4ORAA

Crystal structure of a human calcineurin mutant
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
481
structure length
397
Chain Sequence
PPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELARYLSVLSFEEAKGLDRINERMPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
rcsb
source organism Homo sapiens
molecule tags Hydrolase/metal binding protein
molecule keywords Serine/threonine-protein phosphatase 2B catalytic subunit be
total genus 125
structure length 397
sequence length 481
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4oraA00
4ORBA 3E7AA 1USHA 2QFPA 4KBPA 3H67A 5JJTA 4MOYA 4H2GA 3AV0A 3THOB 3H69A 1S3LA 4ZVZA 3QG5C 3THNA 2WDEA 5JPEA 4H2BA 5EQVA 3CK2A 3E7BA 3JYFA 5IOHA 1QFCA 1SU1A 3H66A 3C5WC 1IT6A 2IE3C 1MF8A 3RL5A 5B8IA 2AHDA 2BQ8X 1Z2XA 4H1YP 1UF3A 1XM7A 2QJCA 2KKNA 4DHLA 3KBPA 1AUIA 2NXFA 1T70A 5F3WA 3QFOA 3RL4A 1JK7A 2HY1A 2P6BA 4TUGA 2IE4C 4UT3B 4IYPC 4LU9A 2Z1AA 3LL8A 5DNYA 2WDCA 4UT3A 3P71C 2YVTA 4MP0A 4ORAA 5GTUA 3ZTVA 3TGHA 3HVQA 2BCDA 1S8EA 3H61A 3H64A 2DFJA 2HYOA 3K7VC 4TUIA 2BDXA 4G9JA 4V0XA 4DT2A 3EGGA 4UT2A 4O43A 2Z06A 4JA9A 3H62B 3AUZA 3FGAC 4LTYA 3H68A 4Q7FA 2NYMC 1XZWA 4KKZA 4WWLA 2QFRA 1G5BA 4JA7A 3V4YA 5HPEA 2XMOA 2Z72A 4FBKA 4HD0A 2R17A 1WAO1 3DSCA 4ZX2A 2NPPC 3PSNA 2A22A 1HP1A 4DSYA 1OIDA 1HPUA 3IB8A 1OIEA 4FCXA 4NZVA 4F0ZA 1S3MA 1QHWA 1FJMA 3RL3A 3GVEA 1HO5A 3DSDA 1S3NA 3IB7A 3RQZA 3QFMA 5C1VA 4V0WA 1NNWA 5INBA 2USHA 3PSOA 1UTEA 4O24A 3ICFA 3H60A 4FBWA 1S70A 1M63A 4H2IA 2CV9A 5JPFA 4MOVA 3N5UA 2IAEC 3QFKA 2Q8UA 4OR9A 2WDFA 4UWQA 3IVEA 4V0VA 2HYPA 5J28A 4I5LC 1II7A 3IVDA 2GJUA 4J6OA 2ZBMA 2NYLC 3C9FA 4O4KA 2JOGA 2O8GA 1W24A 2O8AA 1T71A 1OI8A 1Z2WA 4M0VA 4O5GA 4H2FA 2WDDA 3K7WC 4LACC 4XPNA 4H1SA 3ZU0A 1TCOA 3T1IA 1V73A 3EGHA 3DW8C 3H63A 1S95A 4IL1A 3QFNA 4FBQA 4B2OA 4YKEA 1U32A 1KBPA 4ORCA 4I5NC 1WARA
chains in the Genus database with same CATH superfamily
