4OR9A

Crystal structure of human calcineurin
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
481
structure length
399
Chain Sequence
PPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMARVFSVLRSFEEAKGLDRINERMPPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
rcsb
molecule tags Hydrolase/metal binding protein
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2B catalytic subunit be
total genus 138
structure length 399
sequence length 481
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4or9A00
2HYOA 5F3WA 3IB8A 4V0XA 3P71C 4UWQA 4JA7A 4DT2A 2O8GA 4B2OA 4Q7FA 5J28A 3THNA 3K7WC 4M0VA 2Z72A 2NPPC 2Z06A 2A22A 1S8EA 3N5UA 3KBPA 4DHLA 3FGAC 1V73A 5JPEA 4H1SA 1AUIA 3ZTVA 1S3LA 4ORBA 2WDDA 2WDEA 2WDFA 3RL3A 2IE3C 4O4KA 3DSCA 1XM7A 1SU1A 4ORAA 3QG5C 2KKNA 4JA9A 1G5BA 3HVQA 5HPEA 4UT3B 5INBA 2QFRA 3QFOA 2HYPA 2DFJA 4IL1A 5IOHA 2ZBMA 2XMOA 1Z2XA 4F0ZA 3IVDA 4KKZA 2WDCA 1XZWA 1S70A 1OI8A 3THOB 2BCDA 4G9JA 3CK2A 4H2FA 1IT6A 3JYFA 1QHWA 4FBQA 2NYLC 3PSOA 4MP0A 2USHA 3QFNA 3H68A 4UT2A 4ZX2A 3RQZA 4H2IA 3H66A 2P6BA 2JOGA 2Z1AA 3E7AA 3H62B 4NZVA 5C1VA 1USHA 4DSYA 4H2GA 1II7A 1KBPA 4WWLA 1OIEA 1T70A 3DW8C 1OIDA 3AUZA 4ZVZA 5B8IA 4FBKA 3H69A 2O8AA 3C9FA 4LTYA 4O5GA 3E7BA 4LU9A 4XPNA 3V4YA 5GTUA 1FJMA 4UT3A 4TUIA 3EGGA 4LACC 3QFMA 1S3NA 2R17A 4FCXA 3RL5A 1W24A 4MOYA 1QFCA 3LL8A 4FBWA 1HP1A 1NNWA 3H67A 4H2BA 2GJUA 1JK7A 3EGHA 3TGHA 2NXFA 4I5LC 3H64A 1M63A 3GVEA 4J6OA 5JPFA 3H61A 4ORCA 3H63A 2CV9A 1T71A 1Z2WA 3QFKA 1U32A 3ICFA 4O24A 2BDXA 2BQ8X 2QFPA 1WARA 2AHDA 1WAO1 4HD0A 1TCOA 4MOVA 5JJTA 1HO5A 2HY1A 3C5WC 3ZU0A 2YVTA 4TUGA 4H1YP 2QJCA 3K7VC 1S95A 1UTEA 1HPUA 1UF3A 4OR9A 4YKEA 3RL4A 4V0VA 3AV0A 4V0WA 4IYPC 4O43A 3DSDA 2IAEC 3IB7A 3H60A 5DNYA 3IVEA 4KBPA 3T1IA 4I5NC 2IE4C 5EQVA 1S3MA 3PSNA 2NYMC 1MF8A 2Q8UA
chains in the Genus database with same CATH superfamily
