4NWJA

Crystal structure of phosphopglycerate mutase from staphylococcus aureus in 3-phosphoglyceric acid bound form.
Total Genus 189
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
189
Knots found
sequence length
504
structure length
504
Chain Sequence
AKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGLDVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNAIAHVNSHDSALHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDGRDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAYNAIRNFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVNDGDAVIFYNFRPDRAAQLSEIFANRAFEGFKVEQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQNNNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDECLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTKEGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Complete catalytic cycle of cofactor-independent phosphoglycerate mutase involves a spring-loaded mechanism
pubmed doi rcsb
source organism Staphylococcus aureus subsp. aureus
molecule tags Isomerase
molecule keywords 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
total genus 189
structure length 504
sequence length 504
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.12: Phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
pdb deposition date 2013-12-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01676 Metalloenzyme Metalloenzyme superfamily
A PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4nwjA01
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 4nwjA02
5L0EA 3NKPA 4UPKA 4LRBA 2W5WA 4CYRA 4CXKA 4LQYA 1AUKA 1ANIA 1ALKA 2ZKTA 4CXUA 1P49A 4GTXA 3IDDA 4GTYA 4LRDA 1ZEBA 3TG0A 4LR8A 1ELZA 4ZG6A 5K4PA 4MHXA 1EW8A 4N7TA 3M8YA 1EW9A 3WAXA 5L0KA 2W5VA 1FSUA 3T00A 3TWZA 5LQQA 3NVLA 3NKRA 5DLVA 3B5QA 4LRAA 4ZGAA 3T02A 3WBHA 1HJKA 1ANJA 4MY4A 2X98A 2D1GA 3IGYB 3WAWA 2W8SA 3IGZB 1KH9A 1Y7AA 5AJ9A 3UN5A 3ED4A 2W8DA 3MK1A 4UPLA 1ELYA 4LR9A 5GOVA 1E2SP 3MK0A 4KJGA 1SHQA 1SHNA 3DPCA 1EJJA 4FDIA 5L0BA 1ALHA 4YR1A 4KAVA 2W5XA 5HRTA 4UPIA 3LXQA 1KHKA 1HQAA 4B56A 3SZZA 3BDGB 4FDJA 4NWJA 1KHJA 2GSNA 1ZEFA 2G9YA 2IFYA 4LR7A 3UNYA 1N2LA 2W5SA 3UN3A 3UN2A 2QZUA 3BDGA 1AJAA 2GSOA 4QAXA 2XR9A 1ED8A 1O99A 3NKMA 2RH6A 1EW2A 4CXSA 2IUCA 1E3CP 4GTZA 4UORA 