4U6CA

Hsmetap in complex with [(1r)-1-amino-3-cyclopentylpropyl]phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6cA00
1A16A 4IDYA 4U71A 1Y1NA 1MATA 2GU5A 3BITA 1B59A 2V3YA 2BWTA 2EVCA 3IG4A 4FLJA 2BHAA 3D27A 1YW7A 1XGMA 2GU6A 2G6PA 1WBQA 5CDLA 2OAZA 3FM3A 1R5GA 2GG3A 5CIKA 2BN7A 3PKBA 4B28A 1XGSA 1C23A 1JAWA 2BWVA 4IF7A 2Q94A 4U6WA 1N51A 4FLLA 1W7VA 3CB6A 4U76A 2EVOA 1B6AA 3TAVA 5JHUA 3FMQA 2GG5A 2BWUA 5CDEA 1QXWA 4ZNGA 2OKNA 3MX6A 4U1BA 3RORA 1R58A 2Q95A 2EA2A 2V3XA 2BWXA 3IU7A 2P98A 5CDVA 2BH3A 2Q92A 4U69A 5D6FA 3IU8A 4ZWPA 4U6EA 1XGNA 3BIQA 4FLIA 1YW9A 1CHMA 2GZ5A 1WKMA 2GA2A 2Q96A 3BIPA 2GGCA 5CLSA 2Q8KA 4IKRA 4PNCA 1C27A 4S2RP 3PKDA 3MR1A 4S00A 4U6ZA 1O0XA 5FCFA 4Z7MA 2BWSA 2GU4A 1KP0A 4ZWOA 5FCHA 3TB5A 2BHCA 4EGEA 4IPAA 4FKCA 2GG9A 4IKSA 1PV9A 1C21A 4FLKA 4RZZA 4MATA 4HXXA 1BN5A 3PKAA 2GG7A 2Q93A 1WL6A 2V3ZA 4IECA 2GGBA 4RGZ1 1R5HA 4S01A 4U6CA 4ZWUA 4A6WA 2DFIA 3PKCA 4A6VA 2BHDA 3S6BA 1KQ9A 1KQ0A 1C22A 1WLRA 4U73A 1WL9A 2B3KA 4S2TP 5CE6A 2EVMA 2B3LA 2NQ7A 4R60A 2ZSGA 4IU6A 4OOKA 4KM3A 2BWYA 4U75A 3CB5A 2V6CA 5E5BA 3RVAA 2P9AA 1M35A 2GG8A 4RZYA 1C24A 1XGOA 1YW8A 2GG0A 1YVMA 4PV4A 1QXZA 2HOWA 2GTXA 3L24A 4U70A 1W2MA 2ADUA 3PKEA 1QXYA 2GU7A 2BWWA 1BOAA 3FMRA 3Q6DA 5JFRA 1QZYA 5CNXA 2MATA 2NQ6A 2EA4A 5JI6A 3MATA 1WN1A 2BHBA 2P99A 4IKTA 2IW2A 5D6EA 3IU9A 4IKUA 4FUKA 1YJ3A 4JUQA 3CTZA 2B3HA 4U6JA 2GG2A 4FO7A 4FO8A 1WY2A 3L7GA 2BB7A 4QR8A 1XNZA
chains in the Genus database with same CATH superfamily
1A16A 4IDYA 4U71A 1Y1NA 1MATA 2GU5A 3BITA 1B59A 2V3YA 2BWTA 2EVCA 3IG4A 4FLJA 2BHAA 3D27A 1YW7A 1XGMA 2GU6A 2G6PA 1WBQA 5CDLA 2OAZA 3FM3A 1R5GA 2GG3A 5CIKA 2BN7A 3PKBA 4B28A 1XGSA 1C23A 1JAWA 2BWVA 4IF7A 2Q94A 4U6WA 1N51A 4FLLA 1W7VA 3CB6A 4U76A 2EVOA 1B6AA 3TAVA 5JHUA 3FMQA 2GG5A 2BWUA 5CDEA 1QXWA 4ZNGA 2OKNA 3MX6A 4U1BA 3RORA 1R58A 2Q95A 2EA2A 2V3XA 2BWXA 3IU7A 2P98A 5CDVA 2BH3A 2Q92A 4U69A 5D6FA 3IU8A 4ZWPA 4U6EA 1XGNA 3BIQA 4FLIA 1YW9A 1CHMA 2GZ5A 1WKMA 2GA2A 2Q96A 3BIPA 2GGCA 5CLSA 2Q8KA 4IKRA 4PNCA 1C27A 4S2RP 3PKDA 3MR1A 4S00A 