4Q3UA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor nor-noha
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
345
structure length
336
Chain Sequence
b'PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
source organism Schistosoma mansoni
molecule tags Hydrolase/hydrolase inhibitor
total genus 122
structure length 336
sequence length 345
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3uA00
1P8MA 4Q3RC 3E9BA 4IE3A 4GSVA 3NIQA 4IXUA 1P8RA 1HQ5A 1TBHA 4FCIA 4IU1A 4RLAA 1HQHA 1P8PA 4RHIA 4DZ4A 4Q3PA 1T4RA 1TA1A 3NIOA 1D3VA 1T4PA 4Q41A 3LHLA 1P8NA 1PQ3A 3MJLA 3NIPA 4RHMA 1TBJA 5HJAA 3E6KA 4GSMA 4I06A 1RLAA 3GMZA 5RLAA 3TF3A 1P8QA 1WVAA 4G3HA 3MFWA 4CEVA 1HQFA 3LP4A 4RHKA 4Q3RA 1T4TA 1TBLA 2EF4A 3MMRA 4HXQA 3CEVA 2PHOA 1P8OA 3F80A 4Q3UA 4RHLA 4RHJA 2AEBA 1R1OA 1WOGA 2A0MA 3GN0A 3PZLA 1T5GA 3THJA 4GWCA 1WOHA 4IXVA 4Q42A 5CEVA 1GQ6A 3M1RA 1P8SA 2CEVA 3THEA 4Q3TA 3SJTA 4RHQA 3RLAA 5HJ9A 3E8QA 3LP7A 4Q40A 4MYLA 4GWDA 2EF5A 3SKKA 3KV2A 4IU5A 1HQGA 2EIVA 1T5FA 4FCKA 4MYNA 3THHA 4IE1A 3MFVA 2ZAVA 4MYKA 3E8ZA 4Q3VA 1WOIA 4IU0A 1CEVA 4GSZA 4HWWA 4MXRA 3SL0A 3SL1A 3DJ8A 4IU4A 3E6VA 2RLAA 1ZPEA 1HQXA 2PLLA 1WVBA 1GQ7A 4HZEA 2PHAA 4IE2A 1ZPGA 4ITYA 3TH7A 4Q3SA 1T4SA 4Q3QA 1XFKA 4MYFA
chains in the Genus database with same CATH superfamily
1T64A 1P8MA 5G17A 4Q3RC 2VQQA 4BZ6A 1VKGA 3E9BA 3MAXA 4IE3A 2VQOA 3MENA 3NIQA 4GSVA 4IXUA 5G12A 5G0IA 3ZNSA 1P8RA 1HQ5A 1TBHA 2VQMA 4FCIA 4IU1A 4RLAA 1HQHA 1P8PA 4RN0A 4RHIA 4DZ4A 5D1DA 3F06A 5DC7A 4Q3PA 3EZPA 4QA7A 4QA2A 1T4RA 3MZ6A 1TA1A 5D1CA 4QA1A 5G3WA 3NIOA 1D3VA 1T4PA 4ZURA 5G0GA 4Q41A 5THSA 3LHLA 1P8NA 1PQ3A 3MJLA 4QA5A 5G0XA 4BZ8A 3NIPA 4RHMA 1TBJA 5HJAA 4ZUMA 3E6KA 5EEMA 3Q9FA 4GSMA 4A69A 4I06A 5EFBD 1RLAA 3C0ZA 3GMZA 5RLAA 3TF3A 1P8QA 1WVAA 5EEKA 4G3HA 5G1CA 3MFWA 4CEVA 1HQFA 2VQVA 3LP4A 4LY1A 4Q3RA 1T4TA 1TBLA 2EF4A 3MMRA 2V5XA 4RHKA 5EFNA 5G13A 4HXQA 3CEVA 5IX0A 3Q9BA 2PHOA 1P8OA 3F80A 4Q3UA 4RHLA 4RN2A 5EEIA 3EZTA 3ZNRA 1W22A 5DC8A 4RHJA 2AEBA 1R1OA 4ZUQA 5EF8A 4QA6A 3Q9CA 4QA4A 2VQJA 3EWFA 1WOGA 2A0MA 3GN0A 5EFGA 1T5GA 3PZLA 3THJA 4GWCA 1WOHA 4IXVA 5EENA 1C3SA 4Q42A 5CEVA 3C10A 5EFHA 1GQ6A 4CQFA 2GH6A 3M1RA 1P8SA 3MZ3A 2CEVA 5ICNB 3THEA 4Q3TA 4ZUPA 