4TZCA

Crystal structure of murine cereblon in complex with thalidomide
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
106
structure length
91
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSLETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Protein cereblon
publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
source organism Mus musculus
total genus 20
structure length 91
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzcA00
3WX1A 4TZ4C 4CI1B 3CEZA 3HCGA 2K8DA 2KZNA 1L1DA 3HCHA 3E0MA 2KV1A 3WX2A 4CI3B 3HCJA 4TZCA 3CXKA 3MAOA 3HCIA 5AMHA 4CI2B 4V2ZA 4V30A 4TZUA 4V2YA 4V31A 3E0OA
chains in the Genus database with same CATH superfamily
1H6QA 4TZ4C 3WX1A 4CI1B 1HXRA 2LVLA 3CEZA 3ZD7A 4BPBA 3HCGA 3P3KA 3ZD6A 3GA3A 2W4RA 2QFDA 1FWQA 2K8DA 2KZNA 2RQAA 1L1DA 3HCHA 3E0MA 2KV1A 3WX2A 4A2VA 5E3HA 5F98A 4CI3B 5F9HA 2LOYA 2RMJA 3HCJA 2QFBA 2KWBA 3CXKA 2RQBA 4TZCA 3LRNA 3LRRA 3MAOA 3DJMA 3NCUA 2HR9A 3HCIA 5AMHA 3EBMA 1YZ1A 1TXJA 3FACA 4AY2A 2YKGA 5F9FA 2FU5A 4CI2B 4V2ZA 1H7YA 4A2XA 4V30A 3OG8A 4TZUA 3EQTA 4V2YA 4V31A 3E0OA
chains in the Genus database with same CATH topology
3WX1A 4TZ4C 4CI1B 3CEZA 3HCGA 2K8DA 2KZNA 1L1DA 3HCHA 3E0MA 2KV1A 3WX2A 4CI3B 3HCJA 4TZCA 3CXKA 3MAOA 3HCIA 5AMHA 4CI2B 4V2ZA 4V30A 4TZUA 4V2YA 4V31A 3E0OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WX1 A;  4TZ4 C;  4CI1 B;  3CEZ A;  3HCG A;  2K8D A;  2KZN A;  1L1D A;  3HCH A;  3E0M A;  2KV1 A;  3WX2 A;  4CI3 B;  3HCJ A;  4TZC A;  3CXK A;  3MAO A;  3HCI A;  5AMH A;  4CI2 B;  4V2Z A;  4V30 A;  4TZU A;  4V2Y A;  4V31 A;  3E0O A; 
#chains in the Genus database with same CATH topology
 1H6Q A;  4TZ4 C;  3WX1 A;  4CI1 B;  1HXR A;  2LVL A;  3CEZ A;  3ZD7 A;  4BPB A;  3HCG A;  3P3K A;  3ZD6 A;  3GA3 A;  2W4R A;  2QFD A;  1FWQ A;  2K8D A;  2KZN A;  2RQA A;  1L1D A;  3HCH A;  3E0M A;  2KV1 A;  3WX2 A;  4A2V A;  5E3H A;  5F98 A;  4CI3 B;  5F9H A;  2LOY A;  2RMJ A;  3HCJ A;  2QFB A;  2KWB A;  3CXK A;  2RQB A;  4TZC A;  3LRN A;  3LRR A;  3MAO A;  3DJM A;  3NCU A;  2HR9 A;  3HCI A;  5AMH A;  3EBM A;  1YZ1 A;  1TXJ A;  3FAC A;  4AY2 A;  2YKG A;  5F9F A;  2FU5 A;  4CI2 B;  4V2Z A;  1H7Y A;  4A2X A;  4V30 A;  3OG8 A;  4TZU A;  3EQT A;  4V2Y A;  4V31 A;  3E0O A; 
#chains in the Genus database with same CATH homology
 3WX1 A;  4TZ4 C;  4CI1 B;  3CEZ A;  3HCG A;  2K8D A;  2KZN A;  1L1D A;  3HCH A;  3E0M A;  2KV1 A;  3WX2 A;  4CI3 B;  3HCJ A;  4TZC A;  3CXK A;  3MAO A;  3HCI A;  5AMH A;  4CI2 B;  4V2Z A;  4V30 A;  4TZU A;  4V2Y A;  4V31 A;  3E0O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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