4QFXA

Crystal structure of the tetrameric dgtp/datp-bound samhd1 (rn206) mutant catalytic core
Total Genus 159
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
pubmed doi rcsb
source organism Homo sapiens
total genus 159
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4qfxA01
5TK6A 4TO0A 1YOYA 4QG0A 2GZ4A 4R8ZA 4MLMA 1YNBA 4TO4A 4TO2A 4MCWA 2O08A 2O6IA 5AO3A 4BZBA 4TO5A 2HEKA 2PAQA 4DMBA 4ZWGA 3HC1A 4QFYA 4TNRA 3HI0A 3CCGA 4BZCA 5AO2A 5AO1A 4MLNA 4L7WA 4TNPA 4RXSA 3TM8A 3KH1A 2PQ7A 3TMBA 5AO4A 4TNXA 4QG2A 4RXQA 1VQRA 3TMDA 2OGIA 5TK9A 4L1JB 4RXOA 4QG1A 5TK8A 4MZ7A 2FLOA 4QFZA 4L7EA 3NQWA 4RXRA 2CQZA 1XX7A 4TO1A 5TK7A 4XDSA 4Q7HA 5TKAA 2PGSA 4TO6A 2DQBA 4RXPA 2PARA 3RF0A 4ME4A 3I7AA 2PAUA 4QFXA 3MZOA 3M1TA 4MDZA 3LJXA 3TMCA 4TNZA 4TNYA 4N71A 3MEMA 2Q14A 4LRLA 3U1NA 4QG4A 4ZWEA 1VJ7A 3NR1A 1U6ZA 3P3QA 4TNQA 3BG2A 4N6WA 5AO0A 3IRHA 4TO3A 4X9EA 4L1JA
chains in the Genus database with same CATH superfamily
5TK6A 4TO0A 1YOYA 4QG0A 2GZ4A 4R8ZA 4MLMA 1YNBA 4TO4A 4Q2CA 4TO2A 4MCWA 2O08A 2O6IA 5AO3A 4BZBA 4TO5A 2HEKA 2PAQA 4DMBA 4ZWGA 3HC1A 4QFYA 4TNRA 3HI0A 3CCGA 4BZCA 5AO2A 5AO1A 4MLNA 4L7WA 4TNPA 4RXSA 3TM8A 3KH1A 2PQ7A 3TMBA 5AO4A 4TNXA 4QG2A 4RXQA 1VQRA 3TMDA 2OGIA 4Q2DA 4QQXA 3SKDA 3S4LA 5TK9A 4L1JB 4RXOA 4QG1A 5TK8A 4MZ7A 2FLOA 4QFZA 3GW7A 4L7EA 3NQWA 4RXRA 2CQZA 1XX7A 4QQYA 4TO1A 5TK7A 4XDSA 4Q7HA 5TKAA 2PGSA 4TO6A 2DQBA 4RXPA 2PARA 3RF0A 4ME4A 3I7AA 2PAUA 4QQWA 4QFXA 3MZOA 3M1TA 4MDZA 3LJXA 3TMCA 4TNZA 4TNYA 4N71A 3MEMA 2Q14A 4LRLA 4QQZA 3U1NA 4QG4A 4ZWEA 3KQ5A 1VJ7A 3NR1A 1U6ZA 3P3QA 4TNQA 3SK9A 3BG2A 4N6WA 5AO0A 3IRHA 4TO3A 4X9EA 4L1JA
chains in the Genus database with same CATH topology
5TK6A 4TO0A 1YOYA 4QG0A 2GZ4A 4R8ZA 4MLMA 1YNBA 4TO4A 4Q2CA 4TO2A 4MCWA 2O08A 2O6IA 5AO3A 4BZBA 4TO5A 2HEKA 2PAQA 4DMBA 4ZWGA 3HC1A 4QFYA 4TNRA 3HI0A 3CCGA 4BZCA 5AO2A 5AO1A 4MLNA 4L7WA 4TNPA 4RXSA 3TM8A 3KH1A 2PQ7A 3TMBA 5AO4A 4TNXA 4QG2A 4RXQA 1VQRA 3TMDA 2OGIA 4Q2DA 4QQXA 3SKDA 3S4LA 5TK9A 4L1JB 4RXOA 4QG1A 5TK8A 4MZ7A 2FLOA 4QFZA 3GW7A 4L7EA 3NQWA 4RXRA 2CQZA 1XX7A 4QQYA 4TO1A 5TK7A 4XDSA 4Q7HA 5TKAA 2PGSA 4TO6A 2DQBA 4RXPA 2PARA 3RF0A 4ME4A 3I7AA 2PAUA 4QQWA 4QFXA 3MZOA 3M1TA 4MDZA 3LJXA 3TMCA 4TNZA 4TNYA 4N71A 3MEMA 2Q14A 4LRLA 4QQZA 3U1NA 4QG4A 4ZWEA 3KQ5A 1VJ7A 3NR1A 1U6ZA 3P3QA 4TNQA 3SK9A 3BG2A 4N6WA 5AO0A 3IRHA 4TO3A 4X9EA 4L1JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TK6 A;  4TO0 A;  1YOY A;  4QG0 A;  2GZ4 A;  4R8Z A;  4MLM A;  1YNB A;  4TO4 A;  4TO2 A;  4MCW A;  2O08 A;  2O6I A;  5AO3 A;  4BZB A;  4TO5 A;  2HEK A;  2PAQ A;  4DMB A;  4ZWG A;  3HC1 A;  4QFY A;  4TNR A;  3HI0 A;  3CCG A;  4BZC A;  5AO2 A;  5AO1 A;  4MLN A;  4L7W A;  4TNP A;  4RXS A;  3TM8 A;  3KH1 A;  2PQ7 A;  3TMB A;  5AO4 