4OFAA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Structure of MBD4 bound to G:T mispair DNA
rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 50
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofaA00
1YQMA 1FN7A 1RRQA 1NKUA 1XQPA 1ORPA 1N39A 4EW4A 4B24A 1EBMA 1N3CA 3IHOA 1KG3A 1MUNA 3D4VA 2OFKA 4E9FA 4E9GA 3I0XA 2YG8A 4OFEA 1LWWA 1KO9A 3N0UA 4E9EA 3KTUA 2NOFA 5AN4A 4YPHA 2NOHA 3CWSA 3I0WA 1RRSA 1WEGA 4B21A 4B22A 4EVVA 1N3AA 3OGDA 2NOIA 2JHNA 2JHJA 4DK9A 1P59A 4HSBA 3FHFA 4EJZA 5DPKA 1XG7A 4AI4A 1KG5A 1ORNA 4EJYA 2JG6A 3CVTA 4EA5A 5KN9A 1DIZA 1MPGA 1VRLA 1KEAA 3CWUA 4YOQA 1KG2A 2XHIA 1LWVA 2OFIA 1KG7A 2NOEA 2NOLA 3CVSA 1XQOA 3FHGA 4YPRA 3CWAA 3S6IA 3F0ZA 3IH7A 1WEIA 2YG9A 2NOBA 4PIIA 4OFAA 4B23A 1LWYA 4AI5A 4EA4A 2ABKA 1KG6A 3OH6A 1PVSA 3FSPA 4AIAA 3OH9A 5CHZA 3CWTA 1LMZA 4UNFA 1M3HA 1YQLA 1NGNA 1WEFA 3CW7A 4E9HA 1PU7A 1YQKA 1MUDA 3KNTA 1M3QA 4EW0A 1YQRA 4UOBA 3G0QA 5KN8A 2NOZA 1MUYA 2I5WA 1PU8A 1HU0A 3F10A 1PU6A 4OFHA 3N5NX 2H56A 1P7MA 1KQJA 1KG4A
chains in the Genus database with same CATH superfamily
1YQMA 3OYFA 1FN7A 1RRQA 1NKUA 1XQPA 1ORPA 3OYMA 4E7LA 1N39A 3OS2A 4EW4A 3OYAA 4B24A 1EBMA 1N3CA 3L2RA 3IHOA 1KG3A 1MUNA 3D4VA 4BACA 2OFKA 4E7HA 4E9FA 4ZTFA 3S3MA 2JPSA 3L2UA 4E9GA 3I0XA 2YG8A 3VW4A 4OFEA 5FROA 3OYLA 4E7IA 1LWWA 4ZTJA 1KO9A 3OYNA 3OS1A 3N0UA 4E9EA 3KTUA 4E7JA 2NOFA 5AN4A 4YPHA 2NOHA 3CWSA 3I0WA 1RRSA 1WEGA 3OS0A 4B21A 4B22A 4EVVA 1KG4A 1N3AA 3OGDA 2NOIA 4BE0A 2JHNA 2JHJA 4DK9A 3OYIA 3OYKA 1P59A 4HSBA 2W03A 3FHFA 3OYEA 3OYBA 4EJZA 5DPKA 3OYJA 1XG7A 4AI4A 1KG5A 1ORNA 4EJYA 2JG6A 3CVTA 1U84A 4EA5A 5KN9A 1DIZA 1MPGA 1VRLA 1KEAA 4YOQA 3CWUA 3OYCA 3S3NA 2V75A 1KG2A 2XHIA 1LWVA 2OFIA 1KG7A 2NOEA 4BDZA 2NOLA 3CVSA 1XQOA 3FHGA 4YPRA 3CWAA 3S6IA 3F0ZA 4BE1A 3IH7A 1WEIA 2YG9A 3OYHA 2NOBA 4E7KA 4PIIA 3OYGA 4OFAA 4B23A 3L2WA 3OYDA 1LWYA 4AI5A 4EA4A 2ABKA 1KG6A 3OH6A 4BE2A 1PVSA 3FSPA 4NZGA 4AIAA 3OH9A 5CHZA 3CWTA 1LMZA 3L2VA 3NNQA 4UNFA 1M3HA 1YQLA 1NGNA 4BDYA 1WEFA 3CW7A 4IKFA 4E9HA 1PU7A 5FRMA 1YQKA 3OY9A 1MUDA 3KNTA 5FRNA 1M3QA 4EW0A 1YQRA 4UOBA 2W04A 3S3OA 3G0QA 5KN8A 2NOZA 1MUYA 2I5WA 1PU8A 1HU0A 3F10A 1PU6A 4OFHA 3N5NX 3L2QA 3LCNA 2H56A 1P7MA 1KQJA 3R2XC
chains in the Genus database with same CATH topology
