4P24A

Pore forming toxin
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
293
structure length
292
Chain Sequence
ADSDINIKTGTTDIGSTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNAGPYDRDSWNPVYGNQLFMKTANGSMKAAENFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin
molecule keywords Alpha-hemolysin
publication title Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin.
pubmed doi rcsb
source organism Staphylococcus aureus subsp. aureus mu50
total genus 49
structure length 292
sequence length 293
chains with identical sequence B, C, D, E, F, G
ec nomenclature
pdb deposition date 2014-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4p24A00
4H56A 4U6VA 4YHDA 2YGTA 4TW1B 4P1YB 4IZLA 2QK7A 5K59A 5K59C 3B07B 4Q7GA 3M4EA 4IDJA 3M4DA 4TW1A 4P1XB 4IYAA 4P24A 4I0NA 4P1YA 3ANZA 1T5RA 3LKFA 4IYCA 4IYTA 1LKFA 3ROHA 2LKFA 3M2LA 3B07A 3O44A 2QK7B 4J0OA 1PVLA 4P1XA 7AHLA 3M3RA
chains in the Genus database with same CATH superfamily
1XEZA 4H56A 4U6VA 4YHDA 2YGTA 4TW1B 4P1YB 4IZLA 2QK7A 5K59A 5K59C 3B07B 4Q7GA 3M4EA 4IDJA 3M4DA 4TW1A 4P1XB 4IYAA 4P24A 4I0NA 4P1YA 3ANZA 1T5RA 3LKFA 4IYCA 4IYTA 1LKFA 3ROHA 2LKFA 3M2LA 3B07A 3O44A 2QK7B 4J0OA 1PVLA 4P1XA 7AHLA 3M3RA
chains in the Genus database with same CATH topology
4H56A 4U6VA 4YHDA 2YGTA 4TW1B 4P1YB 4IZLA 2QK7A 5K59A 5K59C 3B07B 4Q7GA 3M4EA 4IDJA 3M4DA 4TW1A 4P1XB 4IYAA 4P24A 4I0NA 4P1YA 3ANZA 1T5RA 3LKFA 4IYCA 4IYTA 1LKFA 3ROHA 2LKFA 3M2LA 3B07A 3O44A 2QK7B 4J0OA 1PVLA 4P1XA 7AHLA 3M3RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H56 A;  4U6V A;  4YHD A;  2YGT A;  4TW1 B;  4P1Y B;  4IZL A;  2QK7 A;  5K59 A;  5K59 C;  3B07 B;  4Q7G A;  3M4E A;  4IDJ A;  3M4D A;  4TW1 A;  4P1X B;  4IYA A;  4P24 A;  4I0N A;  4P1Y A;  3ANZ A;  1T5R A;  3LKF A;  4IYC A;  4IYT A;  1LKF A;  3ROH A;  2LKF A;  3M2L A;  3B07 A;  3O44 A;  2QK7 B;  4J0O A;  1PVL A;  4P1X A;  7AHL A;  3M3R A; 
#chains in the Genus database with same CATH topology
 1XEZ A;  4H56 A;  4U6V A;  4YHD A;  2YGT A;  4TW1 B;  4P1Y B;  4IZL A;  2QK7 A;  5K59 A;  5K59 C;  3B07 B;  4Q7G A;  3M4E A;  4IDJ A;  3M4D A;  4TW1 A;  4P1X B;  4IYA A;  4P24 A;  4I0N A;  4P1Y A;  3ANZ A;  1T5R A;  3LKF A;  4IYC A;  4IYT A;  1LKF A;  3ROH A;  2LKF A;  3M2L A;  3B07 A;  3O44 A;  2QK7 B;  4J0O A;  1PVL A;  4P1X A;  7AHL A;  3M3R A; 
#chains in the Genus database with same CATH homology
 4H56 A;  4U6V A;  4YHD A;  2YGT A;  4TW1 B;  4P1Y B;  4IZL A;  2QK7 A;  5K59 A;  5K59 C;  3B07 B;  4Q7G A;  3M4E A;  4IDJ A;  3M4D A;  4TW1 A;  4P1X B;  4IYA A;  4P24 A;  4I0N A;  4P1Y A;  3ANZ A;  1T5R A;  3LKF A;  4IYC A;  4IYT A;  1LKF A;  3ROH A;  2LKF A;  3M2L A;  3B07 A;  3O44 A;  2QK7 B;  4J0O A;  1PVL A;  4P1X A;  7AHL A;  3M3R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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