4ORBA 3E7AA 1USHA 2QFPA 4KBPA 3E0JA 3H67A 5JJTA 4MOYA 4H2GA 3AV0A 3THOB 3FLOA 1S3LA 3H69A 4ZVZA 3QG5C 3THNA 2WDEA 5JPEA 4H2BA 5EQVA 3CK2A 3E7BA 3JYFA 5IOHA 1QFCA 1SU1A 3H66A 3C5WC 1IT6A 2IE3C 1MF8A 3RL5A 5B8IA 2AHDA 2BQ8X 1Z2XA 4H1YP 1UF3A 1XM7A 2QJCA 2KKNA 4DHLA 3KBPA 1AUIA 2NXFA 1T70A 5F3WA 3QFOA 3RL4A 1JK7A 2HY1A 2P6BA 4TUGA 2IE4C 4UT3B 4IYPC 4LU9A 2Z1AA 3LL8A 5DNYA 2WDCA 4UT3A 3P71C 2YVTA 4MP0A 4ORAA 5GTUA 3ZTVA 3TGHA 3HVQA 2BCDA 1S8EA 3H61A 3H64A 2DFJA 2HYOA 3K7VC 4TUIA 2BDXA 4G9JA 4V0XA 4DT2A 3EGGA 4UT2A 4O43A 2Z06A 4JA9A 3H62B 3AUZA 3FGAC 4LTYA 3H68A 4Q7FA 2NYMC 1XZWA 4KKZA 2DXNA 4WWLA 2QFRA 1G5BA 4JA7A 3V4YA 5HPEA 2XMOA 2Z72A 4FBKA 4HD0A 2R17A 1WAO1 3DSCA 2ZOAA 4ZX2A 3D03A 2NPPC 3PSNA 2A22A 1HP1A 4DSYA 1OIDA 1HPUA 3IB8A 1OIEA 4FCXA 4NZVA 4F0ZA 1S3MA 1QHWA 1FJMA 3RL3A 3GVEA 1HO5A 3DSDA 1S3NA 3IB7A 3RQZA 3QFMA 5C1VA 4V0WA 1NNWA 5INBA 2USHA 3PSOA 1UTEA 4O24A 3ICFA 3H60A 4FBWA 1S70A 1M63A 4H2IA 2CV9A 5JPFA 4MOVA 2DXLA 3N5UA 2IAEC 3QFKA 2Q8UA 4OR9A 2WDFA 4UWQA 3IVEA 4V0VA 2HYPA 2ZO9B 5J28A 4I5LC 1II7A 3IVDA 2GJUA 4J6OA 2ZBMA 2NYLC 3C9FA 4O4KA 2JOGA 2O8GA 1W24A 2O8AA 1T71A 1OI8A 1Z2WA 4M0VA 4O5GA 4H2FA 2WDDA 3K7WC 4LACC 4XPNA 4H1SA 3ZU0A 1TCOA 3T1IA 1V73A 3EGHA 3DW8C 3H63A 1S95A 4IL1A 3QFNA 4FBQA 4B2OA 4YKEA 1U32A 1KBPA 4ORCA 2YEQA 4I5NC 1WARA
chains in the Genus database with same CATH topology
4ORBA 3E7AA 1USHA 2QFPA 4KBPA 3E0JA 3H67A 5JJTA 4MOYA 4H2GA 3AV0A 3THOB 3FLOA 1S3LA 3H69A 4ZVZA 3QG5C 3THNA 2WDEA 5JPEA 4H2BA 5EQVA 3CK2A 3E7BA 3JYFA 5IOHA 1QFCA 1SU1A 3H66A 3C5WC 1IT6A 2IE3C 1MF8A 3RL5A 5B8IA 2AHDA 2BQ8X 1Z2XA 4H1YP 1UF3A 1XM7A 2QJCA 2KKNA 4DHLA 3KBPA 1AUIA 2NXFA 1T70A 5F3WA 3QFOA 3RL4A 1JK7A 2HY1A 2P6BA 4TUGA 2IE4C 4UT3B 4IYPC 4LU9A 2Z1AA 3LL8A 5DNYA 2WDCA 4UT3A 3P71C 2YVTA 4MP0A 4ORAA 5GTUA 3ZTVA 3TGHA 3HVQA 2BCDA 1S8EA 3H61A 3H64A 2DFJA 2HYOA 3K7VC 4TUIA 2BDXA 4G9JA 4V0XA 4DT2A 3EGGA 4UT2A 4O43A 2Z06A 4JA9A 3H62B 3AUZA 3FGAC 4LTYA 3H68A 4Q7FA 2NYMC 1XZWA 4KKZA 2DXNA 4WWLA 2QFRA 1G5BA 4JA7A 3V4YA 5HPEA 2XMOA 2Z72A 4FBKA 4HD0A 2R17A 1WAO1 3DSCA 2ZOAA 4ZX2A 3D03A 2NPPC 3PSNA 2A22A 1HP1A 4DSYA 1OIDA 1HPUA 3IB8A 1OIEA 4FCXA 4NZVA 4F0ZA 1S3MA 1QHWA 1FJMA 3RL3A 3GVEA 1HO5A 3DSDA 1S3NA 3IB7A 3RQZA 3QFMA 5C1VA 4V0WA 1NNWA 5INBA 2USHA 3PSOA 1UTEA 4O24A 3ICFA 3H60A 4FBWA 1S70A 1M63A 4H2IA 2CV9A 5JPFA 4MOVA 2DXLA 3N5UA 2IAEC 3QFKA 2Q8UA 4OR9A 2WDFA 