 4F62A 2AETA 2F7MF 3NPKA 4F6XA 1YHKA 5IKAA 3LVSA 3WCGA 5A0IA 3LK5A 3VJBA 5ERNA 2ZEUA 2H8OA 5ILJA 3DYHA 3LGKA 2ONGA 4E9ZA 4NFJF 3VJCA 5A0KA 5CG6A 1WL2A 2FTZA 5KSXF 3G4DA 4GA3A 4Q23A 3PKOA 3N6KF 3WCDA 5ILIA 3WEGA 2ZCSA 3KRAB 5HN9A 2AZLA 3WCIA 5B0MA 5JV1F 4EA2A 4LLTA 3AQCB 2Q9ZA 1DI1A 2QISA 1N1ZA 5IK9A 4L2XF 2PS8A 3PYAA 1YYQA 4RXEA 3ZCDA 4LPHF 3DYGA 4H5EF 4DXJA
chains in the Genus database with same CATH superfamily
4JZXA 3ICKA 5IM1A 3LDWA 4QPFA 4DEMF 1JFAA 3VJ9A 5DIQF 1FPSA 2E8XA 1HXCA 1KIYA 4KFAA 2F8ZF 1UBYA 1RQJA 3WCJA 1YYUA 1N24A 3WJOA 3Q30A 3V1VA 2E94A 3Q1OA 5EATA 5IMPA 3APZA 3KRFB 5CG5A 4LFEA 3G4FA 3CP6A 4NUAA 3NF2A 4LFGA 1ZW5A 4NKEA 3NRIA 3VJ8A 5I1UA 2Q80A 4OGUA 5DZ2A 3TFNA 2DH4A 1EZFA 3PYBA 2VF6A 4LIXA 2J1OA 3M01A 4NFIF 4WK5A 5ILZA 3ACWA 1VG6A 3LMDA 5IVGA 1VG2A 5IKHA 3B7LA 1YYRA 3QQVA 3SAEA 3TFPA 2E8VA 2Z4VA 4LZCA 5IK6A 1WMWA 1RTRA 1JFGA 3N1WF 3ZL6A 5IMNA 2E8UA 2RAHA 3WSAA 3RYWA 1HM4A 2EWGA 3ZOUA 4E9UA 3CKEA 5AYPA 3V66A 1YJ4A 3QKCA 4OKMA 1DGPA 3LLWA 4LFVF 2P1CA 3DYFA 3RYEA 3S9VA 1V4IA 2Z78A 4KK2A 3WJNA 2Q9YA 4K10A 5IL3A 4LPGF 2PS5A 5ILYA 4NFKF 4RXAA 2AEKA 2E8TA 1YQ7A 1UBVA 3LGZB 4KVDA 3KROB 2ZCQA 4KQSA 3OABB 5DJVF 2OPNA 1N23A 4EA1A 5DJPF 3TFVA 2Z7IA 1V4JA 2E91A 1V4HA 2Z4YA 4RYPA 3ADZA 5EROA 3BNYA 4NKFA 3SDRA 3WEJA 3WCBA 4OMGA 4F6VA 2E8WA 5B00A 3KRPB 3WE9A 1VG4A 2F89F 5DJRF 4KPDA 5ILDA 3MAVA 4ZQ8A 3N5JF 3WEKA 3WCHA 3N0GA 3Q2QA 4KPJA 2PS7A 5H9DA 3PDEA 3KRFA 4LXWA 3ZMBA 1YV5A 4RXDA 4JVJF 3VJAA 4EA0A 2Z4ZA 3ASXA 3AQBB 3WC9A 1YYTA 2ZEVA 3SDVA 4GP1A 2E93A 3EZ3A 3EFQA 5DGNF 3IBAA 3WCAA 4DZWA 1HM7A 3KBKA 4OKZA 2E90A 3N45F 5B0JA 3P5PA 4XQTF 4KVWA 4RXCA 5DHIA 2Q58A 4FJQA 4KKMA 5B0IA 5EAUA 4OMHA 2ZCRA 4KUXA 3WEFA 5E8HA 4KQ5A 4LA5A 3LSNA 3VJDA 3OACB 1UBXA 3N1VF 3LJIA 3P8LA 5DGMF 4P0WA 5JA0F 3WSBA 3V1XA 2F8CF 4LOBA 1YHMA 1N21A 3N49F 4LZ0A 2ZY1A 3SDUA 4FP4A 5B0LA 3EGTA 3TS7A 1YHLA 3M02A 2Z50A 5ILKA 3KRAA 5HN8A 5ERMA 3M00A 4KVIA 2Z7HA 2I19A 3KROA 4N9UA 3P8RA 2E95A 3OABA 5JUZF 4LZ3A 4HD1A 3ZMCA 5B01A 4P0VA 1HX9A 3LZ9A 4H5CF 4KVYA 3KRCB 2AZJA 2E4OA 3CC9A 4PVXF 2FORA 1KIZA 3OYRA 2ONHA 3ICNA 3N46F 2J1PA 3KRPA 3WCCA 5IL8A 5DGSF 4JXNA 1N22A 2OPMA 1VG3A 3ACXA 1WL0A 4H5DF 3WCMA 3N5HF 3WCFA 5IMIA 2Z4XA 2AZKA 4UMJA 3LG5A 1N20A 2O1OA 2OGDA 4E1EA 5JV0F 5IK0A 4RNQA 5A0JA 4XQRF 1UBWA 4GAXA 3W7FA 2Z4WA 4XQSF 3LEEA 2OA6A 2ZCOA 4LTZA 1N1BA 2F9KF 4QXSF 4GP2A 3P41A 1YYSA 5AELA 3M0GA 3S4JA 1HXGA 3Q2ZA 4LTVA 5ILHA 4KWDA 1WKZA 3SDQA 4DWBA 