4CBTA 5G10A 4ZUOA 3SJTA 4RHQA 5G11A 3RLAA 5HJ9A 2VCGA 3E8QA 3LP7A 3Q9EA 3SFFA 4Q40A 5EFKB 4MYLA 4BZ7A 4GWDA 5G0YA 3SFHA 3F07A 5IWGA 2EF5A 3SKKA 2VQWG 3KV2A 5G0HA 4LXZA 4IU5A 5JI5A 1HQGA 2EIVA 1T5FA 5EF7A 4FCKA 4MYNA 5G1AA 3THHA 4IE1A 3MFVA 5LI3A 5EFJD 3MZ7A 2ZAVA 5THTA 4RN1A 1C3RA 2V5WA 3EW8A 4MYKA 4CBYA 3E8ZA 4QA0A 4Q3VA 1WOIA 4IU0A 1CEVA 1T69A 1ZZ3A 4GSZA 4HWWA 4MXRA 3SL0A 3SL1A 3DJ8A 3RQDA 4IU4A 1T67A 5FCWA 3E6VA 5D1BA 5THUA 4BZ9A 5BWZA 3C0YA 5FUEA 2RLAA 1ZPEA 4BZ5A 5G1BA 5DC6A 1HQXA 1ZZ0A 2PLLA 3MZ4A 4QA3A 1WVBA 4BKXB 1C3PA 5A2SA 1GQ7A 5DC5A 4HZEA 2PHAA 4IE2A 5THVA 1ZZ1A 1ZPGA 5EEFA 4ITYA 4ZUNA 5G0JA 3TH7A 4Q3SA 1T4SA 4Q3QA 1XFKA 4MYFA 3F0RA
chains in the Genus database with same CATH topology
1P8MA 4Q3RC 3E9BA 4IE3A 4GSVA 3NIQA 4IXUA 1P8RA 1HQ5A 1TBHA 4FCIA 4IU1A 4RLAA 1HQHA 1P8PA 4RHIA 4DZ4A 4Q3PA 1T4RA 1TA1A 3NIOA 1D3VA 1T4PA 4Q41A 3LHLA 1P8NA 1PQ3A 3MJLA 3NIPA 4RHMA 1TBJA 5HJAA 3E6KA 4GSMA 4I06A 1RLAA 3GMZA 5RLAA 3TF3A 1P8QA 1WVAA 4G3HA 3MFWA 4CEVA 1HQFA 3LP4A 4RHKA 4Q3RA 1T4TA 1TBLA 2EF4A 3MMRA 4HXQA 3CEVA 2PHOA 1P8OA 3F80A 4Q3UA 4RHLA 4RHJA 2AEBA 1R1OA 1WOGA 2A0MA 3GN0A 3PZLA 1T5GA 3THJA 4GWCA 1WOHA 4IXVA 4Q42A 5CEVA 1GQ6A 3M1RA 1P8SA 2CEVA 3THEA 4Q3TA 3SJTA 4RHQA 3RLAA 5HJ9A 3E8QA 3LP7A 4Q40A 4MYLA 4GWDA 2EF5A 3SKKA 3KV2A 4IU5A 1HQGA 2EIVA 1T5FA 4FCKA 4MYNA 3THHA 4IE1A 3MFVA 2ZAVA 4MYKA 3E8ZA 4Q3VA 1WOIA 4IU0A 1CEVA 4GSZA 4HWWA 4MXRA 3SL0A 3SL1A 3DJ8A 4IU4A 3E6VA 2RLAA 1ZPEA 1HQXA 2PLLA 1WVBA 1GQ7A 4HZEA 2PHAA 4IE2A 1ZPGA 4ITYA 3TH7A 4Q3SA 1T4SA 4Q3QA 1XFKA 4MYFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8M A;  4Q3R C;  3E9B A;  4IE3 A;  4GSV A;  3NIQ A;  4IXU A;  1P8R A;  1HQ5 A;  1TBH A;  4FCI A;  4IU1 A;  4RLA A;  1HQH A;  1P8P A;  4RHI A;  4DZ4 A;  4Q3P A;  1T4R A;  1TA1 A;  3NIO A;  1D3V A;  1T4P A;  4Q41 A;  3LHL A;  1P8N A;  1PQ3 A;  3MJL A;  3NIP A;  4RHM A;  1TBJ A;  5HJA A;  3E6K A;  4GSM A;  4I06 A;  1RLA A;  3GMZ A;  5RLA A;  3TF3 A;  1P8Q A;  1WVA A;  4G3H A;  3MFW A;  4CEV A;  1HQF A;  3LP4 A;  4RHK A;  4Q3R A;  1T4T A;  1TBL A;  2EF4 A;  3MMR A;  4HXQ A;  3CEV A;  2PHO A;  1P8O A;  3F80 A;  4Q3U A;  4RHL A;  4RHJ A;  2AEB A;  1R1O A;  1WOG A;  2A0M A;  3GN0 A;  3PZL A;  