4ONTD

Ternary host recognition complex of complement factor h, c3d, and sialic acid
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
126
structure length
126
Chain Sequence
FGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for sialic acid-mediated self-recognition by complement factor H.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 22
structure length 126
sequence length 126
chains with identical sequence E, F
ec nomenclature
pdb deposition date 2014-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4ontD01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4ontD02
2XWBF 4PZ5A 1OK1A 5JPMG 3ZD2A 2KMSA 2RL0A 2W81A 5HYPA 1Q3XA 1GKGA 5HZPB 2XQWC 2ERJA 1ELVA 1OK3A 1GHQB 2LOJA 3CALA 4B2RA 4AYMA 1E88A 2IZ3A 4K12A 2V8EA 2RKYA 1OJVA 1HFIA 2B5ID 4C16A 4B2SA 3OEDC 3OXUD 2YBYA 1OJWA 2A55A 1E5GA 3KXVA 3T5OA 4AYIA 4IGDA 1ZJKA 4CSYA 2KRIA 2JGXA 3INBC 2RKZA 1UOTP 1O9AA 1G4GA 1CKLA 2O39C 2UWNA 1H04P 3ERBA 2RLQA 2IZ4A 1C1ZA 1TPGA 4YNXA 2MCYA 1U5MA 3GXEA 2EHFA 3O8EB 2MCZA 4LOTA 1OJYA 1GKNA 1HCCA 4AYEA 2CG7A 4ZH1D 3MQLA 4F4OC 1HFHA 3OP8A 1OK9A 3M7PA 4ONTD 5FO8C 1FBRA 1QO6A 2JGWA 2XRBA 3SW0X 3TVJA 1VVCA 4A5WB 1GPZA 2JRAA 3IU3I 5HYUB 1PPQA 2CG6A 3RJ3D 2G7IA 4LOSA 3ZD1A 4MUCA 1H2PP 1H2QP 1SRZA 1E8BA 1LY2A 3KZJA 5I0QB 2CKUA 1QUBA 1OK2A 1SS2A 3R62A 3GOVA 2YRAA 1TPMA 1VVDA 5HYTB 4FXGG 3IX0A 3ZRZA 1MD8A 1NWVA 1H03P 4JHSA 2WIIC 3NFPI 4KKDA 1MD7A 4WJG2 4J38B 1G4FA 2RLPA 1TPNA 3EJHA 1QGBA 3L89M 2EC3A 4AYDA 2XWJI 2QY0A 4DJZA 1Z92B 2W80A 2XRDA 2BZMA
chains in the Genus database with same CATH superfamily
2XWBF 4PZ5A 1OK1A 5JPMG 3ZD2A 2X2ZA 2KMSA 2RL0A 2W81A 5HYPA 2ZYCA 3CI0J 1Q3XA 1GKGA 5HZPB 4PO7A 2XQWC 2ERJA 1ELVA 1OK3A 1GHQB 2LOJA 3CALA 4B2RA 4AYMA 2XRDA 1E88A 2IZ3A 4K12A 2V8EA 2RKYA 1OJVA 4N7EA 1HFIA 4C16A 3FGTA 4B2SA 3OEDC 3OXUD 2YBYA 1OJWA 3WSXA 2A55A 3WSYA 1E5GA 1RLHA 3KXVA 3T5OA 3VWOA 4AYIA 4IGDA 1ZJKA 4CSYA 2KRIA 3ZLDA 2JGXA 3INBC 2RKZA 1UOTP 4MSLA 2Y8RA 3NJAA 1O9AA 1G4GA 1CKLA 2O39C 2UWNA 3ZD1A 1H04P 3ERBA 2RLQA 2IZ4A 4YIZA 1C1ZA 1TPGA 