5B03A 2F92F 3IPIA 3WCLA 5HNAA 3N0FA 4NG6A 3WCEA 2AELA 4P0XA 3SDTA 3OACA 4MC3A 1PS1A 2PS4A 3P5RA 4LA6A 1HXAA 4JZBA 3ACYA 3KB9A 4MC0A 5AFXA 3WEHA 4DI5A 3M9UA 3RMGA 4KQUA 1WL3A 4DWGA 3N3LF 3BNXA 5EASA 5B02A 3VJEA 3N3DA 4LLSA 3ICMA 3LOMA 3MZVA 4MC8A 3RBMA 5JV2F 5DW7A 1V4KA 5DHKA 4JYXA 5E8KA 5B0KA 1WL1A 3ID0A 2PS6A 1VG7A 3AQ0A 5AHUB 4JXYA 5ER8A 3NPRA 5C05A 3UCAA 5IN8A 5E8LA 2Z52A 1WY0A 3AE0A 1V4EA 2F94F 3ICZA 3WEIA 3KRCA 2J5CA 4LUUA 3TC1A 4DHDA 2E92A 4PVYF 3PH7A 1RQIA 4N1ZF 5HN7A 3WJKA 4F62A 2AETA 2F7MF 3NPKA 4F6XA 1YHKA 5IKAA 3LVSA 3WCGA 5A0IA 3LK5A 3VJBA 5ERNA 2ZEUA 2H8OA 5ILJA 3DYHA 3LGKA 2ONGA 4E9ZA 4NFJF 3VJCA 5A0KA 5CG6A 1WL2A 2FTZA 5KSXF 3G4DA 4GA3A 4Q23A 3PKOA 3N6KF 3WCDA 5ILIA 3WEGA 2ZCSA 3KRAB 5HN9A 2AZLA 3WCIA 5B0MA 5JV1F 4EA2A 4LLTA 3AQCB 2Q9ZA 1DI1A 2QISA 1N1ZA 5IK9A 4L2XF 2PS8A 3PYAA 1YYQA 4RXEA 3ZCDA 4LPHF 3DYGA 4H5EF 4DXJA
chains in the Genus database with same CATH topology
4JZXA 3ICKA 5IM1A 3LDWA 4QPFA 4DEMF 1JFAA 3VJ9A 5DIQF 1FPSA 2E8XA 1HXCA 1KIYA 4KFAA 2F8ZF 1UBYA 1RQJA 3WCJA 1YYUA 1N24A 3WJOA 3Q30A 3V1VA 2E94A 3Q1OA 5EATA 5IMPA 3APZA 3KRFB 5CG5A 4LFEA 3G4FA 3CP6A 4NUAA 3NF2A 4LFGA 1ZW5A 4NKEA 3NRIA 3VJ8A 5I1UA 2Q80A 4OGUA 5DZ2A 3TFNA 2DH4A 1EZFA 3PYBA 2VF6A 4LIXA 2J1OA 3M01A 4NFIF 4WK5A 5ILZA 3ACWA 1VG6A 3LMDA 5IVGA 1VG2A 5IKHA 3B7LA 1YYRA 3QQVA 3SAEA 3TFPA 2E8VA 2Z4VA 4LZCA 5IK6A 1WMWA 1RTRA 1JFGA 3N1WF 3ZL6A 5IMNA 2E8UA 2RAHA 3WSAA 3RYWA 1HM4A 2EWGA 3ZOUA 4E9UA 3CKEA 5AYPA 3V66A 1YJ4A 3QKCA 4OKMA 1DGPA 3LLWA 4LFVF 2P1CA 3DYFA 3RYEA 3S9VA 1V4IA 2Z78A 4KK2A 3WJNA 2Q9YA 4K10A 5IL3A 4LPGF 2PS5A 5ILYA 4NFKF 4RXAA 2AEKA 2E8TA 1YQ7A 1UBVA 3LGZB 4KVDA 3KROB 2ZCQA 4KQSA 3OABB 5DJVF 2OPNA 1N23A 4EA1A 5DJPF 3TFVA 2Z7IA 1V4JA 2E91A 1V4HA 2Z4YA 4RYPA 3ADZA 5EROA 3BNYA 4NKFA 3SDRA 3WEJA 3WCBA 4OMGA 4F6VA 2E8WA 5B00A 3KRPB 3WE9A 1VG4A 2F89F 5DJRF 4KPDA 5ILDA 3MAVA 4ZQ8A 3N5JF 3WEKA 3WCHA 3N0GA 3Q2QA 4KPJA 2PS7A 5H9DA 3PDEA 3KRFA 4LXWA 3ZMBA 1YV5A 4RXDA 4JVJF 3VJAA 4EA0A 2Z4ZA 3ASXA 3AQBB 3WC9A 1YYTA 2ZEVA 3SDVA 4GP1A 2E93A 3EZ3A 3EFQA 5DGNF 3IBAA 3WCAA 4DZWA 1HM7A 3KBKA 4OKZA 2E90A 3N45F 5B0JA 3P5PA 4XQTF 4KVWA 4RXCA 5DHIA 2Q58A 4FJQA 4KKMA 5B0IA 5EAUA 4OMHA 2ZCRA 4KUXA 3WEFA 5E8HA 4KQ5A 4LA5A 3LSNA 3VJDA 3OACB 1UBXA 3N1VF 3LJIA 3P8LA 5DGMF 4P0WA 5JA0F 3WSBA 3V1XA 2F8CF 4LOBA 1YHMA 1N21A 3N49F 4LZ0A 2ZY1A 3SDUA 4FP4A 5B0LA 3EGTA 3TS7A 1YHLA 3M02A 2Z50A 5ILKA 3KRAA 5HN8A 5ERMA 3M00A 4KVIA 2Z7HA 2I19A 