4RHWA

Crystal structure of apaf-1 card and caspase-9 card complex
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
95
structure length
95
Chain Sequence
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Apoptosis
molecule keywords Apoptotic protease-activating factor 1
total genus 36
structure length 95
sequence length 95
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-10-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4rhwA00
4P4HA 4M9SA 1CWWA 3KATA 4D8OA 1NGRA 2LWEA 4NQKA 2KN6A 4E9MA 2DBGA 2NSNA 1CY5A 2MPCA 2DBHA 2BBRA 2YGSA 2YQFA 2DBDA 4IZ7B 2IB1A 4A2WA 2OF5H 4P4HI 2LWDA 2L6AA 3EZQB 2GF5A 3CL3A 3MOPK 2MS7A 4M9XA 3MOPG 3T6PA 4F42A 3LQRA 1E41A 3MOPA 4F44A 2A9IA 4IZAB 1D2ZA 2F1SA 2G7RA 4N1KA 3LQQA 4JUPA 4EWIA 4I16A 2D96A 2KM6A 4O9LA 2DO9A 3J63A 2N80A 2N7ZA 1A1ZA 2O71A 3YGSP 1ICHA 4UZ0A 1UCPA 4IZ5E 2MN4A 2N1FA 2YU0A 2VGQA 1C15A 1WH4A 4RHWA 1YGOA 1E3YA 4N1LA 3EZQA 4N1JA 1DGNA 2N97A 4A2QA 4RHWE 1Z6TA 2N00A 4LWDA 4M9ZA 2NZ7A 3CRDA 2L9MA 2M5VA 4ZBWA 3QF2A 4QOBA 2MS8A 4O7QA 1N3KA 1DDFA 1D2ZB 2N83A 3J6JA 4FH0A 2DBFA 4DWNA 2OF5A 2HM2Q 2B1WA 1PN5A 2BBZA 1WXPA 2P1HA 3YGSC 2LS7A 1A1WA 2NAQA 4JQWA 4O6XA 1FADA 4O9FA 1WMGA 2A5YB 2YVIA 2MB9A
chains in the Genus database with same CATH superfamily
4P4HA 4M9SA 1CWWA 3KATA 4D8OA 1NGRA 2LWEA 4NQKA 2KN6A 4E9MA 2DBGA 2NSNA 1CY5A 2MPCA 2DBHA 2BBRA 2YGSA 2YQFA 2DBDA 4IZ7B 2IB1A 4A2WA 2OF5H 4P4HI 2LWDA 2L6AA 3EZQB 2GF5A 3CL3A 3MOPK 2MS7A 4M9XA 3MOPG 3T6PA 4F42A 3LQRA 1E41A 3MOPA 4F44A 2A9IA 4IZAB 1D2ZA 2F1SA 2G7RA 4N1KA 3LQQA 4JUPA 4EWIA 4I16A 2D96A 2KM6A 4O9LA 2DO9A 3J63A 2N80A 2N7ZA 1A1ZA 2O71A 3YGSP 1ICHA 4UZ0A 1UCPA 4IZ5E 2MN4A 2N1FA 2YU0A 2VGQA 1C15A 1WH4A 4RHWA 1YGOA 1E3YA 4N1LA 3EZQA 4N1JA 1DGNA 2N97A 4A2QA 4RHWE 1Z6TA 2N00A 4LWDA 2XV9A 4M9ZA 2NZ7A 3CRDA 2L9MA 2M5VA 4ZBWA 3QF2A 4QOBA 2MS8A 4O7QA 1N3KA 1DDFA 1D2ZB 2N83A 3J6JA 4FH0A 2DBFA 2MJMA 4DWNA 2OF5A 2HM2Q 2B1WA 1PN5A 2BBZA 1WXPA 2P1HA 3YGSC 2LS7A 1A1WA 2NAQA 4JQWA 4O6XA 1FADA 4O9FA 1WMGA 2A5YB 2YVIA 2MB9A
chains in the Genus database with same CATH topology
