4QA1A

Crystal structure of a188t hdac8 in complex with m344
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
363
structure length
354
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDTFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 134
structure length 354
sequence length 363
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2014-05-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4qa1A00
5EF7A 5G1CA 1T69A 5EFHA 2VQJA 5DC6A 5IX0A 3F07A 3EW8A 3MZ7A 5EEKA 4BZ7A 5G12A 2VQQA 4CQFA 4A69A 3Q9CA 5EFNA 5ICNB 3MZ4A 5G10A 5DC7A 4ZUPA 5G1AA 5LI3A 3SFHA 1C3RA 5G11A 4QA6A 3C0ZA 4LXZA 5G0HA 5THUA 4BKXB 4QA1A 4CBTA 3MENA 5EFGA 1W22A 2VCGA 3ZNSA 3C0YA 4BZ5A 5JI5A 4RN1A 5THVA 5G17A 4QA4A 2V5XA 5EEMA 4ZUNA 1T67A 2VQWG 5G0YA 1T64A 4RN0A 3SFFA 3EWFA 4QA7A 3F06A 5EEIA 2VQMA 4QA2A 4ZURA 4BZ8A 5DC5A 1VKGA 3MZ3A 4QA5A 2GH6A 3Q9FA 5A2SA 5G13A 2VQOA 3C10A 5G0IA 2VQVA 3EZTA 5IWGA 5EF8A 5FCWA 3MZ6A 3Q9BA 4ZUQA 5G3WA 1ZZ1A 5D1BA 5G0JA 5G0XA 1ZZ0A 4ZUOA 1C3PA 4ZUMA 5EFBD 5THSA 5THTA 3Q9EA 4RN2A 5G0GA 1C3SA 5EENA 5EEFA 3EZPA 5BWZA 5G1BA 4LY1A 5D1CA 4CBYA 4BZ9A 5EFKB 4QA3A 3MAXA 4QA0A 5DC8A 5EFJD 3RQDA 4BZ6A 1ZZ3A 3F0RA 5FUEA 5D1DA 2V5WA 3ZNRA
chains in the Genus database with same CATH superfamily
5EF7A 5G1CA 1T69A 5EFHA 2VQJA 2EF5A 5DC6A 1RLAA 5IX0A 3F07A 3EW8A 3MZ7A 4GSVA 1WVAA 1WVBA 5HJ9A 4Q3SA 3M1RA 5EEKA 4BZ7A 5G12A 2VQQA 1ZPEA 4CQFA 4IU0A 4IE1A 1T4SA 1T5GA 4FCIA 4GWDA 4A69A 3Q9CA 1GQ6A 4RHIA 5EFNA 5ICNB 3DJ8A 3MZ4A 5DC7A 5G10A 4RLAA 4ZUPA 5G1AA 5LI3A 4IU4A 1T5FA 3SFHA 1C3RA 5G11A 4QA6A 3C0ZA 4LXZA 5G0HA 5THUA 5HJAA 4BKXB 4QA1A 1HQFA 2AEBA 4CBTA 5CEVA 3MENA 1P8PA 5EFGA 1W22A 4IE2A 1HQGA 2VCGA 3ZNSA 4ITYA 3F80A 3C0YA 5RLAA 4BZ5A 5JI5A 4RN1A 1P8MA 4MYFA 1T4TA 1WOGA 5THVA 5G17A 1P8RA 1TBHA 4QA4A 2V5XA 3E9BA 4IU5A 5EEMA 4ZUNA 4Q42A 1T67A 2VQWG 4GSMA 2PHOA 3TH7A 1HQXA 4GSZA 5G0YA 1T64A 4RN0A 4I06A 3SFFA 3MFVA 3GMZA 3EWFA 3THEA 1XFKA 4QA7A 4Q3PA 3F06A 3SJTA 5EEIA 1P8NA 3LHLA 5D1DA 4RHKA 2VQMA 4Q3VA 4QA2A 3E8QA 4HZEA 4Q3QA 4ZURA 4BZ8A 1T4PA 5DC5A 1VKGA 3MZ3A 4MYLA 3SL0A 3NIQA 1TA1A 4QA5A 1T4RA 4FCKA 2GH6A 3LP4A 4HXQA 4MYNA 3RLAA 3Q9FA 5A2SA 4IXUA 