4S10C

Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
101
structure length
101
Chain Sequence
VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERDGDARVHVSEEGTEPEAMLQVLGPKPALPAGTED
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model.
pubmed doi rcsb
source organism Lama glama
molecule tags Metal binding protein/immune system
molecule keywords GELSOLIN NANOBODY
total genus 29
structure length 101
sequence length 101
chains with identical sequence D
ec nomenclature
pdb deposition date 2015-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 4s10C00
3TU5B 5KYXA 5KYWA 3CJBG 5KYUB 1PCXA 1QPVA 1T44G 3EG9B 5HVKB 2NUPA 3A5NS 1CNUA 1Q8GA 1D0NA 1YAGG 1MDUA 3EFOB 3EH2A 1VFQA 5FAEA 1WNJA 1F7SA 4KEEA 1C0GS 3FFKA 2KVKA 1NMDG 1P8XA 4PKIG 3CI5G 1AK7A 2MP4A 2VIKA 1WM4A 1X67A 1ESVS 4CBXG 2FH3A 1P8ZG 1TMWA 2NUTB 5IVUA 2LJ8A 2MOTA 2W0IA 2NUPB 2XFAA 2FGHA 1NLVG 1WFSA 2FH1A 4PKHB 2FF3A 1M2OA 1M4JA 1J72A 1T3YA 3CJCG 3A5MS 5HVKD 5A1MA 1PD0A 1EQYS 3EGDA 1VKKA 2QTVA 2FH2A 1SVYA 1AK6A 5KYWB 1YVNG 1NM1G 1CFYA 4BEX1 3Q2BA 1NPHA 4CBUG 4LIZA 1D4XG 1RGIG 4S10C 1SVRA 3A5OS 2HD7A 3FFNA 2VILA 2LXXA 1TVJA 3DAWB 5DD2A 1HQZ1 3EGXB 3EGXA 2NUTA 1C0FS 2L72A 2LLFA 4JD2H 1T2LA 1PD1A 1AHQA 2VACA 3EFOA 2MV2A 1M2VB 1M2VA 1H1VG 1KCQA 1COFA 3FG6A 3EH1A 4KEFA 5KYUA 1T3XA 5KYYB 5KYNA 5KYXB 3CIPG 1DEJS 4PKGG 3L50A 2D8BA 4KEDA 2FF6G 2XF1A 5KYYA 3FG7A 1Q8XA 3A5LS 4Z94G 2FH4A 5L6WC 3EGDB 1V6FA 4CBWG 3EG9A 2I2QA 5FAFA 1UDMA 1JHWA 1SVQA
chains in the Genus database with same CATH superfamily
3TU5B 5KYXA 5KYWA 3CJBG 5KYUB 1PCXA 1QPVA 1T44G 3EG9B 5HVKB 2NUPA 3A5NS 1CNUA 1Q8GA 1D0NA 1YAGG 1MDUA 3EFOB 3EH2A 1VFQA 5FAEA 1WNJA 1F7SA 4KEEA 1C0GS 3FFKA 2KVKA 1NMDG 1P8XA 4PKIG 3CI5G 1AK7A 2MP4A 2VIKA 1WM4A 1X67A 1ESVS 4CBXG 2FH3A 1P8ZG 1TMWA 2NUTB 5IVUA 2LJ8A 2MOTA 2W0IA 2NUPB 2XFAA 2FGHA 1NLVG 1WFSA 2FH1A 4PKHB 2FF3A 1M2OA 1M4JA 1J72A 1T3YA 3DA7A 3CJCG 3A5MS 5HVKD 5A1MA 1PD0A 1EQYS 3EGDA 1VKKA 2QTVA 2FH2A 1SVYA 1AK6A 5KYWB 1YVNG 1NM1G 1CFYA 4BEX1 3Q2BA 1NPHA 4CBUG 4LIZA 1D4XG 1RGIG 4S10C 1SVRA 3A5OS 2HD7A 3FFNA 2VILA 2LXXA 1TVJA 3DAWB 5DD2A 1HQZ1 3EGXB 3EGXA 2NUTA 1C0FS 2L72A 2LLFA 4JD2H 1T2LA 1PD1A 1AHQA 2VACA 3EFOA 2MV2A 1M2VB 1M2VA 1H1VG 1KCQA 1COFA 3FG6A 3EH1A 4KEFA 5KYUA 1T3XA 5KYYB 5KYNA 5KYXB 3CIPG 1DEJS 4PKGG 3L50A 2D8BA 4KEDA 2FF6G 2XF1A 5KYYA 3FG7A 1Q8XA 3A5LS 4Z94G 2FH4A 5L6WC 3EGDB 1V6FA 4CBWG 3EG9A 2I2QA 5FAFA 1UDMA 1JHWA 1SVQA
chains in the Genus database with same CATH topology
