4QHEA

Crystal structure of mg2+ bound human ape1
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
281
structure length
281
Chain Sequence
ASEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords DNA-(apurinic or apyrimidinic site) lyase
total genus 92
structure length 281
sequence length 281
ec nomenclature ec 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
pdb deposition date 2014-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4qheA00
4GEWA 4FVAA 3G2CA 3TEBA 4QH9A 2F1NA 5J3SA 2ISIA 3G91A 5A7JA 4A9CA 1SI6X 1DEWA 4C1RA 5J8NA 2O3CA 5HT2A 2D1KB 3U8UA 4B5IA 3G0AA 1HD7A 4CMLA 4F1HA 3I5VA 4L21A 2IMQX 4B5JA 5DFFA 1DE9A 2V0RA 1SR4B 1DE8A 3CJCD 2JC5A 2O3HA 3GA6A 1BIXA 5A7IA 2V0SA 2A3ZB 2DDSA 3G1KA 3DNIA 3I46A 3N9VA 3I48A 4IEMA 5DV4A 4AWNA 2DNJA 1AKOA 1YJHA 5J3ZA 4L20A 4LNDA 4QHDA 2EI9A 5DFJA 3G3YA 3NGOA 2J63A 2JC4A 3NGQA 5INPA 5CFGA 3G8VA 1Y21A 4RUWA 1VYBA 3G2DA 3WCXA 3MPRA 3G00A 5J3PA 5DFHA 5INKA 4B5HA 2A40B 3W2YA 1WDUA 4QHEA 3I41A 2DDTA 2DDRA 4JG3A 3W3DB 3G38A 3NGNA 3MTCA 2A41B 4GYZA 1I9ZA 4GZ2A 1NTFA 3G4TA 4L1YA 3W2XA 5INQA 3G0RA 3G6SA 1ATND 5INMA 5INNA 4F1IA 2VOAA 4FPVA 3G3CA 5CFEA 5INLA 4CMNA 5DFIA 3FZIA 1I9YA 2F2FB 2XSWA 5DV2A 5INOA 2UYRX 4B5GA 4B5FA 5EWTA 1E9NA 4K6LF 4B5MA 2A42B 4GZ0A 5J42A 1DNKA 1ZWXA 4F1HB 4F1RA 5DG0A 4L1ZA 3NR8A 4PUQA 3L1WA 3K55A 4GZ1A
chains in the Genus database with same CATH superfamily
4GEWA 4FVAA 3G2CA 3TEBA 4QH9A 2F1NA 5J3SA 2ISIA 3G91A 5A7JA 4A9CA 1SI6X 1DEWA 4C1RA 5J8NA 2O3CA 5HT2A 2D1KB 3U8UA 4B5IA 3G0AA 1HD7A 4CMLA 4F1HA 3I5VA 4L21A 2IMQX 4B5JA 5DFFA 1DE9A 2V0RA 1SR4B 1DE8A 3CJCD 2JC5A 2O3HA 3GA6A 1BIXA 5A7IA 2V0SA 2A3ZB 2DDSA 3G1KA 3DNIA 3I46A 3N9VA 3I48A 4IEMA 5DV4A 4AWNA 2DNJA 1AKOA 1YJHA 5J3ZA 4L20A 4LNDA 4QHDA 2EI9A 5DFJA 3G3YA 3NGOA 2J63A 2JC4A 3NGQA 5INPA 5CFGA 3G8VA 1Y21A 4RUWA 1VYBA 3G2DA 3WCXA 3MPRA 3G00A 5J3PA 5DFHA 5INKA 4B5HA 2A40B 3W2YA 1WDUA 4QHEA 3I41A 2DDTA 2DDRA 4JG3A 3W3DB 3G38A 3NGNA 3MTCA 2A41B 4GYZA 1I9ZA 4GZ2A 1NTFA 3G4TA 4L1YA 3W2XA 5INQA 3G0RA 3G6SA 1ATND 5INMA 5INNA 4F1IA 2VOAA 4FPVA 3G3CA 5CFEA 5INLA 4CMNA 5DFIA 3FZIA 1I9YA 2F2FB 2XSWA 5DV2A 5INOA 2UYRX 4B5GA 4B5FA 5EWTA 1E9NA 4K6LF 4B5MA 2A42B 4GZ0A 5J42A 1DNKA 1ZWXA 4F1HB 4F1RA 5DG0A 4L1ZA 3NR8A 4PUQA 3L1WA 3K55A 4GZ1A
chains in the Genus database with same CATH topology
