4S10C

Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis
Total Genus 29
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
101
structure length
101
Chain Sequence
VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERDGDARVHVSEEGTEPEAMLQVLGPKPALPAGTED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Metal binding protein/immune system
molecule keywords GELSOLIN NANOBODY
publication title An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model.
pubmed doi rcsb
source organism Lama glama
total genus 29
structure length 101
sequence length 101
chains with identical sequence D
ec nomenclature
pdb deposition date 2015-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 4s10C00
4KEFA 1AHQA 3EH1A 1Q8XA 1PD1A 3EFOA 1Q8GA 2NUPB 1V6FA 2XFAA 1T3XA 4Z94G 1C0FS 3CJBG 2XF1A 1T2LA 1YAGG 5KYWA 1H1VG 3FFNA 2I2QA 3DAWB 2FF3A 4LIZA 1AK6A 1TMWA 1T3YA 1CNUA 1P8ZG 1NM1G 5DD2A 2NUPA 1NLVG 1CFYA 5KYYB 2MP4A 3A5NS 3L50A 1SVRA 2NUTB 1PD0A 4PKGG 1SVQA 2FGHA 1D0NA 1EQYS 3EGXB 1P8XA 4S10C 4CBXG 4KEEA 3FFKA 1F7SA 3CI5G 1WNJA 5IVUA 1WM4A 2FF6G 1WFSA 3Q2BA 5FAEA 1AK7A 1DEJS 5KYYA 1UDMA 3FG6A 1D4XG 2L72A 1VKKA 4CBUG 5KYXB 3CJCG 5HVKB 5A1MA 2NUTA 4CBWG 3EG9B 3EGDB 2MOTA 1SVYA 2LJ8A 1JHWA 2VACA 3EGXA 5KYUB 4PKHB 5KYNA 2MV2A 1M2VB 1RGIG 2FH4A 1YVNG 3A5LS 3EH2A 5KYXA 1C0GS 1HQZ1 1VFQA 2FH2A 3EG9A 3EGDA 3A5MS 5HVKD 1J72A 2FH3A 5KYUA 1ESVS 2HD7A 2QTVA 3TU5B 1MDUA 2VIKA 1M2OA 4PKIG 2LXXA 3EFOB 4BEX1 1M2VA 2VILA 4KEDA 2KVKA 1NPHA 3CIPG 3FG7A 1PCXA 2FH1A 1COFA 3A5OS 2D8BA 2LLFA 2W0IA 1M4JA 1X67A 1KCQA 5KYWB 1TVJA 1NMDG 1T44G 4JD2H 1QPVA 5FAFA 5L6WC
chains in the Genus database with same CATH superfamily
4KEFA 1AHQA 3EH1A 1Q8XA 1PD1A 3EFOA 1Q8GA 2NUPB 1V6FA 2XFAA 1T3XA 3DA7A 4Z94G 1C0FS 3CJBG 2XF1A 1T2LA 1YAGG 5KYWA 1H1VG 3FFNA 2I2QA 3DAWB 2FF3A 4LIZA 1AK6A 1TMWA 1T3YA 1CNUA 1P8ZG 1NM1G 5DD2A 2NUPA 1NLVG 1CFYA 5KYYB 2MP4A 3A5NS 3L50A 1SVRA 2NUTB 1PD0A 4PKGG 1SVQA 2FGHA 1D0NA 1EQYS 3EGXB 1P8XA 4S10C 4CBXG 4KEEA 3FFKA 1F7SA 3CI5G 1WNJA 5IVUA 1WM4A 2FF6G 1WFSA 3Q2BA 5FAEA 1AK7A 1DEJS 5KYYA 1UDMA 3FG6A 1D4XG 2L72A 1VKKA 4CBUG 5KYXB 3CJCG 5HVKB 5A1MA 2NUTA 4CBWG 3EG9B 3EGDB 2MOTA 1SVYA 2LJ8A 1JHWA 2VACA 3EGXA 5KYUB 4PKHB 5KYNA 2MV2A 1M2VB 1RGIG 2FH4A 1YVNG 3A5LS 3EH2A 5KYXA 1C0GS 1HQZ1 1VFQA 2FH2A 3EG9A 3EGDA 3A5MS 5HVKD 1J72A 2FH3A 5KYUA 1ESVS 2HD7A 2QTVA 3TU5B 1MDUA 2VIKA 1M2OA 4PKIG 2LXXA 3EFOB 4BEX1 1M2VA 2VILA 4KEDA 2KVKA 1NPHA 3CIPG 3FG7A 1PCXA 2FH1A 1COFA 3A5OS 2D8BA 2LLFA 2W0IA 1M4JA 1X67A 1KCQA 5KYWB 1TVJA 1NMDG 1T44G 4JD2H 1QPVA 5FAFA 5L6WC