5G13A 2PLLA 4MXRA 3E6KA 2VQOA 4GWCA 4MYKA 4CEVA 4HWWA 1P8OA 3C10A 5G0IA 2VQVA 3EZTA 1WOHA 1GQ7A 3PZLA 5IWGA 1R1OA 2CEVA 3E8ZA 1TBJA 5EF8A 5FCWA 4Q40A 3SL1A 3MZ6A 3Q9BA 4ZUQA 5G3WA 1ZPGA 4IXVA 1ZZ1A 3NIPA 5D1BA 5G0JA 5G0XA 3LP7A 1HQ5A 3E6VA 4Q41A 1P8QA 4IE3A 1HQHA 1ZZ0A 4Q3RC 4Q3RA 4IU1A 4ZUOA 1C3PA 3MFWA 2EIVA 4ZUMA 2RLAA 4G3HA 1D3VA 5EFBD 5THSA 2A0MA 4RHLA 4RHQA 4RHJA 5THTA 3SKKA 3Q9EA 1CEVA 4RN2A 5G0GA 1C3SA 5EENA 3CEVA 5EEFA 1TBLA 1WOIA 3EZPA 4DZ4A 5G1BA 5BWZA 4LY1A 1PQ3A 5D1CA 4CBYA 2EF4A 3THJA 4Q3TA 4BZ9A 3NIOA 5EFKB 4QA3A 3THHA 3TF3A 3MAXA 3GN0A 4QA0A 5DC8A 3MJLA 5EFJD 3RQDA 1P8SA 4Q3UA 4BZ6A 1ZZ3A 3F0RA 4RHMA 2PHAA 3MMRA 5FUEA 2ZAVA 3KV2A 2V5WA 3ZNRA
chains in the Genus database with same CATH topology
5EF7A 5G1CA 1T69A 5EFHA 2VQJA 5DC6A 5IX0A 3F07A 3EW8A 3MZ7A 5EEKA 4BZ7A 5G12A 2VQQA 4CQFA 4A69A 3Q9CA 5EFNA 5ICNB 3MZ4A 5G10A 5DC7A 4ZUPA 5G1AA 5LI3A 3SFHA 1C3RA 5G11A 4QA6A 3C0ZA 4LXZA 5G0HA 5THUA 4BKXB 4QA1A 4CBTA 3MENA 5EFGA 1W22A 2VCGA 3ZNSA 3C0YA 4BZ5A 5JI5A 4RN1A 5THVA 5G17A 4QA4A 2V5XA 5EEMA 4ZUNA 1T67A 2VQWG 5G0YA 1T64A 4RN0A 3SFFA 3EWFA 4QA7A 3F06A 5EEIA 2VQMA 4QA2A 4ZURA 4BZ8A 5DC5A 1VKGA 3MZ3A 4QA5A 2GH6A 3Q9FA 5A2SA 5G13A 2VQOA 3C10A 5G0IA 2VQVA 3EZTA 5IWGA 5EF8A 5FCWA 3MZ6A 3Q9BA 4ZUQA 5G3WA 1ZZ1A 5D1BA 5G0JA 5G0XA 1ZZ0A 4ZUOA 1C3PA 4ZUMA 5EFBD 5THSA 5THTA 3Q9EA 4RN2A 5G0GA 1C3SA 5EENA 5EEFA 3EZPA 5BWZA 5G1BA 4LY1A 5D1CA 4CBYA 4BZ9A 5EFKB 4QA3A 3MAXA 4QA0A 5DC8A 5EFJD 3RQDA 4BZ6A 1ZZ3A 3F0RA 5FUEA 5D1DA 2V5WA 3ZNRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EF7 A;  5G1C A;  1T69 A;  5EFH A;  2VQJ A;  5DC6 A;  5IX0 A;  3F07 A;  3EW8 A;  3MZ7 A;  5EEK A;  4BZ7 A;  5G12 A;  2VQQ A;  4CQF A;  4A69 A;  3Q9C A;  5EFN A;  5ICN B;  3MZ4 A;  5G10 A;  5DC7 A;  4ZUP A;  5G1A A;  5LI3 A;  3SFH A;  1C3R A;  5G11 A;  4QA6 A;  3C0Z A;  4LXZ A;  5G0H A;  5THU A;  4BKX B;  4QA1 A;  4CBT A;  3MEN A;  5EFG A;  1W22 A;  2VCG A;  3ZNS A;  3C0Y A;  4BZ5 A;  5JI5 A;  4RN1 A;  5THV A;  5G17 A;  4QA4 A;  2V5X A;  5EEM A;  4ZUN A;  1T67 A;  2VQW G;  5G0Y A;  1T64 A;  4RN0 A;  3SFF A;  3EWF A;  4QA7 A;  3F06 A;  5EEI A;  2VQM A;  4QA2 A;  