4PKHB

Complex of adp-actin with the n-terminal actin-binding domain of tropomodulin
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
182
structure length
165
Chain Sequence
VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFGTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Actin cytoskeleton. Mechanism of actin filament pointed-end capping by tropomodulin.
pubmed doi rcsb
molecule tags Contractile protein/actin-binding protein
source organism Homo sapiens
molecule keywords Actin, alpha skeletal muscle
total genus 35
structure length 165
sequence length 182
chains with identical sequence E, G, J
ec nomenclature
pdb deposition date 2014-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 4pkhB00
3EGXB 5DD2A 3FFNA 1C0FS 1ESVS 1M4JA 3CI5G 2NUTA 2MOTA 3Q2BA 2VACA 1WM4A 3FG7A 1V6FA 3TU5B 2MV2A 1M2VB 1NPHA 3EGXA 3DAWB 1AHQA 2KVKA 1M2OA 2L72A 1AK6A 3CIPG 2I2QA 1AK7A 1F7SA 3EH1A 5KYWB 1M2VA 1Q8GA 2FH1A 1WFSA 5FAEA 2NUPB 2W0IA 1JHWA 4BEX1 1PD1A 1NLVG 4JD2H 1D4XG 5FAFA 3A5OS 5KYWA 4KEFA 1SVYA 3A5NS 2FH2A 1NMDG 4KEEA 2NUPA 5KYNA 4S10C 1P8ZG 1D0NA 1KCQA 1P8XA 2MP4A 3EFOB 1VFQA 1T44G 1T2LA 2LJ8A 2FH4A 4CBWG 1WNJA 1Q8XA 1HQZ1 5KYXB 5L6WC 2LXXA 2FH3A 3A5LS 5KYUB 3FFKA 2XFAA 3CJBG 1EQYS 2LLFA 1RGIG 3EFOA 4CBUG 5HVKD 1DEJS 4PKHB 2VILA 2FGHA 4CBXG 1QPVA 2VIKA 4PKIG 5KYXA 5KYUA 1CNUA 1VKKA 2QTVA 2XF1A 3A5MS 1MDUA 1PCXA 1J72A 3EG9B 3EGDB 1H1VG 2HD7A 3L50A 4LIZA 1SVRA 4KEDA 1COFA 1TVJA 5A1MA 1CFYA 2FF6G 3CJCG 3EG9A 1T3YA 3EGDA 1UDMA 4PKGG 1T3XA 2D8BA 2FF3A 1C0GS 1X67A 5KYYB 5HVKB 5IVUA 4Z94G 2NUTB 1SVQA 1TMWA 1NM1G 3EH2A 1PD0A 1YAGG 3FG6A 5KYYA 1YVNG
chains in the Genus database with same CATH superfamily
3EGXB 5DD2A 3FFNA 1C0FS 1ESVS 1M4JA 3CI5G 2NUTA 2MOTA 3Q2BA 2VACA 1WM4A 3FG7A 1V6FA 3TU5B 2MV2A 1M2VB 1NPHA 3EGXA 3DAWB 1AHQA 2KVKA 1M2OA 2L72A 1AK6A 3CIPG 2I2QA 1AK7A 1F7SA 3EH1A 5KYWB 1M2VA 1Q8GA 2FH1A 1WFSA 5FAEA 2NUPB 2W0IA 1JHWA 4BEX1 1PD1A 1NLVG 4JD2H 1D4XG 5FAFA 3A5OS 5KYWA 4KEFA 1SVYA 3A5NS 2FH2A 1NMDG 4KEEA 2NUPA 5KYNA 4S10C 1P8ZG 1D0NA 1KCQA 1P8XA 2MP4A 3EFOB 1VFQA 1T44G 1T2LA 2LJ8A 2FH4A 4CBWG 1WNJA 1Q8XA 1HQZ1 5KYXB 5L6WC 2LXXA 2FH3A 3A5LS 5KYUB 3FFKA 2XFAA 3CJBG 1EQYS 2LLFA 1RGIG 3EFOA 4CBUG 5HVKD 1DEJS 4PKHB 2VILA 2FGHA 3DA7A 4CBXG 1QPVA 2VIKA 4PKIG 5KYXA 5KYUA 1CNUA 1VKKA 2QTVA 2XF1A 3A5MS 1MDUA 1PCXA 1J72A 3EG9B 3EGDB 1H1VG 2HD7A 3L50A 4LIZA 1SVRA 4KEDA 1COFA 1TVJA 5A1MA 1CFYA 2FF6G 3CJCG 3EG9A 1T3YA 3EGDA 1UDMA 4PKGG 1T3XA 2D8BA 2FF3A 1C0GS 1X67A 5KYYB 5HVKB 5IVUA 4Z94G 2NUTB 1SVQA 1TMWA 1NM1G 3EH2A 1PD0A 1YAGG 3FG6A 5KYYA 1YVNG
