4QR8A

Crystal structure of e coli pepq
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
441
structure length
441
Chain Sequence
SLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis of substrate selectivity of E. coli prolidase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
total genus 149
structure length 441
sequence length 441
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2014-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4qr8A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4qr8A02
3S6BA 1M35A 4QR8A 2IW2A 2BHCA 3L24A 2EA2A 3IU8A 4IECA 2BHAA 2Q92A 5CNXA 5FCHA 4ZWUA 1CHMA 1QZYA 1WN1A 2GU7A 4U70A 2Q95A 1BN5A 4B28A 1WL6A 1B6AA 1QXYA 3IL0A 1C22A 2EVMA 1KQ9A 1YVMA 5CDLA 2GG7A 4S2TP 3FM3A 3I7MA 2OKNA 1QXWA 2GG5A 4PV4A 3RORA 2GG0A 2BWWA 1KP0A 2ADUA 1XGMA 1R58A 2BN7A 4RZYA 2GGBA 5D6EA 3FMQA 1QXZA 2ZSGA 2P99A 4U69A 5E5BA 5D6FA 3OVKA 4IU6A 2G6PA 3O5VA 2OAZA 2Q8KA 3BITA 2Q96A 3PN9A 1C27A 3PKCA 4U6ZA 3IU9A 3BIPA 4FLKA 4ZWOA 1W7VA 2BWYA 4FKCA 3OOOA 4U75A 4JUQA 1WKMA 2V6CA 2GGCA 5JI6A 2V3YA 2BWXA 1XGNA 4U73A 1O0XA 2DFIA 4MATA 1YW8A 3IG4A 1W2MA 2Q93A 3PKAA 2BWUA 4Z7MA 1XGSA 2GG9A 4U76A 1Y1NA 3MATA 1JAWA 3PEBA 4U6CA 4IKTA 2BWTA 3TB5A 2V3ZA 3CTZA 2Q94A 5CDVA 2GU5A 4ZWPA 2B3HA 4FUKA 4IF7A 5CDEA 3RVAA 1XNZA 2BHDA 4RGZ1 4U1BA 4U71A 4IKRA 4U6JA 2GG3A 2GA2A 3Q6DA 1YW7A 1C23A 2EVCA 4FO7A 3MX6A 1C21A 4R60A 3D27A 1PV9A 2BWVA 4S01A 1KQ0A 1MATA 4HXXA 4OOKA 4U6WA 4ZNGA 3PKDA 3CB5A 1WLRA 1B59A 1N51A 4PNCA 4S00A 2BB7A 3CB6A 2GG8A 5JFRA 2BH3A 2V3XA 4EGEA 3BIQA 2GU6A 5CIKA 2B3KA 1XGOA 2P9AA 2HOWA 5CLSA 4A6VA 5CE6A 2GG2A 5E2CA 4A6WA 2GTXA 4IKUA 3FMRA 2MATA 2NQ7A 2NQ6A 2GU4A 1A16A 3L7GA 1WL9A 5FCFA 3PKEA 4FLLA 4U6EA 1YJ3A 2B3LA 4IDYA 4FO8A 4IKSA 1YW9A 2GZ5A 4IPAA 3TAVA 1R5GA 2P98A 4KM3A 5JHUA 4S2RP 1BOAA 2EVOA 2BHBA 1WY2A 4FLIA 1WBQA 1C24A 1R5HA 3MR1A 3QOCA 2BWSA 3PKBA 3IU7A 4FLJA 2EA4A 4RZZA
chains in the Genus database with same CATH superfamily