4YNXA 4APLA 2MCYA 2Y8TA 1U5MA 3GXEA 2EHFA 3O8EB 2MCZA 4LOTA 1OJYA 1GKNA 1HCCA 3K3TA 4AYEA 2CG7A 4ZH1D 3MQLA 4F4OC 3ZLEA 1HFHA 3OP8A 1OK9A 3M7PA 4ONTD 5FO8C 1FBRA 1QO6A 2JGWA 2XRBA 3SW0X 3TVJA 1VVCA 4A5WB 1GPZA 2Y8SA 5DN4A 2JRAA 3IU3I 5HYUB 1PPQA 2CG6A 3RJ3D 2G7IA 4LOSA 3FGRA 4MUCA 1H2PP 1H2QP 1SRZA 1E8BA 1LY2A 2I2LA 3KZJA 5I0QB 2CKUA 1QUBA 1OK2A 1SS2A 3R62A 3GOVA 2YRAA 1TPMA 1VVDA 5HYTB 4FXGG 3F6KA 3IX0A 3ZRZA 1MD8A 1NWVA 1H03P 4JHSA 2WIIC 3NFPI 4KKDA 1MD7A 4WJG2 4J38B 5DN5A 4BWCA 1G4FA 2RLPA 1TPNA 3EJHA 1QGBA 3L89M 2EC3A 4AYDA 2XWJI 2QY0A 4DJZA 1Z92B 2W80A 2B5ID 2BZMA
chains in the Genus database with same CATH topology
2XWBF 4PZ5A 1OK1A 5JPMG 3ZD2A 2KMSA 2RL0A 2W81A 5HYPA 1Q3XA 1GKGA 5HZPB 2XQWC 2ERJA 1ELVA 1OK3A 1GHQB 2LOJA 3CALA 4B2RA 4AYMA 1E88A 2IZ3A 4K12A 2V8EA 2RKYA 1OJVA 1HFIA 2B5ID 4C16A 4B2SA 3OEDC 3OXUD 2YBYA 1OJWA 2A55A 1E5GA 3KXVA 3T5OA 4AYIA 4IGDA 1ZJKA 4CSYA 2KRIA 2JGXA 3INBC 2RKZA 1UOTP 1O9AA 1G4GA 1CKLA 2O39C 2UWNA 1H04P 3ERBA 2RLQA 2IZ4A 1C1ZA 1TPGA 4YNXA 2MCYA 1U5MA 3GXEA 2EHFA 3O8EB 2MCZA 4LOTA 1OJYA 1GKNA 1HCCA 4AYEA 2CG7A 4ZH1D 3MQLA 4F4OC 1HFHA 3OP8A 1OK9A 3M7PA 4ONTD 5FO8C 1FBRA 1QO6A 2JGWA 2XRBA 3SW0X 3TVJA 1VVCA 4A5WB 1GPZA 2JRAA 3IU3I 5HYUB 1PPQA 2CG6A 3RJ3D 2G7IA 4LOSA 3ZD1A 4MUCA 1H2PP 1H2QP 1SRZA 1E8BA 1LY2A 3KZJA 5I0QB 2CKUA 1QUBA 1OK2A 1SS2A 3R62A 3GOVA 2YRAA 1TPMA 1VVDA 5HYTB 4FXGG 3IX0A 3ZRZA 1MD8A 1NWVA 1H03P 4JHSA 2WIIC 3NFPI 4KKDA 1MD7A 4WJG2 4J38B 1G4FA 2RLPA 1TPNA 3EJHA 1QGBA 3L89M 2EC3A 4AYDA 2XWJI 2QY0A 4DJZA 1Z92B 2W80A 2XRDA 2BZMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XWB F;  4PZ5 A;  1OK1 A;  5JPM G;  3ZD2 A;  2KMS A;  2RL0 A;  2W81 A;  5HYP A;  1Q3X A;  1GKG A;  5HZP B;  2XQW C;  2ERJ A;  1ELV A;  1OK3 A;  1GHQ B;  2LOJ A;  3CAL A;  4B2R A;  4AYM A;  1E88 A;  2IZ3 A;  4K12 A;  2V8E A;  2RKY A;  1OJV A;  1HFI A;  2B5I D;  4C16 A;  4B2S A;  3OED C;  3OXU D;  2YBY A;  1OJW A;  2A55 A;  1E5G A;  3KXV A;  3T5O A;  4AYI A;  4IGD A;  1ZJK A;  4CSY A;  2KRI A;  2JGX A;  3INB C;  2RKZ A;  1UOT P;  1O9A A;  1G4G A;  1CKL A;  2O39 C;  2UWN A;  1H04 P;  3ERB A;  2RLQ A;  2IZ4 A;  1C1Z A;  1TPG A;  4YNX A;  2MCY A;  1U5M A;  3GXE A;  2EHF A;  3O8E B;  2MCZ A;  4LOT A;  1OJY A;  1GKN A;  1HCC A;  4AYE A;  2CG7 A;  4ZH1 D;  3MQL A;  4F4O C;  1HFH A;  3OP8 A;  1OK9 A;  3M7P A;  4ONT D;  5FO8 C;  1FBR A;  1QO6 A;  2JGW A;  2XRB A;  3SW0 X;  3TVJ A;  1VVC A;  4A5W B;  1GPZ A;  2JRA A;  3IU3 I;  5HYU B;  1PPQ A;  2CG6 A;  3RJ3 D;  2G7I A;  4LOS A;  3ZD1 A;  4MUC A;  1H2P P;  1H2Q P;  1SRZ A;  1E8B A;  1LY2 A;  3KZJ A;  5I0Q B;  2CKU A;  1QUB A;  1OK2 A;  1SS2 A;  3R62 A;  3GOV A;  2YRA A;  1TPM A;  1VVD A;  5HYT B;  4FXG G;  3IX0 A;  3ZRZ A;  1MD8 A;  1NWV A;  1H03 P;  4JHS A;  2WII C;  3NFP I;  4KKD A;  1MD7 A;  4WJG 2;  4J38 B;  1G4F A;  2RLP A;  1TPN A;  3EJH A;  1QGB A;  3L89 M;  2EC3 A;  4AYD A;  2XWJ I;  2QY0 A;  4DJZ A;  1Z92 B;  2W80 A;  2XRD A;  2BZM A; 
#chains in the Genus database with same CATH topology
 2XWB F;  4PZ5 A;  1OK1 A;  5JPM G;  3ZD2 A;  2X2Z A;  2KMS A;  2RL0 A;  2W81 A;  5HYP A;  2ZYC A;  3CI0 J;  1Q3X A;  1GKG A;  5HZP B;  4PO7 A;  2XQW C;  2ERJ A;  1ELV A;  1OK3 A;  1GHQ B;  2LOJ A;  3CAL A;  4B2R A;  4AYM A;  2XRD A;  1E88 A;  2IZ3 A;  4K12 A;  2V8E A;  2RKY A;  1OJV A;  4N7E A;  1HFI A;  4C16 A;  3FGT A;  4B2S A;  3OED C;  3OXU D;  2YBY A;  1OJW A;  3WSX A;  2A55 A;  3WSY A;  1E5G A;  1RLH A;  3KXV A;  3T5O A;  3VWO A;  4AYI A;  4IGD A;  1ZJK A;  4CSY A;  2KRI A;  3ZLD A;  2JGX A;  3INB C;  2RKZ A;  1UOT P;  4MSL A;  2Y8R A;  3NJA A;  1O9A A;  1G4G A;  1CKL A;  2O39 C;  2UWN A;  3ZD1 A;  1H04 P;  3ERB A;  2RLQ A;  2IZ4 A;  4YIZ A;  1C1Z A;  1TPG A;  4YNX A;  4APL A;  2MCY A;  2Y8T A;  1U5M A;  3GXE A;  2EHF A;  3O8E B;  2MCZ A;  4LOT A;  1OJY A;  1GKN A;  1HCC A;  3K3T A;  4AYE A;  2CG7 A;  4ZH1 D;  3MQL A;  4F4O C;  3ZLE A;  1HFH A;  3OP8 A;  1OK9 A;  3M7P A;  4ONT D;  5FO8 C;  1FBR A;  1QO6 A;  2JGW A;  2XRB A;  3SW0 X;  3TVJ A;  1VVC A;  4A5W B;  1GPZ A;  2Y8S A;  5DN4 A;  2JRA A;  3IU3 I;  5HYU