4OFAA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 50
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Structure of MBD4 bound to G:T mispair DNA
rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 50
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofaA00
1KG4A 4OFHA 3N5NX 4YPRA 4OFEA 1ORNA 2NOIA 4B21A 1KG2A 1EBMA 4AI5A 4UOBA 4OFAA 1WEFA 4E9GA 3KTUA 3IH7A 1PVSA 5AN4A 1LWVA 3FSPA 2NOLA 1PU6A 5KN9A 4HSBA 1LWWA 3CWAA 2I5WA 1XQPA 3D4VA 2JHJA 1MPGA 2YG8A 2YG9A 2H56A 1M3HA 1FN7A 3FHGA 5DPKA 4PIIA 3CWTA 1KG3A 3I0XA 4EW4A 1N3AA 1DIZA 3I0WA 2JHNA 3OGDA 1PU7A 1MUDA 1KG7A 4EA5A 1ORPA 3F0ZA 3FHFA 1WEIA 1NKUA 2NOZA 2NOFA 3IHOA 1N3CA 4AIAA 5KN8A 1KG6A 2NOBA 2OFIA 1VRLA 1YQLA 2NOHA 3OH9A 4B23A 1WEGA 3CW7A 2OFKA 4EW0A 3G0QA 1M3QA 4YPHA 1KEAA 4AI4A 4UNFA 1RRSA 5CHZA 1XG7A 3KNTA 3S6IA 2NOEA 4B22A 3N0UA 1NGNA 3CWUA 1LWYA 1KQJA 2XHIA 3F10A 1YQKA 2ABKA 4DK9A 4EJZA 1P59A 1N39A 1MUYA 4YOQA 1KG5A 4EA4A 1HU0A 1LMZA 4B24A 3CVTA 4EJYA 4E9FA 4EVVA 1RRQA 1XQOA 1KO9A 1P7MA 3CVSA 4E9EA 3OH6A 1YQRA 2JG6A 4E9HA 3CWSA 1MUNA 1PU8A 1YQMA
chains in the Genus database with same CATH superfamily
3OY9A 1KG4A 4OFHA 3N5NX 4YPRA 4OFEA 1ORNA 4E7KA 2NOIA 4B21A 1KG2A 1EBMA 4AI5A 3OYAA 3OYFA 4UOBA 4OFAA 1WEFA 4BACA 3OS1A 2JPSA 4E9GA 3KTUA 3OYIA 3IH7A 1PVSA 5AN4A 1LWVA 3FSPA 2NOLA 1PU6A 5KN9A 4HSBA 1LWWA 3OYJA 4NZGA 3CWAA 4E7LA 2I5WA 3OYEA 3OS0A 1XQPA 3D4VA 5FROA 3OYLA 2JHJA 3OYGA 3LCNA 1MPGA 2YG8A 3S3MA 4IKFA 1YQMA 2YG9A 2H56A 3L2QA 1M3HA 1FN7A 3FHGA 5DPKA 3L2RA 4PIIA 3CWTA 1KG3A 3OYDA 3I0XA 4EW4A 1N3AA 1DIZA 3I0WA 2JHNA 3OGDA 1PU7A 2W04A 1MUDA 1KG7A 4BE0A 4EA5A 1ORPA 4ZTFA 3F0ZA 3FHFA 1WEIA 1NKUA 3OYHA 2NOZA 2NOFA 3IHOA 1N3CA 4ZTJA 4AIAA 5KN8A 1KG6A 2NOBA 2OFIA 3OYMA 1VRLA 1YQLA 2NOHA 3OH9A 3L2WA 4B23A 1WEGA 3R2XC 3CW7A 4BDYA 2OFKA 4EW0A 3G0QA 3VW4A 1M3QA 1U84A 4YPHA 1KEAA 4AI4A 4UNFA 1RRSA 2W03A 1XG7A 5CHZA 3KNTA 3S6IA 2NOEA 4B22A 3N0UA 1NGNA 3CWUA 3OYKA 3OS2A 4E7JA 1LWYA 3NNQA 1KQJA 2XHIA 3OYCA 5FRMA 3F10A 3S3OA 4BDZA 3L2UA 4E7HA 1YQKA 2ABKA 3L2VA 4DK9A 4EJZA 1P59A 1N39A 1MUYA 4YOQA 4BE2A 1KG5A 4EA4A 1HU0A 1LMZA 4B24A 3CVTA 4EJYA 3S3NA 4E9FA 4BE1A 4EVVA 4E7IA 1RRQA 3OYNA 1XQOA 1KO9A 1P7MA 3CVSA 4E9EA 3OH6A 3OYBA 1YQRA 5FRNA 2JG6A 4E9HA 3CWSA 1MUNA 1PU8A 2V75A
chains in the Genus database with same CATH topology