4U6ZA 1O0XA 5FCFA 4Z7MA 2BWSA 2GU4A 1KP0A 4ZWOA 5FCHA 3TB5A 2BHCA 4EGEA 4IPAA 4FKCA 2GG9A 4IKSA 1PV9A 1C21A 4FLKA 4RZZA 4MATA 4HXXA 1BN5A 3PKAA 2GG7A 2Q93A 1WL6A 2V3ZA 4IECA 2GGBA 4RGZ1 1R5HA 4S01A 4U6CA 4ZWUA 4A6WA 2DFIA 3PKCA 4A6VA 2BHDA 3S6BA 1KQ9A 1KQ0A 1C22A 1WLRA 4U73A 1WL9A 2B3KA 4S2TP 5CE6A 2EVMA 2B3LA 2NQ7A 4R60A 2ZSGA 4IU6A 4OOKA 4KM3A 2BWYA 4U75A 3CB5A 2V6CA 5E5BA 3RVAA 2P9AA 1M35A 2GG8A 4RZYA 1C24A 1XGOA 1YW8A 2GG0A 1YVMA 4PV4A 1QXZA 2HOWA 2GTXA 3L24A 4U70A 1W2MA 2ADUA 3PKEA 1QXYA 2GU7A 2BWWA 1BOAA 3FMRA 3Q6DA 5JFRA 1QZYA 5CNXA 2MATA 2NQ6A 2EA4A 5JI6A 3MATA 1WN1A 2BHBA 2P99A 4IKTA 2IW2A 5D6EA 3IU9A 4IKUA 4FUKA 1YJ3A 4JUQA 3CTZA 2B3HA 4U6JA 2GG2A 4FO7A 4FO8A 1WY2A 3L7GA 2BB7A 4QR8A 1XNZA
chains in the Genus database with same CATH topology
1A16A 4IDYA 4U71A 1Y1NA 1MATA 2GU5A 3BITA 1B59A 2V3YA 2BWTA 2EVCA 3IG4A 4FLJA 2BHAA 3D27A 1YW7A 1XGMA 2GU6A 2G6PA 1WBQA 5CDLA 2OAZA 3FM3A 1R5GA 2GG3A 5CIKA 2BN7A 3PKBA 4B28A 1XGSA 1C23A 1JAWA 2BWVA 4IF7A 2Q94A 4U6WA 1N51A 4FLLA 1W7VA 3CB6A 4U76A 2EVOA 1B6AA 3TAVA 5JHUA 3FMQA 2GG5A 2BWUA 5CDEA 1QXWA 4ZNGA 2OKNA 3MX6A 4U1BA 3RORA 1R58A 2Q95A 2EA2A 2V3XA 2BWXA 3IU7A 2P98A 5CDVA 2BH3A 2Q92A 4U69A 5D6FA 3IU8A 4ZWPA 4U6EA 1XGNA 3BIQA 4FLIA 1YW9A 1CHMA 2GZ5A 1WKMA 2GA2A 2Q96A 3BIPA 2GGCA 5CLSA 2Q8KA 4IKRA 4PNCA 1C27A 4S2RP 3PKDA 3MR1A 4S00A 4U6ZA 1O0XA 5FCFA 4Z7MA 2BWSA 2GU4A 1KP0A 4ZWOA 5FCHA 3TB5A 2BHCA 4EGEA 4IPAA 4FKCA 2GG9A 4IKSA 1PV9A 1C21A 4FLKA 4RZZA 4MATA 4HXXA 1BN5A 3PKAA 2GG7A 2Q93A 1WL6A 2V3ZA 4IECA 2GGBA 4RGZ1 1R5HA 4S01A 4U6CA 4ZWUA 4A6WA 2DFIA 3PKCA 4A6VA 2BHDA 3S6BA 1KQ9A 1KQ0A 1C22A 1WLRA 4U73A 1WL9A 2B3KA 4S2TP 5CE6A 2EVMA 2B3LA 2NQ7A 4R60A 2ZSGA 4IU6A 4OOKA 4KM3A 2BWYA 4U75A 3CB5A 2V6CA 5E5BA 3RVAA 2P9AA 1M35A 2GG8A 4RZYA 1C24A 1XGOA 1YW8A 2GG0A 1YVMA 4PV4A 1QXZA 2HOWA 2GTXA 3L24A 4U70A 1W2MA 2ADUA 3PKEA 1QXYA 2GU7A 2BWWA 1BOAA 3FMRA 3Q6DA 5JFRA 1QZYA 5CNXA 2MATA 2NQ6A 2EA4A 5JI6A 3MATA 1WN1A 2BHBA 2P99A 4IKTA 2IW2A 5D6EA 3IU9A 4IKUA 4FUKA 1YJ3A 4JUQA 3CTZA 2B3HA 4U6JA 2GG2A 4FO7A 