1N2KA 2GLQA 1ZEDA 1ALJA 1O98A 4ZG9A 3CMRA 3Q3QA 3A52A 5C66A 1B8JA 3BDFA 1ELXA 4UPHA 3T01A 3NKNA 4TN0A 3OT9A 4UOPA 1ED9A 2VQRA 1KH5A 4KJDA 3DYCA 3SZYA 1URAA 3WAYA 5IJQA 4ZG7A 1EQJA 2XRGA 5TJ3A 5DLTA 1KHNA 5GRRA 1ALIA 1EI6A 1HDHA 4CYSA 1KH7A 4GTWA 5EGEA 5LRMA 4LRCA 2GA3A 1E33P 5LRNA 5KXAA 3BDHA 2W5QA 5INHA 3TX0A 3M8WA 4LR2A 5LIAA 1URBA 2IUCB 1K7HA 3MK2A 4LREA 4LRFA 3E2DA 2W5TA 3M8ZA 1E1ZP 4MIVA 3M7VA 1AJCA 2W5RA 4NWXA 1KH4A 1Y6VA 5EGHA 2ANHA 3NKQA 5IJSA 1KHLA 4KAYA 2GSUA 1AJDA 1AJBA 3KD8A 3NKOA 3WAVA 5DLWA 4KM4A 4UOOA 3UO0A
chains in the Genus database with same CATH superfamily
5L0EA 3NKPA 4UPKA 4LRBA 2W5WA 4CYRA 4CXKA 4LQYA 1AUKA 1ANIA 1ALKA 2ZKTA 4CXUA 1P49A 4GTXA 3IDDA 4GTYA 4LRDA 1ZEBA 3TG0A 4LR8A 1ELZA 4ZG6A 5K4PA 4MHXA 1EW8A 4N7TA 3M8YA 1EW9A 3WAXA 5L0KA 2W5VA 1FSUA 3T00A 3TWZA 5LQQA 3NVLA 3NKRA 5DLVA 3B5QA 4LRAA 4ZGAA 3T02A 3WBHA 1HJKA 1ANJA 4MY4A 2X98A 2D1GA 3IGYB 3WAWA 2W8SA 3IGZB 1KH9A 1Y7AA 5AJ9A 3UN5A 3ED4A 2W8DA 3MK1A 4UPLA 1ELYA 4LR9A 5GOVA 1E2SP 3MK0A 4KJGA 1SHQA 1SHNA 3DPCA 1EJJA 4FDIA 5L0BA 1ALHA 4YR1A 4KAVA 2W5XA 5HRTA 4UPIA 3LXQA 1KHKA 1HQAA 4B56A 3SZZA 3BDGB 4FDJA 4NWJA 1KHJA 2GSNA 1ZEFA 2G9YA 2IFYA 4LR7A 3UNYA 1N2LA 2W5SA 3UN3A 3UN2A 2QZUA 3BDGA 1AJAA 2GSOA 4QAXA 2XR9A 1ED8A 1O99A 3NKMA 2RH6A 1EW2A 4CXSA 2IUCA 1E3CP 4GTZA 4UORA 1N2KA 2GLQA 1ZEDA 1ALJA 1O98A 4ZG9A 3CMRA 3Q3QA 3A52A 5C66A 1B8JA 3BDFA 1ELXA 4UPHA 3T01A 3NKNA 4TN0A 3OT9A 4UOPA 1ED9A 2VQRA 1KH5A 4KJDA 3DYCA 3SZYA 1URAA 3WAYA 5IJQA 4ZG7A 1EQJA 2XRGA 5TJ3A 5DLTA 1KHNA 5GRRA 1ALIA 1EI6A 1HDHA 4CYSA 1KH7A 4GTWA 5EGEA 5LRMA 4LRCA 2GA3A 1E33P 5LRNA 5KXAA 3BDHA 2W5QA 5INHA 3TX0A 3M8WA 4LR2A 5LIAA 1URBA 2IUCB 1K7HA 3MK2A 4LREA 4LRFA 3E2DA 2W5TA 3M8ZA 1E1ZP 4MIVA 3M7VA 1AJCA 2W5RA 4NWXA 1KH4A 1Y6VA 5EGHA 2ANHA 3NKQA 5IJSA 1KHLA 4KAYA 2GSUA 1AJDA 1AJBA 3KD8A 3NKOA 3WAVA 5DLWA 4KM4A 4UOOA 3UO0A
chains in the Genus database with same CATH topology
5L0EA 3NKPA 4UPKA 4LRBA 2W5WA 4CYRA 4CXKA 4LQYA 1AUKA 1ANIA 1ALKA 2ZKTA 4CXUA 1P49A 4GTXA 3IDDA 4GTYA 4LRDA 1ZEBA 3TG0A 4LR8A 1ELZA 4ZG6A 5K4PA 4MHXA 1EW8A 4N7TA 3M8YA 1EW9A 3WAXA 5L0KA 2W5VA 1FSUA 3T00A 3TWZA 5LQQA 3NVLA 3NKRA 5DLVA 3B5QA 4LRAA 4ZGAA 3T02A 3WBHA 1HJKA 1ANJA 4MY4A 2X98A 2D1GA 3IGYB 3WAWA 2W8SA 3IGZB 1KH9A 1Y7AA 5AJ9A 3UN5A 