4ZUR A;  4BZ8 A;  5DC5 A;  1VKG A;  3MZ3 A;  4QA5 A;  2GH6 A;  3Q9F A;  5A2S A;  5G13 A;  2VQO A;  3C10 A;  5G0I A;  2VQV A;  3EZT A;  5IWG A;  5EF8 A;  5FCW A;  3MZ6 A;  3Q9B A;  4ZUQ A;  5G3W A;  1ZZ1 A;  5D1B A;  5G0J A;  5G0X A;  1ZZ0 A;  4ZUO A;  1C3P A;  4ZUM A;  5EFB D;  5THS A;  5THT A;  3Q9E A;  4RN2 A;  5G0G A;  1C3S A;  5EEN A;  5EEF A;  3EZP A;  5BWZ A;  5G1B A;  4LY1 A;  5D1C A;  4CBY A;  4BZ9 A;  5EFK B;  4QA3 A;  3MAX A;  4QA0 A;  5DC8 A;  5EFJ D;  3RQD A;  4BZ6 A;  1ZZ3 A;  3F0R A;  5FUE A;  5D1D A;  2V5W A;  3ZNR A; 
#chains in the Genus database with same CATH topology
 5EF7 A;  5G1C A;  1T69 A;  5EFH A;  2VQJ A;  2EF5 A;  5DC6 A;  1RLA A;  5IX0 A;  3F07 A;  3EW8 A;  3MZ7 A;  4GSV A;  1WVA A;  1WVB A;  5HJ9 A;  4Q3S A;  3M1R A;  5EEK A;  4BZ7 A;  5G12 A;  2VQQ A;  1ZPE A;  4CQF A;  4IU0 A;  4IE1 A;  1T4S A;  1T5G A;  4FCI A;  4GWD A;  4A69 A;  3Q9C A;  1GQ6 A;  4RHI A;  5EFN A;  5ICN B;  3DJ8 A;  3MZ4 A;  5DC7 A;  5G10 A;  4RLA A;  4ZUP A;  5G1A A;  5LI3 A;  4IU4 A;  1T5F A;  3SFH A;  1C3R A;  5G11 A;  4QA6 A;  3C0Z A;  4LXZ A;  5G0H A;  5THU A;  5HJA A;  4BKX B;  4QA1 A;  1HQF A;  2AEB A;  4CBT A;  5CEV A;  3MEN A;  1P8P A;  5EFG A;  1W22 A;  4IE2 A;  1HQG A;  2VCG A;  3ZNS A;  4ITY A;  3F80 A;  3C0Y A;  5RLA A;  4BZ5 A;  5JI5 A;  4RN1 A;  1P8M A;  4MYF A;  1T4T A;  1WOG A;  5THV A;  5G17 A;  1P8R A;  1TBH A;  4QA4 A;  2V5X A;  3E9B A;  4IU5 A;  5EEM A;  4ZUN A;  4Q42 A;  1T67 A;  2VQW G;  4GSM A;  2PHO A;  3TH7 A;  1HQX A;  4GSZ A;  5G0Y A;  1T64 A;  4RN0 A;  4I06 A;  3SFF A;  3MFV A;  3GMZ A;  3EWF A;  3THE A;  1XFK A;  4QA7 A;  4Q3P A;  3F06 A;  3SJT A;  5EEI A;  1P8N A;  3LHL A;  5D1D A;  4RHK A;  2VQM A;  4Q3V A;  4QA2 A;  3E8Q A;  4HZE A;  4Q3Q A;  4ZUR A;  4BZ8 A;  1T4P A;  5DC5 A;  1VKG A;  3MZ3 A;  4MYL A;  3SL0 A;  3NIQ A;  1TA1 A;  4QA5 A;  1T4R A;  4FCK A;  2GH6 A;  3LP4 A;  4HXQ A;  4MYN A;  3RLA A;  3Q9F A;  5A2S A;  4IXU A;  5G13 A;  2PLL A;  4MXR A;  3E6K A;  2VQO A;  4GWC A;  4MYK A;  4CEV A;  4HWW A;  1P8O A;  3C10 A;  5G0I A;  2VQV A;  3EZT A;  1WOH A;  1GQ7 A;  3PZL A;  5IWG A;  1R1O A;  2CEV A;  3E8Z