1KG4A 4OFHA 3N5NX 4YPRA 4OFEA 1ORNA 2NOIA 4B21A 1KG2A 1EBMA 4AI5A 4UOBA 4OFAA 1WEFA 4E9GA 3KTUA 3IH7A 1PVSA 5AN4A 1LWVA 3FSPA 2NOLA 1PU6A 5KN9A 4HSBA 1LWWA 3CWAA 2I5WA 1XQPA 3D4VA 2JHJA 1MPGA 2YG8A 2YG9A 2H56A 1M3HA 1FN7A 3FHGA 5DPKA 4PIIA 3CWTA 1KG3A 3I0XA 4EW4A 1N3AA 1DIZA 3I0WA 2JHNA 3OGDA 1PU7A 1MUDA 1KG7A 4EA5A 1ORPA 3F0ZA 3FHFA 1WEIA 1NKUA 2NOZA 2NOFA 3IHOA 1N3CA 4AIAA 5KN8A 1KG6A 2NOBA 2OFIA 1VRLA 1YQLA 2NOHA 3OH9A 4B23A 1WEGA 3CW7A 2OFKA 4EW0A 3G0QA 1M3QA 4YPHA 1KEAA 4AI4A 4UNFA 1RRSA 5CHZA 1XG7A 3KNTA 3S6IA 2NOEA 4B22A 3N0UA 1NGNA 3CWUA 1LWYA 1KQJA 2XHIA 3F10A 1YQKA 2ABKA 4DK9A 4EJZA 1P59A 1N39A 1MUYA 4YOQA 1KG5A 4EA4A 1HU0A 1LMZA 4B24A 3CVTA 4EJYA 4E9FA 4EVVA 1RRQA 1XQOA 1KO9A 1P7MA 3CVSA 4E9EA 3OH6A 1YQRA 2JG6A 4E9HA 3CWSA 1MUNA 1PU8A 1YQMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KG4 A;  4OFH A;  3N5N X;  4YPR A;  4OFE A;  1ORN A;  2NOI A;  4B21 A;  1KG2 A;  1EBM A;  4AI5 A;  4UOB A;  4OFA A;  1WEF A;  4E9G A;  3KTU A;  3IH7 A;  1PVS A;  5AN4 A;  1LWV A;  3FSP A;  2NOL A;  1PU6 A;  5KN9 A;  4HSB A;  1LWW A;  3CWA A;  2I5W A;  1XQP A;  3D4V A;  2JHJ A;  1MPG A;  2YG8 A;  2YG9 A;  2H56 A;  1M3H A;  1FN7 A;  3FHG A;  5DPK A;  4PII A;  3CWT A;  1KG3 A;  3I0X A;  4EW4 A;  1N3A A;  1DIZ A;  3I0W A;  2JHN A;  3OGD A;  1PU7 A;  1MUD A;  1KG7 A;  4EA5 A;  1ORP A;  3F0Z A;  3FHF A;  1WEI A;  1NKU A;  2NOZ A;  2NOF A;  3IHO A;  1N3C A;  4AIA A;  5KN8 A;  1KG6 A;  2NOB A;  2OFI A;  1VRL A;  1YQL A;  2NOH A;  3OH9 A;  4B23 A;  1WEG A;  3CW7 A;  2OFK A;  4EW0 A;  3G0Q A;  1M3Q A;  4YPH A;  1KEA A;  4AI4 A;  4UNF A;  1RRS A;  5CHZ A;  1XG7 A;  3KNT A;  3S6I A;  2NOE A;  4B22 A;  3N0U A;  1NGN A;  3CWU A;  1LWY A;  1KQJ A;  2XHI A;  3F10 A;  1YQK A;  2ABK A;  4DK9 A;  4EJZ A;  1P59 A;  1N39 A;  1MUY A;  4YOQ A;  1KG5 A;  4EA4 A;  1HU0 A;  1LMZ A;  4B24 A;  3CVT A;  4EJY A;  4E9F A;  4EVV A;  1RRQ A;  1XQO A;  1KO9 A;  1P7M A;  3CVS A;  4E9E A;  3OH6 A;  1YQR A;  2JG6 A;  4E9H A;  3CWS A;  1MUN A;  1PU8 A;  1YQM A; 
#chains in the Genus database with same CATH topology
 3OY9 A;  1KG4 A;  4OFH A;  3N5N X;  4YPR A;  4OFE A;  1ORN A;  4E7K A;  2NOI A;  4B21 A;  1KG2 A;  1EBM A;  4AI5 A;  3OYA A;  3OYF A;  4UOB A;  4OFA A;  1WEF A;  4BAC A;  3OS1 A;  2JPS A;  4E9G A;  3KTU A;  3OYI A;  3IH7 A;  1PVS A;  5AN4 A;  1LWV A;  3FSP A;  2NOL A;  1PU6 A;  5KN9 A;  4HSB A;  1LWW A;  3OYJ A;  4NZG A;  3CWA A;  4E7L A;  2I5W A;  3OYE A;  3OS0 A;  1XQP A;  3D4V A;  5FRO A;  3OYL A;  2JHJ A;  3OYG A;  3LCN A;  1MPG A;  2YG8 A;  3S3M A;  4IKF A;  1YQM A;  2YG9 A;  2H56 A;  3L2Q