3S6BA 1M35A 4QR8A 2IW2A 2BHCA 3L24A 2EA2A 3IU8A 4IECA 2BHAA 2Q92A 5CNXA 5FCHA 4ZWUA 1CHMA 1QZYA 1WN1A 2GU7A 4U70A 2Q95A 1BN5A 4B28A 1WL6A 1B6AA 1QXYA 3IL0A 1C22A 2EVMA 1KQ9A 1YVMA 5CDLA 2GG7A 4S2TP 3FM3A 3I7MA 2OKNA 1QXWA 2GG5A 4PV4A 3RORA 2GG0A 2BWWA 1KP0A 2ADUA 1XGMA 1R58A 2BN7A 4RZYA 2GGBA 5D6EA 3FMQA 1QXZA 2ZSGA 2P99A 4U69A 5E5BA 5D6FA 3OVKA 4IU6A 2G6PA 3O5VA 2OAZA 2Q8KA 3BITA 2Q96A 3PN9A 1C27A 3PKCA 4U6ZA 3IU9A 3BIPA 4FLKA 4ZWOA 1W7VA 2BWYA 4FKCA 3OOOA 4U75A 4JUQA 1WKMA 2V6CA 2GGCA 5JI6A 2V3YA 2BWXA 1XGNA 4U73A 1O0XA 2DFIA 4MATA 1YW8A 3IG4A 1W2MA 2Q93A 3PKAA 2BWUA 4Z7MA 1XGSA 2GG9A 4U76A 1Y1NA 3MATA 1JAWA 3PEBA 4U6CA 4IKTA 2BWTA 3TB5A 2V3ZA 3CTZA 2Q94A 5CDVA 2GU5A 4ZWPA 2B3HA 4FUKA 4IF7A 5CDEA 3RVAA 1XNZA 2BHDA 4RGZ1 4U1BA 4U71A 4IKRA 4U6JA 2GG3A 2GA2A 3Q6DA 1YW7A 1C23A 2EVCA 4FO7A 3MX6A 1C21A 4R60A 3D27A 1PV9A 2BWVA 4S01A 1KQ0A 1MATA 4HXXA 4OOKA 4U6WA 4ZNGA 3PKDA 3CB5A 1WLRA 1B59A 1N51A 4PNCA 4S00A 2BB7A 3CB6A 2GG8A 5JFRA 2BH3A 2V3XA 4EGEA 3BIQA 2GU6A 5CIKA 2B3KA 1XGOA 2P9AA 2HOWA 5CLSA 4A6VA 5CE6A 2GG2A 5E2CA 4A6WA 2GTXA 4IKUA 3FMRA 2MATA 2NQ7A 2NQ6A 2GU4A 1A16A 3L7GA 1WL9A 5FCFA 3PKEA 4FLLA 4U6EA 1YJ3A 2B3LA 4IDYA 4FO8A 4IKSA 1YW9A 2GZ5A 4IPAA 3TAVA 1R5GA 2P98A 4KM3A 5JHUA 4S2RP 1BOAA 2EVOA 2BHBA 1WY2A 4FLIA 1WBQA 1C24A 1R5HA 3MR1A 3QOCA 2BWSA 3PKBA 3IU7A 4FLJA 2EA4A 4RZZA
chains in the Genus database with same CATH topology
3S6BA 1M35A 4QR8A 2IW2A 2BHCA 3L24A 2EA2A 3IU8A 4IECA 2BHAA 2Q92A 5CNXA 5FCHA 4ZWUA 1CHMA 1QZYA 1WN1A 2GU7A 4U70A 2Q95A 1BN5A 4B28A 1WL6A 1B6AA 1QXYA 3IL0A 1C22A 2EVMA 1KQ9A 1YVMA 5CDLA 2GG7A 4S2TP 3FM3A 3I7MA 2OKNA 1QXWA 2GG5A 4PV4A 3RORA 2GG0A 2BWWA 1KP0A 2ADUA 1XGMA 1R58A 2BN7A 4RZYA 2GGBA 5D6EA 3FMQA 1QXZA 2ZSGA 2P99A 4U69A 5E5BA 5D6FA 3OVKA 4IU6A 2G6PA 3O5VA 2OAZA 2Q8KA 3BITA 2Q96A 3PN9A 1C27A 3PKCA 4U6ZA 3IU9A 3BIPA 4FLKA 4ZWOA 1W7VA 2BWYA 4FKCA 3OOOA 4U75A 4JUQA 1WKMA 2V6CA 2GGCA 5JI6A 2V3YA 2BWXA 1XGNA 4U73A 1O0XA 2DFIA 4MATA 1YW8A 3IG4A 1W2MA 2Q93A 3PKAA 2BWUA 4Z7MA 1XGSA 2GG9A 4U76A 1Y1NA 3MATA 1JAWA 3PEBA 4U6CA 4IKTA 2BWTA 3TB5A 2V3ZA 3CTZA 2Q94A 5CDVA 2GU5A 4ZWPA 2B3HA 4FUKA 4IF7A 5CDEA 3RVAA 1XNZA 2BHDA 4RGZ1 4U1BA 4U71A 4IKRA 4U6JA 2GG3A 2GA2A 3Q6DA 1YW7A 1C23A 2EVCA 4FO7A 3MX6A 1C21A 4R60A 3D27A 1PV9A 2BWVA 4S01A 1KQ0A 1MATA 4HXXA 4OOKA 4U6WA 4ZNGA 3PKDA 3CB5A 1WLRA 1B59A 1N51A 4PNCA 4S00A 2BB7A 3CB6A 2GG8A 5JFRA 2BH3A 2V3XA 4EGEA 3BIQA 2GU6A 5CIKA 2B3KA 1XGOA 2P9AA 2HOWA 5CLSA 4A6VA 5CE6A 2GG2A 