4TZUA

Crystal structure of murine cereblon in complex with pomalidomide
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
106
structure length
90
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Protein cereblon
publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
source organism Mus musculus
total genus 18
structure length 90
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzuA00
3HCJA 3MAOA 4TZ4C 4CI3B 2KV1A 3WX1A 4CI1B 3WX2A 2KZNA 2K8DA 5AMHA 3E0OA 1L1DA 3HCHA 4V31A 3CXKA 3HCIA 4TZCA 4V30A 4CI2B 3HCGA 4V2YA 4V2ZA 3E0MA 4TZUA 3CEZA
chains in the Genus database with same CATH superfamily
3GA3A 1HXRA 3ZD6A 3LRRA 3HCJA 1H6QA 3MAOA 4TZ4C 2RQBA 4CI3B 2KV1A 2LOYA 5F9HA 3WX1A 2W4RA 4CI1B 4BPBA 1TXJA 3WX2A 2KZNA 1FWQA 2YKGA 2HR9A 4TZUA 2K8DA 5AMHA 5E3HA 1L1DA 3ZD7A 5F9FA 3HCHA 3P3KA 4V31A 3DJMA 4AY2A 3CXKA 3FACA 3HCIA 4TZCA 4V30A 3LRNA 2FU5A 2RMJA 4A2VA 2RQAA 2LVLA 4CI2B 3EQTA 1YZ1A 2QFBA 3EBMA 3HCGA 4V2YA 4V2ZA 5F98A 3OG8A 2QFDA 1H7YA 4A2XA 3NCUA 3E0MA 3E0OA 2KWBA 3CEZA
chains in the Genus database with same CATH topology
3HCJA 3MAOA 4TZ4C 4CI3B 2KV1A 3WX1A 4CI1B 3WX2A 2KZNA 2K8DA 5AMHA 3E0OA 1L1DA 3HCHA 4V31A 3CXKA 3HCIA 4TZCA 4V30A 4CI2B 3HCGA 4V2YA 4V2ZA 3E0MA 4TZUA 3CEZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HCJ A;  3MAO A;  4TZ4 C;  4CI3 B;  2KV1 A;  3WX1 A;  4CI1 B;  3WX2 A;  2KZN A;  2K8D A;  5AMH A;  3E0O A;  1L1D A;  3HCH A;  4V31 A;  3CXK A;  3HCI A;  4TZC A;  4V30 A;  4CI2 B;  3HCG A;  4V2Y A;  4V2Z A;  3E0M A;  4TZU A;  3CEZ A; 
#chains in the Genus database with same CATH topology
 3GA3 A;  1HXR A;  3ZD6 A;  3LRR A;  3HCJ A;  1H6Q A;  3MAO A;  4TZ4 C;  2RQB A;  4CI3 B;  2KV1 A;  2LOY A;  5F9H A;  3WX1 A;  2W4R A;  4CI1 B;  4BPB A;  1TXJ A;  3WX2 A;  2KZN A;  1FWQ A;  2YKG A;  2HR9 A;  4TZU A;  2K8D A;  5AMH A;  5E3H A;  1L1D A;  3ZD7 A;  5F9F A;  3HCH A;  3P3K A;  4V31 A;  3DJM A;  4AY2 A;  3CXK A;  3FAC A;  3HCI A;  4TZC A;  4V30 A;  3LRN A;  2FU5 A;  2RMJ A;  4A2V A;  2RQA A;  2LVL A;  4CI2 B;  3EQT A;  1YZ1 A;  2QFB A;  3EBM A;  3HCG A;  4V2Y A;  4V2Z A;  5F98 A;  3OG8 A;  2QFD A;  1H7Y A;  4A2X A;  3NCU A;  3E0M A;  3E0O A;  2KWB A;  3CEZ A; 
#chains in the Genus database with same CATH homology
 3HCJ A;  3MAO A;  4TZ4 C;  4CI3 B;  2KV1 A;  3WX1 A;  4CI1 B;  3WX2 A;  2KZN A;  2K8D A;  5AMH A;  3E0O A;  1L1D A;  3HCH A;  4V31 A;  3CXK A;  3HCI A;  4TZC A;  4V30 A;  4CI2 B;  3HCG A;  4V2Y A;  4V2Z A;  3E0M A;  4TZU A;  3CEZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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