4ORBA

Crystal structure of mouse calcineurin
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
462
structure length
377
Chain Sequence
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSSFEEAKGLDRINERMPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
rcsb
molecule tags Hydrolase/metal binding protein
source organism Mus musculus
molecule keywords Serine/threonine-protein phosphatase 2B catalytic subunit al
total genus 137
structure length 377
sequence length 462
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4orbA00
2YVTA 2HYPA 3H67A 3THOB 4ZX2A 3K7WC 3AUZA 1WARA 3HVQA 2AHDA 4F0ZA 4LACC 4O24A 3DSDA 1HO5A 1SU1A 2O8GA 2WDFA 4H2FA 4NZVA 4V0VA 1OI8A 2XMOA 3IVEA 5DNYA 2R17A 4MOVA 1U32A 3IVDA 5GTUA 1W24A 4I5LC 3TGHA 4UT2A 4ORCA 5IOHA 3AV0A 3ZTVA 4B2OA 2NYMC 3QFOA 2Z72A 2WDCA 2BDXA 5HPEA 3QFNA 3DSCA 4JA7A 1OIDA 2IAEC 5JPEA 1UTEA 1NNWA 4ORAA 3ZU0A 4H2BA 4Q7FA 3C9FA 4I5NC 3RL4A 1HP1A 2QFPA 3T1IA 1T70A 3RQZA 1S3NA 5INBA 4DHLA 4YKEA 4MOYA 1OIEA 4H1YP 4O43A 2Z06A 2HYOA 1MF8A 1Z2XA 3H60A 1S70A 2KKNA 4DT2A 1S8EA 3PSOA 4H2GA 2DFJA 2BQ8X 2A22A 4V0WA 1WAO1 3LL8A 3ICFA 3H64A 1JK7A 4IYPC 2Q8UA 1II7A 5JJTA 4O5GA 4UWQA 4WWLA 5J28A 3EGHA 3KBPA 3H63A 5B8IA 4J6OA 2USHA 3E7AA 5C1VA 5F3WA 2WDEA 4LU9A 3P71C 4V0XA 1S3LA 1XM7A 1XZWA 3H62B 4FBWA 4KBPA 4FCXA 2QJCA 4H1SA 2P6BA 4XPNA 2NXFA 1S95A 2HY1A 3QFMA 3H61A 4UT3A 3GVEA 1S3MA 1HPUA 2NYLC 3FGAC 3H66A 4H2IA 1M63A 3C5WC 2WDDA 3QG5C 4FBQA 2BCDA 1QFCA 3H68A 3DW8C 5JPFA 3IB8A 4KKZA 2ZBMA 3E7BA 4FBKA 4ORBA 4TUIA 3CK2A 3PSNA 3RL3A 3THNA 2IE3C 1KBPA 3N5UA 2JOGA 1T71A 1UF3A 4UT3B 1Z2WA 4MP0A 4DSYA 1FJMA 3RL5A 1USHA 2Z1AA 2NPPC 3EGGA 1AUIA 3H69A 4ZVZA 1IT6A 1TCOA 4IL1A 4HD0A 4G9JA 2IE4C 3V4YA 4TUGA 4JA9A 1G5BA 4LTYA 2GJUA 4O4KA 4OR9A 1V73A 3JYFA 3QFKA 5EQVA 2O8AA 1QHWA 4M0VA 3K7VC 3IB7A 2QFRA 2CV9A
chains in the Genus database with same CATH superfamily