5E2CA 4A6WA 2GTXA 4IKUA 3FMRA 2MATA 2NQ7A 2NQ6A 2GU4A 1A16A 3L7GA 1WL9A 5FCFA 3PKEA 4FLLA 4U6EA 1YJ3A 2B3LA 4IDYA 4FO8A 4IKSA 1YW9A 2GZ5A 4IPAA 3TAVA 1R5GA 2P98A 4KM3A 5JHUA 4S2RP 1BOAA 2EVOA 2BHBA 1WY2A 4FLIA 1WBQA 1C24A 1R5HA 3MR1A 3QOCA 2BWSA 3PKBA 3IU7A 4FLJA 2EA4A 4RZZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S6B A;  1M35 A;  4QR8 A;  2IW2 A;  2BHC A;  3L24 A;  2EA2 A;  3IU8 A;  4IEC A;  2BHA A;  2Q92 A;  5CNX A;  5FCH A;  4ZWU A;  1CHM A;  1QZY A;  1WN1 A;  2GU7 A;  4U70 A;  2Q95 A;  1BN5 A;  4B28 A;  1WL6 A;  1B6A A;  1QXY A;  3IL0 A;  1C22 A;  2EVM A;  1KQ9 A;  1YVM A;  5CDL A;  2GG7 A;  4S2T P;  3FM3 A;  3I7M A;  2OKN A;  1QXW A;  2GG5 A;  4PV4 A;  3ROR A;  2GG0 A;  2BWW A;  1KP0 A;  2ADU A;  1XGM A;  1R58 A;  2BN7 A;  4RZY A;  2GGB A;  5D6E A;  3FMQ A;  1QXZ A;  2ZSG A;  2P99 A;  4U69 A;  5E5B A;  5D6F A;  3OVK A;  4IU6 A;  2G6P A;  3O5V A;  2OAZ A;  2Q8K A;  3BIT A;  2Q96 A;  3PN9 A;  1C27 A;  3PKC A;  4U6Z A;  3IU9 A;  3BIP A;  4FLK A;  4ZWO A;  1W7V A;  2BWY A;  4FKC A;  3OOO A;  4U75 A;  4JUQ A;  1WKM A;  2V6C A;  2GGC A;  5JI6 A;  2V3Y A;  2BWX A;  1XGN A;  4U73 A;  1O0X A;  2DFI A;  4MAT A;  1YW8 A;  3IG4 A;  1W2M A;  2Q93 A;  3PKA A;  2BWU A;  4Z7M A;  1XGS A;  2GG9 A;  4U76 A;  1Y1N A;  3MAT A;  1JAW A;  3PEB A;  4U6C A;  4IKT A;  2BWT A;  3TB5 A;  2V3Z A;  3CTZ A;  2Q94 A;  5CDV A;  2GU5 A;  4ZWP A;  2B3H A;  4FUK A;  4IF7 A;  5CDE A;  3RVA A;  1XNZ A;  2BHD A;  4RGZ 1;  4U1B A;  4U71 A;  4IKR A;  4U6J A;  2GG3 A;  2GA2 A;  3Q6D A;  1YW7 A;  1C23 A;  2EVC A;  4FO7 A;  3MX6 A;  1C21 A;  4R60 A;  3D27 A;  1PV9 A;  2BWV A;  4S01 A;  1KQ0 A;  1MAT A;  4HXX A;  4OOK A;  4U6W A;  4ZNG A;  3PKD A;  3CB5 A;  1WLR A;  1B59 A;  1N51 A;  4PNC A;  4S00 A;  2BB7 A;  3CB6 A;  2GG8 A;  5JFR A;  2BH3 A;  2V3X A;  4EGE A;  3BIQ A;  2GU6 A;  5CIK A;  2B3K A;  1XGO A;  2P9A A;  2HOW A;  5CLS A;  4A6V A;  5CE6 A;  2GG2 A;  5E2C A;  4A6W A;  2GTX A;  4IKU A;  3FMR A;  2MAT A;  2NQ7 A;  2NQ6 A;  2GU4 A;  1A16 A;  3L7G A;  1WL9 A;  5FCF A;  3PKE A;  4FLL A;  4U6E A;  1YJ3 A;  2B3L A;  4IDY A;  4FO8 A;  4IKS A;  1YW9 A;  2GZ5 A;  4IPA A;  3TAV A;  1R5G A;  2P98 A;  4KM3 A;  5JHU A;  4S2R P;  1BOA A;  2EVO A;  2BHB A;  1WY2 A;  4FLI A;  1WBQ A;  1C24 A;  1R5H A;  3MR1 A;  3QOC A;  2BWS A;  3PKB A;  3IU7 A;  4FLJ A;  2EA4 A;  4RZZ A; 
