4U6VA

Mechanisms of neutralization of a human anti-alpha toxin antibody
Total Genus 68
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
282
structure length
272
Chain Sequence
TDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Immune system
molecule keywords Fab, antigen binding fragment, heavy chain
publication title Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
pubmed doi rcsb
source organism Homo sapiens
total genus 68
structure length 272
sequence length 282
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4u6vA00
5K59C 4P1XA 4IYAA 4IYTA 4TW1B 4J0OA 1LKFA 2YGTA 1PVLA 3ROHA 3M4EA 3M4DA 3ANZA 1T5RA 4TW1A 3LKFA 4U6VA 3O44A 4H56A 3M3RA 4IDJA 3B07B 4P24A 4P1YB 7AHLA 4I0NA 4IYCA 2QK7B 4P1XB 2LKFA 4IZLA 3B07A 4P1YA 3M2LA 4YHDA 4Q7GA 5K59A 2QK7A
chains in the Genus database with same CATH superfamily
5K59C 4P1XA 4IYAA 4IYTA 4TW1B 4J0OA 1LKFA 2YGTA 1PVLA 3ROHA 3M4EA 3M4DA 3ANZA 1T5RA 4TW1A 3LKFA 4U6VA 3O44A 4H56A 1XEZA 3M3RA 4IDJA 3B07B 4P24A 4P1YB 7AHLA 4I0NA 4IYCA 2QK7B 4P1XB 2LKFA 4IZLA 3B07A 4P1YA 3M2LA 4YHDA 4Q7GA 5K59A 2QK7A
chains in the Genus database with same CATH topology
5K59C 4P1XA 4IYAA 4IYTA 4TW1B 4J0OA 1LKFA 2YGTA 1PVLA 3ROHA 3M4EA 3M4DA 3ANZA 1T5RA 4TW1A 3LKFA 4U6VA 3O44A 4H56A 3M3RA 4IDJA 3B07B 4P24A 4P1YB 7AHLA 4I0NA 4IYCA 2QK7B 4P1XB 2LKFA 4IZLA 3B07A 4P1YA 3M2LA 4YHDA 4Q7GA 5K59A 2QK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5K59 C;  4P1X A;  4IYA A;  4IYT A;  4TW1 B;  4J0O A;  1LKF A;  2YGT A;  1PVL A;  3ROH A;  3M4E A;  3M4D A;  3ANZ A;  1T5R A;  4TW1 A;  3LKF A;  4U6V A;  3O44 A;  4H56 A;  3M3R A;  4IDJ A;  3B07 B;  4P24 A;  4P1Y B;  7AHL A;  4I0N A;  4IYC A;  2QK7 B;  4P1X B;  2LKF A;  4IZL A;  3B07 A;  4P1Y A;  3M2L A;  4YHD A;  4Q7G A;  5K59 A;  2QK7 A; 
#chains in the Genus database with same CATH topology
 5K59 C;  4P1X A;  4IYA A;  4IYT A;  4TW1 B;  4J0O A;  1LKF A;  2YGT A;  1PVL A;  3ROH A;  3M4E A;  3M4D A;  3ANZ A;  1T5R A;  4TW1 A;  3LKF A;  4U6V A;  3O44 A;  4H56 A;  1XEZ A;  3M3R A;  4IDJ A;  3B07 B;  4P24 A;  4P1Y B;  7AHL A;  4I0N A;  4IYC A;  2QK7 B;  4P1X B;  2LKF A;  4IZL A;  3B07 A;  4P1Y A;  3M2L A;  4YHD A;  4Q7G A;  5K59 A;  2QK7 A; 
#chains in the Genus database with same CATH homology
 5K59 C;  4P1X A;  4IYA A;  4IYT A;  4TW1 B;  4J0O A;  1LKF A;  2YGT A;  1PVL A;  3ROH A;  3M4E A;  3M4D A;  3ANZ A;  1T5R A;  4TW1 A;  3LKF A;  4U6V A;  3O44 A;  4H56 A;  3M3R A;  4IDJ A;  3B07 B;  4P24 A;  4P1Y B;  7AHL A;  4I0N A;  4IYC A;  2QK7 B;  4P1X B;  2LKF A;  4IZL A;  3B07 A;  4P1Y A;  3M2L A;  4YHD A;  4Q7G A;  5K59 A;  2QK7 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...