3ED4A 2W8DA 3MK1A 4UPLA 1ELYA 4LR9A 5GOVA 1E2SP 3MK0A 4KJGA 1SHQA 1SHNA 3DPCA 1EJJA 4FDIA 5L0BA 1ALHA 4YR1A 4KAVA 2W5XA 5HRTA 4UPIA 3LXQA 1KHKA 1HQAA 4B56A 3SZZA 3BDGB 4FDJA 4NWJA 1KHJA 2GSNA 1ZEFA 2G9YA 2IFYA 4LR7A 3UNYA 1N2LA 2W5SA 3UN3A 3UN2A 2QZUA 3BDGA 1AJAA 2GSOA 4QAXA 2XR9A 1ED8A 1O99A 3NKMA 2RH6A 1EW2A 4CXSA 2IUCA 1E3CP 4GTZA 4UORA 1N2KA 2GLQA 1ZEDA 1ALJA 1O98A 4ZG9A 3CMRA 3Q3QA 3A52A 5C66A 1B8JA 3BDFA 1ELXA 4UPHA 3T01A 3NKNA 4TN0A 3OT9A 4UOPA 1ED9A 2VQRA 1KH5A 4KJDA 3DYCA 3SZYA 1URAA 3WAYA 5IJQA 4ZG7A 1EQJA 2XRGA 5TJ3A 5DLTA 1KHNA 5GRRA 1ALIA 1EI6A 1HDHA 4CYSA 1KH7A 4GTWA 5EGEA 5LRMA 4LRCA 2GA3A 1E33P 5LRNA 5KXAA 3BDHA 2W5QA 5INHA 3TX0A 3M8WA 4LR2A 5LIAA 1URBA 2IUCB 1K7HA 3MK2A 4LREA 4LRFA 3E2DA 2W5TA 3M8ZA 1E1ZP 4MIVA 3M7VA 1AJCA 2W5RA 4NWXA 1KH4A 1Y6VA 5EGHA 2ANHA 3NKQA 5IJSA 1KHLA 4KAYA 2GSUA 1AJDA 1AJBA 3KD8A 3NKOA 3WAVA 5DLWA 4KM4A 4UOOA 3UO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0E A;  3NKP A;  4UPK A;  4LRB A;  2W5W A;  4CYR A;  4CXK A;  4LQY A;  1AUK A;  1ANI A;  1ALK A;  2ZKT A;  4CXU A;  1P49 A;  4GTX A;  3IDD A;  4GTY A;  4LRD A;  1ZEB A;  3TG0 A;  4LR8 A;  1ELZ A;  4ZG6 A;  5K4P A;  4MHX A;  1EW8 A;  4N7T A;  3M8Y A;  1EW9 A;  3WAX A;  5L0K A;  2W5V A;  1FSU A;  3T00 A;  3TWZ A;  5LQQ A;  3NVL A;  3NKR A;  5DLV A;  3B5Q A;  4LRA A;  4ZGA A;  3T02 A;  3WBH A;  1HJK A;  1ANJ A;  4MY4 A;  2X98 A;  2D1G A;  3IGY B;  3WAW A;  2W8S A;  3IGZ B;  1KH9 A;  1Y7A A;  5AJ9 A;  3UN5 A;  3ED4 A;  2W8D A;  3MK1 A;  4UPL A;  1ELY A;  4LR9 A;  5GOV A;  1E2S P;  3MK0 A;  4KJG A;  1SHQ A;  1SHN A;  3DPC A;  1EJJ A;  4FDI A;  5L0B A;  1ALH A;  4YR1 A;  4KAV A;  2W5X A;  5HRT A;  4UPI A;  3LXQ A;  1KHK A;  1HQA A;  4B56 A;  3SZZ A;  3BDG B;  4FDJ A;  4NWJ A;  1KHJ A;  2GSN A;  1ZEF A;  2G9Y A;  2IFY A;  4LR7 A;  3UNY A;  1N2L A;  2W5S A;  3UN3 A;  3UN2 A;  2QZU A;  3BDG A;  1AJA A;  2GSO A;  4QAX A;  2XR9 A;  1ED8 A;  1O99 A;  3NKM A;  2RH6 A;  1EW2 A;  4CXS A;  2IUC A;  1E3C P;  4GTZ A;  4UOR A;  1N2K A;  2GLQ A;  1ZED A;  1ALJ A;  1O98 A;  4ZG9 A;  3CMR A;  3Q3Q A;  3A52 A;  5C66 A;  1B8J A;  3BDF A;  1ELX A;  4UPH A;  3T01 A;  3NKN A;  4TN0 A;  3OT9 A;  4UOP A;  1ED9 A;  2VQR A;  1KH5 A;  4KJD A;  3DYC A;  3SZY A;  1URA A;  3WAY A;  5IJQ A;  