3TU5B 5KYXA 5KYWA 3CJBG 5KYUB 1PCXA 1QPVA 1T44G 3EG9B 5HVKB 2NUPA 3A5NS 1CNUA 1Q8GA 1D0NA 1YAGG 1MDUA 3EFOB 3EH2A 1VFQA 5FAEA 1WNJA 1F7SA 4KEEA 1C0GS 3FFKA 2KVKA 1NMDG 1P8XA 4PKIG 3CI5G 1AK7A 2MP4A 2VIKA 1WM4A 1X67A 1ESVS 4CBXG 2FH3A 1P8ZG 1TMWA 2NUTB 5IVUA 2LJ8A 2MOTA 2W0IA 2NUPB 2XFAA 2FGHA 1NLVG 1WFSA 2FH1A 4PKHB 2FF3A 1M2OA 1M4JA 1J72A 1T3YA 3DA7A 3CJCG 3A5MS 5HVKD 5A1MA 1PD0A 1EQYS 3EGDA 1VKKA 2QTVA 2FH2A 1SVYA 1AK6A 5KYWB 1YVNG 1NM1G 1CFYA 4BEX1 3Q2BA 1NPHA 4CBUG 4LIZA 1D4XG 1RGIG 4S10C 1SVRA 3A5OS 2HD7A 3FFNA 2VILA 2LXXA 1TVJA 3DAWB 5DD2A 1HQZ1 3EGXB 3EGXA 2NUTA 1C0FS 2L72A 2LLFA 4JD2H 1T2LA 1PD1A 1AHQA 2VACA 3EFOA 2MV2A 1M2VB 1M2VA 1H1VG 1KCQA 1COFA 3FG6A 3EH1A 4KEFA 5KYUA 1T3XA 5KYYB 5KYNA 5KYXB 3CIPG 1DEJS 4PKGG 3L50A 2D8BA 4KEDA 2FF6G 2XF1A 5KYYA 3FG7A 1Q8XA 3A5LS 4Z94G 2FH4A 5L6WC 3EGDB 1V6FA 4CBWG 3EG9A 2I2QA 5FAFA 1UDMA 1JHWA 1SVQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TU5 B;  5KYX A;  5KYW A;  3CJB G;  5KYU B;  1PCX A;  1QPV A;  1T44 G;  3EG9 B;  5HVK B;  2NUP A;  3A5N S;  1CNU A;  1Q8G A;  1D0N A;  1YAG G;  1MDU A;  3EFO B;  3EH2 A;  1VFQ A;  5FAE A;  1WNJ A;  1F7S A;  4KEE A;  1C0G S;  3FFK A;  2KVK A;  1NMD G;  1P8X A;  4PKI G;  3CI5 G;  1AK7 A;  2MP4 A;  2VIK A;  1WM4 A;  1X67 A;  1ESV S;  4CBX G;  2FH3 A;  1P8Z G;  1TMW A;  2NUT B;  5IVU A;  2LJ8 A;  2MOT A;  2W0I A;  2NUP B;  2XFA A;  2FGH A;  1NLV G;  1WFS A;  2FH1 A;  4PKH B;  2FF3 A;  1M2O A;  1M4J A;  1J72 A;  1T3Y A;  3CJC G;  3A5M S;  5HVK D;  5A1M A;  1PD0 A;  1EQY S;  3EGD A;  1VKK A;  2QTV A;  2FH2 A;  1SVY A;  1AK6 A;  5KYW B;  1YVN G;  1NM1 G;  1CFY A;  4BEX 1;  3Q2B A;  1NPH A;  4CBU G;  4LIZ A;  1D4X G;  1RGI G;  4S10 C;  1SVR A;  3A5O S;  2HD7 A;  3FFN A;  2VIL A;  2LXX A;  1TVJ A;  3DAW B;  5DD2 A;  1HQZ 1;  3EGX B;  3EGX A;  2NUT A;  1C0F S;  2L72 A;  2LLF A;  4JD2 H;  1T2L A;  1PD1 A;  1AHQ A;  2VAC A;  3EFO A;  2MV2 A;  1M2V B;  1M2V A;  1H1V G;  1KCQ A;  1COF A;  3FG6 A;  3EH1 A;  4KEF A;  5KYU A;  1T3X A;  5KYY B;  5KYN A;  5KYX B;  3CIP G;  1DEJ S;  4PKG G;  3L50 A;  2D8B A;  4KED A;  2FF6 G;  2XF1 A;  5KYY A;  3FG7 A;  1Q8X A;  3A5L S;  4Z94 G;  2FH4 A;  5L6W C;  3EGD B;  1V6F A;  4CBW G;  3EG9 A;  2I2Q A;  5FAF A;  1UDM A;  1JHW A;  1SVQ A; 
#chains in the Genus database with same CATH topology