2YVTA 2HYPA 3H67A 3THOB 4ZX2A 2YEQA 3K7WC 3AUZA 1WARA 3HVQA 2AHDA 4F0ZA 4LACC 4O24A 3DSDA 1HO5A 1SU1A 2O8GA 2WDFA 4H2FA 4NZVA 4V0VA 1OI8A 2XMOA 3IVEA 5DNYA 2R17A 4MOVA 1U32A 3IVDA 5GTUA 1W24A 4I5LC 3TGHA 4UT2A 4ORCA 5IOHA 3AV0A 3ZTVA 4B2OA 2NYMC 3QFOA 2Z72A 2WDCA 2BDXA 5HPEA 3QFNA 3DSCA 4JA7A 1OIDA 2IAEC 5JPEA 1UTEA 1NNWA 4ORAA 3ZU0A 4H2BA 2DXNA 4Q7FA 3C9FA 4I5NC 3RL4A 1HP1A 2QFPA 3T1IA 1T70A 3RQZA 1S3NA 5INBA 4DHLA 4YKEA 4MOYA 1OIEA 4H1YP 4O43A 2Z06A 2HYOA 1MF8A 1Z2XA 3H60A 1S70A 2KKNA 4DT2A 1S8EA 3PSOA 4H2GA 2DFJA 2BQ8X 2ZOAA 2A22A 4V0WA 1WAO1 3LL8A 3ICFA 3H64A 1JK7A 4IYPC 2Q8UA 1II7A 5JJTA 4O5GA 4UWQA 4WWLA 5J28A 3EGHA 3KBPA 3H63A 5B8IA 4J6OA 2USHA 3E7AA 5C1VA 5F3WA 2WDEA 4LU9A 3P71C 4V0XA 1S3LA 1XM7A 2ZO9B 1XZWA 3H62B 3FLOA 4FBWA 4KBPA 4FCXA 2QJCA 4H1SA 2P6BA 4XPNA 2NXFA 1S95A 2HY1A 3QFMA 3H61A 4UT3A 3GVEA 1S3MA 1HPUA 2NYLC 3FGAC 3H66A 4H2IA 1M63A 3C5WC 2WDDA 3QG5C 4FBQA 2BCDA 1QFCA 3H68A 3DW8C 5JPFA 3IB8A 4KKZA 2DXLA 2ZBMA 3E7BA 4FBKA 4ORBA 4TUIA 3CK2A 3PSNA 3RL3A 3THNA 2IE3C 1KBPA 3N5UA 2JOGA 1T71A 1UF3A 4UT3B 1Z2WA 4MP0A 4DSYA 1FJMA 3RL5A 1USHA 2Z1AA 2NPPC 3EGGA 1AUIA 3E0JA 3H69A 1IT6A 1TCOA 4IL1A 4ZVZA 4HD0A 4G9JA 2IE4C 3V4YA 4TUGA 4JA9A 1G5BA 4LTYA 2GJUA 4O4KA 4OR9A 1V73A 3JYFA 3QFKA 5EQVA 2O8AA 1QHWA 4M0VA 3D03A 3K7VC 3IB7A 2QFRA 2CV9A
chains in the Genus database with same CATH topology
2YVTA 2HYPA 3H67A 3THOB 4ZX2A 2YEQA 3K7WC 3AUZA 1WARA 3HVQA 2AHDA 4F0ZA 4LACC 4O24A 3DSDA 1HO5A 1SU1A 2O8GA 2WDFA 4H2FA 4NZVA 4V0VA 1OI8A 2XMOA 3IVEA 5DNYA 2R17A 4MOVA 1U32A 3IVDA 5GTUA 1W24A 4I5LC 3TGHA 4UT2A 4ORCA 5IOHA 3AV0A 3ZTVA 4B2OA 2NYMC 3QFOA 2Z72A 2WDCA 2BDXA 5HPEA 3QFNA 3DSCA 4JA7A 1OIDA 2IAEC 5JPEA 1UTEA 1NNWA 4ORAA 3ZU0A 4H2BA 2DXNA 4Q7FA 3C9FA 4I5NC 3RL4A 1HP1A 2QFPA 3T1IA 1T70A 3RQZA 1S3NA 5INBA 4DHLA 4YKEA 4MOYA 1OIEA 4H1YP 4O43A 2Z06A 2HYOA 1MF8A 1Z2XA 3H60A 1S70A 2KKNA 4DT2A 1S8EA 3PSOA 4H2GA 2DFJA 2BQ8X 2ZOAA 2A22A 4V0WA 1WAO1 3LL8A 3ICFA 3H64A 1JK7A 4IYPC 2Q8UA 1II7A 5JJTA 4O5GA 4UWQA 4WWLA 5J28A 3EGHA 3KBPA 3H63A 5B8IA 4J6OA 2USHA 3E7AA 5C1VA 5F3WA 2WDEA 4LU9A 3P71C 4V0XA 1S3LA 1XM7A 2ZO9B 1XZWA 3H62B 3FLOA 4FBWA 4KBPA 4FCXA 2QJCA 4H1SA 2P6BA 4XPNA 2NXFA 1S95A 2HY1A 3QFMA 3H61A 4UT3A 3GVEA 1S3MA 1HPUA 2NYLC 3FGAC 3H66A 4H2IA 1M63A 3C5WC 2WDDA 3QG5C 4FBQA 2BCDA 1QFCA 3H68A 3DW8C 5JPFA 3IB8A 4KKZA 2DXLA 2ZBMA 3E7BA 4FBKA 4ORBA 4TUIA 3CK2A 3PSNA 