4QA6A

Crystal structure of i243n/y306f hdac8 in complex with a tetrapeptide substrate
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
364
structure length
364
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQNCESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGFNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 130
structure length 364
sequence length 364
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2014-05-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4qa6A00
4BZ9A 1ZZ1A 3MAXA 5G1CA 5EFJD 2V5WA 4ZUNA 3EZPA 5EENA 4BZ5A 4QA1A 3EZTA 3MZ3A 5BWZA 4ZURA 5D1CA 5JI5A 1ZZ3A 5G17A 3MZ6A 2VQVA 3MZ7A 5FCWA 4LXZA 3F06A 4QA7A 5G13A 5THUA 4BZ8A 4QA6A 5G0IA 2VQOA 5G0HA 3MZ4A 5EFBD 2VQQA 3Q9FA 1C3SA 3F0RA 4QA0A 3RQDA 5G11A 3EW8A 5DC6A 5G0GA 1T67A 5EFKB 3SFFA 5IWGA 5EFNA 1W22A 5EFGA 3C10A 5A2SA 5DC8A 1C3RA 4ZUPA 5IX0A 5THTA 5ICNB 5G1BA 3EWFA 4CQFA 4QA4A 4ZUMA 2VCGA 4BZ7A 4RN0A 5G0XA 3Q9EA 5G1AA 5DC5A 4LY1A 5DC7A 4BKXB 4CBYA 2VQWG 5THSA 4A69A 5G3WA 3Q9CA 3C0ZA 3MENA 1T69A 5D1BA 5EEMA 1T64A 5EFHA 4RN1A 4BZ6A 4RN2A 3C0YA 5G0JA 5G10A 5FUEA 3Q9BA 2VQMA 5EEFA 4QA2A 5EEIA 2V5XA 5G12A 5LI3A 3SFHA 1VKGA 5D1DA 5EF7A 4ZUQA 4ZUOA 3ZNSA 1C3PA 5G0YA 5EF8A 4QA5A 2VQJA 5THVA 1ZZ0A 3F07A 3ZNRA 4CBTA 2GH6A 4QA3A 5EEKA
chains in the Genus database with same CATH superfamily
1P8MA 5RLAA 4BZ9A 1ZZ1A 3MAXA 5G1CA 5EFJD 4DZ4A 3SL0A 1WVAA 2V5WA 3EZPA 3MJLA 4GSMA 4IE2A 5EENA 4ZUNA 4Q41A 4BZ5A 4QA1A 4IXUA 3EZTA 3MZ3A 4Q3SA 5BWZA 4IU1A 4ZURA 4Q3VA 3E6KA 2RLAA 1ZZ3A 5D1CA 3MZ6A 5G17A 2VQVA 3MZ7A 4FCIA 4RHLA 3NIQA 4FCKA 5FCWA 1GQ6A 4LXZA 4RLAA 4IU0A 3F06A 3GMZA 4GSZA 3SKKA 4QA7A 5G13A 2EF5A 4Q40A 5THUA 4QA6A 4BZ8A 2ZAVA 3MMRA 3E6VA 3NIPA 2VQOA 1T4PA 5G0IA 1WVBA 3MFWA 1PQ3A 4IE3A 1HQGA 3M1RA 5G0HA 3MZ4A 1WOIA 4IU4A 1TBHA 5EFBD 3THEA 3RLAA 1P8QA 4CEVA 2VQQA 3Q9FA 4MXRA 1C3SA 1WOGA 3F0RA 4QA0A 3GN0A 3RQDA 5G11A 1T4TA 3EW8A 3MFVA 5DC6A 5G0GA 5HJAA 4Q3UA 1D3VA 3DJ8A 3LHLA 4HWWA 3CEVA 2EF4A 1T67A 1ZPGA 4Q3RA 5EFKB 4MYNA 5IWGA 5EFNA 3SFFA 3F80A 1W22A 4GSVA 1HQFA 5EFGA 3C10A 1ZPEA 5A2SA 2PHAA 5DC8A 3PZLA 5JI5A 5HJ9A 3THHA 3TH7A 1C3RA 3SL1A 3LP4A 1HQHA 4MYFA 2PLLA 4Q3RC 4ZUPA 4MYKA 