 3TU5 B;  5KYX A;  5KYW A;  3CJB G;  5KYU B;  1PCX A;  1QPV A;  1T44 G;  3EG9 B;  5HVK B;  2NUP A;  3A5N S;  1CNU A;  1Q8G A;  1D0N A;  1YAG G;  1MDU A;  3EFO B;  3EH2 A;  1VFQ A;  5FAE A;  1WNJ A;  1F7S A;  4KEE A;  1C0G S;  3FFK A;  2KVK A;  1NMD G;  1P8X A;  4PKI G;  3CI5 G;  1AK7 A;  2MP4 A;  2VIK A;  1WM4 A;  1X67 A;  1ESV S;  4CBX G;  2FH3 A;  1P8Z G;  1TMW A;  2NUT B;  5IVU A;  2LJ8 A;  2MOT A;  2W0I A;  2NUP B;  2XFA A;  2FGH A;  1NLV G;  1WFS A;  2FH1 A;  4PKH B;  2FF3 A;  1M2O A;  1M4J A;  1J72 A;  1T3Y A;  3DA7 A;  3CJC G;  3A5M S;  5HVK D;  5A1M A;  1PD0 A;  1EQY S;  3EGD A;  1VKK A;  2QTV A;  2FH2 A;  1SVY A;  1AK6 A;  5KYW B;  1YVN G;  1NM1 G;  1CFY A;  4BEX 1;  3Q2B A;  1NPH A;  4CBU G;  4LIZ A;  1D4X G;  1RGI G;  4S10 C;  1SVR A;  3A5O S;  2HD7 A;  3FFN A;  2VIL A;  2LXX A;  1TVJ A;  3DAW B;  5DD2 A;  1HQZ 1;  3EGX B;  3EGX A;  2NUT A;  1C0F S;  2L72 A;  2LLF A;  4JD2 H;  1T2L A;  1PD1 A;  1AHQ A;  2VAC A;  3EFO A;  2MV2 A;  1M2V B;  1M2V A;  1H1V G;  1KCQ A;  1COF A;  3FG6 A;  3EH1 A;  4KEF A;  5KYU A;  1T3X A;  5KYY B;  5KYN A;  5KYX B;  3CIP G;  1DEJ S;  4PKG G;  3L50 A;  2D8B A;  4KED A;  2FF6 G;  2XF1 A;  5KYY A;  3FG7 A;  1Q8X A;  3A5L S;  4Z94 G;  2FH4 A;  5L6W C;  3EGD B;  1V6F A;  4CBW G;  3EG9 A;  2I2Q A;  5FAF A;  1UDM A;  1JHW A;  1SVQ A; 
#chains in the Genus database with same CATH homology
 3TU5 B;  5KYX A;  5KYW A;  3CJB G;  5KYU B;  1PCX A;  1QPV A;  1T44 G;  3EG9 B;  5HVK B;  2NUP A;  3A5N S;  1CNU A;  1Q8G A;  1D0N A;  1YAG G;  1MDU A;  3EFO B;  3EH2 A;  1VFQ A;  5FAE A;  1WNJ A;  1F7S A;  4KEE A;  1C0G S;  3FFK A;  2KVK A;  1NMD G;  1P8X A;  4PKI G;  3CI5 G;  1AK7 A;  2MP4 A;  2VIK A;  1WM4 A;  1X67 A;  1ESV S;  4CBX G;  2FH3 A;  1P8Z G;  1TMW A;  2NUT B;  5IVU A;  2LJ8 A;  2MOT A;  2W0I A;  2NUP B;  2XFA A;  2FGH A;  1NLV G;  1WFS A;  2FH1 A;  4PKH B;  2FF3 A;  1M2O A;  1M4J A;  1J72 A;  1T3Y A;  3DA7 A;  3CJC G;  3A5M S;  5HVK D;  5A1M A;  1PD0 A;  1EQY S;  3EGD A;  1VKK A;  2QTV A;  2FH2 A;  1SVY A;  1AK6 A;  5KYW B;  1YVN G;  1NM1 G;  1CFY A;  4BEX 1;  3Q2B A;  1NPH A;  4CBU G;  4LIZ A;  1D4X G;  1RGI G;  4S10 C;  1SVR A;  3A5O S;  2HD7 A;  3FFN A;  2VIL A;  2LXX A;  1TVJ A;  3DAW B;  5DD2 A;  1HQZ 1;  3EGX B;  3EGX A;  2NUT A;  1C0F S;  2L72 A;  2LLF A;  4JD2 H;  1T2L A;  1PD1 A;  1AHQ A;  2VAC A;  3EFO A;  2MV2 A;  1M2V B;  1M2V A;  1H1V G;  1KCQ A;  1COF A;  3FG6 A;  3EH1 A;  4KEF A;  5KYU A;  1T3X A;  5KYY B;  5KYN A;  5KYX B;  3CIP G;  1DEJ S;  4PKG G;  3L50 A;  2D8B A;  4KED A;  2FF6 G;  2XF1 A;  5KYY A;  3FG7 A;  1Q8X A;  3A5L S;  4Z94 G;  2FH4 A;  5L6W C;  3EGD B;  1V6F A;  4CBW G;  3EG9 A;  2I2Q A;  5FAF A;  1UDM A;  1JHW A;  1SVQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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