4FO8A 1WY2A 3L7GA 2BB7A 4QR8A 1XNZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A16 A;  4IDY A;  4U71 A;  1Y1N A;  1MAT A;  2GU5 A;  3BIT A;  1B59 A;  2V3Y A;  2BWT A;  2EVC A;  3IG4 A;  4FLJ A;  2BHA A;  3D27 A;  1YW7 A;  1XGM A;  2GU6 A;  2G6P A;  1WBQ A;  5CDL A;  2OAZ A;  3FM3 A;  1R5G A;  2GG3 A;  5CIK A;  2BN7 A;  3PKB A;  4B28 A;  1XGS A;  1C23 A;  1JAW A;  2BWV A;  4IF7 A;  2Q94 A;  4U6W A;  1N51 A;  4FLL A;  1W7V A;  3CB6 A;  4U76 A;  2EVO A;  1B6A A;  3TAV A;  5JHU A;  3FMQ A;  2GG5 A;  2BWU A;  5CDE A;  1QXW A;  4ZNG A;  2OKN A;  3MX6 A;  4U1B A;  3ROR A;  1R58 A;  2Q95 A;  2EA2 A;  2V3X A;  2BWX A;  3IU7 A;  2P98 A;  5CDV A;  2BH3 A;  2Q92 A;  4U69 A;  5D6F A;  3IU8 A;  4ZWP A;  4U6E A;  1XGN A;  3BIQ A;  4FLI A;  1YW9 A;  1CHM A;  2GZ5 A;  1WKM A;  2GA2 A;  2Q96 A;  3BIP A;  2GGC A;  5CLS A;  2Q8K A;  4IKR A;  4PNC A;  1C27 A;  4S2R P;  3PKD A;  3MR1 A;  4S00 A;  4U6Z A;  1O0X A;  5FCF A;  4Z7M A;  2BWS A;  2GU4 A;  1KP0 A;  4ZWO A;  5FCH A;  3TB5 A;  2BHC A;  4EGE A;  4IPA A;  4FKC A;  2GG9 A;  4IKS A;  1PV9 A;  1C21 A;  4FLK A;  4RZZ A;  4MAT A;  4HXX A;  1BN5 A;  3PKA A;  2GG7 A;  2Q93 A;  1WL6 A;  2V3Z A;  4IEC A;  2GGB A;  4RGZ 1;  1R5H A;  4S01 A;  4U6C A;  4ZWU A;  4A6W A;  2DFI A;  3PKC A;  4A6V A;  2BHD A;  3S6B A;  1KQ9 A;  1KQ0 A;  1C22 A;  1WLR A;  4U73 A;  1WL9 A;  2B3K A;  4S2T P;  5CE6 A;  2EVM A;  2B3L A;  2NQ7 A;  4R60 A;  2ZSG A;  4IU6 A;  4OOK A;  4KM3 A;  2BWY A;  4U75 A;  3CB5 A;  2V6C A;  5E5B A;  3RVA A;  2P9A A;  1M35 A;  2GG8 A;  4RZY A;  1C24 A;  1XGO A;  1YW8 A;  2GG0 A;  1YVM A;  4PV4 A;  1QXZ A;  2HOW A;  2GTX A;  3L24 A;  4U70 A;  1W2M A;  2ADU A;  3PKE A;  1QXY A;  2GU7 A;  2BWW A;  1BOA A;  3FMR A;  3Q6D A;  5JFR A;  1QZY A;  5CNX A;  2MAT A;  2NQ6 A;  2EA4 A;  5JI6 A;  3MAT A;  1WN1 A;  2BHB A;  2P99 A;  4IKT A;  2IW2 A;  5D6E A;  3IU9 A;  4IKU A;  4FUK A;  1YJ3 A;  4JUQ A;  3CTZ A;  2B3H A;  4U6J A;  2GG2 A;  4FO7 A;  4FO8 A;  1WY2 A;  3L7G A;  2BB7 A;  4QR8 A;  1XNZ A; 