1YQMA 1FN7A 1RRQA 1NKUA 1XQPA 1ORPA 1N39A 4EW4A 4B24A 1EBMA 1N3CA 3IHOA 1KG3A 1MUNA 3D4VA 2OFKA 4E9FA 4E9GA 3I0XA 2YG8A 4OFEA 1LWWA 1KO9A 3N0UA 4E9EA 3KTUA 2NOFA 5AN4A 4YPHA 2NOHA 3CWSA 3I0WA 1RRSA 1WEGA 4B21A 4B22A 4EVVA 1N3AA 3OGDA 2NOIA 2JHNA 2JHJA 4DK9A 1P59A 4HSBA 3FHFA 4EJZA 5DPKA 1XG7A 4AI4A 1KG5A 1ORNA 4EJYA 2JG6A 3CVTA 4EA5A 5KN9A 1DIZA 1MPGA 1VRLA 1KEAA 3CWUA 4YOQA 1KG2A 2XHIA 1LWVA 2OFIA 1KG7A 2NOEA 2NOLA 3CVSA 1XQOA 3FHGA 4YPRA 3CWAA 3S6IA 3F0ZA 3IH7A 1WEIA 2YG9A 2NOBA 4PIIA 4OFAA 4B23A 1LWYA 4AI5A 4EA4A 2ABKA 1KG6A 3OH6A 1PVSA 3FSPA 4AIAA 3OH9A 5CHZA 3CWTA 1LMZA 4UNFA 1M3HA 1YQLA 1NGNA 1WEFA 3CW7A 4E9HA 1PU7A 1YQKA 1MUDA 3KNTA 1M3QA 4EW0A 1YQRA 4UOBA 3G0QA 5KN8A 2NOZA 1MUYA 2I5WA 1PU8A 1HU0A 3F10A 1PU6A 4OFHA 3N5NX 2H56A 1P7MA 1KQJA 1KG4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YQM A;  1FN7 A;  1RRQ A;  1NKU A;  1XQP A;  1ORP A;  1N39 A;  4EW4 A;  4B24 A;  1EBM A;  1N3C A;  3IHO A;  1KG3 A;  1MUN A;  3D4V A;  2OFK A;  4E9F A;  4E9G A;  3I0X A;  2YG8 A;  4OFE A;  1LWW A;  1KO9 A;  3N0U A;  4E9E A;  3KTU A;  2NOF A;  5AN4 A;  4YPH A;  2NOH A;  3CWS A;  3I0W A;  1RRS A;  1WEG A;  4B21 A;  4B22 A;  4EVV A;  1N3A A;  3OGD A;  2NOI A;  2JHN A;  2JHJ A;  4DK9 A;  1P59 A;  4HSB A;  3FHF A;  4EJZ A;  5DPK A;  1XG7 A;  4AI4 A;  1KG5 A;  1ORN A;  4EJY A;  2JG6 A;  3CVT A;  4EA5 A;  5KN9 A;  1DIZ A;  1MPG A;  1VRL A;  1KEA A;  3CWU A;  4YOQ A;  1KG2 A;  2XHI A;  1LWV A;  2OFI A;  1KG7 A;  2NOE A;  2NOL A;  3CVS A;  1XQO A;  3FHG A;  4YPR A;  3CWA A;  3S6I A;  3F0Z A;  3IH7 A;  1WEI A;  2YG9 A;  2NOB A;  4PII A;  4OFA A;  4B23 A;  1LWY A;  4AI5 A;  4EA4 A;  2ABK A;  1KG6 A;  3OH6 A;  1PVS A;  3FSP A;  4AIA A;  3OH9 A;  5CHZ A;  3CWT A;  1LMZ A;  4UNF A;  1M3H A;  1YQL A;  1NGN A;  1WEF A;  3CW7 A;  4E9H A;  1PU7 A;  1YQK A;  1MUD A;  3KNT A;  1M3Q A;  4EW0 A;  1YQR A;  4UOB A;  3G0Q A;  5KN8 A;  2NOZ A;  1MUY A;  2I5W A;  1PU8 A;  1HU0 A;  3F10 A;  1PU6 A;  4OFH A;  3N5N X;  2H56 A;  1P7M A;  1KQJ A;  1KG4 A; 
#chains in the Genus database with same CATH topology
 1YQM A;  3OYF A;  1FN7 A;  1RRQ A;  1NKU A;  1XQP A;  1ORP A;  3OYM A;  4E7L A;  1N39 A;  3OS2 A;  4EW4 A;  3OYA A;  4B24 A;  1EBM A;  1N3C A;  3L2R A;  3IHO A;  1KG3 A;  1MUN A;  3D4V A;  4BAC A;  2OFK A;  4E7H A;  4E9F A;  4ZTF A;  3S3M A;  2JPS A;  3L2U A;  4E9G A;  3I0X A;  2YG8 A;  3VW4 A;  4OFE A;  5FRO A;  3OYL A;  4E7I A;  1LWW A;  4ZTJ A;  1KO9 A;  3OYN A;  3OS1 A;  3N0U A;  4E9E A;  3KTU A;  4E7J A;  2NOF A;  5AN4 A;  4YPH A;  2NOH A;  3CWS A;  3I0W A;  1RRS A;  1WEG A;  3OS0 A;  4B21 A;  4B22 A;  4EVV A;  1KG4 A;  1N3A A;  3OGD A;  2NOI