4QFZA

Crystal structure of the tetrameric dgtp/dttp-bound samhd1 (rn206) mutant catalytic core
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
pubmed doi rcsb
source organism Homo sapiens
total genus 162
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4qfzA01
4XDSA 2FLOA 3BG2A 4TO0A 3U1NA 5TK8A 4ZWGA 3TMDA 3P3QA 4RXOA 4TNYA 4RXRA 2CQZA 3HC1A 2GZ4A 5AO0A 4TO1A 5TK9A 2O6IA 4MDZA 3RF0A 4QG4A 4BZBA 1U6ZA 3TMBA 4TNZA 2PQ7A 4RXPA 4TNPA 4RXSA 1VJ7A 2PAUA 1YOYA 4QG2A 2O08A 3CCGA 4ZWEA 5AO2A 3NR1A 2PGSA 4TO6A 3I7AA 4L1JB 4L7EA 4QFYA 5AO3A 4TNRA 3M1TA 3NQWA 4N71A 4QFXA 1XX7A 4RXQA 4ME4A 4TO4A 1YNBA 3LJXA 4L7WA 4MCWA 2HEKA 3MZOA 4N6WA 4LRLA 4R8ZA 5TK6A 5TK7A 4TO2A 2PAQA 3IRHA 3HI0A 4QG1A 2DQBA 3MEMA 5AO1A 2Q14A 3TM8A 4MZ7A 4TNQA 4MLNA 4TNXA 3TMCA 4QFZA 1VQRA 4X9EA 4MLMA 4L1JA 4QG0A 5TKAA 4TO3A 2OGIA 4Q7HA 4BZCA 4DMBA 4TO5A 5AO4A 3KH1A 2PARA
chains in the Genus database with same CATH superfamily
4XDSA 3KQ5A 2FLOA 3BG2A 4TO0A 3U1NA 5TK8A 4ZWGA 3TMDA 3P3QA 4RXOA 3SK9A 4TNYA 4RXRA 2CQZA 3HC1A 2GZ4A 5AO0A 4TO1A 5TK9A 2O6IA 4MDZA 3RF0A 4QG4A 4BZBA 1U6ZA 3TMBA 4TNZA 4Q2DA 2PQ7A 4RXPA 4TNPA 4RXSA 1VJ7A 2PAUA 1YOYA 4QG2A 2O08A 3CCGA 4ZWEA 5AO2A 3NR1A 2PGSA 4TO6A 3I7AA 4L1JB 4L7EA 4QFYA 5AO3A 4QQWA 4QQXA 4TNRA 3M1TA 3NQWA 4N71A 4QFXA 1XX7A 4RXQA 4ME4A 3GW7A 4TO4A 1YNBA 3LJXA 4L7WA 4MCWA 2HEKA 3MZOA 4N6WA 4LRLA 4R8ZA 5TK6A 5TK7A 4TO2A 2PAQA 3IRHA 3HI0A 4QG1A 4QQZA 2DQBA 3S4LA 3MEMA 5AO1A 2Q14A 3TM8A 4MZ7A 4TNQA 4MLNA 4TNXA 3TMCA 4QFZA 1VQRA 4X9EA 4MLMA 4L1JA 4QQYA 4QG0A 3SKDA 5TKAA 4TO3A 2OGIA 4Q7HA 4BZCA 4DMBA 4Q2CA 4TO5A 5AO4A 3KH1A 2PARA
chains in the Genus database with same CATH topology
4XDSA 3KQ5A 2FLOA 3BG2A 4TO0A 3U1NA 5TK8A 4ZWGA 3TMDA 3P3QA 4RXOA 3SK9A 4TNYA 4RXRA 2CQZA 3HC1A 2GZ4A 5AO0A 4TO1A 5TK9A 2O6IA 4MDZA 3RF0A 4QG4A 4BZBA 1U6ZA 3TMBA 4TNZA 4Q2DA 2PQ7A 4RXPA 4TNPA 4RXSA 1VJ7A 2PAUA 1YOYA 4QG2A 2O08A 3CCGA 4ZWEA 5AO2A 3NR1A 2PGSA 4TO6A 3I7AA 4L1JB 4L7EA 4QFYA 5AO3A 4QQWA 4QQXA 4TNRA 3M1TA 3NQWA 4N71A 4QFXA 1XX7A 4RXQA 4ME4A 3GW7A 4TO4A 1YNBA 3LJXA 4L7WA 4MCWA 2HEKA 3MZOA 4N6WA 4LRLA 4R8ZA 5TK6A 5TK7A 4TO2A 2PAQA 3IRHA 3HI0A 4QG1A 4QQZA 2DQBA 3S4LA 3MEMA 5AO1A 2Q14A 3TM8A 4MZ7A 4TNQA 4MLNA 4TNXA 3TMCA 4QFZA 1VQRA 4X9EA 4MLMA 4L1JA 4QQYA 4QG0A 3SKDA 5TKAA 4TO3A 2OGIA 4Q7HA 4BZCA 4DMBA 4Q2CA 4TO5A 5AO4A 3KH1A 2PARA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4XDS A;  2FLO A;  3BG2 A;  4TO0 A;  3U1N A;  5TK8 A;  4ZWG A;  3TMD A;  3P3Q A;  4RXO A;  4TNY A;  4RXR A;  2CQZ A;  3HC1 A;  2GZ4 A;  5AO0 A;  4TO1 A;  5TK9 A;  2O6I A;  4MDZ A;  3RF0 A;  4QG4 A;  4BZB A;  1U6Z A;  3TMB A;  4TNZ A;  2PQ7 A;  4RXP A;  4TNP A;  4RXS A;  1VJ7 A;  2PAU A;  1YOY A;  4QG2 A;  2O08 A;  3CCG A;  4ZWE A;  5AO2 A;  3NR1 A;  2PGS A;  