B;  1PPQ A;  2CG6 A;  3RJ3 D;  2G7I A;  4LOS A;  3FGR A;  4MUC A;  1H2P P;  1H2Q P;  1SRZ A;  1E8B A;  1LY2 A;  2I2L A;  3KZJ A;  5I0Q B;  2CKU A;  1QUB A;  1OK2 A;  1SS2 A;  3R62 A;  3GOV A;  2YRA A;  1TPM A;  1VVD A;  5HYT B;  4FXG G;  3F6K A;  3IX0 A;  3ZRZ A;  1MD8 A;  1NWV A;  1H03 P;  4JHS A;  2WII C;  3NFP I;  4KKD A;  1MD7 A;  4WJG 2;  4J38 B;  5DN5 A;  4BWC A;  1G4F A;  2RLP A;  1TPN A;  3EJH A;  1QGB A;  3L89 M;  2EC3 A;  4AYD A;  2XWJ I;  2QY0 A;  4DJZ A;  1Z92 B;  2W80 A;  2B5I D;  2BZM A; 
#chains in the Genus database with same CATH homology
 2XWB F;  4PZ5 A;  1OK1 A;  5JPM G;  3ZD2 A;  2KMS A;  2RL0 A;  2W81 A;  5HYP A;  1Q3X A;  1GKG A;  5HZP B;  2XQW C;  2ERJ A;  1ELV A;  1OK3 A;  1GHQ B;  2LOJ A;  3CAL A;  4B2R A;  4AYM A;  1E88 A;  2IZ3 A;  4K12 A;  2V8E A;  2RKY A;  1OJV A;  1HFI A;  2B5I D;  4C16 A;  4B2S A;  3OED C;  3OXU D;  2YBY A;  1OJW A;  2A55 A;  1E5G A;  3KXV A;  3T5O A;  4AYI A;  4IGD A;  1ZJK A;  4CSY A;  2KRI A;  2JGX A;  3INB C;  2RKZ A;  1UOT P;  1O9A A;  1G4G A;  1CKL A;  2O39 C;  2UWN A;  1H04 P;  3ERB A;  2RLQ A;  2IZ4 A;  1C1Z A;  1TPG A;  4YNX A;  2MCY A;  1U5M A;  3GXE A;  2EHF A;  3O8E B;  2MCZ A;  4LOT A;  1OJY A;  1GKN A;  1HCC A;  4AYE A;  2CG7 A;  4ZH1 D;  3MQL A;  4F4O C;  1HFH A;  3OP8 A;  1OK9 A;  3M7P A;  4ONT D;  5FO8 C;  1FBR A;  1QO6 A;  2JGW A;  2XRB A;  3SW0 X;  3TVJ A;  1VVC A;  4A5W B;  1GPZ A;  2JRA A;  3IU3 I;  5HYU B;  1PPQ A;  2CG6 A;  3RJ3 D;  2G7I A;  4LOS A;  3ZD1 A;  4MUC A;  1H2P P;  1H2Q P;  1SRZ A;  1E8B A;  1LY2 A;  3KZJ A;  5I0Q B;  2CKU A;  1QUB A;  1OK2 A;  1SS2 A;  3R62 A;  3GOV A;  2YRA A;  1TPM A;  1VVD A;  5HYT B;  4FXG G;  3IX0 A;  3ZRZ A;  1MD8 A;  1NWV A;  1H03 P;  4JHS A;  2WII C;  3NFP I;  4KKD A;  1MD7 A;  4WJG 2;  4J38 B;  1G4F A;  2RLP A;  1TPN A;  3EJH A;  1QGB A;  3L89 M;  2EC3 A;  4AYD A;  2XWJ I;  2QY0 A;  4DJZ A;  1Z92 B;  2W80 A;  2XRD A;  2BZM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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