2HYOA 5F3WA 3IB8A 4V0XA 3P71C 4UWQA 4JA7A 4DT2A 2O8GA 4B2OA 4Q7FA 5J28A 3THNA 3K7WC 4M0VA 2Z72A 2NPPC 2Z06A 2A22A 1S8EA 3N5UA 3KBPA 4DHLA 3FGAC 1V73A 3FLOA 4H1SA 5JPEA 1AUIA 3ZTVA 1S3LA 4ORBA 2WDDA 2WDEA 2WDFA 3RL3A 2IE3C 4O4KA 3DSCA 1XM7A 1SU1A 4ORAA 3QG5C 2KKNA 4JA9A 1G5BA 3HVQA 5HPEA 4UT3B 5INBA 2QFRA 3QFOA 2HYPA 2DFJA 4IL1A 5IOHA 2ZBMA 2XMOA 1Z2XA 4F0ZA 3IVDA 4KKZA 2WDCA 1XZWA 1S70A 1OI8A 3THOB 2BCDA 4G9JA 3CK2A 4H2FA 1IT6A 3D03A 3JYFA 1QHWA 4FBQA 2NYLC 3PSOA 4MP0A 2USHA 3QFNA 3H68A 4UT2A 4ZX2A 3RQZA 4H2IA 3H66A 2ZO9B 2DXLA 2P6BA 2JOGA 2Z1AA 3E7AA 3H62B 4NZVA 5C1VA 1USHA 4DSYA 2ZOAA 4H2GA 1II7A 1KBPA 4WWLA 1OIEA 1T70A 3DW8C 1OIDA 3AUZA 4ZVZA 5B8IA 4FBKA 3H69A 2O8AA 3C9FA 2YEQA 4LTYA 4O5GA 3E7BA 4LU9A 4XPNA 3V4YA 5GTUA 1FJMA 4UT3A 4TUIA 3EGGA 4LACC 3QFMA 1S3NA 2R17A 4FCXA 3RL5A 1W24A 4MOYA 1QFCA 3LL8A 4FBWA 1HP1A 1NNWA 3H67A 4H2BA 2GJUA 1JK7A 3EGHA 3TGHA 2NXFA 4I5LC 3H64A 1M63A 3GVEA 4J6OA 5JPFA 3H61A 4ORCA 3H63A 2CV9A 3E0JA 1T71A 1Z2WA 3QFKA 1U32A 3ICFA 4O24A 2DXNA 2BDXA 2BQ8X 2QFPA 1WARA 2AHDA 1WAO1 4HD0A 1TCOA 4MOVA 5JJTA 1HO5A 2HY1A 3C5WC 3ZU0A 2YVTA 4TUGA 4H1YP 2QJCA 3K7VC 1S95A 1UTEA 1HPUA 1UF3A 4OR9A 4YKEA 3RL4A 4V0VA 3AV0A 4V0WA 4IYPC 4O43A 3DSDA 2IAEC 3IB7A 3H60A 5DNYA 3IVEA 4KBPA 3T1IA 4I5NC 2IE4C 5EQVA 1S3MA 3PSNA 2NYMC 1MF8A 2Q8UA
chains in the Genus database with same CATH topology
2HYOA 5F3WA 3IB8A 4V0XA 3P71C 4UWQA 4JA7A 4DT2A 2O8GA 4B2OA 4Q7FA 5J28A 3THNA 3K7WC 4M0VA 2Z72A 2NPPC 2Z06A 2A22A 1S8EA 3N5UA 3KBPA 4DHLA 3FGAC 1V73A 3FLOA 4H1SA 5JPEA 1AUIA 3ZTVA 1S3LA 4ORBA 2WDDA 2WDEA 2WDFA 3RL3A 2IE3C 4O4KA 3DSCA 1XM7A 1SU1A 4ORAA 3QG5C 2KKNA 4JA9A 1G5BA 3HVQA 5HPEA 4UT3B 5INBA 2QFRA 3QFOA 2HYPA 2DFJA 4IL1A 5IOHA 2ZBMA 2XMOA 1Z2XA 4F0ZA 3IVDA 4KKZA 2WDCA 1XZWA 1S70A 1OI8A 3THOB 2BCDA 4G9JA 3CK2A 4H2FA 1IT6A 3D03A 3JYFA 1QHWA 4FBQA 2NYLC 3PSOA 4MP0A 2USHA 3QFNA 3H68A 4UT2A 4ZX2A 3RQZA 4H2IA 3H66A 2ZO9B 2DXLA 2P6BA 2JOGA 2Z1AA 3E7AA 3H62B 4NZVA 5C1VA 1USHA 4DSYA 2ZOAA 4H2GA 1II7A 1KBPA 4WWLA 1OIEA 1T70A 3DW8C 1OIDA 3AUZA 4ZVZA 5B8IA 4FBKA 3H69A 2O8AA 3C9FA 2YEQA 4LTYA 4O5GA 3E7BA 4LU9A 4XPNA 3V4YA 5GTUA 1FJMA 4UT3A 4TUIA 3EGGA 4LACC 3QFMA 1S3NA 2R17A 4FCXA 3RL5A 1W24A 4MOYA 1QFCA 3LL8A 4FBWA 1HP1A 1NNWA 3H67A 4H2BA 2GJUA 1JK7A 3EGHA 3TGHA 2NXFA 4I5LC 3H64A 1M63A 3GVEA 4J6OA 5JPFA 3H61A 4ORCA 3H63A 2CV9A 3E0JA 1T71A 1Z2WA 3QFKA 1U32A 3ICFA 4O24A 2DXNA 2BDXA 