#chains in the Genus database with same CATH topology
 1A16 A;  4IDY A;  4U71 A;  1Y1N A;  1MAT A;  2GU5 A;  3BIT A;  1B59 A;  2V3Y A;  2BWT A;  2EVC A;  3IG4 A;  4FLJ A;  2BHA A;  3D27 A;  1YW7 A;  1XGM A;  2GU6 A;  2G6P A;  1WBQ A;  5CDL A;  2OAZ A;  3FM3 A;  1R5G A;  2GG3 A;  5CIK A;  2BN7 A;  3PKB A;  4B28 A;  1XGS A;  1C23 A;  1JAW A;  2BWV A;  4IF7 A;  2Q94 A;  4U6W A;  1N51 A;  4FLL A;  1W7V A;  3CB6 A;  4U76 A;  2EVO A;  1B6A A;  3TAV A;  5JHU A;  3FMQ A;  2GG5 A;  2BWU A;  5CDE A;  1QXW A;  4ZNG A;  2OKN A;  3MX6 A;  4U1B A;  3ROR A;  1R58 A;  2Q95 A;  2EA2 A;  2V3X A;  2BWX A;  3IU7 A;  2P98 A;  5CDV A;  2BH3 A;  2Q92 A;  4U69 A;  5D6F A;  3IU8 A;  4ZWP A;  4U6E A;  1XGN A;  3BIQ A;  4FLI A;  1YW9 A;  1CHM A;  2GZ5 A;  1WKM A;  2GA2 A;  2Q96 A;  3BIP A;  2GGC A;  5CLS A;  2Q8K A;  4IKR A;  4PNC A;  1C27 A;  4S2R P;  3PKD A;  3MR1 A;  4S00 A;  4U6Z A;  1O0X A;  5FCF A;  4Z7M A;  2BWS A;  2GU4 A;  1KP0 A;  4ZWO A;  5FCH A;  3TB5 A;  2BHC A;  4EGE A;  4IPA A;  4FKC A;  2GG9 A;  4IKS A;  1PV9 A;  1C21 A;  4FLK A;  4RZZ A;  4MAT A;  4HXX A;  1BN5 A;  3PKA A;  2GG7 A;  2Q93 A;  1WL6 A;  2V3Z A;  4IEC A;  2GGB A;  4RGZ 1;  1R5H A;  4S01 A;  4U6C A;  4ZWU A;  4A6W A;  2DFI A;  3PKC A;  4A6V A;  2BHD A;  3S6B A;  1KQ9 A;  1KQ0 A;  1C22 A;  1WLR A;  4U73 A;  1WL9 A;  2B3K A;  4S2T P;  5CE6 A;  2EVM A;  2B3L A;  2NQ7 A;  4R60 A;  2ZSG A;  4IU6 A;  4OOK A;  4KM3 A;  2BWY A;  4U75 A;  3CB5 A;  2V6C A;  5E5B A;  3RVA A;  2P9A A;  1M35 A;  2GG8 A;  4RZY A;  1C24 A;  1XGO A;  1YW8 A;  2GG0 A;  1YVM A;  4PV4 A;  1QXZ A;  2HOW A;  2GTX A;  3L24 A;  4U70 A;  1W2M A;  2ADU A;  3PKE A;  1QXY A;  2GU7 A;  2BWW A;  1BOA A;  3FMR A;  3Q6D A;  5JFR A;  1QZY A;  5CNX A;  2MAT A;  2NQ6 A;  2EA4 A;  5JI6 A;  3MAT A;  1WN1 A;  2BHB A;  2P99 A;  4IKT A;  2IW2 A;  5D6E A;  3IU9 A;  4IKU A;  4FUK A;  1YJ3 A;  4JUQ A;  3CTZ A;  2B3H A;  4U6J A;  2GG2 A;  4FO7 A;  4FO8 A;  1WY2 A;  3L7G A;  2BB7 A;  4QR8 A;  1XNZ A; 
#chains in the Genus database with same CATH homology
