4RR2A

Crystal structure of human primase
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
415
structure length
389
Chain Sequence
METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the human primase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA primase small subunit
total genus 131
structure length 389
sequence length 415
chains with identical sequence C
ec nomenclature ec 2.7.7.-:
pdb deposition date 2014-11-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4rr2A00
2FAQA 4LILA 4MM2A 4RR2A 4BPWA 4LIMA 2FARA 4BPUA 4MHQA 1ZT2A 4LIKA 4BPXA 5EXRA 2FAOA
chains in the Genus database with same CATH superfamily
2FAQA 4LILA 1G71A 4MM2A 1V34A 4RR2A 4BPWA 4LIMA 2FARA 4BPUA 4MHQA 1ZT2A 4LIKA 4BPXA 5EXRA 2ATZA 1V33A 2FAOA
chains in the Genus database with same CATH topology
2FAQA 4LILA 1G71A 4MM2A 1V34A 4RR2A 4BPWA 4LIMA 2FARA 4BPUA 4MHQA 1ZT2A 4LIKA 4BPXA 5EXRA 1V33A 2FAOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FAQ A;  4LIL A;  4MM2 A;  4RR2 A;  4BPW A;  4LIM A;  2FAR A;  4BPU A;  4MHQ A;  1ZT2 A;  4LIK A;  4BPX A;  5EXR A;  2FAO A; 
#chains in the Genus database with same CATH topology
 2FAQ A;  4LIL A;  1G71 A;  4MM2 A;  1V34 A;  4RR2 A;  4BPW A;  4LIM A;  2FAR A;  4BPU A;  4MHQ A;  1ZT2 A;  4LIK A;  4BPX A;  5EXR A;  2ATZ A;  1V33 A;  2FAO A; 
#chains in the Genus database with same CATH homology
 2FAQ A;  4LIL A;  1G71 A;  4MM2 A;  1V34 A;  4RR2 A;  4BPW A;  4LIM A;  2FAR A;  4BPU A;  4MHQ A;  1ZT2 A;  4LIK A;  4BPX A;  5EXR A;  1V33 A;  2FAO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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