chains in the Genus database with same CATH topology
4KEFA 1AHQA 3EH1A 1Q8XA 1PD1A 3EFOA 1Q8GA 2NUPB 1V6FA 2XFAA 1T3XA 3DA7A 4Z94G 1C0FS 3CJBG 2XF1A 1T2LA 1YAGG 5KYWA 1H1VG 3FFNA 2I2QA 3DAWB 2FF3A 4LIZA 1AK6A 1TMWA 1T3YA 1CNUA 1P8ZG 1NM1G 5DD2A 2NUPA 1NLVG 1CFYA 5KYYB 2MP4A 3A5NS 3L50A 1SVRA 2NUTB 1PD0A 4PKGG 1SVQA 2FGHA 1D0NA 1EQYS 3EGXB 1P8XA 4S10C 4CBXG 4KEEA 3FFKA 1F7SA 3CI5G 1WNJA 5IVUA 1WM4A 2FF6G 1WFSA 3Q2BA 5FAEA 1AK7A 1DEJS 5KYYA 1UDMA 3FG6A 1D4XG 2L72A 1VKKA 4CBUG 5KYXB 3CJCG 5HVKB 5A1MA 2NUTA 4CBWG 3EG9B 3EGDB 2MOTA 1SVYA 2LJ8A 1JHWA 2VACA 3EGXA 5KYUB 4PKHB 5KYNA 2MV2A 1M2VB 1RGIG 2FH4A 1YVNG 3A5LS 3EH2A 5KYXA 1C0GS 1HQZ1 1VFQA 2FH2A 3EG9A 3EGDA 3A5MS 5HVKD 1J72A 2FH3A 5KYUA 1ESVS 2HD7A 2QTVA 3TU5B 1MDUA 2VIKA 1M2OA 4PKIG 2LXXA 3EFOB 4BEX1 1M2VA 2VILA 4KEDA 2KVKA 1NPHA 3CIPG 3FG7A 1PCXA 2FH1A 1COFA 3A5OS 2D8BA 2LLFA 2W0IA 1M4JA 1X67A 1KCQA 5KYWB 1TVJA 1NMDG 1T44G 4JD2H 1QPVA 5FAFA 5L6WC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KEF A;  1AHQ A;  3EH1 A;  1Q8X A;  1PD1 A;  3EFO A;  1Q8G A;  2NUP B;  1V6F A;  2XFA A;  1T3X A;  4Z94 G;  1C0F S;  3CJB G;  2XF1 A;  1T2L A;  1YAG G;  5KYW A;  1H1V G;  3FFN A;  2I2Q A;  3DAW B;  2FF3 A;  4LIZ A;  1AK6 A;  1TMW A;  1T3Y A;  1CNU A;  1P8Z G;  1NM1 G;  5DD2 A;  2NUP A;  1NLV G;  1CFY A;  5KYY B;  2MP4 A;  3A5N S;  3L50 A;  1SVR A;  2NUT B;  1PD0 A;  4PKG G;  1SVQ A;  2FGH A;  1D0N A;  1EQY S;  3EGX B;  1P8X A;  4S10 C;  4CBX G;  4KEE A;  3FFK A;  1F7S A;  3CI5 G;  1WNJ A;  5IVU A;  1WM4 A;  2FF6 G;  1WFS A;  3Q2B A;  5FAE A;  1AK7 A;  1DEJ S;  5KYY A;  1UDM A;  3FG6 A;  1D4X G;  2L72 A;  1VKK A;  4CBU G;  5KYX B;  3CJC G;  5HVK B;  5A1M A;  2NUT A;  4CBW G;  3EG9 B;  3EGD B;  2MOT A;  1SVY A;  2LJ8 A;  1JHW A;  2VAC A;  3EGX A;  5KYU B;  4PKH B;  5KYN A;  2MV2 A;  1M2V B;  1RGI G;  2FH4 A;  1YVN G;  3A5L S;  3EH2 A;  5KYX A;  1C0G S;  1HQZ 1;  1VFQ A;  2FH2 A;  3EG9 A;  3EGD A;  3A5M S;  5HVK D;  1J72 A;  2FH3 A;  5KYU A;  1ESV S;  2HD7 A;  2QTV A;  3TU5 B;  1MDU A;  2VIK A;  1M2O A;  4PKI G;  2LXX A;  3EFO B;  4BEX 1;  1M2V A;  2VIL A;  4KED A;  2KVK A;  1NPH A;  3CIP G;  3FG7 A;  1PCX A;  2FH1 A;  1COF A;  3A5O S;  2D8B A;  2LLF A;  2W0I A;  1M4J A;  1X67 A;  1KCQ A;  5KYW B;  1TVJ A;  1NMD G;  1T44 G;  4JD2 H;  1QPV A;  5FAF A;  5L6W C; 
#chains in the Genus database with same CATH topology
