4RHWA

Crystal structure of apaf-1 card and caspase-9 card complex
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
95
structure length
95
Chain Sequence
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Apoptosis
molecule keywords Apoptotic protease-activating factor 1
total genus 36
structure length 95
sequence length 95
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-10-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4rhwA00
4QOBA 2KM6A 3J63A 4ZBWA 2N7ZA 1CWWA 1CY5A 3YGSC 2DO9A 2N80A 3CL3A 1A1ZA 3KATA 3EZQA 1DGNA 2KN6A 4RHWA 1E41A 2M5VA 2BBRA 1D2ZB 3YGSP 3J6JA 3MOPK 4N1KA 4F44A 2F1SA 4RHWE 2O71A 4NQKA 4P4HI 1YGOA 4LWDA 2LWEA 4IZAB 4A2QA 2DBHA 4UZ0A 1Z6TA 2MN4A 4O7QA 2OF5A 1DDFA 3LQRA 4I16A 2MB9A 2A9IA 2NZ7A 2L9MA 4A2WA 1PN5A 1WH4A 4EWIA 2G7RA 1N3KA 1UCPA 2LWDA 2HM2Q 2L6AA 2VGQA 4M9ZA 2GF5A 3T6PA 1FADA 2YGSA 2N00A 2DBDA 2OF5H 2A5YB 4E9MA 2N97A 1D2ZA 2MPCA 1A1WA 2DBFA 4N1LA 4JQWA 4JUPA 2LS7A 4N1JA 4P4HA 1ICHA 4M9SA 4D8OA 4O9FA 2YU0A 4IZ7B 2IB1A 2N1FA 2YVIA 1E3YA 3LQQA 2NSNA 2NAQA 2BBZA 2MS8A 4M9XA 2N83A 2DBGA 1NGRA 3CRDA 3EZQB 2P1HA 4FH0A 4IZ5E 4O9LA 3MOPG 4DWNA 1WXPA 3MOPA 4O6XA 2D96A 2B1WA 2MS7A 1C15A 1WMGA 3QF2A 2YQFA 4F42A
chains in the Genus database with same CATH superfamily
4QOBA 2KM6A 3J63A 4ZBWA 2N7ZA 2XV9A 1CWWA 1CY5A 3YGSC 2DO9A 2N80A 3CL3A 1A1ZA 3KATA 3EZQA 1DGNA 2KN6A 4RHWA 1E41A 2M5VA 2BBRA 1D2ZB 3YGSP 3J6JA 3MOPK 4N1KA 4F44A 2F1SA 4RHWE 2O71A 4NQKA 4P4HI 1YGOA 4LWDA 2LWEA 4IZAB 4A2QA 2DBHA 4UZ0A 1Z6TA 2MN4A 4O7QA 2OF5A 1DDFA 3LQRA 4I16A 2MB9A 2A9IA 2NZ7A 2L9MA 4A2WA 1PN5A 1WH4A 4EWIA 2G7RA 1N3KA 1UCPA 2LWDA 2HM2Q 2L6AA 2VGQA 4M9ZA 2GF5A 3T6PA 1FADA 2YGSA 2N00A 2DBDA 2OF5H 2A5YB 4E9MA 2N97A 1D2ZA 2MPCA 1A1WA 2DBFA 4N1LA 4JQWA 4JUPA 2LS7A 4N1JA 4P4HA 1ICHA 4M9SA 4D8OA 4O9FA 2YU0A 4IZ7B 2IB1A 2N1FA 2YVIA 1E3YA 3LQQA 2NSNA 2NAQA 2BBZA 2MS8A 4M9XA 2N83A 2DBGA 1NGRA 3CRDA 3EZQB 2P1HA 4FH0A 4IZ5E 4O9LA 3MOPG 4DWNA 1WXPA 3MOPA 4O6XA 2D96A 2B1WA 2MS7A 1C15A 1WMGA 2MJMA 3QF2A 2YQFA 4F42A
chains in the Genus database with same CATH topology
