4TPHA

Selectivity mechanism of a bacterial homologue of the human drug peptide transporters pept1 and pept2
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
485
structure length
453
Chain Sequence
VSKTHSFMTVSLIELWERFGYYGMQALIVYFMVQRLGFDDSRANLVWSACAALIYVSPAIGGWVGDKILGTKRTMLLGAGILSVGYALMTVPTENTWFMFSALGVIVVGNGLFKPNAGNLVRKIYESKIDSAFTIYYMAVNVGSTFSMLLTPWIKDYVNAQYGNEFGWHAAFAVCCVGILVGLGNYALMHKSLANYGSEPDTRPVNKKSLAIVLALAALSVVASAIILEYEDVARVFVYAAGVAVLGIFFHLERAGLIAALILTVQTVFFFIFYQQMSTSLALFALRNVDWDFQVFGTHLWTWSPAQFQALNPIWIMVLSPVLAWIAAKFALGFAVVAIGFFIYGFAGQFAVNGKTSSWVMIWGYASYSLGELLVSGLGLAMIARMMGAYFVASGISQYLGGVVANFASVPQDLVDPLQTLPVYTNLFNKLGVAAVVCTIIALAVLPLMRRLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
pubmed doi rcsb
molecule keywords Proton:oligopeptide symporter POT family
molecule tags Membrane protein
source organism Shewanella oneidensis
total genus 187
structure length 453
sequence length 485
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-06-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00854 PTR2 POT family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4tphA00
1PW4A 1PV6A 3O7PA 4QIQA 3WDOA 4ZW9A 4YBQA 1PV7A 4IU8A 5EQIA 4D2DA 2Y5YA 4JREA 5EQGA 4IKWA 4IKVA 4Q65A 5D58A 4TPHA 5D59A 4IKZA 4PYPA 5GXBA 4GBYA 4JA3A 5A2NA 4LEPA 2CFQA 4YB9D 4U4TA 4LDSA 2V8NA 4ZWCA 4ZWBA 4D2BA 4OAAA 4ZYRA 5C65A 4IKXA 4APSA 4GBZA 4D2CA 4JR9A 5A2OA 2XUTA 2CFPA 4OH3A 5EQHA 5D6KA 4IU9A 4XNIA 4TPJA 4U4VA 4W6VA 4XNJA 4U4WA 4GC0A 4UVMA 4J05A 4TPGA 4IKYA 3O7QA
chains in the Genus database with same CATH superfamily
2INTA 3QT2C 3DGCL 4YPGC 4Q65A 1M4CA 3PIWA 4DKCA 3NCFA 5FUCA 1CNT1 4OH3A 5D22A 4GC0A 1M47A 2KZ1A 1PW6A 1PW4A 3QB1A 4QIQA 1ITLA 3PO2D 4ZF7A 2L3OA 3LB6B 1EERA 3IRHA 4IKZA 5FLMD 4O9HA 2CFQA 4ZWCA 4ZWBA 4NN7A 4GBZA 2HYMB 4A3CD 2R7ZD 2O27A 2B8XA 5L6YC 4ZS7A 4A3ED 5C4XD 4A3DD 1BGCA 4YBQA 1Y6NL 4TPHA 2GMFA 5A2NA 4O6KA 4A3KD 1BCNA 3HOZD 5A2OA 1HGUA 3HOXD 4U4VA 3DLQI 1EXZA 3UF2A 4TPGA 3AYHA 3BESL 3NCBA 1BUYA 5C3ED 5KNHI 4RS1A 1PV7A 1FG9A 1RCBA 3B5KA 3HMXB 2B91A 4BBSD 3I4ND 3UEZE 2LMSA 4D2BA 4IKXA 1V7MV 4A3LD 4NN5A 3HHRA 1Y1VD 3HOVD 1AU1A 1IL6A 3QAZA 3G6DA 3HOYD 1F6FA 5EQGA 4MHLA 2Q7NB 4GS7A 