4IE1A 5IX0A 5THTA 5ICNB 4Q3TA 1P8RA 3TF3A 4ITYA 3E8ZA 1R1OA 2A0MA 5G1BA 1GQ7A 3EWFA 4CQFA 1TA1A 4QA4A 4ZUMA 3THJA 3SJTA 1T5FA 2VCGA 1TBJA 4RN0A 4BZ7A 4RHQA 5G0XA 1P8NA 3Q9EA 4RHJA 5DC5A 1CEVA 4LY1A 4G3HA 3E8QA 5DC7A 5G1AA 4BKXB 4IXVA 4CBYA 2VQWG 5THSA 4A69A 2PHOA 1P8PA 4Q3QA 5G3WA 3Q9CA 2AEBA 3C0ZA 3LP7A 3MENA 4GWCA 1T69A 4GWDA 5D1BA 5EEMA 1T64A 5EFHA 4RN1A 4BZ6A 4RHKA 1T4SA 3C0YA 4RN2A 1HQXA 3KV2A 4RHMA 5G0JA 5G10A 5FUEA 1WOHA 4Q42A 3Q9BA 2VQMA 3E9BA 5EEFA 4QA2A 4I06A 1XFKA 5EEIA 2V5XA 5G12A 5LI3A 1P8SA 1RLAA 4HXQA 3SFHA 1HQ5A 1VKGA 2CEVA 1T5GA 1T4RA 5D1DA 5EF7A 4ZUQA 5CEVA 4ZUOA 3ZNSA 1C3PA 4IU5A 4RHIA 5EF8A 5G0YA 4QA5A 2VQJA 4Q3PA 5THVA 1ZZ0A 3F07A 1P8OA 4MYLA 2EIVA 2GH6A 3ZNRA 4CBTA 4QA3A 4HZEA 3NIOA 5EEKA 1TBLA
chains in the Genus database with same CATH topology
4BZ9A 1ZZ1A 3MAXA 5G1CA 5EFJD 2V5WA 4ZUNA 3EZPA 5EENA 4BZ5A 4QA1A 3EZTA 3MZ3A 5BWZA 4ZURA 5D1CA 5JI5A 1ZZ3A 5G17A 3MZ6A 2VQVA 3MZ7A 5FCWA 4LXZA 3F06A 4QA7A 5G13A 5THUA 4BZ8A 4QA6A 5G0IA 2VQOA 5G0HA 3MZ4A 5EFBD 2VQQA 3Q9FA 1C3SA 3F0RA 4QA0A 3RQDA 5G11A 3EW8A 5DC6A 5G0GA 1T67A 5EFKB 3SFFA 5IWGA 5EFNA 1W22A 5EFGA 3C10A 5A2SA 5DC8A 1C3RA 4ZUPA 5IX0A 5THTA 5ICNB 5G1BA 3EWFA 4CQFA 4QA4A 4ZUMA 2VCGA 4BZ7A 4RN0A 5G0XA 3Q9EA 5G1AA 5DC5A 4LY1A 5DC7A 4BKXB 4CBYA 2VQWG 5THSA 4A69A 5G3WA 3Q9CA 3C0ZA 3MENA 1T69A 5D1BA 5EEMA 1T64A 5EFHA 4RN1A 4BZ6A 4RN2A 3C0YA 5G0JA 5G10A 5FUEA 3Q9BA 2VQMA 5EEFA 4QA2A 5EEIA 2V5XA 5G12A 5LI3A 3SFHA 1VKGA 5D1DA 5EF7A 4ZUQA 4ZUOA 3ZNSA 1C3PA 5G0YA 5EF8A 4QA5A 2VQJA 5THVA 1ZZ0A 3F07A 3ZNRA 4CBTA 2GH6A 4QA3A 5EEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BZ9 A;  1ZZ1 A;  3MAX A;  5G1C A;  5EFJ D;  2V5W A;  4ZUN A;  3EZP A;  5EEN A;  4BZ5 A;  4QA1 A;  3EZT A;  3MZ3 A;  5BWZ A;  4ZUR A;  5D1C A;  5JI5 A;  1ZZ3 A;  5G17 A;  3MZ6 A;  2VQV A;  3MZ7 A;  5FCW A;  4LXZ A;  3F06 A;  4QA7 A;  5G13 A;  5THU A;  4BZ8 A;  4QA6 A;  5G0I A;  2VQO A;  5G0H A;  3MZ4 A;  5EFB D;  2VQQ A;  3Q9F A;  1C3S A;  3F0R A;  4QA0 A;  3RQD A;  5G11 A;  3EW8 A;  5DC6 A;  5G0G A;  1T67 A;  5EFK B;  3SFF A;  5IWG A;  5EFN A;  1W22 A;  5EFG A;  3C10 A;  5A2S A;  5DC8 A;  1C3R A;  4ZUP A;  5IX0 A;  5THT