3RL3A 3THNA 2IE3C 1KBPA 3N5UA 2JOGA 1T71A 1UF3A 4UT3B 1Z2WA 4MP0A 4DSYA 1FJMA 3RL5A 1USHA 2Z1AA 2NPPC 3EGGA 1AUIA 3E0JA 3H69A 1IT6A 1TCOA 4IL1A 4ZVZA 4HD0A 4G9JA 2IE4C 3V4YA 4TUGA 4JA9A 1G5BA 4LTYA 2GJUA 4O4KA 4OR9A 1V73A 3JYFA 3QFKA 5EQVA 2O8AA 1QHWA 4M0VA 3D03A 3K7VC 3IB7A 2QFRA 2CV9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YVT A;  2HYP A;  3H67 A;  3THO B;  4ZX2 A;  3K7W C;  3AUZ A;  1WAR A;  3HVQ A;  2AHD A;  4F0Z A;  4LAC C;  4O24 A;  3DSD A;  1HO5 A;  1SU1 A;  2O8G A;  2WDF A;  4H2F A;  4NZV A;  4V0V A;  1OI8 A;  2XMO A;  3IVE A;  5DNY A;  2R17 A;  4MOV A;  1U32 A;  3IVD A;  5GTU A;  1W24 A;  4I5L C;  3TGH A;  4UT2 A;  4ORC A;  5IOH A;  3AV0 A;  3ZTV A;  4B2O A;  2NYM C;  3QFO A;  2Z72 A;  2WDC A;  2BDX A;  5HPE A;  3QFN A;  3DSC A;  4JA7 A;  1OID A;  2IAE C;  5JPE A;  1UTE A;  1NNW A;  4ORA A;  3ZU0 A;  4H2B A;  4Q7F A;  3C9F A;  4I5N C;  3RL4 A;  1HP1 A;  2QFP A;  3T1I A;  1T70 A;  3RQZ A;  1S3N A;  5INB A;  4DHL A;  4YKE A;  4MOY A;  1OIE A;  4H1Y P;  4O43 A;  2Z06 A;  2HYO A;  1MF8 A;  1Z2X A;  3H60 A;  1S70 A;  2KKN A;  4DT2 A;  1S8E A;  3PSO A;  4H2G A;  2DFJ A;  2BQ8 X;  2A22 A;  4V0W A;  1WAO 1;  3LL8 A;  3ICF A;  3H64 A;  1JK7 A;  4IYP C;  2Q8U A;  1II7 A;  5JJT A;  4O5G A;  4UWQ A;  4WWL A;  5J28 A;  3EGH A;  3KBP A;  3H63 A;  5B8I A;  4J6O A;  2USH A;  3E7A A;  5C1V A;  5F3W A;  2WDE A;  4LU9 A;  3P71 C;  4V0X A;  1S3L A;  1XM7 A;  1XZW A;  3H62 B;  4FBW A;  4KBP A;  4FCX A;  2QJC A;  4H1S A;  2P6B A;  4XPN A;  2NXF A;  1S95 A;  2HY1 A;  3QFM A;  3H61 A;  4UT3 A;  3GVE A;  1S3M A;  1HPU A;  2NYL C;  3FGA C;  3H66 A;  4H2I A;  1M63 A;  3C5W C;  2WDD A;  3QG5 C;  4FBQ A;  2BCD A;  1QFC A;  3H68 A;  3DW8 C;  5JPF A;  3IB8 A;  4KKZ A;  2ZBM A;  3E7B A;  4FBK A;  4ORB A;  4TUI A;  3CK2 A;  3PSN A;  3RL3 A;  3THN A;  2IE3 C;  1KBP A;  3N5U A;  2JOG A;  1T71 A;  1UF3 A;  4UT3 B;  1Z2W A;  4MP0 A;  4DSY A;  1FJM A;  3RL5 A;  1USH A;  2Z1A A;  2NPP C;  3EGG A;  1AUI A;  3H69 A;  4ZVZ A;  1IT6 A;  1TCO A;  4IL1 A;  4HD0 A;  4G9J A;  2IE4 C;  3V4Y A;  4TUG A;  4JA9 A;  1G5B A;  4LTY A;  2GJU A;  4O4K A;  4OR9 A;  1V73 A;  3JYF A;  3QFK A;  5EQV A;  2O8A A;  1QHW A;  4M0V A;  3K7V C;  3IB7 A;  2QFR A;  2CV9 A; 