3KROA 4N9UA 3P8RA 2E95A 3OABA 5JUZF 4LZ3A 4HD1A 3ZMCA 5B01A 4P0VA 1HX9A 3LZ9A 4H5CF 4KVYA 3KRCB 2AZJA 2E4OA 3CC9A 4PVXF 2FORA 1KIZA 3OYRA 2ONHA 3ICNA 3N46F 2J1PA 3KRPA 3WCCA 5IL8A 5DGSF 4JXNA 1N22A 2OPMA 1VG3A 3ACXA 1WL0A 4H5DF 3WCMA 3N5HF 3WCFA 5IMIA 2Z4XA 2AZKA 4UMJA 3LG5A 1N20A 2O1OA 2OGDA 4E1EA 5JV0F 5IK0A 4RNQA 5A0JA 4XQRF 1UBWA 4GAXA 3W7FA 2Z4WA 4XQSF 3LEEA 2OA6A 2ZCOA 4LTZA 1N1BA 2F9KF 4QXSF 4GP2A 3P41A 1YYSA 5AELA 3M0GA 3S4JA 1HXGA 3Q2ZA 4LTVA 5ILHA 4KWDA 1WKZA 3SDQA 4DWBA 5B03A 2F92F 3IPIA 3WCLA 5HNAA 3N0FA 4NG6A 3WCEA 2AELA 4P0XA 3SDTA 3OACA 4MC3A 1PS1A 2PS4A 3P5RA 4LA6A 1HXAA 4JZBA 3ACYA 3KB9A 4MC0A 5AFXA 3WEHA 4DI5A 3M9UA 3RMGA 4KQUA 1WL3A 4DWGA 3N3LF 3BNXA 5EASA 5B02A 3VJEA 3N3DA 4LLSA 3ICMA 3LOMA 3MZVA 4MC8A 3RBMA 5JV2F 5DW7A 1V4KA 5DHKA 4JYXA 5E8KA 5B0KA 1WL1A 3ID0A 2PS6A 1VG7A 3AQ0A 5AHUB 4JXYA 5ER8A 3NPRA 5C05A 3UCAA 5IN8A 5E8LA 2Z52A 1WY0A 3AE0A 1V4EA 2F94F 3ICZA 3WEIA 3KRCA 2J5CA 4LUUA 3TC1A 4DHDA 2E92A 4PVYF 3PH7A 1RQIA 4N1ZF 5HN7A 3WJKA 4F62A 2AETA 2F7MF 3NPKA 4F6XA 1YHKA 5IKAA 3LVSA 3WCGA 5A0IA 3LK5A 3VJBA 5ERNA 2ZEUA 2H8OA 5ILJA 3DYHA 3LGKA 2ONGA 4E9ZA 4NFJF 3VJCA 5A0KA 5CG6A 1WL2A 2FTZA 5KSXF 3G4DA 4GA3A 4Q23A 3PKOA 3N6KF 3WCDA 5ILIA 3WEGA 2ZCSA 3KRAB 5HN9A 2AZLA 3WCIA 5B0MA 5JV1F 4EA2A 4LLTA 3AQCB 2Q9ZA 1DI1A 2QISA 1N1ZA 5IK9A 4L2XF 2PS8A 3PYAA 1YYQA 4RXEA 3ZCDA 4LPHF 3DYGA 4H5EF 4DXJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JZX A;  3ICK A;  5IM1 A;  3LDW A;  4QPF A;  4DEM F;  1JFA A;  3VJ9 A;  5DIQ F;  1FPS A;  2E8X A;  1HXC A;  1KIY A;  4KFA A;  2F8Z F;  1UBY A;  1RQJ A;  3WCJ A;  1YYU A;  1N24 A;  3WJO A;  3Q30 A;  3V1V A;  2E94 A;  3Q1O A;  5EAT A;  5IMP A;  3APZ A;  3KRF B;  5CG5 A;  4LFE A;  3G4F A;  3CP6 A;  4NUA A;  3NF2 A;  4LFG A;  1ZW5 A;  4NKE A;  3NRI A;  3VJ8 A;  5I1U A;  2Q80 A;  4OGU A;  5DZ2 A;  3TFN A;  2DH4 A;  1EZF A;  3PYB A;  2VF6 A;  4LIX A;  2J1O A;  3M01 A;  4NFI F;  4WK5 A;  5ILZ A;  3ACW A;  1VG6 A;  3LMD A;  5IVG A;  1VG2 A;  5IKH A;  3B7L A;  1YYR A;  3QQV A;  3SAE A;  3TFP A;  2E8V A;  2Z4V A;  4LZC A;  5IK6 A;  1WMW A;  1RTR A;  1JFG A;  3N1W F;  3ZL6 A;  5IMN A;  2E8U A;  2RAH A;  3WSA A;  3RYW A;  1HM4 A;  2EWG A;  3ZOU A;  4E9U A;  3CKE A;  5AYP A;  3V66 A;  1YJ4 A;  3QKC A;  4OKM A;  1DGP A;  3LLW A;  4LFV F;  2P1C A;  3DYF A;  3RYE A;  3S9V A;  1V4I A;  2Z78 A;  4KK2 A;  3WJN A;  2Q9Y A;  4K10 A;  5IL3 A;  4LPG F;  2PS5 A;  5ILY A;  4NFK