chains in the Genus database with same CATH topology
3EGXB 5DD2A 3FFNA 1C0FS 1ESVS 1M4JA 3CI5G 2NUTA 2MOTA 3Q2BA 2VACA 1WM4A 3FG7A 1V6FA 3TU5B 2MV2A 1M2VB 1NPHA 3EGXA 3DAWB 1AHQA 2KVKA 1M2OA 2L72A 1AK6A 3CIPG 2I2QA 1AK7A 1F7SA 3EH1A 5KYWB 1M2VA 1Q8GA 2FH1A 1WFSA 5FAEA 2NUPB 2W0IA 1JHWA 4BEX1 1PD1A 1NLVG 4JD2H 1D4XG 5FAFA 3A5OS 5KYWA 4KEFA 1SVYA 3A5NS 2FH2A 1NMDG 4KEEA 2NUPA 5KYNA 4S10C 1P8ZG 1D0NA 1KCQA 1P8XA 2MP4A 3EFOB 1VFQA 1T44G 1T2LA 2LJ8A 2FH4A 4CBWG 1WNJA 1Q8XA 1HQZ1 5KYXB 5L6WC 2LXXA 2FH3A 3A5LS 5KYUB 3FFKA 2XFAA 3CJBG 1EQYS 2LLFA 1RGIG 3EFOA 4CBUG 5HVKD 1DEJS 4PKHB 2VILA 2FGHA 3DA7A 4CBXG 1QPVA 2VIKA 4PKIG 5KYXA 5KYUA 1CNUA 1VKKA 2QTVA 2XF1A 3A5MS 1MDUA 1PCXA 1J72A 3EG9B 3EGDB 1H1VG 2HD7A 3L50A 4LIZA 1SVRA 4KEDA 1COFA 1TVJA 5A1MA 1CFYA 2FF6G 3CJCG 3EG9A 1T3YA 3EGDA 1UDMA 4PKGG 1T3XA 2D8BA 2FF3A 1C0GS 1X67A 5KYYB 5HVKB 5IVUA 4Z94G 2NUTB 1SVQA 1TMWA 1NM1G 3EH2A 1PD0A 1YAGG 3FG6A 5KYYA 1YVNG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EGX B;  5DD2 A;  3FFN A;  1C0F S;  1ESV S;  1M4J A;  3CI5 G;  2NUT A;  2MOT A;  3Q2B A;  2VAC A;  1WM4 A;  3FG7 A;  1V6F A;  3TU5 B;  2MV2 A;  1M2V B;  1NPH A;  3EGX A;  3DAW B;  1AHQ A;  2KVK A;  1M2O A;  2L72 A;  1AK6 A;  3CIP G;  2I2Q A;  1AK7 A;  1F7S A;  3EH1 A;  5KYW B;  1M2V A;  1Q8G A;  2FH1 A;  1WFS A;  5FAE A;  2NUP B;  2W0I A;  1JHW A;  4BEX 1;  1PD1 A;  1NLV G;  4JD2 H;  1D4X G;  5FAF A;  3A5O S;  5KYW A;  4KEF A;  1SVY A;  3A5N S;  2FH2 A;  1NMD G;  4KEE A;  2NUP A;  5KYN A;  4S10 C;  1P8Z G;  1D0N A;  1KCQ A;  1P8X A;  2MP4 A;  3EFO B;  1VFQ A;  1T44 G;  1T2L A;  2LJ8 A;  2FH4 A;  4CBW G;  1WNJ A;  1Q8X A;  1HQZ 1;  5KYX B;  5L6W C;  2LXX A;  2FH3 A;  3A5L S;  5KYU B;  3FFK A;  2XFA A;  3CJB G;  1EQY S;  2LLF A;  1RGI G;  3EFO A;  4CBU G;  5HVK D;  1DEJ S;  4PKH B;  2VIL A;  2FGH A;  4CBX G;  1QPV A;  2VIK A;  4PKI G;  5KYX A;  5KYU A;  1CNU A;  1VKK A;  2QTV A;  2XF1 A;  3A5M S;  1MDU A;  1PCX A;  1J72 A;  3EG9 B;  3EGD B;  1H1V G;  2HD7 A;  3L50 A;  4LIZ A;  1SVR A;  4KED A;  1COF A;  1TVJ A;  5A1M A;  1CFY A;  2FF6 G;  3CJC G;  3EG9 A;  1T3Y A;  3EGD A;  1UDM A;  4PKG G;  1T3X A;  2D8B A;  2FF3 A;  1C0G S;  1X67 A;  5KYY B;  5HVK B;  5IVU A;  4Z94 G;  2NUT B;  1SVQ A;  1TMW A;  1NM1 G;  3EH2 A;  1PD0 A;  1YAG G;  3FG6 A;  5KYY A;  1YVN G; 
#chains in the Genus database with same CATH topology