#chains in the Genus database with same CATH topology
 3S6B A;  1M35 A;  4QR8 A;  2IW2 A;  2BHC A;  3L24 A;  2EA2 A;  3IU8 A;  4IEC A;  2BHA A;  2Q92 A;  5CNX A;  5FCH A;  4ZWU A;  1CHM A;  1QZY A;  1WN1 A;  2GU7 A;  4U70 A;  2Q95 A;  1BN5 A;  4B28 A;  1WL6 A;  1B6A A;  1QXY A;  3IL0 A;  1C22 A;  2EVM A;  1KQ9 A;  1YVM A;  5CDL A;  2GG7 A;  4S2T P;  3FM3 A;  3I7M A;  2OKN A;  1QXW A;  2GG5 A;  4PV4 A;  3ROR A;  2GG0 A;  2BWW A;  1KP0 A;  2ADU A;  1XGM A;  1R58 A;  2BN7 A;  4RZY A;  2GGB A;  5D6E A;  3FMQ A;  1QXZ A;  2ZSG A;  2P99 A;  4U69 A;  5E5B A;  5D6F A;  3OVK A;  4IU6 A;  2G6P A;  3O5V A;  2OAZ A;  2Q8K A;  3BIT A;  2Q96 A;  3PN9 A;  1C27 A;  3PKC A;  4U6Z A;  3IU9 A;  3BIP A;  4FLK A;  4ZWO A;  1W7V A;  2BWY A;  4FKC A;  3OOO A;  4U75 A;  4JUQ A;  1WKM A;  2V6C A;  2GGC A;  5JI6 A;  2V3Y A;  2BWX A;  1XGN A;  4U73 A;  1O0X A;  2DFI A;  4MAT A;  1YW8 A;  3IG4 A;  1W2M A;  2Q93 A;  3PKA A;  2BWU A;  4Z7M A;  1XGS A;  2GG9 A;  4U76 A;  1Y1N A;  3MAT A;  1JAW A;  3PEB A;  4U6C A;  4IKT A;  2BWT A;  3TB5 A;  2V3Z A;  3CTZ A;  2Q94 A;  5CDV A;  2GU5 A;  4ZWP A;  2B3H A;  4FUK A;  4IF7 A;  5CDE A;  3RVA A;  1XNZ A;  2BHD A;  4RGZ 1;  4U1B A;  4U71 A;  4IKR A;  4U6J A;  2GG3 A;  2GA2 A;  3Q6D A;  1YW7 A;  1C23 A;  2EVC A;  4FO7 A;  3MX6 A;  1C21 A;  4R60 A;  3D27 A;  1PV9 A;  2BWV A;  4S01 A;  1KQ0 A;  1MAT A;  4HXX A;  4OOK A;  4U6W A;  4ZNG A;  3PKD A;  3CB5 A;  1WLR A;  1B59 A;  1N51 A;  4PNC A;  4S00 A;  2BB7 A;  3CB6 A;  2GG8 A;  5JFR A;  2BH3 A;  2V3X A;  4EGE A;  3BIQ A;  2GU6 A;  5CIK A;  2B3K A;  1XGO A;  2P9A A;  2HOW A;  5CLS A;  4A6V A;  5CE6 A;  2GG2 A;  5E2C A;  4A6W A;  2GTX A;  4IKU A;  3FMR A;  2MAT A;  2NQ7 A;  2NQ6 A;  2GU4 A;  1A16 A;  3L7G A;  1WL9 A;  5FCF A;  3PKE A;  4FLL A;  4U6E A;  1YJ3 A;  2B3L A;  4IDY A;  4FO8 A;  4IKS A;  1YW9 A;  2GZ5 A;  4IPA A;  3TAV A;  1R5G A;  2P98 A;  4KM3 A;  5JHU A;  4S2R P;  1BOA A;  2EVO A;  2BHB A;  1WY2 A;  4FLI A;  1WBQ A;  1C24 A;  1R5H A;  3MR1 A;  3QOC A;  2BWS A;  3PKB A;  3IU7 A;  4FLJ A;  2EA4 A;  4RZZ A; 