A;  5ICN B;  5G1B A;  3EWF A;  4CQF A;  4QA4 A;  4ZUM A;  2VCG A;  4BZ7 A;  4RN0 A;  5G0X A;  3Q9E A;  5G1A A;  5DC5 A;  4LY1 A;  5DC7 A;  4BKX B;  4CBY A;  2VQW G;  5THS A;  4A69 A;  5G3W A;  3Q9C A;  3C0Z A;  3MEN A;  1T69 A;  5D1B A;  5EEM A;  1T64 A;  5EFH A;  4RN1 A;  4BZ6 A;  4RN2 A;  3C0Y A;  5G0J A;  5G10 A;  5FUE A;  3Q9B A;  2VQM A;  5EEF A;  4QA2 A;  5EEI A;  2V5X A;  5G12 A;  5LI3 A;  3SFH A;  1VKG A;  5D1D A;  5EF7 A;  4ZUQ A;  4ZUO A;  3ZNS A;  1C3P A;  5G0Y A;  5EF8 A;  4QA5 A;  2VQJ A;  5THV A;  1ZZ0 A;  3F07 A;  3ZNR A;  4CBT A;  2GH6 A;  4QA3 A;  5EEK A; 
#chains in the Genus database with same CATH topology
 1P8M A;  5RLA A;  4BZ9 A;  1ZZ1 A;  3MAX A;  5G1C A;  5EFJ D;  4DZ4 A;  3SL0 A;  1WVA A;  2V5W A;  3EZP A;  3MJL A;  4GSM A;  4IE2 A;  5EEN A;  4ZUN A;  4Q41 A;  4BZ5 A;  4QA1 A;  4IXU A;  3EZT A;  3MZ3 A;  4Q3S A;  5BWZ A;  4IU1 A;  4ZUR A;  4Q3V A;  3E6K A;  2RLA A;  1ZZ3 A;  5D1C A;  3MZ6 A;  5G17 A;  2VQV A;  3MZ7 A;  4FCI A;  4RHL A;  3NIQ A;  4FCK A;  5FCW A;  1GQ6 A;  4LXZ A;  4RLA A;  4IU0 A;  3F06 A;  3GMZ A;  4GSZ A;  3SKK A;  4QA7 A;  5G13 A;  2EF5 A;  4Q40 A;  5THU A;  4QA6 A;  4BZ8 A;  2ZAV A;  3MMR A;  3E6V A;  3NIP A;  2VQO A;  1T4P A;  5G0I A;  1WVB A;  3MFW A;  1PQ3 A;  4IE3 A;  1HQG A;  3M1R A;  5G0H A;  3MZ4 A;  1WOI A;  4IU4 A;  1TBH A;  5EFB D;  3THE A;  3RLA A;  1P8Q A;  4CEV A;  2VQQ A;  3Q9F A;  4MXR A;  1C3S A;  1WOG A;  3F0R A;  4QA0 A;  3GN0 A;  3RQD A;  5G11 A;  1T4T A;  3EW8 A;  3MFV A;  5DC6 A;  5G0G A;  5HJA A;  4Q3U A;  1D3V A;  3DJ8 A;  3LHL A;  4HWW A;  3CEV A;  2EF4 A;  1T67 A;  1ZPG A;  4Q3R A;  5EFK B;  4MYN A;  5IWG A;  5EFN A;  3SFF A;  3F80 A;  1W22 A;  4GSV A;  1HQF A;  5EFG A;  3C10 A;  1ZPE A;  5A2S A;  2PHA A;  5DC8 A;  3PZL A;  5JI5 A;  5HJ9 A;  3THH A;  3TH7 A;  1C3R A;  3SL1 A;  3LP4 A;  1HQH A;  4MYF A;  2PLL A;  4Q3R C;  4ZUP A;  4MYK A;  4IE1 A;  5IX0 A;  5THT A;  5ICN B;  4Q3T A;  1P8R A;  3TF3 A;  4ITY A;  3E8Z A;  1R1O A;  2A0M A;  5G1B A;  1GQ7 A;  3EWF A;  4CQF A;  1TA1 A;  4QA4 A;  4ZUM A;  3THJ A;  3SJT A;  1T5F A;  2VCG A;  1TBJ A;  4RN0 A;  4BZ7 A;  4RHQ A;  5G0X A;  1P8N A;  3Q9E