2BQ8X 2QFPA 1WARA 2AHDA 1WAO1 4HD0A 1TCOA 4MOVA 5JJTA 1HO5A 2HY1A 3C5WC 3ZU0A 2YVTA 4TUGA 4H1YP 2QJCA 3K7VC 1S95A 1UTEA 1HPUA 1UF3A 4OR9A 4YKEA 3RL4A 4V0VA 3AV0A 4V0WA 4IYPC 4O43A 3DSDA 2IAEC 3IB7A 3H60A 5DNYA 3IVEA 4KBPA 3T1IA 4I5NC 2IE4C 5EQVA 1S3MA 3PSNA 2NYMC 1MF8A 2Q8UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HYO A;  5F3W A;  3IB8 A;  4V0X A;  3P71 C;  4UWQ A;  4JA7 A;  4DT2 A;  2O8G A;  4B2O A;  4Q7F A;  5J28 A;  3THN A;  3K7W C;  4M0V A;  2Z72 A;  2NPP C;  2Z06 A;  2A22 A;  1S8E A;  3N5U A;  3KBP A;  4DHL A;  3FGA C;  1V73 A;  5JPE A;  4H1S A;  1AUI A;  3ZTV A;  1S3L A;  4ORB A;  2WDD A;  2WDE A;  2WDF A;  3RL3 A;  2IE3 C;  4O4K A;  3DSC A;  1XM7 A;  1SU1 A;  4ORA A;  3QG5 C;  2KKN A;  4JA9 A;  1G5B A;  3HVQ A;  5HPE A;  4UT3 B;  5INB A;  2QFR A;  3QFO A;  2HYP A;  2DFJ A;  4IL1 A;  5IOH A;  2ZBM A;  2XMO A;  1Z2X A;  4F0Z A;  3IVD A;  4KKZ A;  2WDC A;  1XZW A;  1S70 A;  1OI8 A;  3THO B;  2BCD A;  4G9J A;  3CK2 A;  4H2F A;  1IT6 A;  3JYF A;  1QHW A;  4FBQ A;  2NYL C;  3PSO A;  4MP0 A;  2USH A;  3QFN A;  3H68 A;  4UT2 A;  4ZX2 A;  3RQZ A;  4H2I A;  3H66 A;  2P6B A;  2JOG A;  2Z1A A;  3E7A A;  3H62 B;  4NZV A;  5C1V A;  1USH A;  4DSY A;  4H2G A;  1II7 A;  1KBP A;  4WWL A;  1OIE A;  1T70 A;  3DW8 C;  1OID A;  3AUZ A;  4ZVZ A;  5B8I A;  4FBK A;  3H69 A;  2O8A A;  3C9F A;  4LTY A;  4O5G A;  3E7B A;  4LU9 A;  4XPN A;  3V4Y A;  5GTU A;  1FJM A;  4UT3 A;  4TUI A;  3EGG A;  4LAC C;  3QFM A;  1S3N A;  2R17 A;  4FCX A;  3RL5 A;  1W24 A;  4MOY A;  1QFC A;  3LL8 A;  4FBW A;  1HP1 A;  1NNW A;  3H67 A;  4H2B A;  2GJU A;  1JK7 A;  3EGH A;  3TGH A;  2NXF A;  4I5L C;  3H64 A;  1M63 A;  3GVE A;  4J6O A;  5JPF A;  3H61 A;  4ORC A;  3H63 A;  2CV9 A;  1T71 A;  1Z2W A;  3QFK A;  1U32 A;  3ICF A;  4O24 A;  2BDX A;  2BQ8 X;  2QFP A;  1WAR A;  2AHD A;  1WAO 1;  4HD0 A;  1TCO A;  4MOV A;  5JJT A;  1HO5 A;  2HY1 A;  3C5W C;  3ZU0 A;  2YVT A;  4TUG A;  4H1Y P;  2QJC A;  3K7V C;  1S95 A;  1UTE A;  1HPU A;  1UF3 A;  4OR9 A;  4YKE A;  3RL4 A;  4V0V A;  3AV0 A;  4V0W A;  4IYP C;  4O43 A;  3DSD A;  2IAE C;  3IB7 A;  3H60 A;  5DNY A;  3IVE A;  4KBP A;  3T1I A;  4I5N C;  2IE4 C;  5EQV A;  1S3M A;  3PSN A;  2NYM C;  1MF8 A;  2Q8U A; 
