4Q3RC

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
345
structure length
333
Chain Sequence
b'KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
source organism Schistosoma mansoni
molecule tags Hydrolase/hydrolase inhibitor
total genus 126
structure length 333
sequence length 345
chains with identical sequence D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3rC00
1T4TA 4I06A 2AEBA 1HQ5A 1T5FA 3F80A 4Q3SA 1WOGA 4MYLA 2EIVA 4RHMA 3LP7A 1TBJA 4IU1A 4Q3VA 4IE2A 1T4RA 3THJA 1P8QA 4RHQA 1HQXA 3MFWA 1P8NA 1WOHA 2ZAVA 4Q40A 4Q3QA 1CEVA 4HWWA 4MYFA 3THHA 2EF5A 4Q3PA 3LHLA 3E8ZA 1T4SA 5HJ9A 4Q42A 2PLLA 1WVBA 3NIQA 4HZEA 3SJTA 4GSMA 4Q41A 4RHKA 2CEVA 2A0MA 3M1RA 4HXQA 5RLAA 3TF3A 3DJ8A 3E9BA 4IU4A 1RLAA 4IXUA 3SKKA 3CEVA 2EF4A 1WVAA 1T5GA 4RHLA 1HQHA 1TBHA 3LP4A 4Q3RC 1WOIA 4Q3TA 1P8SA 1ZPGA 4G3HA 3E8QA 3E6VA 3GMZA 3E6KA 4RHIA 1D3VA 3MMRA 4RHJA 1GQ6A 3NIPA 4GSVA 4FCIA 4RLAA 4GWCA 3NIOA 4ITYA 1P8RA 1P8OA 4IXVA 2RLAA 1ZPEA 1P8MA 1HQGA 3PZLA 2PHOA 4GSZA 3RLAA 2PHAA 3THEA 4CEVA 4DZ4A 4MYNA 4FCKA 4GWDA 1R1OA 4IE3A 3GN0A 1TA1A 3SL0A 3TH7A 4IE1A 4Q3RA 1TBLA 1XFKA 4Q3UA 5HJAA 4MYKA 4MXRA 1GQ7A 3MFVA 1P8PA 4IU5A 3MJLA 4IU0A 3SL1A 1HQFA 1T4PA 1PQ3A 3KV2A 5CEVA
chains in the Genus database with same CATH superfamily
1T4TA 4I06A 2AEBA 4ZUOA 1HQ5A 1T5FA 3F80A 3SFHA 5G0GA 5FUEA 4BZ7A 4Q3SA 1C3RA 1WOGA 4MYLA 5G12A 2EIVA 5D1DA 4RHMA 3LP7A 3Q9BA 1TBJA 5THTA 4IU1A 1ZZ3A 4Q3VA 4IE2A 1T4RA 4ZUNA 5DC7A 3THJA 2VQOA 1P8QA 4RHQA 4ZUPA 5G1AA 1HQXA 5DC6A 3MFWA 1P8NA 1WOHA 2VQMA 2ZAVA 4Q40A 5EF8A 5G0XA 4Q3QA 1CEVA 4HWWA 4MYFA 3THHA 2EF5A 2VQJA 4Q3PA 5G0HA 3LHLA 5EEIA 3E8ZA 1T4SA 3EZPA 4QA4A 1C3SA 2V5WA 5EEFA 5G0IA 5HJ9A 5G0JA 1C3PA 4Q42A 2PLLA 5JI5A 1WVBA 5THUA 3NIQA 5LI3A 4HZEA 3SJTA 2VCGA 5G1CA 4GSMA 4LXZA 4Q41A 4RHKA 2GH6A 4A69A 4BZ5A 5THVA 3F06A 2CEVA 2A0MA 3M1RA 3MAXA 4HXQA 5RLAA 3TF3A 3ZNRA 3Q9CA 3DJ8A 3E9BA 4IU4A 1RLAA 4IXUA 3C0YA 1W22A 4CBTA 3SKKA 4ZURA 3CEVA 2EF4A 5G0YA 1WVAA 1T5GA 1T67A 3MZ4A 4RHLA 3RQDA 1HQHA 1TBHA 3LP4A 4Q3RC 1ZZ1A 1WOIA 5FCWA 4ZUMA 4Q3TA 5A2SA 1P8SA 3C10A 1ZPGA 3F0RA 5G17A 4G3HA 5EFBD 3Q9EA 5EFKB 4QA6A 3ZNSA 1T69A 4BKXB 3E8QA 5EEMA 3E6VA 3GMZA 4LY1A 3MZ7A 3E6KA 5G10A 3EWFA 1ZZ0A 4RHIA 