4ZG7 A;  1EQJ A;  2XRG A;  5TJ3 A;  5DLT A;  1KHN A;  5GRR A;  1ALI A;  1EI6 A;  1HDH A;  4CYS A;  1KH7 A;  4GTW A;  5EGE A;  5LRM A;  4LRC A;  2GA3 A;  1E33 P;  5LRN A;  5KXA A;  3BDH A;  2W5Q A;  5INH A;  3TX0 A;  3M8W A;  4LR2 A;  5LIA A;  1URB A;  2IUC B;  1K7H A;  3MK2 A;  4LRE A;  4LRF A;  3E2D A;  2W5T A;  3M8Z A;  1E1Z P;  4MIV A;  3M7V A;  1AJC A;  2W5R A;  4NWX A;  1KH4 A;  1Y6V A;  5EGH A;  2ANH A;  3NKQ A;  5IJS A;  1KHL A;  4KAY A;  2GSU A;  1AJD A;  1AJB A;  3KD8 A;  3NKO A;  3WAV A;  5DLW A;  4KM4 A;  4UOO A;  3UO0 A; 
#chains in the Genus database with same CATH topology
 5L0E A;  3NKP A;  4UPK A;  4LRB A;  2W5W A;  4CYR A;  4CXK A;  4LQY A;  1AUK A;  1ANI A;  1ALK A;  2ZKT A;  4CXU A;  1P49 A;  4GTX A;  3IDD A;  4GTY A;  4LRD A;  1ZEB A;  3TG0 A;  4LR8 A;  1ELZ A;  4ZG6 A;  5K4P A;  4MHX A;  1EW8 A;  4N7T A;  3M8Y A;  1EW9 A;  3WAX A;  5L0K A;  2W5V A;  1FSU A;  3T00 A;  3TWZ A;  5LQQ A;  3NVL A;  3NKR A;  5DLV A;  3B5Q A;  4LRA A;  4ZGA A;  3T02 A;  3WBH A;  1HJK A;  1ANJ A;  4MY4 A;  2X98 A;  2D1G A;  3IGY B;  3WAW A;  2W8S A;  3IGZ B;  1KH9 A;  1Y7A A;  5AJ9 A;  3UN5 A;  3ED4 A;  2W8D A;  3MK1 A;  4UPL A;  1ELY A;  4LR9 A;  5GOV A;  1E2S P;  3MK0 A;  4KJG A;  1SHQ A;  1SHN A;  3DPC A;  1EJJ A;  4FDI A;  5L0B A;  1ALH A;  4YR1 A;  4KAV A;  2W5X A;  5HRT A;  4UPI A;  3LXQ A;  1KHK A;  1HQA A;  4B56 A;  3SZZ A;  3BDG B;  4FDJ A;  4NWJ A;  1KHJ A;  2GSN A;  1ZEF A;  2G9Y A;  2IFY A;  4LR7 A;  3UNY A;  1N2L A;  2W5S A;  3UN3 A;  3UN2 A;  2QZU A;  3BDG A;  1AJA A;  2GSO A;  4QAX A;  2XR9 A;  1ED8 A;  1O99 A;  3NKM A;  2RH6 A;  1EW2 A;  4CXS A;  2IUC A;  1E3C P;  4GTZ A;  4UOR A;  1N2K A;  2GLQ A;  1ZED A;  1ALJ A;  1O98 A;  4ZG9 A;  3CMR A;  3Q3Q A;  3A52 A;  5C66 A;  1B8J A;  3BDF A;  1ELX A;  4UPH A;  3T01 A;  3NKN A;  4TN0 A;  3OT9 A;  4UOP A;  1ED9 A;  2VQR A;  1KH5 A;  4KJD A;  3DYC A;  3SZY A;  1URA A;  3WAY A;  5IJQ A;  4ZG7 A;  1EQJ A;  2XRG A;  5TJ3 A;  5DLT A;  1KHN A;  5GRR A;  1ALI A;  1EI6 A;  1HDH A;  4CYS A;  1KH7 A;  4GTW A;  5EGE A;  5LRM A;  4LRC A;  2GA3 A;  1E33 P;  5LRN A;  5KXA A;  3BDH A;  2W5Q A;  5INH A;  3TX0 A;  3M8W A;  4LR2 A;  5LIA A;  1URB A;  2IUC B;  1K7H A;  3MK2 A;  4LRE A;  4LRF A;  3E2D A;  2W5T A;  3M8Z A;  1E1Z P;  4MIV A;  3M7V A;  1AJC A;  2W5R A;  4NWX A;  1KH4 A;  1Y6V A;  5EGH A;  2ANH A;  3NKQ A;  5IJS A;  1KHL A;  4KAY A;  2GSU A;  1AJD A;  1AJB A;  3KD8 A;  3NKO A;  3WAV A;  5DLW A;  4KM4 A;  4UOO A;  3UO0 A; 