4UWQA 3IVEA 4V0VA 2HYPA 2ZO9B 5J28A 4I5LC 1II7A 3IVDA 2GJUA 4J6OA 2ZBMA 2NYLC 3C9FA 4O4KA 2JOGA 2O8GA 1W24A 2O8AA 1T71A 1OI8A 1Z2WA 4M0VA 4O5GA 4H2FA 2WDDA 3K7WC 4LACC 4XPNA 4H1SA 3ZU0A 1TCOA 3T1IA 1V73A 3EGHA 3DW8C 3H63A 1S95A 4IL1A 3QFNA 4FBQA 4B2OA 4YKEA 1U32A 1KBPA 4ORCA 2YEQA 4I5NC 1WARA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ORB A;  3E7A A;  1USH A;  2QFP A;  4KBP A;  3H67 A;  5JJT A;  4MOY A;  4H2G A;  3AV0 A;  3THO B;  3H69 A;  1S3L A;  4ZVZ A;  3QG5 C;  3THN A;  2WDE A;  5JPE A;  4H2B A;  5EQV A;  3CK2 A;  3E7B A;  3JYF A;  5IOH A;  1QFC A;  1SU1 A;  3H66 A;  3C5W C;  1IT6 A;  2IE3 C;  1MF8 A;  3RL5 A;  5B8I A;  2AHD A;  2BQ8 X;  1Z2X A;  4H1Y P;  1UF3 A;  1XM7 A;  2QJC A;  2KKN A;  4DHL A;  3KBP A;  1AUI A;  2NXF A;  1T70 A;  5F3W A;  3QFO A;  3RL4 A;  1JK7 A;  2HY1 A;  2P6B A;  4TUG A;  2IE4 C;  4UT3 B;  4IYP C;  4LU9 A;  2Z1A A;  3LL8 A;  5DNY A;  2WDC A;  4UT3 A;  3P71 C;  2YVT A;  4MP0 A;  4ORA A;  5GTU A;  3ZTV A;  3TGH A;  3HVQ A;  2BCD A;  1S8E A;  3H61 A;  3H64 A;  2DFJ A;  2HYO A;  3K7V C;  4TUI A;  2BDX A;  4G9J A;  4V0X A;  4DT2 A;  3EGG A;  4UT2 A;  4O43 A;  2Z06 A;  4JA9 A;  3H62 B;  3AUZ A;  3FGA C;  4LTY A;  3H68 A;  4Q7F A;  2NYM C;  1XZW A;  4KKZ A;  4WWL A;  2QFR A;  1G5B A;  4JA7 A;  3V4Y A;  5HPE A;  2XMO A;  2Z72 A;  4FBK A;  4HD0 A;  2R17 A;  1WAO 1;  3DSC A;  4ZX2 A;  2NPP C;  3PSN A;  2A22 A;  1HP1 A;  4DSY A;  1OID A;  1HPU A;  3IB8 A;  1OIE A;  4FCX A;  4NZV A;  4F0Z A;  1S3M A;  1QHW A;  1FJM A;  3RL3 A;  3GVE A;  1HO5 A;  3DSD A;  1S3N A;  3IB7 A;  3RQZ A;  3QFM A;  5C1V A;  4V0W A;  1NNW A;  5INB A;  2USH A;  3PSO A;  1UTE A;  4O24 A;  3ICF A;  3H60 A;  4FBW A;  1S70 A;  1M63 A;  4H2I A;  2CV9 A;  5JPF A;  4MOV A;  3N5U A;  2IAE C;  3QFK A;  2Q8U A;  4OR9 A;  2WDF A;  4UWQ A;  3IVE A;  4V0V A;  2HYP A;  5J28 A;  4I5L C;  1II7 A;  3IVD A;  2GJU A;  4J6O A;  2ZBM A;  2NYL C;  3C9F A;  4O4K A;  2JOG A;  2O8G A;  1W24 A;  2O8A A;  1T71 A;  1OI8 A;  1Z2W A;  4M0V A;  4O5G A;  4H2F A;  2WDD A;  3K7W C;  4LAC C;  4XPN A;  4H1S A;  3ZU0 A;  1TCO A;  3T1I A;  1V73 A;  3EGH A;  3DW8 C;  3H63 A;  1S95 A;  4IL1 A;  3QFN A;  4FBQ A;  4B2O A;  4YKE A;  1U32 A;  1KBP A;  4ORC A;  4I5N C;  1WAR A; 