1T5G A;  3THJ A;  4GWC A;  1WOH A;  4IXV A;  4Q42 A;  5CEV A;  1GQ6 A;  3M1R A;  1P8S A;  2CEV A;  3THE A;  4Q3T A;  3SJT A;  4RHQ A;  3RLA A;  5HJ9 A;  3E8Q A;  3LP7 A;  4Q40 A;  4MYL A;  4GWD A;  2EF5 A;  3SKK A;  3KV2 A;  4IU5 A;  1HQG A;  2EIV A;  1T5F A;  4FCK A;  4MYN A;  3THH A;  4IE1 A;  3MFV A;  2ZAV A;  4MYK A;  3E8Z A;  4Q3V A;  1WOI A;  4IU0 A;  1CEV A;  4GSZ A;  4HWW A;  4MXR A;  3SL0 A;  3SL1 A;  3DJ8 A;  4IU4 A;  3E6V A;  2RLA A;  1ZPE A;  1HQX A;  2PLL A;  1WVB A;  1GQ7 A;  4HZE A;  2PHA A;  4IE2 A;  1ZPG A;  4ITY A;  3TH7 A;  4Q3S A;  1T4S A;  4Q3Q A;  1XFK A;  4MYF A; 
#chains in the Genus database with same CATH topology
 1T64 A;  1P8M A;  5G17 A;  4Q3R C;  2VQQ A;  4BZ6 A;  1VKG A;  3E9B A;  3MAX A;  4IE3 A;  2VQO A;  3MEN A;  3NIQ A;  4GSV A;  4IXU A;  5G12 A;  5G0I A;  3ZNS A;  1P8R A;  1HQ5 A;  1TBH A;  2VQM A;  4FCI A;  4IU1 A;  4RLA A;  1HQH A;  1P8P A;  4RN0 A;  4RHI A;  4DZ4 A;  5D1D A;  3F06 A;  5DC7 A;  4Q3P A;  3EZP A;  4QA7 A;  4QA2 A;  1T4R A;  3MZ6 A;  1TA1 A;  5D1C A;  4QA1 A;  5G3W A;  3NIO A;  1D3V A;  1T4P A;  4ZUR A;  5G0G A;  4Q41 A;  5THS A;  3LHL A;  1P8N A;  1PQ3 A;  3MJL A;  4QA5 A;  5G0X A;  4BZ8 A;  3NIP A;  4RHM A;  1TBJ A;  5HJA A;  4ZUM A;  3E6K A;  5EEM A;  3Q9F A;  4GSM A;  4A69 A;  4I06 A;  5EFB D;  1RLA A;  3C0Z A;  3GMZ A;  5RLA A;  3TF3 A;  1P8Q A;  1WVA A;  5EEK A;  4G3H A;  5G1C A;  3MFW A;  4CEV A;  1HQF A;  2VQV A;  3LP4 A;  4LY1 A;  4Q3R A;  1T4T A;  1TBL A;  2EF4 A;  3MMR A;  2V5X A;  4RHK A;  5EFN A;  5G13 A;  4HXQ A;  3CEV A;  5IX0 A;  3Q9B A;  2PHO A;  1P8O A;  3F80 A;  4Q3U A;  4RHL A;  4RN2 A;  5EEI A;  3EZT A;  3ZNR A;  1W22 A;  5DC8 A;  4RHJ A;  2AEB A;  1R1O A;  4ZUQ A;  5EF8 A;  4QA6 A;  3Q9C A;  4QA4 A;  2VQJ A;  3EWF A;  1WOG A;  2A0M A;  3GN0 A;  5EFG A;  1T5G A;  3PZL A;  3THJ A;  4GWC A;  1WOH A;  4IXV A;  5EEN A;  1C3S A;  4Q42 A;  5CEV A;  3C10 A;  5EFH A;  1GQ6 A;  4CQF A;  2GH6 A;  3M1R A;  1P8S A;  3MZ3 A;  2CEV A;  5ICN B;  3THE A;  4Q3T A;  4ZUP A;  4CBT A;  5G10 A;  4ZUO A;  3SJT A;  4RHQ A;  5G11 A;  3RLA A;  5HJ9 A;  2VCG A;  3E8Q A;  3LP7 A;  3Q9E A;  3SFF A;  4Q40 A;  5EFK B;  4MYL A;  4BZ7 A;  4GWD A;  5G0Y A;  3SFH A;  