F;  4RXA A;  2AEK A;  2E8T A;  1YQ7 A;  1UBV A;  3LGZ B;  4KVD A;  3KRO B;  2ZCQ A;  4KQS A;  3OAB B;  5DJV F;  2OPN A;  1N23 A;  4EA1 A;  5DJP F;  3TFV A;  2Z7I A;  1V4J A;  2E91 A;  1V4H A;  2Z4Y A;  4RYP A;  3ADZ A;  5ERO A;  3BNY A;  4NKF A;  3SDR A;  3WEJ A;  3WCB A;  4OMG A;  4F6V A;  2E8W A;  5B00 A;  3KRP B;  3WE9 A;  1VG4 A;  2F89 F;  5DJR F;  4KPD A;  5ILD A;  3MAV A;  4ZQ8 A;  3N5J F;  3WEK A;  3WCH A;  3N0G A;  3Q2Q A;  4KPJ A;  2PS7 A;  5H9D A;  3PDE A;  3KRF A;  4LXW A;  3ZMB A;  1YV5 A;  4RXD A;  4JVJ F;  3VJA A;  4EA0 A;  2Z4Z A;  3ASX A;  3AQB B;  3WC9 A;  1YYT A;  2ZEV A;  3SDV A;  4GP1 A;  2E93 A;  3EZ3 A;  3EFQ A;  5DGN F;  3IBA A;  3WCA A;  4DZW A;  1HM7 A;  3KBK A;  4OKZ A;  2E90 A;  3N45 F;  5B0J A;  3P5P A;  4XQT F;  4KVW A;  4RXC A;  5DHI A;  2Q58 A;  4FJQ A;  4KKM A;  5B0I A;  5EAU A;  4OMH A;  2ZCR A;  4KUX A;  3WEF A;  5E8H A;  4KQ5 A;  4LA5 A;  3LSN A;  3VJD A;  3OAC B;  1UBX A;  3N1V F;  3LJI A;  3P8L A;  5DGM F;  4P0W A;  5JA0 F;  3WSB A;  3V1X A;  2F8C F;  4LOB A;  1YHM A;  1N21 A;  3N49 F;  4LZ0 A;  2ZY1 A;  3SDU A;  4FP4 A;  5B0L A;  3EGT A;  3TS7 A;  1YHL A;  3M02 A;  2Z50 A;  5ILK A;  3KRA A;  5HN8 A;  5ERM A;  3M00 A;  4KVI A;  2Z7H A;  2I19 A;  3KRO A;  4N9U A;  3P8R A;  2E95 A;  3OAB A;  5JUZ F;  4LZ3 A;  4HD1 A;  3ZMC A;  5B01 A;  4P0V A;  1HX9 A;  3LZ9 A;  4H5C F;  4KVY A;  3KRC B;  2AZJ A;  2E4O A;  3CC9 A;  4PVX F;  2FOR A;  1KIZ A;  3OYR A;  2ONH A;  3ICN A;  3N46 F;  2J1P A;  3KRP A;  3WCC A;  5IL8 A;  5DGS F;  4JXN A;  1N22 A;  2OPM A;  1VG3 A;  3ACX A;  1WL0 A;  4H5D F;  3WCM A;  3N5H F;  3WCF A;  5IMI A;  2Z4X A;  2AZK A;  4UMJ A;  3LG5 A;  1N20 A;  2O1O A;  2OGD A;  4E1E A;  5JV0 F;  5IK0 A;  4RNQ A;  5A0J A;  4XQR F;  1UBW A;  4GAX A;  3W7F A;  2Z4W A;  4XQS F;  3LEE A;  2OA6 A;  2ZCO A;  4LTZ A;  1N1B A;  2F9K F;  4QXS F;  4GP2 A;  3P41 A;  1YYS A;  5AEL A;  3M0G A;  3S4J A;  1HXG A;  3Q2Z A;  4LTV A;  5ILH A;  4KWD A;  1WKZ A;  3SDQ A;  4DWB A;  5B03 A;  2F92 F;  3IPI A;  3WCL A;  5HNA A;  3N0F A;  4NG6 A;  3WCE A;  2AEL A;  4P0X A;  3SDT A;  3OAC A;  4MC3 A;  1PS1 A;  2PS4 A;  3P5R A;  4LA6 A;  1HXA A;  4JZB A;  3ACY A;  3KB9 A;  4MC0 A;  5AFX A;  3WEH A;  4DI5 A;  3M9U A;  3RMG A;  4KQU A;  1WL3 A;  4DWG A;  3N3L F;  3BNX A;  5EAS A;  5B02 A;  3VJE A;  3N3D A;  4LLS A;  3ICM A;  3LOM A;  3MZV A;  4MC8 A;  3RBM A;  5JV2 F;  5DW7 A;  1V4K A;  5DHK A;  4JYX