4QA0A 1D3VA 2VQQA 3F07A 3MMRA 4RHJA 1GQ6A 3NIPA 5EFJD 4CQFA 4GSVA 4FCIA 4RLAA 4GWCA 3NIOA 5ICNB 5G3WA 4ITYA 5EEKA 4CBYA 1P8RA 4QA1A 4BZ9A 3EW8A 1P8OA 4IXVA 4BZ6A 2RLAA 1ZPEA 5D1BA 1P8MA 1HQGA 3MZ3A 2PHOA 3PZLA 4GSZA 2PHAA 3MZ6A 4RN0A 5G13A 3RLAA 3THEA 4CEVA 4MYNA 4DZ4A 3EZTA 1T64A 4FCKA 4QA7A 4GWDA 5DC8A 2VQWG 1HQFA 5G11A 3MENA 4ZUQA 4IE3A 3GN0A 1TA1A 5IWGA 5EFNA 3SL0A 3TH7A 4RN2A 2VQVA 4IE1A 4Q3RA 5D1CA 1VKGA 1TBLA 5BWZA 4QA3A 5EFHA 5DC5A 1XFKA 4Q3UA 3Q9FA 5EENA 3SFFA 5THSA 4RN1A 5HJAA 4MYKA 4MXRA 4QA5A 3C0ZA 1GQ7A 5EFGA 3MFVA 1P8PA 5IX0A 4IU5A 3MJLA 4IU0A 5G1BA 4QA2A 2V5XA 5EF7A 3SL1A 1R1OA 1T4PA 1PQ3A 3KV2A 4BZ8A 5CEVA
chains in the Genus database with same CATH topology
1T4TA 4I06A 2AEBA 1HQ5A 1T5FA 3F80A 4Q3SA 1WOGA 4MYLA 2EIVA 4RHMA 3LP7A 1TBJA 4IU1A 4Q3VA 4IE2A 1T4RA 3THJA 1P8QA 4RHQA 1HQXA 3MFWA 1P8NA 1WOHA 2ZAVA 4Q40A 4Q3QA 1CEVA 4HWWA 4MYFA 3THHA 2EF5A 4Q3PA 3LHLA 3E8ZA 1T4SA 5HJ9A 4Q42A 2PLLA 1WVBA 3NIQA 4HZEA 3SJTA 4GSMA 4Q41A 4RHKA 2CEVA 2A0MA 3M1RA 4HXQA 5RLAA 3TF3A 3DJ8A 3E9BA 4IU4A 1RLAA 4IXUA 3SKKA 3CEVA 2EF4A 1WVAA 1T5GA 4RHLA 1HQHA 1TBHA 3LP4A 4Q3RC 1WOIA 4Q3TA 1P8SA 1ZPGA 4G3HA 3E8QA 3E6VA 3GMZA 3E6KA 4RHIA 1D3VA 3MMRA 4RHJA 1GQ6A 3NIPA 4GSVA 4FCIA 4RLAA 4GWCA 3NIOA 4ITYA 1P8RA 1P8OA 4IXVA 2RLAA 1ZPEA 1P8MA 1HQGA 3PZLA 2PHOA 4GSZA 3RLAA 2PHAA 3THEA 4CEVA 4DZ4A 4MYNA 4FCKA 4GWDA 1R1OA 4IE3A 3GN0A 1TA1A 3SL0A 3TH7A 4IE1A 4Q3RA 1TBLA 1XFKA 4Q3UA 5HJAA 4MYKA 4MXRA 1GQ7A 3MFVA 1P8PA 4IU5A 3MJLA 4IU0A 3SL1A 1HQFA 1T4PA 1PQ3A 3KV2A 5CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T4T A;  4I06 A;  2AEB A;  1HQ5 A;  1T5F A;  3F80 A;  4Q3S A;  1WOG A;  4MYL A;  2EIV A;  4RHM A;  3LP7 A;  1TBJ A;  4IU1 A;  4Q3V A;  4IE2 A;  1T4R A;  3THJ A;  1P8Q A;  4RHQ A;  1HQX A;  3MFW A;  1P8N A;  1WOH A;  2ZAV A;  4Q40 A;  4Q3Q A;  1CEV A;  4HWW A;  4MYF A;  3THH A;  2EF5 A;  4Q3P A;  3LHL A;  3E8Z A;  1T4S A;  5HJ9 A;  4Q42 A;  2PLL A;  1WVB A;  3NIQ A;  4HZE A;  3SJT A;  4GSM A;  4Q41 A;  4RHK A;  2CEV A;  2A0M A;  3M1R A;  4HXQ A;  5RLA A;  3TF3 A;  3DJ8 A;  3E9B A;  4IU4 A;  1RLA A;  4IXU A;  3SKK A;  3CEV A;  2EF4 A;  1WVA A;  1T5G A;  4RHL A;  1HQH A;  1TBH A;  3LP4 A;  4Q3R C;  1WOI A;  