 4KEF A;  1AHQ A;  3EH1 A;  1Q8X A;  1PD1 A;  3EFO A;  1Q8G A;  2NUP B;  1V6F A;  2XFA A;  1T3X A;  3DA7 A;  4Z94 G;  1C0F S;  3CJB G;  2XF1 A;  1T2L A;  1YAG G;  5KYW A;  1H1V G;  3FFN A;  2I2Q A;  3DAW B;  2FF3 A;  4LIZ A;  1AK6 A;  1TMW A;  1T3Y A;  1CNU A;  1P8Z G;  1NM1 G;  5DD2 A;  2NUP A;  1NLV G;  1CFY A;  5KYY B;  2MP4 A;  3A5N S;  3L50 A;  1SVR A;  2NUT B;  1PD0 A;  4PKG G;  1SVQ A;  2FGH A;  1D0N A;  1EQY S;  3EGX B;  1P8X A;  4S10 C;  4CBX G;  4KEE A;  3FFK A;  1F7S A;  3CI5 G;  1WNJ A;  5IVU A;  1WM4 A;  2FF6 G;  1WFS A;  3Q2B A;  5FAE A;  1AK7 A;  1DEJ S;  5KYY A;  1UDM A;  3FG6 A;  1D4X G;  2L72 A;  1VKK A;  4CBU G;  5KYX B;  3CJC G;  5HVK B;  5A1M A;  2NUT A;  4CBW G;  3EG9 B;  3EGD B;  2MOT A;  1SVY A;  2LJ8 A;  1JHW A;  2VAC A;  3EGX A;  5KYU B;  4PKH B;  5KYN A;  2MV2 A;  1M2V B;  1RGI G;  2FH4 A;  1YVN G;  3A5L S;  3EH2 A;  5KYX A;  1C0G S;  1HQZ 1;  1VFQ A;  2FH2 A;  3EG9 A;  3EGD A;  3A5M S;  5HVK D;  1J72 A;  2FH3 A;  5KYU A;  1ESV S;  2HD7 A;  2QTV A;  3TU5 B;  1MDU A;  2VIK A;  1M2O A;  4PKI G;  2LXX A;  3EFO B;  4BEX 1;  1M2V A;  2VIL A;  4KED A;  2KVK A;  1NPH A;  3CIP G;  3FG7 A;  1PCX A;  2FH1 A;  1COF A;  3A5O S;  2D8B A;  2LLF A;  2W0I A;  1M4J A;  1X67 A;  1KCQ A;  5KYW B;  1TVJ A;  1NMD G;  1T44 G;  4JD2 H;  1QPV A;  5FAF A;  5L6W C; 
#chains in the Genus database with same CATH homology
 4KEF A;  1AHQ A;  3EH1 A;  1Q8X A;  1PD1 A;  3EFO A;  1Q8G A;  2NUP B;  1V6F A;  2XFA A;  1T3X A;  3DA7 A;  4Z94 G;  1C0F S;  3CJB G;  2XF1 A;  1T2L A;  1YAG G;  5KYW A;  1H1V G;  3FFN A;  2I2Q A;  3DAW B;  2FF3 A;  4LIZ A;  1AK6 A;  1TMW A;  1T3Y A;  1CNU A;  1P8Z G;  1NM1 G;  5DD2 A;  2NUP A;  1NLV G;  1CFY A;  5KYY B;  2MP4 A;  3A5N S;  3L50 A;  1SVR A;  2NUT B;  1PD0 A;  4PKG G;  1SVQ A;  2FGH A;  1D0N A;  1EQY S;  3EGX B;  1P8X A;  4S10 C;  4CBX G;  4KEE A;  3FFK A;  1F7S A;  3CI5 G;  1WNJ A;  5IVU A;  1WM4 A;  2FF6 G;  1WFS A;  3Q2B A;  5FAE A;  1AK7 A;  1DEJ S;  5KYY A;  1UDM A;  3FG6 A;  1D4X G;  2L72 A;  1VKK A;  4CBU G;  5KYX B;  3CJC G;  5HVK B;  5A1M A;  2NUT A;  4CBW G;  3EG9 B;  3EGD B;  2MOT A;  1SVY A;  2LJ8 A;  1JHW A;  2VAC A;  3EGX A;  5KYU B;  4PKH B;  5KYN A;  2MV2 A;  1M2V B;  1RGI G;  2FH4 A;  1YVN G;  3A5L S;  3EH2 A;  5KYX A;  1C0G S;  1HQZ 1;  1VFQ A;  2FH2 A;  3EG9 A;  3EGD A;  3A5M S;  5HVK D;  1J72 A;  2FH3 A;  5KYU A;  1ESV S;  2HD7 A;  2QTV A;  3TU5 B;  1MDU A;  2VIK A;  1M2O A;  4PKI G;  2LXX A;  3EFO B;  4BEX 1;  1M2V A;  2VIL A;  4KED A;  2KVK A;  1NPH A;  3CIP G;  3FG7 A;  1PCX A;  2FH1 A;  1COF A;  3A5O S;  2D8B A;  2LLF A;  2W0I A;  1M4J A;  1X67 A;  1KCQ A;  5KYW B;  1TVJ A;  1NMD G;  1T44 G;  4JD2 H;  1QPV A;  5FAF A;  5L6W C; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...