#chains in the Genus database with same CATH topology
 2HYO A;  5F3W A;  3IB8 A;  4V0X A;  3P71 C;  4UWQ A;  4JA7 A;  4DT2 A;  2O8G A;  4B2O A;  4Q7F A;  5J28 A;  3THN A;  3K7W C;  4M0V A;  2Z72 A;  2NPP C;  2Z06 A;  2A22 A;  1S8E A;  3N5U A;  3KBP A;  4DHL A;  3FGA C;  1V73 A;  3FLO A;  4H1S A;  5JPE A;  1AUI A;  3ZTV A;  1S3L A;  4ORB A;  2WDD A;  2WDE A;  2WDF A;  3RL3 A;  2IE3 C;  4O4K A;  3DSC A;  1XM7 A;  1SU1 A;  4ORA A;  3QG5 C;  2KKN A;  4JA9 A;  1G5B A;  3HVQ A;  5HPE A;  4UT3 B;  5INB A;  2QFR A;  3QFO A;  2HYP A;  2DFJ A;  4IL1 A;  5IOH A;  2ZBM A;  2XMO A;  1Z2X A;  4F0Z A;  3IVD A;  4KKZ A;  2WDC A;  1XZW A;  1S70 A;  1OI8 A;  3THO B;  2BCD A;  4G9J A;  3CK2 A;  4H2F A;  1IT6 A;  3D03 A;  3JYF A;  1QHW A;  4FBQ A;  2NYL C;  3PSO A;  4MP0 A;  2USH A;  3QFN A;  3H68 A;  4UT2 A;  4ZX2 A;  3RQZ A;  4H2I A;  3H66 A;  2ZO9 B;  2DXL A;  2P6B A;  2JOG A;  2Z1A A;  3E7A A;  3H62 B;  4NZV A;  5C1V A;  1USH A;  4DSY A;  2ZOA A;  4H2G A;  1II7 A;  1KBP A;  4WWL A;  1OIE A;  1T70 A;  3DW8 C;  1OID A;  3AUZ A;  4ZVZ A;  5B8I A;  4FBK A;  3H69 A;  2O8A A;  3C9F A;  2YEQ A;  4LTY A;  4O5G A;  3E7B A;  4LU9 A;  4XPN A;  3V4Y A;  5GTU A;  1FJM A;  4UT3 A;  4TUI A;  3EGG A;  4LAC C;  3QFM A;  1S3N A;  2R17 A;  4FCX A;  3RL5 A;  1W24 A;  4MOY A;  1QFC A;  3LL8 A;  4FBW A;  1HP1 A;  1NNW A;  3H67 A;  4H2B A;  2GJU A;  1JK7 A;  3EGH A;  3TGH A;  2NXF A;  4I5L C;  3H64 A;  1M63 A;  3GVE A;  4J6O A;  5JPF A;  3H61 A;  4ORC A;  3H63 A;  2CV9 A;  3E0J A;  1T71 A;  1Z2W A;  3QFK A;  1U32 A;  3ICF A;  4O24 A;  2DXN A;  2BDX A;  2BQ8 X;  2QFP A;  1WAR A;  2AHD A;  1WAO 1;  4HD0 A;  1TCO A;  4MOV A;  5JJT A;  1HO5 A;  2HY1 A;  3C5W C;  3ZU0 A;  2YVT A;  4TUG A;  4H1Y P;  2QJC A;  3K7V C;  1S95 A;  1UTE A;  1HPU A;  1UF3 A;  4OR9 A;  4YKE A;  3RL4 A;  4V0V A;  3AV0 A;  4V0W A;  4IYP C;  4O43 A;  3DSD A;  2IAE C;  3IB7 A;  3H60 A;  5DNY A;  3IVE A;  4KBP A;  3T1I A;  4I5N C;  2IE4 C;  5EQV A;  1S3M A;  3PSN A;  2NYM C;  1MF8 A;  2Q8U A; 