4Q3T A;  1P8S A;  1ZPG A;  4G3H A;  3E8Q A;  3E6V A;  3GMZ A;  3E6K A;  4RHI A;  1D3V A;  3MMR A;  4RHJ A;  1GQ6 A;  3NIP A;  4GSV A;  4FCI A;  4RLA A;  4GWC A;  3NIO A;  4ITY A;  1P8R A;  1P8O A;  4IXV A;  2RLA A;  1ZPE A;  1P8M A;  1HQG A;  3PZL A;  2PHO A;  4GSZ A;  3RLA A;  2PHA A;  3THE A;  4CEV A;  4DZ4 A;  4MYN A;  4FCK A;  4GWD A;  1R1O A;  4IE3 A;  3GN0 A;  1TA1 A;  3SL0 A;  3TH7 A;  4IE1 A;  4Q3R A;  1TBL A;  1XFK A;  4Q3U A;  5HJA A;  4MYK A;  4MXR A;  1GQ7 A;  3MFV A;  1P8P A;  4IU5 A;  3MJL A;  4IU0 A;  3SL1 A;  1HQF A;  1T4P A;  1PQ3 A;  3KV2 A;  5CEV A; 
#chains in the Genus database with same CATH topology
 1T4T A;  4I06 A;  2AEB A;  4ZUO A;  1HQ5 A;  1T5F A;  3F80 A;  3SFH A;  5G0G A;  5FUE A;  4BZ7 A;  4Q3S A;  1C3R A;  1WOG A;  4MYL A;  5G12 A;  2EIV A;  5D1D A;  4RHM A;  3LP7 A;  3Q9B A;  1TBJ A;  5THT A;  4IU1 A;  1ZZ3 A;  4Q3V A;  4IE2 A;  1T4R A;  4ZUN A;  5DC7 A;  3THJ A;  2VQO A;  1P8Q A;  4RHQ A;  4ZUP A;  5G1A A;  1HQX A;  5DC6 A;  3MFW A;  1P8N A;  1WOH A;  2VQM A;  2ZAV A;  4Q40 A;  5EF8 A;  5G0X A;  4Q3Q A;  1CEV A;  4HWW A;  4MYF A;  3THH A;  2EF5 A;  2VQJ A;  4Q3P A;  5G0H A;  3LHL A;  5EEI A;  3E8Z A;  1T4S A;  3EZP A;  4QA4 A;  1C3S A;  2V5W A;  5EEF A;  5G0I A;  5HJ9 A;  5G0J A;  1C3P A;  4Q42 A;  2PLL A;  5JI5 A;  1WVB A;  5THU A;  3NIQ A;  5LI3 A;  4HZE A;  3SJT A;  2VCG A;  5G1C A;  4GSM A;  4LXZ A;  4Q41 A;  4RHK A;  2GH6 A;  4A69 A;  4BZ5 A;  5THV A;  3F06 A;  2CEV A;  2A0M A;  3M1R A;  3MAX A;  4HXQ A;  5RLA A;  3TF3 A;  3ZNR A;  3Q9C A;  3DJ8 A;  3E9B A;  4IU4 A;  1RLA A;  4IXU A;  3C0Y A;  1W22 A;  4CBT A;  3SKK A;  4ZUR A;  3CEV A;  2EF4 A;  5G0Y A;  1WVA A;  1T5G A;  1T67 A;  3MZ4 A;  4RHL A;  3RQD A;  1HQH A;  1TBH A;  3LP4 A;  4Q3R C;  1ZZ1 A;  1WOI A;  5FCW A;  4ZUM A;  4Q3T A;  5A2S A;  1P8S A;  3C10 A;  1ZPG A;  3F0R A;  5G17 A;  4G3H A;  5EFB D;  3Q9E A;  5EFK B;  4QA6 A;  3ZNS A;  1T69 A;  4BKX B;  3E8Q A;  5EEM A;  3E6V A;  3GMZ A;  4LY1 A;  3MZ7 A;  3E6K A;  5G10 A;  3EWF A;  1ZZ0 A;  4RHI A;  4QA0 A;  1D3V A;  2VQQ A;  3F07 A;  3MMR A;  4RHJ A;  1GQ6 A;  3NIP A;  5EFJ D;  4CQF A;  4GSV A;  4FCI A;  4RLA A;  4GWC A;  3NIO A;  5ICN B;  5G3W A;  