#chains in the Genus database with same CATH topology
 2YVT A;  2HYP A;  3H67 A;  3THO B;  4ZX2 A;  2YEQ A;  3K7W C;  3AUZ A;  1WAR A;  3HVQ A;  2AHD A;  4F0Z A;  4LAC C;  4O24 A;  3DSD A;  1HO5 A;  1SU1 A;  2O8G A;  2WDF A;  4H2F A;  4NZV A;  4V0V A;  1OI8 A;  2XMO A;  3IVE A;  5DNY A;  2R17 A;  4MOV A;  1U32 A;  3IVD A;  5GTU A;  1W24 A;  4I5L C;  3TGH A;  4UT2 A;  4ORC A;  5IOH A;  3AV0 A;  3ZTV A;  4B2O A;  2NYM C;  3QFO A;  2Z72 A;  2WDC A;  2BDX A;  5HPE A;  3QFN A;  3DSC A;  4JA7 A;  1OID A;  2IAE C;  5JPE A;  1UTE A;  1NNW A;  4ORA A;  3ZU0 A;  4H2B A;  2DXN A;  4Q7F A;  3C9F A;  4I5N C;  3RL4 A;  1HP1 A;  2QFP A;  3T1I A;  1T70 A;  3RQZ A;  1S3N A;  5INB A;  4DHL A;  4YKE A;  4MOY A;  1OIE A;  4H1Y P;  4O43 A;  2Z06 A;  2HYO A;  1MF8 A;  1Z2X A;  3H60 A;  1S70 A;  2KKN A;  4DT2 A;  1S8E A;  3PSO A;  4H2G A;  2DFJ A;  2BQ8 X;  2ZOA A;  2A22 A;  4V0W A;  1WAO 1;  3LL8 A;  3ICF A;  3H64 A;  1JK7 A;  4IYP C;  2Q8U A;  1II7 A;  5JJT A;  4O5G A;  4UWQ A;  4WWL A;  5J28 A;  3EGH A;  3KBP A;  3H63 A;  5B8I A;  4J6O A;  2USH A;  3E7A A;  5C1V A;  5F3W A;  2WDE A;  4LU9 A;  3P71 C;  4V0X A;  1S3L A;  1XM7 A;  2ZO9 B;  1XZW A;  3H62 B;  3FLO A;  4FBW A;  4KBP A;  4FCX A;  2QJC A;  4H1S A;  2P6B A;  4XPN A;  2NXF A;  1S95 A;  2HY1 A;  3QFM A;  3H61 A;  4UT3 A;  3GVE A;  1S3M A;  1HPU A;  2NYL C;  3FGA C;  3H66 A;  4H2I A;  1M63 A;  3C5W C;  2WDD A;  3QG5 C;  4FBQ A;  2BCD A;  1QFC A;  3H68 A;  3DW8 C;  5JPF A;  3IB8 A;  4KKZ A;  2DXL A;  2ZBM A;  3E7B A;  4FBK A;  4ORB A;  4TUI A;  3CK2 A;  3PSN A;  3RL3 A;  3THN A;  2IE3 C;  1KBP A;  3N5U A;  2JOG A;  1T71 A;  1UF3 A;  4UT3 B;  1Z2W A;  4MP0 A;  4DSY A;  1FJM A;  3RL5 A;  1USH A;  2Z1A A;  2NPP C;  3EGG A;  1AUI A;  3E0J A;  3H69 A;  1IT6 A;  1TCO A;  4IL1 A;  4ZVZ A;  4HD0 A;  4G9J A;  2IE4 C;  3V4Y A;  4TUG A;  4JA9 A;  1G5B A;  4LTY A;  2GJU A;  4O4K A;  4OR9 A;  1V73 A;  3JYF A;  3QFK A;  5EQV A;  2O8A A;  1QHW A;  4M0V A;  3D03 A;  3K7V C;  3IB7 A;  2QFR A;  2CV9 A; 