4P4HA 4M9SA 1CWWA 3KATA 4D8OA 1NGRA 2LWEA 4NQKA 2KN6A 4E9MA 2DBGA 2NSNA 1CY5A 2MPCA 2DBHA 2BBRA 2YGSA 2YQFA 2DBDA 4IZ7B 2IB1A 4A2WA 2OF5H 4P4HI 2LWDA 2L6AA 3EZQB 2GF5A 3CL3A 3MOPK 2MS7A 4M9XA 3MOPG 3T6PA 4F42A 3LQRA 1E41A 3MOPA 4F44A 2A9IA 4IZAB 1D2ZA 2F1SA 2G7RA 4N1KA 3LQQA 4JUPA 4EWIA 4I16A 2D96A 2KM6A 4O9LA 2DO9A 3J63A 2N80A 2N7ZA 1A1ZA 2O71A 3YGSP 1ICHA 4UZ0A 1UCPA 4IZ5E 2MN4A 2N1FA 2YU0A 2VGQA 1C15A 1WH4A 4RHWA 1YGOA 1E3YA 4N1LA 3EZQA 4N1JA 1DGNA 2N97A 4A2QA 4RHWE 1Z6TA 2N00A 4LWDA 2XV9A 4M9ZA 2NZ7A 3CRDA 2L9MA 2M5VA 4ZBWA 3QF2A 4QOBA 2MS8A 4O7QA 1N3KA 1DDFA 1D2ZB 2N83A 3J6JA 4FH0A 2DBFA 2MJMA 4DWNA 2OF5A 2HM2Q 2B1WA 1PN5A 2BBZA 1WXPA 2P1HA 3YGSC 2LS7A 1A1WA 2NAQA 4JQWA 4O6XA 1FADA 4O9FA 1WMGA 2A5YB 2YVIA 2MB9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P4H A;  4M9S A;  1CWW A;  3KAT A;  4D8O A;  1NGR A;  2LWE A;  4NQK A;  2KN6 A;  4E9M A;  2DBG A;  2NSN A;  1CY5 A;  2MPC A;  2DBH A;  2BBR A;  2YGS A;  2YQF A;  2DBD A;  4IZ7 B;  2IB1 A;  4A2W A;  2OF5 H;  4P4H I;  2LWD A;  2L6A A;  3EZQ B;  2GF5 A;  3CL3 A;  3MOP K;  2MS7 A;  4M9X A;  3MOP G;  3T6P A;  4F42 A;  3LQR A;  1E41 A;  3MOP A;  4F44 A;  2A9I A;  4IZA B;  1D2Z A;  2F1S A;  2G7R A;  4N1K A;  3LQQ A;  4JUP A;  4EWI A;  4I16 A;  2D96 A;  2KM6 A;  4O9L A;  2DO9 A;  3J63 A;  2N80 A;  2N7Z A;  1A1Z A;  2O71 A;  3YGS P;  1ICH A;  4UZ0 A;  1UCP A;  4IZ5 E;  2MN4 A;  2N1F A;  2YU0 A;  2VGQ A;  1C15 A;  1WH4 A;  4RHW A;  1YGO A;  1E3Y A;  4N1L A;  3EZQ A;  4N1J A;  1DGN A;  2N97 A;  4A2Q A;  4RHW E;  1Z6T A;  2N00 A;  4LWD A;  4M9Z A;  2NZ7 A;  3CRD A;  2L9M A;  2M5V A;  4ZBW A;  3QF2 A;  4QOB A;  2MS8 A;  4O7Q A;  1N3K A;  1DDF A;  1D2Z B;  2N83 A;  3J6J A;  4FH0 A;  2DBF A;  4DWN A;  2OF5 A;  2HM2 Q;  2B1W A;  1PN5 A;  2BBZ A;  1WXP A;  2P1H A;  3YGS C;  2LS7 A;  1A1W A;  2NAQ A;  4JQW A;  4O6X A;  1FAD A;  4O9F A;  1WMG A;  2A5Y B;  2YVI A;  2MB9 A; 
#chains in the Genus database with same CATH topology