A;  4RHJ A;  5DC5 A;  1CEV A;  4LY1 A;  4G3H A;  3E8Q A;  5DC7 A;  5G1A A;  4BKX B;  4IXV A;  4CBY A;  2VQW G;  5THS A;  4A69 A;  2PHO A;  1P8P A;  4Q3Q A;  5G3W A;  3Q9C A;  2AEB A;  3C0Z A;  3LP7 A;  3MEN A;  4GWC A;  1T69 A;  4GWD A;  5D1B A;  5EEM A;  1T64 A;  5EFH A;  4RN1 A;  4BZ6 A;  4RHK A;  1T4S A;  3C0Y A;  4RN2 A;  1HQX A;  3KV2 A;  4RHM A;  5G0J A;  5G10 A;  5FUE A;  1WOH A;  4Q42 A;  3Q9B A;  2VQM A;  3E9B A;  5EEF A;  4QA2 A;  4I06 A;  1XFK A;  5EEI A;  2V5X A;  5G12 A;  5LI3 A;  1P8S A;  1RLA A;  4HXQ A;  3SFH A;  1HQ5 A;  1VKG A;  2CEV A;  1T5G A;  1T4R A;  5D1D A;  5EF7 A;  4ZUQ A;  5CEV A;  4ZUO A;  3ZNS A;  1C3P A;  4IU5 A;  4RHI A;  5EF8 A;  5G0Y A;  4QA5 A;  2VQJ A;  4Q3P A;  5THV A;  1ZZ0 A;  3F07 A;  1P8O A;  4MYL A;  2EIV A;  2GH6 A;  3ZNR A;  4CBT A;  4QA3 A;  4HZE A;  3NIO A;  5EEK A;  1TBL A; 
#chains in the Genus database with same CATH homology
 4BZ9 A;  1ZZ1 A;  3MAX A;  5G1C A;  5EFJ D;  2V5W A;  4ZUN A;  3EZP A;  5EEN A;  4BZ5 A;  4QA1 A;  3EZT A;  3MZ3 A;  5BWZ A;  4ZUR A;  5D1C A;  5JI5 A;  1ZZ3 A;  5G17 A;  3MZ6 A;  2VQV A;  3MZ7 A;  5FCW A;  4LXZ A;  3F06 A;  4QA7 A;  5G13 A;  5THU A;  4BZ8 A;  4QA6 A;  5G0I A;  2VQO A;  5G0H A;  3MZ4 A;  5EFB D;  2VQQ A;  3Q9F A;  1C3S A;  3F0R A;  4QA0 A;  3RQD A;  5G11 A;  3EW8 A;  5DC6 A;  5G0G A;  1T67 A;  5EFK B;  3SFF A;  5IWG A;  5EFN A;  1W22 A;  5EFG A;  3C10 A;  5A2S A;  5DC8 A;  1C3R A;  4ZUP A;  5IX0 A;  5THT A;  5ICN B;  5G1B A;  3EWF A;  4CQF A;  4QA4 A;  4ZUM A;  2VCG A;  4BZ7 A;  4RN0 A;  5G0X A;  3Q9E A;  5G1A A;  5DC5 A;  4LY1 A;  5DC7 A;  4BKX B;  4CBY A;  2VQW G;  5THS A;  4A69 A;  5G3W A;  3Q9C A;  3C0Z A;  3MEN A;  1T69 A;  5D1B A;  5EEM A;  1T64 A;  5EFH A;  4RN1 A;  4BZ6 A;  4RN2 A;  3C0Y A;  5G0J A;  5G10 A;  5FUE A;  3Q9B A;  2VQM A;  5EEF A;  4QA2 A;  5EEI A;  2V5X A;  5G12 A;  5LI3 A;  3SFH A;  1VKG A;  5D1D A;  5EF7 A;  4ZUQ A;  4ZUO A;  3ZNS A;  1C3P A;  5G0Y A;  5EF8 A;  4QA5 A;  2VQJ A;  5THV A;  1ZZ0 A;  3F07 A;  3ZNR A;  4CBT A;  2GH6 A;  4QA3 A;  5EEK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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