4YQXA 5IP7D 1M4RA 3SE3B 4NEMA 3S9DA 1GNCA 4U4WA 2D48A 2Z3QA 1Y1WD 1WU3I 4WRLB 1ITMA 4ZW9A 5IYDD 3EW3A 1RW5A 3EJJA 1CD9A 1PY2A 3BPLA 2Q98A 4I77Z 2R93D 1BGEA 4BBRD 4YDYI 2C35A 1VLKA 1ETEA 3O7PA 4PS4A 1HWGA 1D9GA 5TS9A 1IRLA 1YKBA 3WCYI 2Q14A 1CYLA 4PYPA 4GBYA 3BPNA 3TGXB 5IP9D 2B63D 5C44D 5C65A 3HOWD 3FKID 4XNIA 2JA5D 2L3YA 3UF5A 1BP3A 1B5LA 1KF9A 3WDOA 1HZIA 1NBPA 5EQIA 2Y5YA 5D58A 4A3FD 1D9CA 5IYBD 2B8UA 2H24A 5D28B 4OAAA 3L5WI 4BXXD 3OG6A 1ITFA 1EKUA 3PIVA 4Z5RD 2D9QA 1Z92A 2ILKA 4IKWA 3I4MD 1V7NV 1I1RB 4FA8E 1Y6ML 1M48A 2B90A 3D48P 1AXIA 5D6KA 4IU9A 5C7XA 3DI2A 1LK3A 4IU8A 1M4BA 4IKVA 5D59A 1A7MA 3N06A 4NI9A 4LDSA 2ERJD 3QB7A 1JLIA 1ITIA 1RFBA 2LAGA 1PGRA 3OQ3A 4W6VA 3G9VB 1IARA 1CSGA 4LRLA 1PV6A 3DUHC 2Z3RA 4DKDA 1CN4C 3HOUD 1WCMD 3PO3D 1J7VL 4JA3A 1Y6KL 4APSA 4D2CA 4JR9A 2O6IA 4BY7D 4DKEA 4XNJA 4YUEC 4DOHA 5IYCD 2XQBA 1N1FA 4JREA 3L5XA 4NN6A 1M4AA 3H0GD 2JA7D 3LB6A 1Z7CA 1BGDA 4ZYRA 3MZGA 2E9WC 3SE4B 5LQBA 4A3GD 1FYHA 3HHCA 1LKIA 1ILKA 4CNIC 3DI3A 1HWHA 2R92D 3QWRB 3D87A 4EXPA 5GXBA 1GA3A 5D71A 4U4TA 2JA6D 3NCCA 2XUTA 3NPZA 4BY1D 4J05A 4IKYA 4X51A 3O7QA 2CYKA 3H3VE 3NCEA 3N0PA 4A3MD 1Y14A 2B5IA 1LQSL 4D2DA 3INKC 1HUWA 1A22A 2B8YA 1M49A 1HULA 3D85C 4A3JD 5EQHA 1HIJA 1IK0A 4GRWA 3BPOA 2B8ZA 4NI7A 1SCFA 4DKFA 1AX8A 4NEJA 1EMRA 1INRA 4J4LC 2IL6A 1QVNA 4NKQC 5FHXA 1RHGA 4LEPA 4YB9D 2V8NA 1F45B 2CFPA 3OG4A 2O26A 2PSMA 1ALUA 1EVSA 1P9MB 5D72A 3UX9A 4A3BD 1BBNA 5E4EA 1IJZA 1PVHB 2OQPA 5D70A 4EXNA 4A93D 4A3ID 2VUMD 3VA2A 1HIKA 4TPJA 4UVMA 2JA8D 3Q1SI
chains in the Genus database with same CATH topology
1PW4A 1PV6A 3O7PA 4QIQA 3WDOA 4ZW9A 4YBQA 1PV7A 4IU8A 5EQIA 4D2DA 2Y5YA 4JREA 5EQGA 4IKWA 4IKVA 4Q65A 5D58A 4TPHA 5D59A 4IKZA 4PYPA 5GXBA 4GBYA 4JA3A 5A2NA 4LEPA 2CFQA 4YB9D 4U4TA 4LDSA 2V8NA 4ZWCA 4ZWBA 4D2BA 4OAAA 4ZYRA 5C65A 4IKXA 4APSA 4GBZA 4D2CA 4JR9A 5A2OA 2XUTA 2CFPA 4OH3A 5EQHA 5D6KA 4IU9A 4XNIA 4TPJA 4U4VA 4W6VA 4XNJA 4U4WA 4GC0A 4UVMA 4J05A 4TPGA 4IKYA 3O7QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PW4 A;  1PV6 A;  3O7P A;  4QIQ A;  3WDO A;  4ZW9 A;  4YBQ A;  1PV7 A;  4IU8 A;  5EQI A;  4D2D A;  2Y5Y A;  4JRE A;  5EQG A;  4IKW A;  4IKV A;  4Q65 A;  5D58 A;  4TPH A;  5D59 