A;  5E8K A;  5B0K A;  1WL1 A;  3ID0 A;  2PS6 A;  1VG7 A;  3AQ0 A;  5AHU B;  4JXY A;  5ER8 A;  3NPR A;  5C05 A;  3UCA A;  5IN8 A;  5E8L A;  2Z52 A;  1WY0 A;  3AE0 A;  1V4E A;  2F94 F;  3ICZ A;  3WEI A;  3KRC A;  2J5C A;  4LUU A;  3TC1 A;  4DHD A;  2E92 A;  4PVY F;  3PH7 A;  1RQI A;  4N1Z F;  5HN7 A;  3WJK A;  4F62 A;  2AET A;  2F7M F;  3NPK A;  4F6X A;  1YHK A;  5IKA A;  3LVS A;  3WCG A;  5A0I A;  3LK5 A;  3VJB A;  5ERN A;  2ZEU A;  2H8O A;  5ILJ A;  3DYH A;  3LGK A;  2ONG A;  4E9Z A;  4NFJ F;  3VJC A;  5A0K A;  5CG6 A;  1WL2 A;  2FTZ A;  5KSX F;  3G4D A;  4GA3 A;  4Q23 A;  3PKO A;  3N6K F;  3WCD A;  5ILI A;  3WEG A;  2ZCS A;  3KRA B;  5HN9 A;  2AZL A;  3WCI A;  5B0M A;  5JV1 F;  4EA2 A;  4LLT A;  3AQC B;  2Q9Z A;  1DI1 A;  2QIS A;  1N1Z A;  5IK9 A;  4L2X F;  2PS8 A;  3PYA A;  1YYQ A;  4RXE A;  3ZCD A;  4LPH F;  3DYG A;  4H5E F;  4DXJ A; 
#chains in the Genus database with same CATH topology
 4JZX A;  3ICK A;  5IM1 A;  3LDW A;  4QPF A;  4DEM F;  1JFA A;  3VJ9 A;  5DIQ F;  1FPS A;  2E8X A;  1HXC A;  1KIY A;  4KFA A;  2F8Z F;  1UBY A;  1RQJ A;  3WCJ A;  1YYU A;  1N24 A;  3WJO A;  3Q30 A;  3V1V A;  2E94 A;  3Q1O A;  5EAT A;  5IMP A;  3APZ A;  3KRF B;  5CG5 A;  4LFE A;  3G4F A;  3CP6 A;  4NUA A;  3NF2 A;  4LFG A;  1ZW5 A;  4NKE A;  3NRI A;  3VJ8 A;  5I1U A;  2Q80 A;  4OGU A;  5DZ2 A;  3TFN A;  2DH4 A;  1EZF A;  3PYB A;  2VF6 A;  4LIX A;  2J1O A;  3M01 A;  4NFI F;  4WK5 A;  5ILZ A;  3ACW A;  1VG6 A;  3LMD A;  5IVG A;  1VG2 A;  5IKH A;  3B7L A;  1YYR A;  3QQV A;  3SAE A;  3TFP A;  2E8V A;  2Z4V A;  4LZC A;  5IK6 A;  1WMW A;  1RTR A;  1JFG A;  3N1W F;  3ZL6 A;  5IMN A;  2E8U A;  2RAH A;  3WSA A;  3RYW A;  1HM4 A;  2EWG A;  3ZOU A;  4E9U A;  3CKE A;  5AYP A;  3V66 A;  1YJ4 A;  3QKC A;  4OKM A;  1DGP A;  3LLW A;  4LFV F;  2P1C A;  3DYF A;  3RYE A;  3S9V A;  1V4I A;  2Z78 A;  4KK2 A;  3WJN A;  2Q9Y A;  4K10 A;  5IL3 A;  4LPG F;  2PS5 A;  5ILY A;  4NFK F;  4RXA A;  2AEK A;  2E8T A;  1YQ7 A;  1UBV A;  3LGZ B;  4KVD A;  3KRO B;  2ZCQ A;  4KQS A;  3OAB B;  5DJV F;  2OPN A;  1N23 A;  4EA1 A;  5DJP F;  3TFV A;  2Z7I A;  1V4J A;  2E91 A;  1V4H A;  2Z4Y A;  4RYP A;  3ADZ A;  5ERO A;  3BNY A;  4NKF A;  3SDR A;  3WEJ A;  3WCB A;  4OMG A;  4F6V A;  2E8W A;  5B00 A;  3KRP B;  3WE9 A;  1VG4 A;  2F89 F;  5DJR F;  4KPD A;  5ILD A;  3MAV A;  4ZQ8 A;  3N5J F;  3WEK A;  3WCH A;  3N0G A;  3Q2Q A;  4KPJ A;  2PS7 A;  5H9D A;  3PDE A;  3KRF