4QOBA 2KM6A 3J63A 4ZBWA 2N7ZA 2XV9A 1CWWA 1CY5A 3YGSC 2DO9A 2N80A 3CL3A 1A1ZA 3KATA 3EZQA 1DGNA 2KN6A 4RHWA 1E41A 2M5VA 2BBRA 1D2ZB 3YGSP 3J6JA 3MOPK 4N1KA 4F44A 2F1SA 4RHWE 2O71A 4NQKA 4P4HI 1YGOA 4LWDA 2LWEA 4IZAB 4A2QA 2DBHA 4UZ0A 1Z6TA 2MN4A 4O7QA 2OF5A 1DDFA 3LQRA 4I16A 2MB9A 2A9IA 2NZ7A 2L9MA 4A2WA 1PN5A 1WH4A 4EWIA 2G7RA 1N3KA 1UCPA 2LWDA 2HM2Q 2L6AA 2VGQA 4M9ZA 2GF5A 3T6PA 1FADA 2YGSA 2N00A 2DBDA 2OF5H 2A5YB 4E9MA 2N97A 1D2ZA 2MPCA 1A1WA 2DBFA 4N1LA 4JQWA 4JUPA 2LS7A 4N1JA 4P4HA 1ICHA 4M9SA 4D8OA 4O9FA 2YU0A 4IZ7B 2IB1A 2N1FA 2YVIA 1E3YA 3LQQA 2NSNA 2NAQA 2BBZA 2MS8A 4M9XA 2N83A 2DBGA 1NGRA 3CRDA 3EZQB 2P1HA 4FH0A 4IZ5E 4O9LA 3MOPG 4DWNA 1WXPA 3MOPA 4O6XA 2D96A 2B1WA 2MS7A 1C15A 1WMGA 2MJMA 3QF2A 2YQFA 4F42A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QOB A;  2KM6 A;  3J63 A;  4ZBW A;  2N7Z A;  1CWW A;  1CY5 A;  3YGS C;  2DO9 A;  2N80 A;  3CL3 A;  1A1Z A;  3KAT A;  3EZQ A;  1DGN A;  2KN6 A;  4RHW A;  1E41 A;  2M5V A;  2BBR A;  1D2Z B;  3YGS P;  3J6J A;  3MOP K;  4N1K A;  4F44 A;  2F1S A;  4RHW E;  2O71 A;  4NQK A;  4P4H I;  1YGO A;  4LWD A;  2LWE A;  4IZA B;  4A2Q A;  2DBH A;  4UZ0 A;  1Z6T A;  2MN4 A;  4O7Q A;  2OF5 A;  1DDF A;  3LQR A;  4I16 A;  2MB9 A;  2A9I A;  2NZ7 A;  2L9M A;  4A2W A;  1PN5 A;  1WH4 A;  4EWI A;  2G7R A;  1N3K A;  1UCP A;  2LWD A;  2HM2 Q;  2L6A A;  2VGQ A;  4M9Z A;  2GF5 A;  3T6P A;  1FAD A;  2YGS A;  2N00 A;  2DBD A;  2OF5 H;  2A5Y B;  4E9M A;  2N97 A;  1D2Z A;  2MPC A;  1A1W A;  2DBF A;  4N1L A;  4JQW A;  4JUP A;  2LS7 A;  4N1J A;  4P4H A;  1ICH A;  4M9S A;  4D8O A;  4O9F A;  2YU0 A;  4IZ7 B;  2IB1 A;  2N1F A;  2YVI A;  1E3Y A;  3LQQ A;  2NSN A;  2NAQ A;  2BBZ A;  2MS8 A;  4M9X A;  2N83 A;  2DBG A;  1NGR A;  3CRD A;  3EZQ B;  2P1H A;  4FH0 A;  4IZ5 E;  4O9L A;  3MOP G;  4DWN A;  1WXP A;  3MOP A;  4O6X A;  2D96 A;  2B1W A;  2MS7 A;  1C15 A;  1WMG A;  3QF2 A;  2YQF A;  4F42 A; 
#chains in the Genus database with same CATH topology