A;  4IKZ A;  4PYP A;  5GXB A;  4GBY A;  4JA3 A;  5A2N A;  4LEP A;  2CFQ A;  4YB9 D;  4U4T A;  4LDS A;  2V8N A;  4ZWC A;  4ZWB A;  4D2B A;  4OAA A;  4ZYR A;  5C65 A;  4IKX A;  4APS A;  4GBZ A;  4D2C A;  4JR9 A;  5A2O A;  2XUT A;  2CFP A;  4OH3 A;  5EQH A;  5D6K A;  4IU9 A;  4XNI A;  4TPJ A;  4U4V A;  4W6V A;  4XNJ A;  4U4W A;  4GC0 A;  4UVM A;  4J05 A;  4TPG A;  4IKY A;  3O7Q A; 
#chains in the Genus database with same CATH topology
 2INT A;  3QT2 C;  3DGC L;  4YPG C;  4Q65 A;  1M4C A;  3PIW A;  4DKC A;  3NCF A;  5FUC A;  1CNT 1;  4OH3 A;  5D22 A;  4GC0 A;  1M47 A;  2KZ1 A;  1PW6 A;  1PW4 A;  3QB1 A;  4QIQ A;  1ITL A;  3PO2 D;  4ZF7 A;  2L3O A;  3LB6 B;  1EER A;  3IRH A;  4IKZ A;  5FLM D;  4O9H A;  2CFQ A;  4ZWC A;  4ZWB A;  4NN7 A;  4GBZ A;  2HYM B;  4A3C D;  2R7Z D;  2O27 A;  2B8X A;  5L6Y C;  4ZS7 A;  4A3E D;  5C4X D;  4A3D D;  1BGC A;  4YBQ A;  1Y6N L;  4TPH A;  2GMF A;  5A2N A;  4O6K A;  4A3K D;  1BCN A;  3HOZ D;  5A2O A;  1HGU A;  3HOX D;  4U4V A;  3DLQ I;  1EXZ A;  3UF2 A;  4TPG A;  3AYH A;  3BES L;  3NCB A;  1BUY A;  5C3E D;  5KNH I;  4RS1 A;  1PV7 A;  1FG9 A;  1RCB A;  3B5K A;  3HMX B;  2B91 A;  4BBS D;  3I4N D;  3UEZ E;  2LMS A;  4D2B A;  4IKX A;  1V7M V;  4A3L D;  4NN5 A;  3HHR A;  1Y1V D;  3HOV D;  1AU1 A;  1IL6 A;  3QAZ A;  3G6D A;  3HOY D;  1F6F A;  5EQG A;  4MHL A;  2Q7N B;  4GS7 A;  4YQX A;  5IP7 D;  1M4R A;  3SE3 B;  4NEM A;  3S9D A;  1GNC A;  4U4W A;  2D48 A;  2Z3Q A;  1Y1W D;  1WU3 I;  4WRL B;  1ITM A;  4ZW9 A;  5IYD D;  3EW3 A;  1RW5 A;  3EJJ A;  1CD9 A;  1PY2 A;  3BPL A;  2Q98 A;  4I77 Z;  2R93 D;  1BGE A;  4BBR D;  4YDY I;  2C35 A;  1VLK A;  1ETE A;  3O7P A;  4PS4 A;  1HWG A;  1D9G A;  5TS9 A;  1IRL A;  1YKB A;  3WCY I;  2Q14 A;  1CYL A;  4PYP A;  4GBY A;  3BPN A;  3TGX B;  5IP9 D;  2B63 D;  5C44 D;  5C65 A;  3HOW D;  3FKI D;  4XNI A;  2JA5 D;  2L3Y A;  3UF5 A;  1BP3 A;  1B5L A;  1KF9 A;  3WDO A;  1HZI A;  1NBP A;  5EQI A;  2Y5Y A;  5D58 A;  4A3F D;  1D9C A;  5IYB D;  2B8U A;  2H24 A;  5D28 B;  4OAA A;  3L5W I;  4BXX D;  3OG6 A;  1ITF A;  1EKU A;  3PIV A;  4Z5R D;  2D9Q A;  1Z92 A;  2ILK A;  4IKW A;  3I4M D;  1V7N V;  1I1R B;  4FA8 E;  1Y6M L;  1M48 A;  2B90 