4NYIS

Approach for targeting ras with small molecules that activate sos-mediated nucleotide exchange
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
481
structure length
472
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEENMAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPase HRas
total genus 176
structure length 472
sequence length 481
ec nomenclature
pdb deposition date 2013-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4nyiS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4nyiS01
4MGKE 1XD2C 4NYIS 4US1S 3CF6E 5CM8A 3KSYA 1BKDS 1NVXS 4JGWA 4NYJS 4MGIE 3T6AA 4F7ZA 3T6GA 3QXLA 4URWS 2BYVE 2II0A 4US0S 4URZS 1NVVS 4URXS 4MH0E 2IJES 1NVWS 4NYMS 1XD4A 1NVUS 4L9MA 5CM9A 4URUS 4US2S 4URYS 4MGZE 4MGYE 4URVS
chains in the Genus database with same CATH superfamily
4MGKE 1XD2C 4NYIS 4US1S 3CF6E 5CM8A 3KSYA 1BKDS 1NVXS 4JGWA 4NYJS 4MGIE 3T6AA 4F7ZA 3T6GA 3QXLA 4URWS 2BYVE 2II0A 4US0S 4URZS 1NVVS 4URXS 4MH0E 2IJES 1NVWS 4NYMS 1XD4A 1NVUS 4L9MA 5CM9A 4URUS 4US2S 4URYS 4MGZE 4MGYE 4URVS
chains in the Genus database with same CATH topology
4MGKE 1XD2C 4NYIS 4US1S 3CF6E 5CM8A 3KSYA 1BKDS 1NVXS 4JGWA 4NYJS 4MGIE 3T6AA 4F7ZA 3T6GA 3QXLA 4URWS 2BYVE 2II0A 4US0S 4URZS 1NVVS 4URXS 4MH0E 2IJES 1NVWS 4NYMS 1XD4A 1NVUS 4L9MA 5CM9A 4URUS 4US2S 4URYS 4MGZE 4MGYE 4URVS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MGK E;  1XD2 C;  4NYI S;  4US1 S;  3CF6 E;  5CM8 A;  3KSY A;  1BKD S;  1NVX S;  4JGW A;  4NYJ S;  4MGI E;  3T6A A;  4F7Z A;  3T6G A;  3QXL A;  4URW S;  2BYV E;  2II0 A;  4US0 S;  4URZ S;  1NVV S;  4URX S;  4MH0 E;  2IJE S;  1NVW S;  4NYM S;  1XD4 A;  1NVU S;  4L9M A;  5CM9 A;  4URU S;  4US2 S;  4URY S;  4MGZ E;  4MGY E;  4URV S; 
#chains in the Genus database with same CATH topology
 4MGK E;  1XD2 C;  4NYI S;  4US1 S;  3CF6 E;  5CM8 A;  3KSY A;  1BKD S;  1NVX S;  4JGW A;  4NYJ S;  4MGI E;  3T6A A;  4F7Z A;  3T6G A;  3QXL A;  4URW S;  2BYV E;  2II0 A;  4US0 S;  4URZ S;  1NVV S;  4URX S;  4MH0 E;  2IJE S;  1NVW S;  4NYM S;  1XD4 A;  1NVU S;  4L9M A;  5CM9 A;  4URU S;  4US2 S;  4URY S;  4MGZ E;  4MGY E;  4URV S; 
#chains in the Genus database with same CATH homology
 4MGK E;  1XD2 C;  4NYI S;  4US1 S;  3CF6 E;  5CM8 A;  3KSY A;  1BKD S;  1NVX S;  4JGW A;  4NYJ S;  4MGI E;  3T6A A;  4F7Z A;  3T6G A;  3QXL A;  4URW S;  2BYV E;  2II0 A;  4US0 S;  4URZ S;  1NVV S;  4URX S;  4MH0 E;  2IJE S;  1NVW S;  4NYM S;  1XD4 A;  1NVU S;  4L9M A;  5CM9 A;  4URU S;  4US2 S;  4URY S;  4MGZ E;  4MGY E;  4URV S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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