4U91A

Gephe in complex with para-phenyl crosslinked glycine receptor beta subunit derived dimeric peptide
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
418
structure length
415
Chain Sequence
SPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors.
pubmed doi rcsb
molecule tags Transfer protein / structural protein
source organism Rattus norvegicus
molecule keywords Gephyrin
total genus 106
structure length 415
sequence length 418
ec nomenclature ec 2.10.1.1: Molybdopterin molybdotransferase.
pdb deposition date 2014-08-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00994 MoCF_biosynth Probable molybdopterin binding domain
A PF03453 MoeA_N MoeA N-terminal region (domain I and II)
A PF03454 MoeA_C MoeA C-terminal region (domain IV)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.340.10 Mainly Beta Beta Barrel Beta-clip MoeA, C-terminal, domain IV 4u91A04
2.170.190.11 Mainly Beta Beta Complex Molybdopterin biosynthesis moeA protein; domain 3 Molybdopterin biosynthesis moea protein, domain 3. 4u91A03
3.40.980.10 Alpha Beta 3-Layer(aba) Sandwich Molybdenum Cofactor Biosythetic Enzyme; Chain A MoaB/Mog-like domain 4u91A01
3.90.105.10 Alpha Beta Alpha-Beta Complex Molybdopterin biosynthesis moea protein, domain 2 Molybdopterin biosynthesis moea protein, domain 2 4u91A02
2NQMA 1G8RA 5ERTA 4UOCA 2NQVA 2G2CA 2NRSA 4UUWA 1DI7A 4PD1A 5G2RA 4TWGA 2NQRA 2FU3A 3K6AA 3MCIA 3MCJA 3MCHA 1R2KA 1DI6A 1O8QA 1O8OA 1WU2A 1UUXA 2NRPA 4CT8A 2X3LA 4LHBA 4CTAA 1XI8A 2NQUA 5ERQA 3PZYA 2NROA 1MKZA 2IS8A 1IHCA 2FTSA 1O8NA 3OI9A 4U91A 1UZ5A 4PD0A 2PBQA 2NQSA 2NQQA 5ERSA 4TK1A 5ERRA 3IWTA 1Y5EA 3RFQA 4TK3A 4TK4A 4XCWA 5ERVA 3KBQA 2F7YA 1UUYA 1EAVA 5G2SA 4CT9A 4U90A 1T3EA 4UUXA 2G4RA 2QQ1A 3TCRA 5ERUA 4CTAB 2NQKA 1G8LA 2F7WA 1JLJA 2NQNA 1FC5A 4NWOA
chains in the Genus database with same CATH superfamily
2NQMA 1G8RA 5ERTA 4UOCA 2NQVA 5D6GA 2G2CA 4NWBA 1I6VD 2NRSA 1YZYA 4UUWA 1DI7A 5DMHA 4PD1A 5G2RA 4TWGA 2NQRA 2FU3A 3K6AA 3MCIA 3MCJA 3MCHA 1HQMD 1R2KA 1DI6A 1O8QA 1O8OA 1WU2A 1UUXA 2NRPA 4CT8A 2X3LA 4LHBA 4CTAA 3JSYA 1XI8A 2NQUA 5ERQA 3PZYA 2NROA 1MKZA 2IS8A 1IHCA 5D8HB 2FTSA 1O8NA 3OI9A 4U91A 1UZ5A 4PD0A 2PBQA 2NQSA 2NQQA 5ERSA 4TK1A 5ERRA 3IWTA 1Y5EA 3RFQA 4TK3A 4TK4A 4XCWA 5ERVA 3KBQA 2F7YA 1UUYA 1EAVA 5G2SA 4CT9A 3DQQA 4U90A 1T3EA 4UUXA 2G4RA 2QQ1A 3TCRA 5ERUA 4CTAB 2NQKA 1G8LA 2F7WA 1JLJA 2NQNA 1FC5A 1IW7D 4NWOA
chains in the Genus database with same CATH topology