#chains in the Genus database with same CATH homology
 5L0E A;  3NKP A;  4UPK A;  4LRB A;  2W5W A;  4CYR A;  4CXK A;  4LQY A;  1AUK A;  1ANI A;  1ALK A;  2ZKT A;  4CXU A;  1P49 A;  4GTX A;  3IDD A;  4GTY A;  4LRD A;  1ZEB A;  3TG0 A;  4LR8 A;  1ELZ A;  4ZG6 A;  5K4P A;  4MHX A;  1EW8 A;  4N7T A;  3M8Y A;  1EW9 A;  3WAX A;  5L0K A;  2W5V A;  1FSU A;  3T00 A;  3TWZ A;  5LQQ A;  3NVL A;  3NKR A;  5DLV A;  3B5Q A;  4LRA A;  4ZGA A;  3T02 A;  3WBH A;  1HJK A;  1ANJ A;  4MY4 A;  2X98 A;  2D1G A;  3IGY B;  3WAW A;  2W8S A;  3IGZ B;  1KH9 A;  1Y7A A;  5AJ9 A;  3UN5 A;  3ED4 A;  2W8D A;  3MK1 A;  4UPL A;  1ELY A;  4LR9 A;  5GOV A;  1E2S P;  3MK0 A;  4KJG A;  1SHQ A;  1SHN A;  3DPC A;  1EJJ A;  4FDI A;  5L0B A;  1ALH A;  4YR1 A;  4KAV A;  2W5X A;  5HRT A;  4UPI A;  3LXQ A;  1KHK A;  1HQA A;  4B56 A;  3SZZ A;  3BDG B;  4FDJ A;  4NWJ A;  1KHJ A;  2GSN A;  1ZEF A;  2G9Y A;  2IFY A;  4LR7 A;  3UNY A;  1N2L A;  2W5S A;  3UN3 A;  3UN2 A;  2QZU A;  3BDG A;  1AJA A;  2GSO A;  4QAX A;  2XR9 A;  1ED8 A;  1O99 A;  3NKM A;  2RH6 A;  1EW2 A;  4CXS A;  2IUC A;  1E3C P;  4GTZ A;  4UOR A;  1N2K A;  2GLQ A;  1ZED A;  1ALJ A;  1O98 A;  4ZG9 A;  3CMR A;  3Q3Q A;  3A52 A;  5C66 A;  1B8J A;  3BDF A;  1ELX A;  4UPH A;  3T01 A;  3NKN A;  4TN0 A;  3OT9 A;  4UOP A;  1ED9 A;  2VQR A;  1KH5 A;  4KJD A;  3DYC A;  3SZY A;  1URA A;  3WAY A;  5IJQ A;  4ZG7 A;  1EQJ A;  2XRG A;  5TJ3 A;  5DLT A;  1KHN A;  5GRR A;  1ALI A;  1EI6 A;  1HDH A;  4CYS A;  1KH7 A;  4GTW A;  5EGE A;  5LRM A;  4LRC A;  2GA3 A;  1E33 P;  5LRN A;  5KXA A;  3BDH A;  2W5Q A;  5INH A;  3TX0 A;  3M8W A;  4LR2 A;  5LIA A;  1URB A;  2IUC B;  1K7H A;  3MK2 A;  4LRE A;  4LRF A;  3E2D A;  2W5T A;  3M8Z A;  1E1Z P;  4MIV A;  3M7V A;  1AJC A;  2W5R A;  4NWX A;  1KH4 A;  1Y6V A;  5EGH A;  2ANH A;  3NKQ A;  5IJS A;  1KHL A;  4KAY A;  2GSU A;  1AJD A;  1AJB A;  3KD8 A;  3NKO A;  3WAV A;  5DLW A;  4KM4 A;  4UOO A;  3UO0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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