#chains in the Genus database with same CATH topology
 4ORB A;  3E7A A;  1USH A;  2QFP A;  4KBP A;  3E0J A;  3H67 A;  5JJT A;  4MOY A;  4H2G A;  3AV0 A;  3THO B;  3FLO A;  1S3L A;  3H69 A;  4ZVZ A;  3QG5 C;  3THN A;  2WDE A;  5JPE A;  4H2B A;  5EQV A;  3CK2 A;  3E7B A;  3JYF A;  5IOH A;  1QFC A;  1SU1 A;  3H66 A;  3C5W C;  1IT6 A;  2IE3 C;  1MF8 A;  3RL5 A;  5B8I A;  2AHD A;  2BQ8 X;  1Z2X A;  4H1Y P;  1UF3 A;  1XM7 A;  2QJC A;  2KKN A;  4DHL A;  3KBP A;  1AUI A;  2NXF A;  1T70 A;  5F3W A;  3QFO A;  3RL4 A;  1JK7 A;  2HY1 A;  2P6B A;  4TUG A;  2IE4 C;  4UT3 B;  4IYP C;  4LU9 A;  2Z1A A;  3LL8 A;  5DNY A;  2WDC A;  4UT3 A;  3P71 C;  2YVT A;  4MP0 A;  4ORA A;  5GTU A;  3ZTV A;  3TGH A;  3HVQ A;  2BCD A;  1S8E A;  3H61 A;  3H64 A;  2DFJ A;  2HYO A;  3K7V C;  4TUI A;  2BDX A;  4G9J A;  4V0X A;  4DT2 A;  3EGG A;  4UT2 A;  4O43 A;  2Z06 A;  4JA9 A;  3H62 B;  3AUZ A;  3FGA C;  4LTY A;  3H68 A;  4Q7F A;  2NYM C;  1XZW A;  4KKZ A;  2DXN A;  4WWL A;  2QFR A;  1G5B A;  4JA7 A;  3V4Y A;  5HPE A;  2XMO A;  2Z72 A;  4FBK A;  4HD0 A;  2R17 A;  1WAO 1;  3DSC A;  2ZOA A;  4ZX2 A;  3D03 A;  2NPP C;  3PSN A;  2A22 A;  1HP1 A;  4DSY A;  1OID A;  1HPU A;  3IB8 A;  1OIE A;  4FCX A;  4NZV A;  4F0Z A;  1S3M A;  1QHW A;  1FJM A;  3RL3 A;  3GVE A;  1HO5 A;  3DSD A;  1S3N A;  3IB7 A;  3RQZ A;  3QFM A;  5C1V A;  4V0W A;  1NNW A;  5INB A;  2USH A;  3PSO A;  1UTE A;  4O24 A;  3ICF A;  3H60 A;  4FBW A;  1S70 A;  1M63 A;  4H2I A;  2CV9 A;  5JPF A;  4MOV A;  2DXL A;  3N5U A;  2IAE C;  3QFK A;  2Q8U A;  4OR9 A;  2WDF A;  4UWQ A;  3IVE A;  4V0V A;  2HYP A;  2ZO9 B;  5J28 A;  4I5L C;  1II7 A;  3IVD A;  2GJU A;  4J6O A;  2ZBM A;  2NYL C;  3C9F A;  4O4K A;  2JOG A;  2O8G A;  1W24 A;  2O8A A;  1T71 A;  1OI8 A;  1Z2W A;  4M0V A;  4O5G A;  4H2F A;  2WDD A;  3K7W C;  4LAC C;  4XPN A;  4H1S A;  3ZU0 A;  1TCO A;  3T1I A;  1V73 A;  3EGH A;  3DW8 C;  3H63 A;  1S95 A;  4IL1 A;  3QFN A;  4FBQ A;  4B2O A;  4YKE A;  1U32 A;  1KBP A;  4ORC A;  2YEQ A;  4I5N C;  1WAR A; 