A;  4TNX A;  4QG2 A;  4RXQ A;  1VQR A;  3TMD A;  2OGI A;  5TK9 A;  4L1J B;  4RXO A;  4QG1 A;  5TK8 A;  4MZ7 A;  2FLO A;  4QFZ A;  4L7E A;  3NQW A;  4RXR A;  2CQZ A;  1XX7 A;  4TO1 A;  5TK7 A;  4XDS A;  4Q7H A;  5TKA A;  2PGS A;  4TO6 A;  2DQB A;  4RXP A;  2PAR A;  3RF0 A;  4ME4 A;  3I7A A;  2PAU A;  4QFX A;  3MZO A;  3M1T A;  4MDZ A;  3LJX A;  3TMC A;  4TNZ A;  4TNY A;  4N71 A;  3MEM A;  2Q14 A;  4LRL A;  3U1N A;  4QG4 A;  4ZWE A;  1VJ7 A;  3NR1 A;  1U6Z A;  3P3Q A;  4TNQ A;  3BG2 A;  4N6W A;  5AO0 A;  3IRH A;  4TO3 A;  4X9E A;  4L1J A; 
#chains in the Genus database with same CATH topology
 5TK6 A;  4TO0 A;  1YOY A;  4QG0 A;  2GZ4 A;  4R8Z A;  4MLM A;  1YNB A;  4TO4 A;  4Q2C A;  4TO2 A;  4MCW A;  2O08 A;  2O6I A;  5AO3 A;  4BZB A;  4TO5 A;  2HEK A;  2PAQ A;  4DMB A;  4ZWG A;  3HC1 A;  4QFY A;  4TNR A;  3HI0 A;  3CCG A;  4BZC A;  5AO2 A;  5AO1 A;  4MLN A;  4L7W A;  4TNP A;  4RXS A;  3TM8 A;  3KH1 A;  2PQ7 A;  3TMB A;  5AO4 A;  4TNX A;  4QG2 A;  4RXQ A;  1VQR A;  3TMD A;  2OGI A;  4Q2D A;  4QQX A;  3SKD A;  3S4L A;  5TK9 A;  4L1J B;  4RXO A;  4QG1 A;  5TK8 A;  4MZ7 A;  2FLO A;  4QFZ A;  3GW7 A;  4L7E A;  3NQW A;  4RXR A;  2CQZ A;  1XX7 A;  4QQY A;  4TO1 A;  5TK7 A;  4XDS A;  4Q7H A;  5TKA A;  2PGS A;  4TO6 A;  2DQB A;  4RXP A;  2PAR A;  3RF0 A;  4ME4 A;  3I7A A;  2PAU A;  4QQW A;  4QFX A;  3MZO A;  3M1T A;  4MDZ A;  3LJX A;  3TMC A;  4TNZ A;  4TNY A;  4N71 A;  3MEM A;  2Q14 A;  4LRL A;  4QQZ A;  3U1N A;  4QG4 A;  4ZWE A;  3KQ5 A;  1VJ7 A;  3NR1 A;  1U6Z A;  3P3Q A;  4TNQ A;  3SK9 A;  3BG2 A;  4N6W A;  5AO0 A;  3IRH A;  4TO3 A;  4X9E A;  4L1J A; 
#chains in the Genus database with same CATH homology
 5TK6 A;  4TO0 A;  1YOY A;  4QG0 A;  2GZ4 A;  4R8Z A;  4MLM A;  1YNB A;  4TO4 A;  4Q2C A;  4TO2 A;  4MCW A;  2O08 A;  2O6I A;  5AO3 A;  4BZB A;  4TO5 A;  2HEK A;  2PAQ A;  4DMB A;  4ZWG A;  3HC1 A;  4QFY A;  4TNR A;  3HI0 A;  3CCG A;  4BZC A;  5AO2 A;  5AO1 A;  4MLN A;  4L7W A;  4TNP A;  4RXS A;  3TM8 A;  3KH1 A;  2PQ7 A;  3TMB A;  5AO4 A;  4TNX A;  4QG2 A;  4RXQ A;  1VQR A;  3TMD A;  2OGI A;  4Q2D A;  4QQX A;  3SKD A;  3S4L A;  5TK9 A;  4L1J B;  4RXO A;  4QG1 A;  5TK8 A;  4MZ7 A;  2FLO A;  4QFZ A;  3GW7 A;  4L7E A;  3NQW A;  4RXR A;  2CQZ A;  1XX7 A;  4QQY A;  4TO1 A;  5TK7 A;  4XDS A;  4Q7H A;  5TKA A;  2PGS A;  4TO6 A;  2DQB A;  4RXP A;  2PAR A;  3RF0 A;  4ME4 A;  3I7A A;  2PAU A;  4QQW A;  4QFX A;  3MZO A;  3M1T A;  4MDZ A;  3LJX A;  3TMC A;  4TNZ A;  4TNY A;  4N71 A;  3MEM A;  2Q14 A;  4LRL A;  4QQZ A;  3U1N A;  4QG4 A;  4ZWE A;  3KQ5 A;  1VJ7 A;  3NR1 A;  1U6Z A;  3P3Q A;  4TNQ A;  3SK9 A;  3BG2 A;  4N6W A;  5AO0 A;  3IRH A;  4TO3 A;  4X9E A;  4L1J A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...