A;  1M3H A;  1FN7 A;  3FHG A;  5DPK A;  3L2R A;  4PII A;  3CWT A;  1KG3 A;  3OYD A;  3I0X A;  4EW4 A;  1N3A A;  1DIZ A;  3I0W A;  2JHN A;  3OGD A;  1PU7 A;  2W04 A;  1MUD A;  1KG7 A;  4BE0 A;  4EA5 A;  1ORP A;  4ZTF A;  3F0Z A;  3FHF A;  1WEI A;  1NKU A;  3OYH A;  2NOZ A;  2NOF A;  3IHO A;  1N3C A;  4ZTJ A;  4AIA A;  5KN8 A;  1KG6 A;  2NOB A;  2OFI A;  3OYM A;  1VRL A;  1YQL A;  2NOH A;  3OH9 A;  3L2W A;  4B23 A;  1WEG A;  3R2X C;  3CW7 A;  4BDY A;  2OFK A;  4EW0 A;  3G0Q A;  3VW4 A;  1M3Q A;  1U84 A;  4YPH A;  1KEA A;  4AI4 A;  4UNF A;  1RRS A;  2W03 A;  1XG7 A;  5CHZ A;  3KNT A;  3S6I A;  2NOE A;  4B22 A;  3N0U A;  1NGN A;  3CWU A;  3OYK A;  3OS2 A;  4E7J A;  1LWY A;  3NNQ A;  1KQJ A;  2XHI A;  3OYC A;  5FRM A;  3F10 A;  3S3O A;  4BDZ A;  3L2U A;  4E7H A;  1YQK A;  2ABK A;  3L2V A;  4DK9 A;  4EJZ A;  1P59 A;  1N39 A;  1MUY A;  4YOQ A;  4BE2 A;  1KG5 A;  4EA4 A;  1HU0 A;  1LMZ A;  4B24 A;  3CVT A;  4EJY A;  3S3N A;  4E9F A;  4BE1 A;  4EVV A;  4E7I A;  1RRQ A;  3OYN A;  1XQO A;  1KO9 A;  1P7M A;  3CVS A;  4E9E A;  3OH6 A;  3OYB A;  1YQR A;  5FRN A;  2JG6 A;  4E9H A;  3CWS A;  1MUN A;  1PU8 A;  2V75 A; 
#chains in the Genus database with same CATH homology
 1KG4 A;  4OFH A;  3N5N X;  4YPR A;  4OFE A;  1ORN A;  2NOI A;  4B21 A;  1KG2 A;  1EBM A;  4AI5 A;  4UOB A;  4OFA A;  1WEF A;  4E9G A;  3KTU A;  3IH7 A;  1PVS A;  5AN4 A;  1LWV A;  3FSP A;  2NOL A;  1PU6 A;  5KN9 A;  4HSB A;  1LWW A;  3CWA A;  2I5W A;  1XQP A;  3D4V A;  2JHJ A;  1MPG A;  2YG8 A;  2YG9 A;  2H56 A;  1M3H A;  1FN7 A;  3FHG A;  5DPK A;  4PII A;  3CWT A;  1KG3 A;  3I0X A;  4EW4 A;  1N3A A;  1DIZ A;  3I0W A;  2JHN A;  3OGD A;  1PU7 A;  1MUD A;  1KG7 A;  4EA5 A;  1ORP A;  3F0Z A;  3FHF A;  1WEI A;  1NKU A;  2NOZ A;  2NOF A;  3IHO A;  1N3C A;  4AIA A;  5KN8 A;  1KG6 A;  2NOB A;  2OFI A;  1VRL A;  1YQL A;  2NOH A;  3OH9 A;  4B23 A;  1WEG A;  3CW7 A;  2OFK A;  4EW0 A;  3G0Q A;  1M3Q A;  4YPH A;  1KEA A;  4AI4 A;  4UNF A;  1RRS A;  5CHZ A;  1XG7 A;  3KNT A;  3S6I A;  2NOE A;  4B22 A;  3N0U A;  1NGN A;  3CWU A;  1LWY A;  1KQJ A;  2XHI A;  3F10 A;  1YQK A;  2ABK A;  4DK9 A;  4EJZ A;  1P59 A;  1N39 A;  1MUY A;  4YOQ A;  1KG5 A;  4EA4 A;  1HU0 A;  1LMZ A;  4B24 A;  3CVT A;  4EJY A;  4E9F A;  4EVV A;  1RRQ A;  1XQO A;  1KO9 A;  1P7M A;  3CVS A;  4E9E A;  3OH6 A;  1YQR A;  2JG6 A;  4E9H A;  3CWS A;  1MUN A;  1PU8 A;  1YQM A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...