#chains in the Genus database with same CATH homology
 3S6B A;  1M35 A;  4QR8 A;  2IW2 A;  2BHC A;  3L24 A;  2EA2 A;  3IU8 A;  4IEC A;  2BHA A;  2Q92 A;  5CNX A;  5FCH A;  4ZWU A;  1CHM A;  1QZY A;  1WN1 A;  2GU7 A;  4U70 A;  2Q95 A;  1BN5 A;  4B28 A;  1WL6 A;  1B6A A;  1QXY A;  3IL0 A;  1C22 A;  2EVM A;  1KQ9 A;  1YVM A;  5CDL A;  2GG7 A;  4S2T P;  3FM3 A;  3I7M A;  2OKN A;  1QXW A;  2GG5 A;  4PV4 A;  3ROR A;  2GG0 A;  2BWW A;  1KP0 A;  2ADU A;  1XGM A;  1R58 A;  2BN7 A;  4RZY A;  2GGB A;  5D6E A;  3FMQ A;  1QXZ A;  2ZSG A;  2P99 A;  4U69 A;  5E5B A;  5D6F A;  3OVK A;  4IU6 A;  2G6P A;  3O5V A;  2OAZ A;  2Q8K A;  3BIT A;  2Q96 A;  3PN9 A;  1C27 A;  3PKC A;  4U6Z A;  3IU9 A;  3BIP A;  4FLK A;  4ZWO A;  1W7V A;  2BWY A;  4FKC A;  3OOO A;  4U75 A;  4JUQ A;  1WKM A;  2V6C A;  2GGC A;  5JI6 A;  2V3Y A;  2BWX A;  1XGN A;  4U73 A;  1O0X A;  2DFI A;  4MAT A;  1YW8 A;  3IG4 A;  1W2M A;  2Q93 A;  3PKA A;  2BWU A;  4Z7M A;  1XGS A;  2GG9 A;  4U76 A;  1Y1N A;  3MAT A;  1JAW A;  3PEB A;  4U6C A;  4IKT A;  2BWT A;  3TB5 A;  2V3Z A;  3CTZ A;  2Q94 A;  5CDV A;  2GU5 A;  4ZWP A;  2B3H A;  4FUK A;  4IF7 A;  5CDE A;  3RVA A;  1XNZ A;  2BHD A;  4RGZ 1;  4U1B A;  4U71 A;  4IKR A;  4U6J A;  2GG3 A;  2GA2 A;  3Q6D A;  1YW7 A;  1C23 A;  2EVC A;  4FO7 A;  3MX6 A;  1C21 A;  4R60 A;  3D27 A;  1PV9 A;  2BWV A;  4S01 A;  1KQ0 A;  1MAT A;  4HXX A;  4OOK A;  4U6W A;  4ZNG A;  3PKD A;  3CB5 A;  1WLR A;  1B59 A;  1N51 A;  4PNC A;  4S00 A;  2BB7 A;  3CB6 A;  2GG8 A;  5JFR A;  2BH3 A;  2V3X A;  4EGE A;  3BIQ A;  2GU6 A;  5CIK A;  2B3K A;  1XGO A;  2P9A A;  2HOW A;  5CLS A;  4A6V A;  5CE6 A;  2GG2 A;  5E2C A;  4A6W A;  2GTX A;  4IKU A;  3FMR A;  2MAT A;  2NQ7 A;  2NQ6 A;  2GU4 A;  1A16 A;  3L7G A;  1WL9 A;  5FCF A;  3PKE A;  4FLL A;  4U6E A;  1YJ3 A;  2B3L A;  4IDY A;  4FO8 A;  4IKS A;  1YW9 A;  2GZ5 A;  4IPA A;  3TAV A;  1R5G A;  2P98 A;  4KM3 A;  5JHU A;  4S2R P;  1BOA A;  2EVO A;  2BHB A;  1WY2 A;  4FLI A;  1WBQ A;  1C24 A;  1R5H A;  3MR1 A;  3QOC A;  2BWS A;  3PKB A;  3IU7 A;  4FLJ A;  2EA4 A;  4RZZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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