4GEWA 4FVAA 3G2CA 3TEBA 4QH9A 2F1NA 5J3SA 2ISIA 3G91A 5A7JA 4A9CA 1SI6X 1DEWA 4C1RA 5J8NA 2O3CA 5HT2A 2D1KB 3U8UA 4B5IA 3G0AA 1HD7A 4CMLA 4F1HA 3I5VA 4L21A 2IMQX 4B5JA 5DFFA 1DE9A 2V0RA 1SR4B 1DE8A 3CJCD 2JC5A 2O3HA 3GA6A 1BIXA 5A7IA 2V0SA 2A3ZB 2DDSA 3G1KA 3DNIA 3I46A 3N9VA 3I48A 4IEMA 5DV4A 4AWNA 2DNJA 1AKOA 1YJHA 5J3ZA 4L20A 4LNDA 4QHDA 2EI9A 5DFJA 3G3YA 3NGOA 2J63A 2JC4A 3NGQA 5INPA 5CFGA 3G8VA 1Y21A 4RUWA 1VYBA 3G2DA 3WCXA 3MPRA 3G00A 5J3PA 5DFHA 5INKA 4B5HA 2A40B 3W2YA 1WDUA 4QHEA 3I41A 2DDTA 2DDRA 4JG3A 3W3DB 3G38A 3NGNA 3MTCA 2A41B 4GYZA 1I9ZA 4GZ2A 1NTFA 3G4TA 4L1YA 3W2XA 5INQA 3G0RA 3G6SA 1ATND 5INMA 5INNA 4F1IA 2VOAA 4FPVA 3G3CA 5CFEA 5INLA 4CMNA 5DFIA 3FZIA 1I9YA 2F2FB 2XSWA 5DV2A 5INOA 2UYRX 4B5GA 4B5FA 5EWTA 1E9NA 4K6LF 4B5MA 2A42B 4GZ0A 5J42A 1DNKA 1ZWXA 4F1HB 4F1RA 5DG0A 4L1ZA 3NR8A 4PUQA 3L1WA 3K55A 4GZ1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GEW A;  4FVA A;  3G2C A;  3TEB A;  4QH9 A;  2F1N A;  5J3S A;  2ISI A;  3G91 A;  5A7J A;  4A9C A;  1SI6 X;  1DEW A;  4C1R A;  5J8N A;  2O3C A;  5HT2 A;  2D1K B;  3U8U A;  4B5I A;  3G0A A;  1HD7 A;  4CML A;  4F1H A;  3I5V A;  4L21 A;  2IMQ X;  4B5J A;  5DFF A;  1DE9 A;  2V0R A;  1SR4 B;  1DE8 A;  3CJC D;  2JC5 A;  2O3H A;  3GA6 A;  1BIX A;  5A7I A;  2V0S A;  2A3Z B;  2DDS A;  3G1K A;  3DNI A;  3I46 A;  3N9V A;  3I48 A;  4IEM A;  5DV4 A;  4AWN A;  2DNJ A;  1AKO A;  1YJH A;  5J3Z A;  4L20 A;  4LND A;  4QHD A;  2EI9 A;  5DFJ A;  3G3Y A;  3NGO A;  2J63 A;  2JC4 A;  3NGQ A;  5INP A;  5CFG A;  3G8V A;  1Y21 A;  4RUW A;  1VYB A;  3G2D A;  3WCX A;  3MPR A;  3G00 A;  5J3P A;  5DFH A;  5INK A;  4B5H A;  2A40 B;  3W2Y A;  1WDU A;  4QHE A;  3I41 A;  2DDT A;  2DDR A;  4JG3 A;  3W3D B;  3G38 A;  3NGN A;  3MTC A;  2A41 B;  4GYZ A;  1I9Z A;  4GZ2 A;  1NTF A;  3G4T A;  4L1Y A;  3W2X A;  5INQ A;  3G0R A;  3G6S A;  1ATN D;  5INM A;  5INN A;  4F1I A;  2VOA A;  4FPV A;  3G3C A;  5CFE A;  5INL A;  4CMN A;  5DFI A;  3FZI A;  1I9Y A;  2F2F B;  2XSW A;  5DV2 A;  5INO A;  2UYR X;  4B5G A;  4B5F A;  5EWT A;  1E9N A;  4K6L F;  4B5M A;  2A42 B;  4GZ0 A;  5J42 A;  1DNK A;  1ZWX A;  4F1H B;  4F1R A;  5DG0 A;  4L1Z A;  3NR8 A;  4PUQ A;  3L1W A;  3K55 A;  4GZ1 A; 
#chains in the Genus database with same CATH topology