A;  4LXW A;  3ZMB A;  1YV5 A;  4RXD A;  4JVJ F;  3VJA A;  4EA0 A;  2Z4Z A;  3ASX A;  3AQB B;  3WC9 A;  1YYT A;  2ZEV A;  3SDV A;  4GP1 A;  2E93 A;  3EZ3 A;  3EFQ A;  5DGN F;  3IBA A;  3WCA A;  4DZW A;  1HM7 A;  3KBK A;  4OKZ A;  2E90 A;  3N45 F;  5B0J A;  3P5P A;  4XQT F;  4KVW A;  4RXC A;  5DHI A;  2Q58 A;  4FJQ A;  4KKM A;  5B0I A;  5EAU A;  4OMH A;  2ZCR A;  4KUX A;  3WEF A;  5E8H A;  4KQ5 A;  4LA5 A;  3LSN A;  3VJD A;  3OAC B;  1UBX A;  3N1V F;  3LJI A;  3P8L A;  5DGM F;  4P0W A;  5JA0 F;  3WSB A;  3V1X A;  2F8C F;  4LOB A;  1YHM A;  1N21 A;  3N49 F;  4LZ0 A;  2ZY1 A;  3SDU A;  4FP4 A;  5B0L A;  3EGT A;  3TS7 A;  1YHL A;  3M02 A;  2Z50 A;  5ILK A;  3KRA A;  5HN8 A;  5ERM A;  3M00 A;  4KVI A;  2Z7H A;  2I19 A;  3KRO A;  4N9U A;  3P8R A;  2E95 A;  3OAB A;  5JUZ F;  4LZ3 A;  4HD1 A;  3ZMC A;  5B01 A;  4P0V A;  1HX9 A;  3LZ9 A;  4H5C F;  4KVY A;  3KRC B;  2AZJ A;  2E4O A;  3CC9 A;  4PVX F;  2FOR A;  1KIZ A;  3OYR A;  2ONH A;  3ICN A;  3N46 F;  2J1P A;  3KRP A;  3WCC A;  5IL8 A;  5DGS F;  4JXN A;  1N22 A;  2OPM A;  1VG3 A;  3ACX A;  1WL0 A;  4H5D F;  3WCM A;  3N5H F;  3WCF A;  5IMI A;  2Z4X A;  2AZK A;  4UMJ A;  3LG5 A;  1N20 A;  2O1O A;  2OGD A;  4E1E A;  5JV0 F;  5IK0 A;  4RNQ A;  5A0J A;  4XQR F;  1UBW A;  4GAX A;  3W7F A;  2Z4W A;  4XQS F;  3LEE A;  2OA6 A;  2ZCO A;  4LTZ A;  1N1B A;  2F9K F;  4QXS F;  4GP2 A;  3P41 A;  1YYS A;  5AEL A;  3M0G A;  3S4J A;  1HXG A;  3Q2Z A;  4LTV A;  5ILH A;  4KWD A;  1WKZ A;  3SDQ A;  4DWB A;  5B03 A;  2F92 F;  3IPI A;  3WCL A;  5HNA A;  3N0F A;  4NG6 A;  3WCE A;  2AEL A;  4P0X A;  3SDT A;  3OAC A;  4MC3 A;  1PS1 A;  2PS4 A;  3P5R A;  4LA6 A;  1HXA A;  4JZB A;  3ACY A;  3KB9 A;  4MC0 A;  5AFX A;  3WEH A;  4DI5 A;  3M9U A;  3RMG A;  4KQU A;  1WL3 A;  4DWG A;  3N3L F;  3BNX A;  5EAS A;  5B02 A;  3VJE A;  3N3D A;  4LLS A;  3ICM A;  3LOM A;  3MZV A;  4MC8 A;  3RBM A;  5JV2 F;  5DW7 A;  1V4K A;  5DHK A;  4JYX A;  5E8K A;  5B0K A;  1WL1 A;  3ID0 A;  2PS6 A;  1VG7 A;  3AQ0 A;  5AHU B;  4JXY A;  5ER8 A;  3NPR A;  5C05 A;  3UCA A;  5IN8 A;  5E8L A;  2Z52 A;  1WY0 A;  3AE0 A;  1V4E A;  2F94 F;  3ICZ A;  3WEI A;  3KRC A;  2J5C A;  4LUU A;  3TC1 A;  4DHD A;  2E92 A;  4PVY F;  3PH7 A;  1RQI A;  4N1Z F;  5HN7 A;  3WJK A;  4F62 A;  2AET A;  2F7M F;  3NPK A;  4F6X A;  1YHK A;  5IKA A;  3LVS A;  3WCG A;  5A0I A;  3LK5 A;  3VJB A;  5ERN A;  2ZEU A;  2H8O A;  5ILJ A;  3DYH A;  3LGK A;  2ONG