 4P4H A;  4M9S A;  1CWW A;  3KAT A;  4D8O A;  1NGR A;  2LWE A;  4NQK A;  2KN6 A;  4E9M A;  2DBG A;  2NSN A;  1CY5 A;  2MPC A;  2DBH A;  2BBR A;  2YGS A;  2YQF A;  2DBD A;  4IZ7 B;  2IB1 A;  4A2W A;  2OF5 H;  4P4H I;  2LWD A;  2L6A A;  3EZQ B;  2GF5 A;  3CL3 A;  3MOP K;  2MS7 A;  4M9X A;  3MOP G;  3T6P A;  4F42 A;  3LQR A;  1E41 A;  3MOP A;  4F44 A;  2A9I A;  4IZA B;  1D2Z A;  2F1S A;  2G7R A;  4N1K A;  3LQQ A;  4JUP A;  4EWI A;  4I16 A;  2D96 A;  2KM6 A;  4O9L A;  2DO9 A;  3J63 A;  2N80 A;  2N7Z A;  1A1Z A;  2O71 A;  3YGS P;  1ICH A;  4UZ0 A;  1UCP A;  4IZ5 E;  2MN4 A;  2N1F A;  2YU0 A;  2VGQ A;  1C15 A;  1WH4 A;  4RHW A;  1YGO A;  1E3Y A;  4N1L A;  3EZQ A;  4N1J A;  1DGN A;  2N97 A;  4A2Q A;  4RHW E;  1Z6T A;  2N00 A;  4LWD A;  2XV9 A;  4M9Z A;  2NZ7 A;  3CRD A;  2L9M A;  2M5V A;  4ZBW A;  3QF2 A;  4QOB A;  2MS8 A;  4O7Q A;  1N3K A;  1DDF A;  1D2Z B;  2N83 A;  3J6J A;  4FH0 A;  2DBF A;  2MJM A;  4DWN A;  2OF5 A;  2HM2 Q;  2B1W A;  1PN5 A;  2BBZ A;  1WXP A;  2P1H A;  3YGS C;  2LS7 A;  1A1W A;  2NAQ A;  4JQW A;  4O6X A;  1FAD A;  4O9F A;  1WMG A;  2A5Y B;  2YVI A;  2MB9 A; 
#chains in the Genus database with same CATH homology
 4P4H A;  4M9S A;  1CWW A;  3KAT A;  4D8O A;  1NGR A;  2LWE A;  4NQK A;  2KN6 A;  4E9M A;  2DBG A;  2NSN A;  1CY5 A;  2MPC A;  2DBH A;  2BBR A;  2YGS A;  2YQF A;  2DBD A;  4IZ7 B;  2IB1 A;  4A2W A;  2OF5 H;  4P4H I;  2LWD A;  2L6A A;  3EZQ B;  2GF5 A;  3CL3 A;  3MOP K;  2MS7 A;  4M9X A;  3MOP G;  3T6P A;  4F42 A;  3LQR A;  1E41 A;  3MOP A;  4F44 A;  2A9I A;  4IZA B;  1D2Z A;  2F1S A;  2G7R A;  4N1K A;  3LQQ A;  4JUP A;  4EWI A;  4I16 A;  2D96 A;  2KM6 A;  4O9L A;  2DO9 A;  3J63 A;  2N80 A;  2N7Z A;  1A1Z A;  2O71 A;  3YGS P;  1ICH A;  4UZ0 A;  1UCP A;  4IZ5 E;  2MN4 A;  2N1F A;  2YU0 A;  2VGQ A;  1C15 A;  1WH4 A;  4RHW A;  1YGO A;  1E3Y A;  4N1L A;  3EZQ A;  4N1J A;  1DGN A;  2N97 A;  4A2Q A;  4RHW E;  1Z6T A;  2N00 A;  4LWD A;  2XV9 A;  4M9Z A;  2NZ7 A;  3CRD A;  2L9M A;  2M5V A;  4ZBW A;  3QF2 A;  4QOB A;  2MS8 A;  4O7Q A;  1N3K A;  1DDF A;  1D2Z B;  2N83 A;  3J6J A;  4FH0 A;  2DBF A;  2MJM A;  4DWN A;  2OF5 A;  2HM2 Q;  2B1W A;  1PN5 A;  2BBZ A;  1WXP A;  2P1H A;  3YGS C;  2LS7 A;  1A1W A;  2NAQ A;  4JQW A;  4O6X A;  1FAD A;  4O9F A;  1WMG A;  2A5Y B;  2YVI A;  2MB9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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