3F07 A;  5IWG A;  2EF5 A;  3SKK A;  2VQW G;  3KV2 A;  5G0H A;  4LXZ A;  4IU5 A;  5JI5 A;  1HQG A;  2EIV A;  1T5F A;  5EF7 A;  4FCK A;  4MYN A;  5G1A A;  3THH A;  4IE1 A;  3MFV A;  5LI3 A;  5EFJ D;  3MZ7 A;  2ZAV A;  5THT A;  4RN1 A;  1C3R A;  2V5W A;  3EW8 A;  4MYK A;  4CBY A;  3E8Z A;  4QA0 A;  4Q3V A;  1WOI A;  4IU0 A;  1CEV A;  1T69 A;  1ZZ3 A;  4GSZ A;  4HWW A;  4MXR A;  3SL0 A;  3SL1 A;  3DJ8 A;  3RQD A;  4IU4 A;  1T67 A;  5FCW A;  3E6V A;  5D1B A;  5THU A;  4BZ9 A;  5BWZ A;  3C0Y A;  5FUE A;  2RLA A;  1ZPE A;  4BZ5 A;  5G1B A;  5DC6 A;  1HQX A;  1ZZ0 A;  2PLL A;  3MZ4 A;  4QA3 A;  1WVB A;  4BKX B;  1C3P A;  5A2S A;  1GQ7 A;  5DC5 A;  4HZE A;  2PHA A;  4IE2 A;  5THV A;  1ZZ1 A;  1ZPG A;  5EEF A;  4ITY A;  4ZUN A;  5G0J A;  3TH7 A;  4Q3S A;  1T4S A;  4Q3Q A;  1XFK A;  4MYF A;  3F0R A; 
#chains in the Genus database with same CATH homology
 1P8M A;  4Q3R C;  3E9B A;  4IE3 A;  4GSV A;  3NIQ A;  4IXU A;  1P8R A;  1HQ5 A;  1TBH A;  4FCI A;  4IU1 A;  4RLA A;  1HQH A;  1P8P A;  4RHI A;  4DZ4 A;  4Q3P A;  1T4R A;  1TA1 A;  3NIO A;  1D3V A;  1T4P A;  4Q41 A;  3LHL A;  1P8N A;  1PQ3 A;  3MJL A;  3NIP A;  4RHM A;  1TBJ A;  5HJA A;  3E6K A;  4GSM A;  4I06 A;  1RLA A;  3GMZ A;  5RLA A;  3TF3 A;  1P8Q A;  1WVA A;  4G3H A;  3MFW A;  4CEV A;  1HQF A;  3LP4 A;  4RHK A;  4Q3R A;  1T4T A;  1TBL A;  2EF4 A;  3MMR A;  4HXQ A;  3CEV A;  2PHO A;  1P8O A;  3F80 A;  4Q3U A;  4RHL A;  4RHJ A;  2AEB A;  1R1O A;  1WOG A;  2A0M A;  3GN0 A;  3PZL A;  1T5G A;  3THJ A;  4GWC A;  1WOH A;  4IXV A;  4Q42 A;  5CEV A;  1GQ6 A;  3M1R A;  1P8S A;  2CEV A;  3THE A;  4Q3T A;  3SJT A;  4RHQ A;  3RLA A;  5HJ9 A;  3E8Q A;  3LP7 A;  4Q40 A;  4MYL A;  4GWD A;  2EF5 A;  3SKK A;  3KV2 A;  4IU5 A;  1HQG A;  2EIV A;  1T5F A;  4FCK A;  4MYN A;  3THH A;  4IE1 A;  3MFV A;  2ZAV A;  4MYK A;  3E8Z A;  4Q3V A;  1WOI A;  4IU0 A;  1CEV A;  4GSZ A;  4HWW A;  4MXR A;  3SL0 A;  3SL1 A;  3DJ8 A;  4IU4 A;  3E6V A;  2RLA A;  1ZPE A;  1HQX A;  2PLL A;  1WVB A;  1GQ7 A;  4HZE A;  2PHA A;  4IE2 A;  1ZPG A;  4ITY A;  3TH7 A;  4Q3S A;  1T4S A;  4Q3Q A;  1XFK A;  4MYF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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