 1A16 A;  4IDY A;  4U71 A;  1Y1N A;  1MAT A;  2GU5 A;  3BIT A;  1B59 A;  2V3Y A;  2BWT A;  2EVC A;  3IG4 A;  4FLJ A;  2BHA A;  3D27 A;  1YW7 A;  1XGM A;  2GU6 A;  2G6P A;  1WBQ A;  5CDL A;  2OAZ A;  3FM3 A;  1R5G A;  2GG3 A;  5CIK A;  2BN7 A;  3PKB A;  4B28 A;  1XGS A;  1C23 A;  1JAW A;  2BWV A;  4IF7 A;  2Q94 A;  4U6W A;  1N51 A;  4FLL A;  1W7V A;  3CB6 A;  4U76 A;  2EVO A;  1B6A A;  3TAV A;  5JHU A;  3FMQ A;  2GG5 A;  2BWU A;  5CDE A;  1QXW A;  4ZNG A;  2OKN A;  3MX6 A;  4U1B A;  3ROR A;  1R58 A;  2Q95 A;  2EA2 A;  2V3X A;  2BWX A;  3IU7 A;  2P98 A;  5CDV A;  2BH3 A;  2Q92 A;  4U69 A;  5D6F A;  3IU8 A;  4ZWP A;  4U6E A;  1XGN A;  3BIQ A;  4FLI A;  1YW9 A;  1CHM A;  2GZ5 A;  1WKM A;  2GA2 A;  2Q96 A;  3BIP A;  2GGC A;  5CLS A;  2Q8K A;  4IKR A;  4PNC A;  1C27 A;  4S2R P;  3PKD A;  3MR1 A;  4S00 A;  4U6Z A;  1O0X A;  5FCF A;  4Z7M A;  2BWS A;  2GU4 A;  1KP0 A;  4ZWO A;  5FCH A;  3TB5 A;  2BHC A;  4EGE A;  4IPA A;  4FKC A;  2GG9 A;  4IKS A;  1PV9 A;  1C21 A;  4FLK A;  4RZZ A;  4MAT A;  4HXX A;  1BN5 A;  3PKA A;  2GG7 A;  2Q93 A;  1WL6 A;  2V3Z A;  4IEC A;  2GGB A;  4RGZ 1;  1R5H A;  4S01 A;  4U6C A;  4ZWU A;  4A6W A;  2DFI A;  3PKC A;  4A6V A;  2BHD A;  3S6B A;  1KQ9 A;  1KQ0 A;  1C22 A;  1WLR A;  4U73 A;  1WL9 A;  2B3K A;  4S2T P;  5CE6 A;  2EVM A;  2B3L A;  2NQ7 A;  4R60 A;  2ZSG A;  4IU6 A;  4OOK A;  4KM3 A;  2BWY A;  4U75 A;  3CB5 A;  2V6C A;  5E5B A;  3RVA A;  2P9A A;  1M35 A;  2GG8 A;  4RZY A;  1C24 A;  1XGO A;  1YW8 A;  2GG0 A;  1YVM A;  4PV4 A;  1QXZ A;  2HOW A;  2GTX A;  3L24 A;  4U70 A;  1W2M A;  2ADU A;  3PKE A;  1QXY A;  2GU7 A;  2BWW A;  1BOA A;  3FMR A;  3Q6D A;  5JFR A;  1QZY A;  5CNX A;  2MAT A;  2NQ6 A;  2EA4 A;  5JI6 A;  3MAT A;  1WN1 A;  2BHB A;  2P99 A;  4IKT A;  2IW2 A;  5D6E A;  3IU9 A;  4IKU A;  4FUK A;  1YJ3 A;  4JUQ A;  3CTZ A;  2B3H A;  4U6J A;  2GG2 A;  4FO7 A;  4FO8 A;  1WY2 A;  3L7G A;  2BB7 A;  4QR8 A;  1XNZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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