 4QOB A;  2KM6 A;  3J63 A;  4ZBW A;  2N7Z A;  2XV9 A;  1CWW A;  1CY5 A;  3YGS C;  2DO9 A;  2N80 A;  3CL3 A;  1A1Z A;  3KAT A;  3EZQ A;  1DGN A;  2KN6 A;  4RHW A;  1E41 A;  2M5V A;  2BBR A;  1D2Z B;  3YGS P;  3J6J A;  3MOP K;  4N1K A;  4F44 A;  2F1S A;  4RHW E;  2O71 A;  4NQK A;  4P4H I;  1YGO A;  4LWD A;  2LWE A;  4IZA B;  4A2Q A;  2DBH A;  4UZ0 A;  1Z6T A;  2MN4 A;  4O7Q A;  2OF5 A;  1DDF A;  3LQR A;  4I16 A;  2MB9 A;  2A9I A;  2NZ7 A;  2L9M A;  4A2W A;  1PN5 A;  1WH4 A;  4EWI A;  2G7R A;  1N3K A;  1UCP A;  2LWD A;  2HM2 Q;  2L6A A;  2VGQ A;  4M9Z A;  2GF5 A;  3T6P A;  1FAD A;  2YGS A;  2N00 A;  2DBD A;  2OF5 H;  2A5Y B;  4E9M A;  2N97 A;  1D2Z A;  2MPC A;  1A1W A;  2DBF A;  4N1L A;  4JQW A;  4JUP A;  2LS7 A;  4N1J A;  4P4H A;  1ICH A;  4M9S A;  4D8O A;  4O9F A;  2YU0 A;  4IZ7 B;  2IB1 A;  2N1F A;  2YVI A;  1E3Y A;  3LQQ A;  2NSN A;  2NAQ A;  2BBZ A;  2MS8 A;  4M9X A;  2N83 A;  2DBG A;  1NGR A;  3CRD A;  3EZQ B;  2P1H A;  4FH0 A;  4IZ5 E;  4O9L A;  3MOP G;  4DWN A;  1WXP A;  3MOP A;  4O6X A;  2D96 A;  2B1W A;  2MS7 A;  1C15 A;  1WMG A;  2MJM A;  3QF2 A;  2YQF A;  4F42 A; 
#chains in the Genus database with same CATH homology
 4QOB A;  2KM6 A;  3J63 A;  4ZBW A;  2N7Z A;  2XV9 A;  1CWW A;  1CY5 A;  3YGS C;  2DO9 A;  2N80 A;  3CL3 A;  1A1Z A;  3KAT A;  3EZQ A;  1DGN A;  2KN6 A;  4RHW A;  1E41 A;  2M5V A;  2BBR A;  1D2Z B;  3YGS P;  3J6J A;  3MOP K;  4N1K A;  4F44 A;  2F1S A;  4RHW E;  2O71 A;  4NQK A;  4P4H I;  1YGO A;  4LWD A;  2LWE A;  4IZA B;  4A2Q A;  2DBH A;  4UZ0 A;  1Z6T A;  2MN4 A;  4O7Q A;  2OF5 A;  1DDF A;  3LQR A;  4I16 A;  2MB9 A;  2A9I A;  2NZ7 A;  2L9M A;  4A2W A;  1PN5 A;  1WH4 A;  4EWI A;  2G7R A;  1N3K A;  1UCP A;  2LWD A;  2HM2 Q;  2L6A A;  2VGQ A;  4M9Z A;  2GF5 A;  3T6P A;  1FAD A;  2YGS A;  2N00 A;  2DBD A;  2OF5 H;  2A5Y B;  4E9M A;  2N97 A;  1D2Z A;  2MPC A;  1A1W A;  2DBF A;  4N1L A;  4JQW A;  4JUP A;  2LS7 A;  4N1J A;  4P4H A;  1ICH A;  4M9S A;  4D8O A;  4O9F A;  2YU0 A;  4IZ7 B;  2IB1 A;  2N1F A;  2YVI A;  1E3Y A;  3LQQ A;  2NSN A;  2NAQ A;  2BBZ A;  2MS8 A;  4M9X A;  2N83 A;  2DBG A;  1NGR A;  3CRD A;  3EZQ B;  2P1H A;  4FH0 A;  4IZ5 E;  4O9L A;  3MOP G;  4DWN A;  1WXP A;  3MOP A;  4O6X A;  2D96 A;  2B1W A;  2MS7 A;  1C15 A;  1WMG A;  2MJM A;  3QF2 A;  2YQF A;  4F42 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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