A;  4E9Z A;  4NFJ F;  3VJC A;  5A0K A;  5CG6 A;  1WL2 A;  2FTZ A;  5KSX F;  3G4D A;  4GA3 A;  4Q23 A;  3PKO A;  3N6K F;  3WCD A;  5ILI A;  3WEG A;  2ZCS A;  3KRA B;  5HN9 A;  2AZL A;  3WCI A;  5B0M A;  5JV1 F;  4EA2 A;  4LLT A;  3AQC B;  2Q9Z A;  1DI1 A;  2QIS A;  1N1Z A;  5IK9 A;  4L2X F;  2PS8 A;  3PYA A;  1YYQ A;  4RXE A;  3ZCD A;  4LPH F;  3DYG A;  4H5E F;  4DXJ A; 
#chains in the Genus database with same CATH homology
 4JZX A;  3ICK A;  5IM1 A;  3LDW A;  4QPF A;  4DEM F;  1JFA A;  3VJ9 A;  5DIQ F;  1FPS A;  2E8X A;  1HXC A;  1KIY A;  4KFA A;  2F8Z F;  1UBY A;  1RQJ A;  3WCJ A;  1YYU A;  1N24 A;  3WJO A;  3Q30 A;  3V1V A;  2E94 A;  3Q1O A;  5EAT A;  5IMP A;  3APZ A;  3KRF B;  5CG5 A;  4LFE A;  3G4F A;  3CP6 A;  4NUA A;  3NF2 A;  4LFG A;  1ZW5 A;  4NKE A;  3NRI A;  3VJ8 A;  5I1U A;  2Q80 A;  4OGU A;  5DZ2 A;  3TFN A;  2DH4 A;  1EZF A;  3PYB A;  2VF6 A;  4LIX A;  2J1O A;  3M01 A;  4NFI F;  4WK5 A;  5ILZ A;  3ACW A;  1VG6 A;  3LMD A;  5IVG A;  1VG2 A;  5IKH A;  3B7L A;  1YYR A;  3QQV A;  3SAE A;  3TFP A;  2E8V A;  2Z4V A;  4LZC A;  5IK6 A;  1WMW A;  1RTR A;  1JFG A;  3N1W F;  3ZL6 A;  5IMN A;  2E8U A;  2RAH A;  3WSA A;  3RYW A;  1HM4 A;  2EWG A;  3ZOU A;  4E9U A;  3CKE A;  5AYP A;  3V66 A;  1YJ4 A;  3QKC A;  4OKM A;  1DGP A;  3LLW A;  4LFV F;  2P1C A;  3DYF A;  3RYE A;  3S9V A;  1V4I A;  2Z78 A;  4KK2 A;  3WJN A;  2Q9Y A;  4K10 A;  5IL3 A;  4LPG F;  2PS5 A;  5ILY A;  4NFK F;  4RXA A;  2AEK A;  2E8T A;  1YQ7 A;  1UBV A;  3LGZ B;  4KVD A;  3KRO B;  2ZCQ A;  4KQS A;  3OAB B;  5DJV F;  2OPN A;  1N23 A;  4EA1 A;  5DJP F;  3TFV A;  2Z7I A;  1V4J A;  2E91 A;  1V4H A;  2Z4Y A;  4RYP A;  3ADZ A;  5ERO A;  3BNY A;  4NKF A;  3SDR A;  3WEJ A;  3WCB A;  4OMG A;  4F6V A;  2E8W A;  5B00 A;  3KRP B;  3WE9 A;  1VG4 A;  2F89 F;  5DJR F;  4KPD A;  5ILD A;  3MAV A;  4ZQ8 A;  3N5J F;  3WEK A;  3WCH A;  3N0G A;  3Q2Q A;  4KPJ A;  2PS7 A;  5H9D A;  3PDE A;  3KRF A;  4LXW A;  3ZMB A;  1YV5 A;  4RXD A;  4JVJ F;  3VJA A;  4EA0 A;  2Z4Z A;  3ASX A;  3AQB B;  3WC9 A;  1YYT A;  2ZEV A;  3SDV A;  4GP1 A;  2E93 A;  3EZ3 A;  3EFQ A;  5DGN F;  3IBA A;  3WCA A;  4DZW A;  1HM7 A;  3KBK A;  4OKZ A;  2E90 A;  3N45 F;  5B0J A;  3P5P A;  4XQT F;  4KVW A;  4RXC A;  5DHI A;  2Q58 A;  4FJQ A;  4KKM A;  5B0I A;  5EAU A;  4OMH A;  2ZCR A;  4KUX A;  3WEF A;  5E8H A;  4KQ5 A;  4LA5 A;  3LSN A;  3VJD A;  3OAC B;  1UBX A;  3N1V F;  3LJI A;  3P8L A;  