#chains in the Genus database with same CATH homology
 2HYO A;  5F3W A;  3IB8 A;  4V0X A;  3P71 C;  4UWQ A;  4JA7 A;  4DT2 A;  2O8G A;  4B2O A;  4Q7F A;  5J28 A;  3THN A;  3K7W C;  4M0V A;  2Z72 A;  2NPP C;  2Z06 A;  2A22 A;  1S8E A;  3N5U A;  3KBP A;  4DHL A;  3FGA C;  1V73 A;  3FLO A;  4H1S A;  5JPE A;  1AUI A;  3ZTV A;  1S3L A;  4ORB A;  2WDD A;  2WDE A;  2WDF A;  3RL3 A;  2IE3 C;  4O4K A;  3DSC A;  1XM7 A;  1SU1 A;  4ORA A;  3QG5 C;  2KKN A;  4JA9 A;  1G5B A;  3HVQ A;  5HPE A;  4UT3 B;  5INB A;  2QFR A;  3QFO A;  2HYP A;  2DFJ A;  4IL1 A;  5IOH A;  2ZBM A;  2XMO A;  1Z2X A;  4F0Z A;  3IVD A;  4KKZ A;  2WDC A;  1XZW A;  1S70 A;  1OI8 A;  3THO B;  2BCD A;  4G9J A;  3CK2 A;  4H2F A;  1IT6 A;  3D03 A;  3JYF A;  1QHW A;  4FBQ A;  2NYL C;  3PSO A;  4MP0 A;  2USH A;  3QFN A;  3H68 A;  4UT2 A;  4ZX2 A;  3RQZ A;  4H2I A;  3H66 A;  2ZO9 B;  2DXL A;  2P6B A;  2JOG A;  2Z1A A;  3E7A A;  3H62 B;  4NZV A;  5C1V A;  1USH A;  4DSY A;  2ZOA A;  4H2G A;  1II7 A;  1KBP A;  4WWL A;  1OIE A;  1T70 A;  3DW8 C;  1OID A;  3AUZ A;  4ZVZ A;  5B8I A;  4FBK A;  3H69 A;  2O8A A;  3C9F A;  2YEQ A;  4LTY A;  4O5G A;  3E7B A;  4LU9 A;  4XPN A;  3V4Y A;  5GTU A;  1FJM A;  4UT3 A;  4TUI A;  3EGG A;  4LAC C;  3QFM A;  1S3N A;  2R17 A;  4FCX A;  3RL5 A;  1W24 A;  4MOY A;  1QFC A;  3LL8 A;  4FBW A;  1HP1 A;  1NNW A;  3H67 A;  4H2B A;  2GJU A;  1JK7 A;  3EGH A;  3TGH A;  2NXF A;  4I5L C;  3H64 A;  1M63 A;  3GVE A;  4J6O A;  5JPF A;  3H61 A;  4ORC A;  3H63 A;  2CV9 A;  3E0J A;  1T71 A;  1Z2W A;  3QFK A;  1U32 A;  3ICF A;  4O24 A;  2DXN A;  2BDX A;  2BQ8 X;  2QFP A;  1WAR A;  2AHD A;  1WAO 1;  4HD0 A;  1TCO A;  4MOV A;  5JJT A;  1HO5 A;  2HY1 A;  3C5W C;  3ZU0 A;  2YVT A;  4TUG A;  4H1Y P;  2QJC A;  3K7V C;  1S95 A;  1UTE A;  1HPU A;  1UF3 A;  4OR9 A;  4YKE A;  3RL4 A;  4V0V A;  3AV0 A;  4V0W A;  4IYP C;  4O43 A;  3DSD A;  2IAE C;  3IB7 A;  3H60 A;  5DNY A;  3IVE A;  4KBP A;  3T1I A;  4I5N C;  2IE4 C;  5EQV A;  1S3M A;  3PSN A;  2NYM C;  1MF8 A;  2Q8U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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