#chains in the Genus database with same CATH homology
 2YVT A;  2HYP A;  3H67 A;  3THO B;  4ZX2 A;  2YEQ A;  3K7W C;  3AUZ A;  1WAR A;  3HVQ A;  2AHD A;  4F0Z A;  4LAC C;  4O24 A;  3DSD A;  1HO5 A;  1SU1 A;  2O8G A;  2WDF A;  4H2F A;  4NZV A;  4V0V A;  1OI8 A;  2XMO A;  3IVE A;  5DNY A;  2R17 A;  4MOV A;  1U32 A;  3IVD A;  5GTU A;  1W24 A;  4I5L C;  3TGH A;  4UT2 A;  4ORC A;  5IOH A;  3AV0 A;  3ZTV A;  4B2O A;  2NYM C;  3QFO A;  2Z72 A;  2WDC A;  2BDX A;  5HPE A;  3QFN A;  3DSC A;  4JA7 A;  1OID A;  2IAE C;  5JPE A;  1UTE A;  1NNW A;  4ORA A;  3ZU0 A;  4H2B A;  2DXN A;  4Q7F A;  3C9F A;  4I5N C;  3RL4 A;  1HP1 A;  2QFP A;  3T1I A;  1T70 A;  3RQZ A;  1S3N A;  5INB A;  4DHL A;  4YKE A;  4MOY A;  1OIE A;  4H1Y P;  4O43 A;  2Z06 A;  2HYO A;  1MF8 A;  1Z2X A;  3H60 A;  1S70 A;  2KKN A;  4DT2 A;  1S8E A;  3PSO A;  4H2G A;  2DFJ A;  2BQ8 X;  2ZOA A;  2A22 A;  4V0W A;  1WAO 1;  3LL8 A;  3ICF A;  3H64 A;  1JK7 A;  4IYP C;  2Q8U A;  1II7 A;  5JJT A;  4O5G A;  4UWQ A;  4WWL A;  5J28 A;  3EGH A;  3KBP A;  3H63 A;  5B8I A;  4J6O A;  2USH A;  3E7A A;  5C1V A;  5F3W A;  2WDE A;  4LU9 A;  3P71 C;  4V0X A;  1S3L A;  1XM7 A;  2ZO9 B;  1XZW A;  3H62 B;  3FLO A;  4FBW A;  4KBP A;  4FCX A;  2QJC A;  4H1S A;  2P6B A;  4XPN A;  2NXF A;  1S95 A;  2HY1 A;  3QFM A;  3H61 A;  4UT3 A;  3GVE A;  1S3M A;  1HPU A;  2NYL C;  3FGA C;  3H66 A;  4H2I A;  1M63 A;  3C5W C;  2WDD A;  3QG5 C;  4FBQ A;  2BCD A;  1QFC A;  3H68 A;  3DW8 C;  5JPF A;  3IB8 A;  4KKZ A;  2DXL A;  2ZBM A;  3E7B A;  4FBK A;  4ORB A;  4TUI A;  3CK2 A;  3PSN A;  3RL3 A;  3THN A;  2IE3 C;  1KBP A;  3N5U A;  2JOG A;  1T71 A;  1UF3 A;  4UT3 B;  1Z2W A;  4MP0 A;  4DSY A;  1FJM A;  3RL5 A;  1USH A;  2Z1A A;  2NPP C;  3EGG A;  1AUI A;  3E0J A;  3H69 A;  1IT6 A;  1TCO A;  4IL1 A;  4ZVZ A;  4HD0 A;  4G9J A;  2IE4 C;  3V4Y A;  4TUG A;  4JA9 A;  1G5B A;  4LTY A;  2GJU A;  4O4K A;  4OR9 A;  1V73 A;  3JYF A;  3QFK A;  5EQV A;  2O8A A;  1QHW A;  4M0V A;  3D03 A;  3K7V C;  3IB7 A;  2QFR A;  2CV9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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