A;  3D48 P;  1AXI A;  5D6K A;  4IU9 A;  5C7X A;  3DI2 A;  1LK3 A;  4IU8 A;  1M4B A;  4IKV A;  5D59 A;  1A7M A;  3N06 A;  4NI9 A;  4LDS A;  2ERJ D;  3QB7 A;  1JLI A;  1ITI A;  1RFB A;  2LAG A;  1PGR A;  3OQ3 A;  4W6V A;  3G9V B;  1IAR A;  1CSG A;  4LRL A;  1PV6 A;  3DUH C;  2Z3R A;  4DKD A;  1CN4 C;  3HOU D;  1WCM D;  3PO3 D;  1J7V L;  4JA3 A;  1Y6K L;  4APS A;  4D2C A;  4JR9 A;  2O6I A;  4BY7 D;  4DKE A;  4XNJ A;  4YUE C;  4DOH A;  5IYC D;  2XQB A;  1N1F A;  4JRE A;  3L5X A;  4NN6 A;  1M4A A;  3H0G D;  2JA7 D;  3LB6 A;  1Z7C A;  1BGD A;  4ZYR A;  3MZG A;  2E9W C;  3SE4 B;  5LQB A;  4A3G D;  1FYH A;  3HHC A;  1LKI A;  1ILK A;  4CNI C;  3DI3 A;  1HWH A;  2R92 D;  3QWR B;  3D87 A;  4EXP A;  5GXB A;  1GA3 A;  5D71 A;  4U4T A;  2JA6 D;  3NCC A;  2XUT A;  3NPZ A;  4BY1 D;  4J05 A;  4IKY A;  4X51 A;  3O7Q A;  2CYK A;  3H3V E;  3NCE A;  3N0P A;  4A3M D;  1Y14 A;  2B5I A;  1LQS L;  4D2D A;  3INK C;  1HUW A;  1A22 A;  2B8Y A;  1M49 A;  1HUL A;  3D85 C;  4A3J D;  5EQH A;  1HIJ A;  1IK0 A;  4GRW A;  3BPO A;  2B8Z A;  4NI7 A;  1SCF A;  4DKF A;  1AX8 A;  4NEJ A;  1EMR A;  1INR A;  4J4L C;  2IL6 A;  1QVN A;  4NKQ C;  5FHX A;  1RHG A;  4LEP A;  4YB9 D;  2V8N A;  1F45 B;  2CFP A;  3OG4 A;  2O26 A;  2PSM A;  1ALU A;  1EVS A;  1P9M B;  5D72 A;  3UX9 A;  4A3B D;  1BBN A;  5E4E A;  1IJZ A;  1PVH B;  2OQP A;  5D70 A;  4EXN A;  4A93 D;  4A3I D;  2VUM D;  3VA2 A;  1HIK A;  4TPJ A;  4UVM A;  2JA8 D;  3Q1S I; 
#chains in the Genus database with same CATH homology
 1PW4 A;  1PV6 A;  3O7P A;  4QIQ A;  3WDO A;  4ZW9 A;  4YBQ A;  1PV7 A;  4IU8 A;  5EQI A;  4D2D A;  2Y5Y A;  4JRE A;  5EQG A;  4IKW A;  4IKV A;  4Q65 A;  5D58 A;  4TPH A;  5D59 A;  4IKZ A;  4PYP A;  5GXB A;  4GBY A;  4JA3 A;  5A2N A;  4LEP A;  2CFQ A;  4YB9 D;  4U4T A;  4LDS A;  2V8N A;  4ZWC A;  4ZWB A;  4D2B A;  4OAA A;  4ZYR A;  5C65 A;  4IKX A;  4APS A;  4GBZ A;  4D2C A;  4JR9 A;  5A2O A;  2XUT A;  2CFP A;  4OH3 A;  5EQH A;  5D6K A;  4IU9 A;  4XNI A;  4TPJ A;  4U4V A;  4W6V A;  4XNJ A;  4U4W A;  4GC0 A;  4UVM A;  4J05 A;  4TPG A;  4IKY A;  3O7Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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