A;  4BE0 A;  2JHN A;  2JHJ A;  4DK9 A;  3OYI A;  3OYK A;  1P59 A;  4HSB A;  2W03 A;  3FHF A;  3OYE A;  3OYB A;  4EJZ A;  5DPK A;  3OYJ A;  1XG7 A;  4AI4 A;  1KG5 A;  1ORN A;  4EJY A;  2JG6 A;  3CVT A;  1U84 A;  4EA5 A;  5KN9 A;  1DIZ A;  1MPG A;  1VRL A;  1KEA A;  4YOQ A;  3CWU A;  3OYC A;  3S3N A;  2V75 A;  1KG2 A;  2XHI A;  1LWV A;  2OFI A;  1KG7 A;  2NOE A;  4BDZ A;  2NOL A;  3CVS A;  1XQO A;  3FHG A;  4YPR A;  3CWA A;  3S6I A;  3F0Z A;  4BE1 A;  3IH7 A;  1WEI A;  2YG9 A;  3OYH A;  2NOB A;  4E7K A;  4PII A;  3OYG A;  4OFA A;  4B23 A;  3L2W A;  3OYD A;  1LWY A;  4AI5 A;  4EA4 A;  2ABK A;  1KG6 A;  3OH6 A;  4BE2 A;  1PVS A;  3FSP A;  4NZG A;  4AIA A;  3OH9 A;  5CHZ A;  3CWT A;  1LMZ A;  3L2V A;  3NNQ A;  4UNF A;  1M3H A;  1YQL A;  1NGN A;  4BDY A;  1WEF A;  3CW7 A;  4IKF A;  4E9H A;  1PU7 A;  5FRM A;  1YQK A;  3OY9 A;  1MUD A;  3KNT A;  5FRN A;  1M3Q A;  4EW0 A;  1YQR A;  4UOB A;  2W04 A;  3S3O A;  3G0Q A;  5KN8 A;  2NOZ A;  1MUY A;  2I5W A;  1PU8 A;  1HU0 A;  3F10 A;  1PU6 A;  4OFH A;  3N5N X;  3L2Q A;  3LCN A;  2H56 A;  1P7M A;  1KQJ A;  3R2X C; 
#chains in the Genus database with same CATH homology
 1YQM A;  1FN7 A;  1RRQ A;  1NKU A;  1XQP A;  1ORP A;  1N39 A;  4EW4 A;  4B24 A;  1EBM A;  1N3C A;  3IHO A;  1KG3 A;  1MUN A;  3D4V A;  2OFK A;  4E9F A;  4E9G A;  3I0X A;  2YG8 A;  4OFE A;  1LWW A;  1KO9 A;  3N0U A;  4E9E A;  3KTU A;  2NOF A;  5AN4 A;  4YPH A;  2NOH A;  3CWS A;  3I0W A;  1RRS A;  1WEG A;  4B21 A;  4B22 A;  4EVV A;  1N3A A;  3OGD A;  2NOI A;  2JHN A;  2JHJ A;  4DK9 A;  1P59 A;  4HSB A;  3FHF A;  4EJZ A;  5DPK A;  1XG7 A;  4AI4 A;  1KG5 A;  1ORN A;  4EJY A;  2JG6 A;  3CVT A;  4EA5 A;  5KN9 A;  1DIZ A;  1MPG A;  1VRL A;  1KEA A;  3CWU A;  4YOQ A;  1KG2 A;  2XHI A;  1LWV A;  2OFI A;  1KG7 A;  2NOE A;  2NOL A;  3CVS A;  1XQO A;  3FHG A;  4YPR A;  3CWA A;  3S6I A;  3F0Z A;  3IH7 A;  1WEI A;  2YG9 A;  2NOB A;  4PII A;  4OFA A;  4B23 A;  1LWY A;  4AI5 A;  4EA4 A;  2ABK A;  1KG6 A;  3OH6 A;  1PVS A;  3FSP A;  4AIA A;  3OH9 A;  5CHZ A;  3CWT A;  1LMZ A;  4UNF A;  1M3H A;  1YQL A;  1NGN A;  1WEF A;  3CW7 A;  4E9H A;  1PU7 A;  1YQK A;  1MUD A;  3KNT A;  1M3Q A;  4EW0 A;  1YQR A;  4UOB A;  3G0Q A;  5KN8 A;  2NOZ A;  1MUY A;  2I5W A;  1PU8 A;  1HU0 A;  3F10 A;  1PU6 A;  4OFH A;  3N5N X;  2H56 A;  1P7M A;  1KQJ A;  1KG4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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