4TO6 A;  3I7A A;  4L1J B;  4L7E A;  4QFY A;  5AO3 A;  4TNR A;  3M1T A;  3NQW A;  4N71 A;  4QFX A;  1XX7 A;  4RXQ A;  4ME4 A;  4TO4 A;  1YNB A;  3LJX A;  4L7W A;  4MCW A;  2HEK A;  3MZO A;  4N6W A;  4LRL A;  4R8Z A;  5TK6 A;  5TK7 A;  4TO2 A;  2PAQ A;  3IRH A;  3HI0 A;  4QG1 A;  2DQB A;  3MEM A;  5AO1 A;  2Q14 A;  3TM8 A;  4MZ7 A;  4TNQ A;  4MLN A;  4TNX A;  3TMC A;  4QFZ A;  1VQR A;  4X9E A;  4MLM A;  4L1J A;  4QG0 A;  5TKA A;  4TO3 A;  2OGI A;  4Q7H A;  4BZC A;  4DMB A;  4TO5 A;  5AO4 A;  3KH1 A;  2PAR A; 
#chains in the Genus database with same CATH topology
 4XDS A;  3KQ5 A;  2FLO A;  3BG2 A;  4TO0 A;  3U1N A;  5TK8 A;  4ZWG A;  3TMD A;  3P3Q A;  4RXO A;  3SK9 A;  4TNY A;  4RXR A;  2CQZ A;  3HC1 A;  2GZ4 A;  5AO0 A;  4TO1 A;  5TK9 A;  2O6I A;  4MDZ A;  3RF0 A;  4QG4 A;  4BZB A;  1U6Z A;  3TMB A;  4TNZ A;  4Q2D A;  2PQ7 A;  4RXP A;  4TNP A;  4RXS A;  1VJ7 A;  2PAU A;  1YOY A;  4QG2 A;  2O08 A;  3CCG A;  4ZWE A;  5AO2 A;  3NR1 A;  2PGS A;  4TO6 A;  3I7A A;  4L1J B;  4L7E A;  4QFY A;  5AO3 A;  4QQW A;  4QQX A;  4TNR A;  3M1T A;  3NQW A;  4N71 A;  4QFX A;  1XX7 A;  4RXQ A;  4ME4 A;  3GW7 A;  4TO4 A;  1YNB A;  3LJX A;  4L7W A;  4MCW A;  2HEK A;  3MZO A;  4N6W A;  4LRL A;  4R8Z A;  5TK6 A;  5TK7 A;  4TO2 A;  2PAQ A;  3IRH A;  3HI0 A;  4QG1 A;  4QQZ A;  2DQB A;  3S4L A;  3MEM A;  5AO1 A;  2Q14 A;  3TM8 A;  4MZ7 A;  4TNQ A;  4MLN A;  4TNX A;  3TMC A;  4QFZ A;  1VQR A;  4X9E A;  4MLM A;  4L1J A;  4QQY A;  4QG0 A;  3SKD A;  5TKA A;  4TO3 A;  2OGI A;  4Q7H A;  4BZC A;  4DMB A;  4Q2C A;  4TO5 A;  5AO4 A;  3KH1 A;  2PAR A; 
#chains in the Genus database with same CATH homology
 4XDS A;  3KQ5 A;  2FLO A;  3BG2 A;  4TO0 A;  3U1N A;  5TK8 A;  4ZWG A;  3TMD A;  3P3Q A;  4RXO A;  3SK9 A;  4TNY A;  4RXR A;  2CQZ A;  3HC1 A;  2GZ4 A;  5AO0 A;  4TO1 A;  5TK9 A;  2O6I A;  4MDZ A;  3RF0 A;  4QG4 A;  4BZB A;  1U6Z A;  3TMB A;  4TNZ A;  4Q2D A;  2PQ7 A;  4RXP A;  4TNP A;  4RXS A;  1VJ7 A;  2PAU A;  1YOY A;  4QG2 A;  2O08 A;  3CCG A;  4ZWE A;  5AO2 A;  3NR1 A;  2PGS A;  4TO6 A;  3I7A A;  4L1J B;  4L7E A;  4QFY A;  5AO3 A;  4QQW A;  4QQX A;  4TNR A;  3M1T A;  3NQW A;  4N71 A;  4QFX A;  1XX7 A;  4RXQ A;  4ME4 A;  3GW7 A;  4TO4 A;  1YNB A;  3LJX A;  4L7W A;  4MCW A;  2HEK A;  3MZO A;  4N6W A;  4LRL A;  4R8Z A;  5TK6 A;  5TK7 A;  4TO2 A;  2PAQ A;  3IRH A;  3HI0 A;  4QG1 A;  4QQZ A;  2DQB A;  3S4L A;  3MEM A;  5AO1 A;  2Q14 A;  3TM8 A;  4MZ7 A;  4TNQ A;  4MLN A;  4TNX A;  3TMC A;  4QFZ A;  1VQR A;  4X9E A;  4MLM A;  4L1J A;  4QQY A;  4QG0 A;  3SKD A;  5TKA A;  4TO3 A;  2OGI A;  4Q7H A;  4BZC A;  4DMB A;  4Q2C A;  4TO5 A;  5AO4 A;  3KH1 A;  2PAR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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