4ITY A;  5EEK A;  4CBY A;  1P8R A;  4QA1 A;  4BZ9 A;  3EW8 A;  1P8O A;  4IXV A;  4BZ6 A;  2RLA A;  1ZPE A;  5D1B A;  1P8M A;  1HQG A;  3MZ3 A;  2PHO A;  3PZL A;  4GSZ A;  2PHA A;  3MZ6 A;  4RN0 A;  5G13 A;  3RLA A;  3THE A;  4CEV A;  4MYN A;  4DZ4 A;  3EZT A;  1T64 A;  4FCK A;  4QA7 A;  4GWD A;  5DC8 A;  2VQW G;  1HQF A;  5G11 A;  3MEN A;  4ZUQ A;  4IE3 A;  3GN0 A;  1TA1 A;  5IWG A;  5EFN A;  3SL0 A;  3TH7 A;  4RN2 A;  2VQV A;  4IE1 A;  4Q3R A;  5D1C A;  1VKG A;  1TBL A;  5BWZ A;  4QA3 A;  5EFH A;  5DC5 A;  1XFK A;  4Q3U A;  3Q9F A;  5EEN A;  3SFF A;  5THS A;  4RN1 A;  5HJA A;  4MYK A;  4MXR A;  4QA5 A;  3C0Z A;  1GQ7 A;  5EFG A;  3MFV A;  1P8P A;  5IX0 A;  4IU5 A;  3MJL A;  4IU0 A;  5G1B A;  4QA2 A;  2V5X A;  5EF7 A;  3SL1 A;  1R1O A;  1T4P A;  1PQ3 A;  3KV2 A;  4BZ8 A;  5CEV A; 
#chains in the Genus database with same CATH homology
 1T4T A;  4I06 A;  2AEB A;  1HQ5 A;  1T5F A;  3F80 A;  4Q3S A;  1WOG A;  4MYL A;  2EIV A;  4RHM A;  3LP7 A;  1TBJ A;  4IU1 A;  4Q3V A;  4IE2 A;  1T4R A;  3THJ A;  1P8Q A;  4RHQ A;  1HQX A;  3MFW A;  1P8N A;  1WOH A;  2ZAV A;  4Q40 A;  4Q3Q A;  1CEV A;  4HWW A;  4MYF A;  3THH A;  2EF5 A;  4Q3P A;  3LHL A;  3E8Z A;  1T4S A;  5HJ9 A;  4Q42 A;  2PLL A;  1WVB A;  3NIQ A;  4HZE A;  3SJT A;  4GSM A;  4Q41 A;  4RHK A;  2CEV A;  2A0M A;  3M1R A;  4HXQ A;  5RLA A;  3TF3 A;  3DJ8 A;  3E9B A;  4IU4 A;  1RLA A;  4IXU A;  3SKK A;  3CEV A;  2EF4 A;  1WVA A;  1T5G A;  4RHL A;  1HQH A;  1TBH A;  3LP4 A;  4Q3R C;  1WOI A;  4Q3T A;  1P8S A;  1ZPG A;  4G3H A;  3E8Q A;  3E6V A;  3GMZ A;  3E6K A;  4RHI A;  1D3V A;  3MMR A;  4RHJ A;  1GQ6 A;  3NIP A;  4GSV A;  4FCI A;  4RLA A;  4GWC A;  3NIO A;  4ITY A;  1P8R A;  1P8O A;  4IXV A;  2RLA A;  1ZPE A;  1P8M A;  1HQG A;  3PZL A;  2PHO A;  4GSZ A;  3RLA A;  2PHA A;  3THE A;  4CEV A;  4DZ4 A;  4MYN A;  4FCK A;  4GWD A;  1R1O A;  4IE3 A;  3GN0 A;  1TA1 A;  3SL0 A;  3TH7 A;  4IE1 A;  4Q3R A;  1TBL A;  1XFK A;  4Q3U A;  5HJA A;  4MYK A;  4MXR A;  1GQ7 A;  3MFV A;  1P8P A;  4IU5 A;  3MJL A;  4IU0 A;  3SL1 A;  1HQF A;  1T4P A;  1PQ3 A;  3KV2 A;  5CEV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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