 4GEW A;  4FVA A;  3G2C A;  3TEB A;  4QH9 A;  2F1N A;  5J3S A;  2ISI A;  3G91 A;  5A7J A;  4A9C A;  1SI6 X;  1DEW A;  4C1R A;  5J8N A;  2O3C A;  5HT2 A;  2D1K B;  3U8U A;  4B5I A;  3G0A A;  1HD7 A;  4CML A;  4F1H A;  3I5V A;  4L21 A;  2IMQ X;  4B5J A;  5DFF A;  1DE9 A;  2V0R A;  1SR4 B;  1DE8 A;  3CJC D;  2JC5 A;  2O3H A;  3GA6 A;  1BIX A;  5A7I A;  2V0S A;  2A3Z B;  2DDS A;  3G1K A;  3DNI A;  3I46 A;  3N9V A;  3I48 A;  4IEM A;  5DV4 A;  4AWN A;  2DNJ A;  1AKO A;  1YJH A;  5J3Z A;  4L20 A;  4LND A;  4QHD A;  2EI9 A;  5DFJ A;  3G3Y A;  3NGO A;  2J63 A;  2JC4 A;  3NGQ A;  5INP A;  5CFG A;  3G8V A;  1Y21 A;  4RUW A;  1VYB A;  3G2D A;  3WCX A;  3MPR A;  3G00 A;  5J3P A;  5DFH A;  5INK A;  4B5H A;  2A40 B;  3W2Y A;  1WDU A;  4QHE A;  3I41 A;  2DDT A;  2DDR A;  4JG3 A;  3W3D B;  3G38 A;  3NGN A;  3MTC A;  2A41 B;  4GYZ A;  1I9Z A;  4GZ2 A;  1NTF A;  3G4T A;  4L1Y A;  3W2X A;  5INQ A;  3G0R A;  3G6S A;  1ATN D;  5INM A;  5INN A;  4F1I A;  2VOA A;  4FPV A;  3G3C A;  5CFE A;  5INL A;  4CMN A;  5DFI A;  3FZI A;  1I9Y A;  2F2F B;  2XSW A;  5DV2 A;  5INO A;  2UYR X;  4B5G A;  4B5F A;  5EWT A;  1E9N A;  4K6L F;  4B5M A;  2A42 B;  4GZ0 A;  5J42 A;  1DNK A;  1ZWX A;  4F1H B;  4F1R A;  5DG0 A;  4L1Z A;  3NR8 A;  4PUQ A;  3L1W A;  3K55 A;  4GZ1 A; 
#chains in the Genus database with same CATH homology
 4GEW A;  4FVA A;  3G2C A;  3TEB A;  4QH9 A;  2F1N A;  5J3S A;  2ISI A;  3G91 A;  5A7J A;  4A9C A;  1SI6 X;  1DEW A;  4C1R A;  5J8N A;  2O3C A;  5HT2 A;  2D1K B;  3U8U A;  4B5I A;  3G0A A;  1HD7 A;  4CML A;  4F1H A;  3I5V A;  4L21 A;  2IMQ X;  4B5J A;  5DFF A;  1DE9 A;  2V0R A;  1SR4 B;  1DE8 A;  3CJC D;  2JC5 A;  2O3H A;  3GA6 A;  1BIX A;  5A7I A;  2V0S A;  2A3Z B;  2DDS A;  3G1K A;  3DNI A;  3I46 A;  3N9V A;  3I48 A;  4IEM A;  5DV4 A;  4AWN A;  2DNJ A;  1AKO A;  1YJH A;  5J3Z A;  4L20 A;  4LND A;  4QHD A;  2EI9 A;  5DFJ A;  3G3Y A;  3NGO A;  2J63 A;  2JC4 A;  3NGQ A;  5INP A;  5CFG A;  3G8V A;  1Y21 A;  4RUW A;  1VYB A;  3G2D A;  3WCX A;  3MPR A;  3G00 A;  5J3P A;  5DFH A;  5INK A;  4B5H A;  2A40 B;  3W2Y A;  1WDU A;  4QHE A;  3I41 A;  2DDT A;  2DDR A;  4JG3 A;  3W3D B;  3G38 A;  3NGN A;  3MTC A;  2A41 B;  4GYZ A;  1I9Z A;  4GZ2 A;  1NTF A;  3G4T A;  4L1Y A;  3W2X A;  5INQ A;  3G0R A;  3G6S A;  1ATN D;  5INM A;  5INN A;  4F1I A;  2VOA A;  4FPV A;  3G3C A;  5CFE A;  5INL A;  4CMN A;  5DFI A;  3FZI A;  1I9Y A;  2F2F B;  2XSW A;  5DV2 A;  5INO A;  2UYR X;  4B5G A;  4B5F A;  5EWT A;  1E9N A;  4K6L F;  4B5M A;  2A42 B;  4GZ0 A;  5J42 A;  1DNK A;  1ZWX A;  4F1H B;  4F1R A;  5DG0 A;  4L1Z A;  3NR8 A;  4PUQ A;  3L1W A;  3K55 A;  4GZ1 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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