5DGM F;  4P0W A;  5JA0 F;  3WSB A;  3V1X A;  2F8C F;  4LOB A;  1YHM A;  1N21 A;  3N49 F;  4LZ0 A;  2ZY1 A;  3SDU A;  4FP4 A;  5B0L A;  3EGT A;  3TS7 A;  1YHL A;  3M02 A;  2Z50 A;  5ILK A;  3KRA A;  5HN8 A;  5ERM A;  3M00 A;  4KVI A;  2Z7H A;  2I19 A;  3KRO A;  4N9U A;  3P8R A;  2E95 A;  3OAB A;  5JUZ F;  4LZ3 A;  4HD1 A;  3ZMC A;  5B01 A;  4P0V A;  1HX9 A;  3LZ9 A;  4H5C F;  4KVY A;  3KRC B;  2AZJ A;  2E4O A;  3CC9 A;  4PVX F;  2FOR A;  1KIZ A;  3OYR A;  2ONH A;  3ICN A;  3N46 F;  2J1P A;  3KRP A;  3WCC A;  5IL8 A;  5DGS F;  4JXN A;  1N22 A;  2OPM A;  1VG3 A;  3ACX A;  1WL0 A;  4H5D F;  3WCM A;  3N5H F;  3WCF A;  5IMI A;  2Z4X A;  2AZK A;  4UMJ A;  3LG5 A;  1N20 A;  2O1O A;  2OGD A;  4E1E A;  5JV0 F;  5IK0 A;  4RNQ A;  5A0J A;  4XQR F;  1UBW A;  4GAX A;  3W7F A;  2Z4W A;  4XQS F;  3LEE A;  2OA6 A;  2ZCO A;  4LTZ A;  1N1B A;  2F9K F;  4QXS F;  4GP2 A;  3P41 A;  1YYS A;  5AEL A;  3M0G A;  3S4J A;  1HXG A;  3Q2Z A;  4LTV A;  5ILH A;  4KWD A;  1WKZ A;  3SDQ A;  4DWB A;  5B03 A;  2F92 F;  3IPI A;  3WCL A;  5HNA A;  3N0F A;  4NG6 A;  3WCE A;  2AEL A;  4P0X A;  3SDT A;  3OAC A;  4MC3 A;  1PS1 A;  2PS4 A;  3P5R A;  4LA6 A;  1HXA A;  4JZB A;  3ACY A;  3KB9 A;  4MC0 A;  5AFX A;  3WEH A;  4DI5 A;  3M9U A;  3RMG A;  4KQU A;  1WL3 A;  4DWG A;  3N3L F;  3BNX A;  5EAS A;  5B02 A;  3VJE A;  3N3D A;  4LLS A;  3ICM A;  3LOM A;  3MZV A;  4MC8 A;  3RBM A;  5JV2 F;  5DW7 A;  1V4K A;  5DHK A;  4JYX A;  5E8K A;  5B0K A;  1WL1 A;  3ID0 A;  2PS6 A;  1VG7 A;  3AQ0 A;  5AHU B;  4JXY A;  5ER8 A;  3NPR A;  5C05 A;  3UCA A;  5IN8 A;  5E8L A;  2Z52 A;  1WY0 A;  3AE0 A;  1V4E A;  2F94 F;  3ICZ A;  3WEI A;  3KRC A;  2J5C A;  4LUU A;  3TC1 A;  4DHD A;  2E92 A;  4PVY F;  3PH7 A;  1RQI A;  4N1Z F;  5HN7 A;  3WJK A;  4F62 A;  2AET A;  2F7M F;  3NPK A;  4F6X A;  1YHK A;  5IKA A;  3LVS A;  3WCG A;  5A0I A;  3LK5 A;  3VJB A;  5ERN A;  2ZEU A;  2H8O A;  5ILJ A;  3DYH A;  3LGK A;  2ONG A;  4E9Z A;  4NFJ F;  3VJC A;  5A0K A;  5CG6 A;  1WL2 A;  2FTZ A;  5KSX F;  3G4D A;  4GA3 A;  4Q23 A;  3PKO A;  3N6K F;  3WCD A;  5ILI A;  3WEG A;  2ZCS A;  3KRA B;  5HN9 A;  2AZL A;  3WCI A;  5B0M A;  5JV1 F;  4EA2 A;  4LLT A;  3AQC B;  2Q9Z A;  1DI1 A;  2QIS A;  1N1Z A;  5IK9 A;  4L2X F;  2PS8 A;  3PYA A;  1YYQ A;  4RXE A;  3ZCD A;  4LPH F;  3DYG A;  4H5E F;  4DXJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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