#chains in the Genus database with same CATH homology
 4ORB A;  3E7A A;  1USH A;  2QFP A;  4KBP A;  3E0J A;  3H67 A;  5JJT A;  4MOY A;  4H2G A;  3AV0 A;  3THO B;  3FLO A;  1S3L A;  3H69 A;  4ZVZ A;  3QG5 C;  3THN A;  2WDE A;  5JPE A;  4H2B A;  5EQV A;  3CK2 A;  3E7B A;  3JYF A;  5IOH A;  1QFC A;  1SU1 A;  3H66 A;  3C5W C;  1IT6 A;  2IE3 C;  1MF8 A;  3RL5 A;  5B8I A;  2AHD A;  2BQ8 X;  1Z2X A;  4H1Y P;  1UF3 A;  1XM7 A;  2QJC A;  2KKN A;  4DHL A;  3KBP A;  1AUI A;  2NXF A;  1T70 A;  5F3W A;  3QFO A;  3RL4 A;  1JK7 A;  2HY1 A;  2P6B A;  4TUG A;  2IE4 C;  4UT3 B;  4IYP C;  4LU9 A;  2Z1A A;  3LL8 A;  5DNY A;  2WDC A;  4UT3 A;  3P71 C;  2YVT A;  4MP0 A;  4ORA A;  5GTU A;  3ZTV A;  3TGH A;  3HVQ A;  2BCD A;  1S8E A;  3H61 A;  3H64 A;  2DFJ A;  2HYO A;  3K7V C;  4TUI A;  2BDX A;  4G9J A;  4V0X A;  4DT2 A;  3EGG A;  4UT2 A;  4O43 A;  2Z06 A;  4JA9 A;  3H62 B;  3AUZ A;  3FGA C;  4LTY A;  3H68 A;  4Q7F A;  2NYM C;  1XZW A;  4KKZ A;  2DXN A;  4WWL A;  2QFR A;  1G5B A;  4JA7 A;  3V4Y A;  5HPE A;  2XMO A;  2Z72 A;  4FBK A;  4HD0 A;  2R17 A;  1WAO 1;  3DSC A;  2ZOA A;  4ZX2 A;  3D03 A;  2NPP C;  3PSN A;  2A22 A;  1HP1 A;  4DSY A;  1OID A;  1HPU A;  3IB8 A;  1OIE A;  4FCX A;  4NZV A;  4F0Z A;  1S3M A;  1QHW A;  1FJM A;  3RL3 A;  3GVE A;  1HO5 A;  3DSD A;  1S3N A;  3IB7 A;  3RQZ A;  3QFM A;  5C1V A;  4V0W A;  1NNW A;  5INB A;  2USH A;  3PSO A;  1UTE A;  4O24 A;  3ICF A;  3H60 A;  4FBW A;  1S70 A;  1M63 A;  4H2I A;  2CV9 A;  5JPF A;  4MOV A;  2DXL A;  3N5U A;  2IAE C;  3QFK A;  2Q8U A;  4OR9 A;  2WDF A;  4UWQ A;  3IVE A;  4V0V A;  2HYP A;  2ZO9 B;  5J28 A;  4I5L C;  1II7 A;  3IVD A;  2GJU A;  4J6O A;  2ZBM A;  2NYL C;  3C9F A;  4O4K A;  2JOG A;  2O8G A;  1W24 A;  2O8A A;  1T71 A;  1OI8 A;  1Z2W A;  4M0V A;  4O5G A;  4H2F A;  2WDD A;  3K7W C;  4LAC C;  4XPN A;  4H1S A;  3ZU0 A;  1TCO A;  3T1I A;  1V73 A;  3EGH A;  3DW8 C;  3H63 A;  1S95 A;  4IL1 A;  3QFN A;  4FBQ A;  4B2O A;  4YKE A;  1U32 A;  1KBP A;  4ORC A;  2YEQ A;  4I5N C;  1WAR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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