 3EGX B;  5DD2 A;  3FFN A;  1C0F S;  1ESV S;  1M4J A;  3CI5 G;  2NUT A;  2MOT A;  3Q2B A;  2VAC A;  1WM4 A;  3FG7 A;  1V6F A;  3TU5 B;  2MV2 A;  1M2V B;  1NPH A;  3EGX A;  3DAW B;  1AHQ A;  2KVK A;  1M2O A;  2L72 A;  1AK6 A;  3CIP G;  2I2Q A;  1AK7 A;  1F7S A;  3EH1 A;  5KYW B;  1M2V A;  1Q8G A;  2FH1 A;  1WFS A;  5FAE A;  2NUP B;  2W0I A;  1JHW A;  4BEX 1;  1PD1 A;  1NLV G;  4JD2 H;  1D4X G;  5FAF A;  3A5O S;  5KYW A;  4KEF A;  1SVY A;  3A5N S;  2FH2 A;  1NMD G;  4KEE A;  2NUP A;  5KYN A;  4S10 C;  1P8Z G;  1D0N A;  1KCQ A;  1P8X A;  2MP4 A;  3EFO B;  1VFQ A;  1T44 G;  1T2L A;  2LJ8 A;  2FH4 A;  4CBW G;  1WNJ A;  1Q8X A;  1HQZ 1;  5KYX B;  5L6W C;  2LXX A;  2FH3 A;  3A5L S;  5KYU B;  3FFK A;  2XFA A;  3CJB G;  1EQY S;  2LLF A;  1RGI G;  3EFO A;  4CBU G;  5HVK D;  1DEJ S;  4PKH B;  2VIL A;  2FGH A;  3DA7 A;  4CBX G;  1QPV A;  2VIK A;  4PKI G;  5KYX A;  5KYU A;  1CNU A;  1VKK A;  2QTV A;  2XF1 A;  3A5M S;  1MDU A;  1PCX A;  1J72 A;  3EG9 B;  3EGD B;  1H1V G;  2HD7 A;  3L50 A;  4LIZ A;  1SVR A;  4KED A;  1COF A;  1TVJ A;  5A1M A;  1CFY A;  2FF6 G;  3CJC G;  3EG9 A;  1T3Y A;  3EGD A;  1UDM A;  4PKG G;  1T3X A;  2D8B A;  2FF3 A;  1C0G S;  1X67 A;  5KYY B;  5HVK B;  5IVU A;  4Z94 G;  2NUT B;  1SVQ A;  1TMW A;  1NM1 G;  3EH2 A;  1PD0 A;  1YAG G;  3FG6 A;  5KYY A;  1YVN G; 
#chains in the Genus database with same CATH homology
 3EGX B;  5DD2 A;  3FFN A;  1C0F S;  1ESV S;  1M4J A;  3CI5 G;  2NUT A;  2MOT A;  3Q2B A;  2VAC A;  1WM4 A;  3FG7 A;  1V6F A;  3TU5 B;  2MV2 A;  1M2V B;  1NPH A;  3EGX A;  3DAW B;  1AHQ A;  2KVK A;  1M2O A;  2L72 A;  1AK6 A;  3CIP G;  2I2Q A;  1AK7 A;  1F7S A;  3EH1 A;  5KYW B;  1M2V A;  1Q8G A;  2FH1 A;  1WFS A;  5FAE A;  2NUP B;  2W0I A;  1JHW A;  4BEX 1;  1PD1 A;  1NLV G;  4JD2 H;  1D4X G;  5FAF A;  3A5O S;  5KYW A;  4KEF A;  1SVY A;  3A5N S;  2FH2 A;  1NMD G;  4KEE A;  2NUP A;  5KYN A;  4S10 C;  1P8Z G;  1D0N A;  1KCQ A;  1P8X A;  2MP4 A;  3EFO B;  1VFQ A;  1T44 G;  1T2L A;  2LJ8 A;  2FH4 A;  4CBW G;  1WNJ A;  1Q8X A;  1HQZ 1;  5KYX B;  5L6W C;  2LXX A;  2FH3 A;  3A5L S;  5KYU B;  3FFK A;  2XFA A;  3CJB G;  1EQY S;  2LLF A;  1RGI G;  3EFO A;  4CBU G;  5HVK D;  1DEJ S;  4PKH B;  2VIL A;  2FGH A;  3DA7 A;  4CBX G;  1QPV A;  2VIK A;  4PKI G;  5KYX A;  5KYU A;  1CNU A;  1VKK A;  2QTV A;  2XF1 A;  3A5M S;  1MDU A;  1PCX A;  1J72 A;  3EG9 B;  3EGD B;  1H1V G;  2HD7 A;  3L50 A;  4LIZ A;  1SVR A;  4KED A;  1COF A;  1TVJ A;  5A1M A;  1CFY A;  2FF6 G;  3CJC G;  3EG9 A;  1T3Y A;  3EGD A;  1UDM A;  4PKG G;  1T3X A;  2D8B A;  2FF3 A;  1C0G S;  1X67 A;  5KYY B;  5HVK B;  5IVU A;  4Z94 G;  2NUT B;  1SVQ A;  1TMW A;  1NM1 G;  3EH2 A;  1PD0 A;  1YAG G;  3FG6 A;  5KYY A;  1YVN G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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