2NQMA 1G8RA 5ERTA 4UOCA 2NQVA 5D6GA 2G2CA 4NWBA 1I6VD 2NRSA 4UUWA 1DI7A 4PD1A 5G2RA 4TWGA 2NQRA 2FU3A 3K6AA 3MCIA 3MCJA 3MCHA 1HQMD 1R2KA 1DI6A 1O8QA 1O8OA 1WU2A 1UUXA 2NRPA 4CT8A 2X3LA 4LHBA 4CTAA 3JSYA 1XI8A 2NQUA 5ERQA 3PZYA 2NROA 1MKZA 2IS8A 1IHCA 5D8HB 2FTSA 1O8NA 3OI9A 4U91A 1UZ5A 4PD0A 2PBQA 2NQSA 2NQQA 5ERSA 4TK1A 5ERRA 3IWTA 1Y5EA 3RFQA 4TK3A 4TK4A 4XCWA 5ERVA 3KBQA 2F7YA 1UUYA 1EAVA 5G2SA 4CT9A 4U90A 1T3EA 4UUXA 2G4RA 2QQ1A 3TCRA 5ERUA 4CTAB 2NQKA 1G8LA 2F7WA 1JLJA 2NQNA 1FC5A 1IW7D 4NWOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NQM A;  1G8R A;  5ERT A;  4UOC A;  2NQV A;  2G2C A;  2NRS A;  4UUW A;  1DI7 A;  4PD1 A;  5G2R A;  4TWG A;  2NQR A;  2FU3 A;  3K6A A;  3MCI A;  3MCJ A;  3MCH A;  1R2K A;  1DI6 A;  1O8Q A;  1O8O A;  1WU2 A;  1UUX A;  2NRP A;  4CT8 A;  2X3L A;  4LHB A;  4CTA A;  1XI8 A;  2NQU A;  5ERQ A;  3PZY A;  2NRO A;  1MKZ A;  2IS8 A;  1IHC A;  2FTS A;  1O8N A;  3OI9 A;  4U91 A;  1UZ5 A;  4PD0 A;  2PBQ A;  2NQS A;  2NQQ A;  5ERS A;  4TK1 A;  5ERR A;  3IWT A;  1Y5E A;  3RFQ A;  4TK3 A;  4TK4 A;  4XCW A;  5ERV A;  3KBQ A;  2F7Y A;  1UUY A;  1EAV A;  5G2S A;  4CT9 A;  4U90 A;  1T3E A;  4UUX A;  2G4R A;  2QQ1 A;  3TCR A;  5ERU A;  4CTA B;  2NQK A;  1G8L A;  2F7W A;  1JLJ A;  2NQN A;  1FC5 A;  4NWO A; 
#chains in the Genus database with same CATH topology
 2NQM A;  1G8R A;  5ERT A;  4UOC A;  2NQV A;  5D6G A;  2G2C A;  4NWB A;  1I6V D;  2NRS A;  1YZY A;  4UUW A;  1DI7 A;  5DMH A;  4PD1 A;  5G2R A;  4TWG A;  2NQR A;  2FU3 A;  3K6A A;  3MCI A;  3MCJ A;  3MCH A;  1HQM D;  1R2K A;  1DI6 A;  1O8Q A;  1O8O A;  1WU2 A;  1UUX A;  2NRP A;  4CT8 A;  2X3L A;  4LHB A;  4CTA A;  3JSY A;  1XI8 A;  2NQU A;  5ERQ A;  3PZY A;  2NRO A;  1MKZ A;  2IS8 A;  1IHC A;  5D8H B;  2FTS A;  1O8N A;  3OI9 A;  4U91 A;  1UZ5 A;  4PD0 A;  2PBQ A;  2NQS A;  2NQQ A;  5ERS A;  4TK1 A;  5ERR A;  3IWT A;  1Y5E A;  3RFQ A;  4TK3 A;  4TK4 A;  4XCW A;  5ERV A;  3KBQ A;  2F7Y A;  1UUY A;  1EAV A;  5G2S A;  4CT9 A;  3DQQ A;  4U90 A;  1T3E A;  4UUX A;  2G4R A;  2QQ1 A;  3TCR A;  5ERU A;  4CTA B;  2NQK A;  1G8L A;  2F7W A;  1JLJ A;  2NQN A;  1FC5 A;  1IW7 D;  4NWO A; 
#chains in the Genus database with same CATH homology
 2NQM A;  1G8R A;  5ERT A;  4UOC A;  2NQV A;  5D6G A;  2G2C A;  4NWB A;  1I6V D;  2NRS A;  4UUW A;  1DI7 A;  4PD1 A;  5G2R A;  4TWG A;  2NQR A;  2FU3 A;  3K6A A;  3MCI A;  3MCJ A;  3MCH A;  1HQM D;  1R2K A;  1DI6 A;  1O8Q A;  1O8O A;  1WU2 A;  1UUX A;  2NRP A;  4CT8 A;  2X3L A;  4LHB A;  4CTA A;  3JSY A;  1XI8 A;  2NQU A;  5ERQ A;  3PZY A;  2NRO A;  1MKZ A;  2IS8 A;  1IHC A;  5D8H B;  2FTS A;  1O8N A;  3OI9 A;  4U91 A;  1UZ5 A;  4PD0 A;  2PBQ A;  2NQS A;  2NQQ A;  5ERS A;  4TK1 A;  5ERR A;  3IWT A;  1Y5E A;  3RFQ A;  4TK3 A;  4TK4 A;  4XCW A;  5ERV A;  3KBQ A;  2F7Y A;  1UUY A;  1EAV A;  5G2S A;  4CT9 A;  4U90 A;  1T3E A;  4UUX A;  2G4R A;  2QQ1 A;  3TCR A;  5ERU A;  4CTA B;  2NQK A;  1G8L A;  2F7W A;  1JLJ A;  2NQN A;  1FC5 A;  1IW7 D;  4NWO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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