A;  1TBJ A;  5EF8 A;  5FCW A;  4Q40 A;  3SL1 A;  3MZ6 A;  3Q9B A;  4ZUQ A;  5G3W A;  1ZPG A;  4IXV A;  1ZZ1 A;  3NIP A;  5D1B A;  5G0J A;  5G0X A;  3LP7 A;  1HQ5 A;  3E6V A;  4Q41 A;  1P8Q A;  4IE3 A;  1HQH A;  1ZZ0 A;  4Q3R C;  4Q3R A;  4IU1 A;  4ZUO A;  1C3P A;  3MFW A;  2EIV A;  4ZUM A;  2RLA A;  4G3H A;  1D3V A;  5EFB D;  5THS A;  2A0M A;  4RHL A;  4RHQ A;  4RHJ A;  5THT A;  3SKK A;  3Q9E A;  1CEV A;  4RN2 A;  5G0G A;  1C3S A;  5EEN A;  3CEV A;  5EEF A;  1TBL A;  1WOI A;  3EZP A;  4DZ4 A;  5G1B A;  5BWZ A;  4LY1 A;  1PQ3 A;  5D1C A;  4CBY A;  2EF4 A;  3THJ A;  4Q3T A;  4BZ9 A;  3NIO A;  5EFK B;  4QA3 A;  3THH A;  3TF3 A;  3MAX A;  3GN0 A;  4QA0 A;  5DC8 A;  3MJL A;  5EFJ D;  3RQD A;  1P8S A;  4Q3U A;  4BZ6 A;  1ZZ3 A;  3F0R A;  4RHM A;  2PHA A;  3MMR A;  5FUE A;  2ZAV A;  3KV2 A;  2V5W A;  3ZNR A; 
#chains in the Genus database with same CATH homology
 5EF7 A;  5G1C A;  1T69 A;  5EFH A;  2VQJ A;  5DC6 A;  5IX0 A;  3F07 A;  3EW8 A;  3MZ7 A;  5EEK A;  4BZ7 A;  5G12 A;  2VQQ A;  4CQF A;  4A69 A;  3Q9C A;  5EFN A;  5ICN B;  3MZ4 A;  5G10 A;  5DC7 A;  4ZUP A;  5G1A A;  5LI3 A;  3SFH A;  1C3R A;  5G11 A;  4QA6 A;  3C0Z A;  4LXZ A;  5G0H A;  5THU A;  4BKX B;  4QA1 A;  4CBT A;  3MEN A;  5EFG A;  1W22 A;  2VCG A;  3ZNS A;  3C0Y A;  4BZ5 A;  5JI5 A;  4RN1 A;  5THV A;  5G17 A;  4QA4 A;  2V5X A;  5EEM A;  4ZUN A;  1T67 A;  2VQW G;  5G0Y A;  1T64 A;  4RN0 A;  3SFF A;  3EWF A;  4QA7 A;  3F06 A;  5EEI A;  2VQM A;  4QA2 A;  4ZUR A;  4BZ8 A;  5DC5 A;  1VKG A;  3MZ3 A;  4QA5 A;  2GH6 A;  3Q9F A;  5A2S A;  5G13 A;  2VQO A;  3C10 A;  5G0I A;  2VQV A;  3EZT A;  5IWG A;  5EF8 A;  5FCW A;  3MZ6 A;  3Q9B A;  4ZUQ A;  5G3W A;  1ZZ1 A;  5D1B A;  5G0J A;  5G0X A;  1ZZ0 A;  4ZUO A;  1C3P A;  4ZUM A;  5EFB D;  5THS A;  5THT A;  3Q9E A;  4RN2 A;  5G0G A;  1C3S A;  5EEN A;  5EEF A;  3EZP A;  5BWZ A;  5G1B A;  4LY1 A;  5D1C A;  4CBY A;  4BZ9 A;  5EFK B;  4QA3 A;  3MAX A;  4QA0 A;  5DC8 A;  5EFJ D;  3RQD A;  4BZ6 A;  1ZZ3 A;  3F0R A;  5FUE A;  5D1D A;  2V5W A;  3ZNR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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