4UM3P

Engineered ls-achbp with alpha4-alpha4 binding pocket in complex with ns3920
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
205
structure length
201
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity
pubmed doi rcsb
molecule keywords ACETYLCHOLINE BINDING PROTEIN
molecule tags Signaling protein
source organism Lymnaea stagnalis
total genus 47
structure length 201
sequence length 205
ec nomenclature
pdb deposition date 2014-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4um3P00
2BR8A 3LSVA 5AFMB 3P50A 4HFBA 3U8NA 2YMEA 2Y58A 4ZK4A 3UQ4A 2C9TA 3GUAA 5AFMA 3P4WA 2BG9A 3WTIA 3RIFA 3UU4A 2BYRA 3UU8A 4HFEA 2XNVA 3C84A 5CFBA 3WTHA 5LG3A 3U8KA 2Y57A 2ZJVA 2W8GA 4X5TA 4QACA 4TWDA 2WNLA 4F8HA 2WN9A 4TNVA 3UU6A 5KE4A 1UX2A 5J0ZA 2WZYA 3UUBA 3WTLA 4QH5A 4IL4A 4A98A 2Y7YA 3UU3A 4QABA 4ALXA 4D01A 5AFNA 2ZJUA 4B5DA 4UM3S 2XYTA 2WNCA 2XQ3A 2XNUA 3JADA 3ZDHA 2X00D 5AFKA 2BJ0A 2XQ6A 4UM1A 5AINA 5L47A 2QC1B 4QH4A 4ILCA 2XZ5A 3EI0A 3TLTA 4HFDA 4LMJA 2BYNA 4UXUA 3WTJA 3WTKA 5HEHA 4XHEA 2YKSA 5L4EA 4AFTA 3U8LA 5CO5A 5SYOA 5L4HA 5AFJA 2XQ4A 3SIOA 2XQ8A 4TWHA 4ZRUA 4XK9A 3TLVA 1UV6A 4Z91A 3C79A 3PEOA 2PH9A 3U8JA 5FJVA 4DBMA 3WTNA 4AFHA 4ILAA 3WTOA 4TWFA 3IGQA 4LMKA 2XQ9A 4ZZBA 4A97A 2BG9E 2XQ7A 3JAEA 4NZBA 5BW2A 4PIRA 4EZ1A 2YMDA 4UM3P 3SQ6A 4BFQA 4HFIA 4ZZCA 4HFHA 4HFCA 3ZDGA 3PMZA 3SH1A 2YN6A 3T4MA 4ILBA 2BG9C 3EHZA 4ZR6A 2UZ6A 3UQ7A 2BR7A 4UM3A 3TLUA 5HEJA 2BYQA 1I9BA 4IREA 2XYSA 2YOEA 5TVCA 5LXBA 2PGZA 4UY2A 3RIAA 3UU5A 5KZUA 3RQUA 3EAMA 4Z90A 2W8FA 2BG9B 5J5FA 1UW6A 3WIPA 2XNTA 4FRRA 3RQWA 4COFA 4TNWA 2VL0A 2WNJA 5JMEA 5J5IA 2XQAA 3JAFA 3RI5A 3WTMA 4NPPA 5HEUA 4QAAA 4LMLA 4BQTA 5HEOA 2XQ5A 2X00A 2XZ6A 3RHWA 4ZJTA 5HEGA 3U8MA 4QH1A 5HCMA 2Y54A 4WV9A 3ZKRA 3TLWA 5J5GA 4ZJSA 5AFHA 3TLSA 4ZK1A 4AFGA 5AFLA 5BP0A 5IUXA 5BRXA 2Y56A 2BYSA 4HQPA 5J5HA 4IL9A 2BYPA 3SQ9A 5HCJA
chains in the Genus database with same CATH superfamily
2BR8A 3LSVA 5AFMB 3P50A 4HFBA 3U8NA 2YMEA 2Y58A 4ZK4A 3UQ4A 2C9TA 3GUAA 5AFMA 3P4WA 2BG9A 3WTIA 3RIFA 3UU4A 2BYRA 3UU8A 4HFEA 2XNVA 3C84A 5CFBA 3WTHA 5LG3A 3U8KA 2Y57A 2ZJVA 2W8GA 4X5TA 4QACA 4TWDA 2WNLA 4F8HA 2WN9A 4TNVA 3UU6A 5KE4A 1UX2A 5J0ZA 2WZYA 3UUBA 3WTLA 4QH5A 4IL4A 4A98A 2Y7YA 3UU3A 4QABA 4ALXA 4D01A 5AFNA 2ZJUA 4B5DA 4UM3S 2XYTA 2WNCA 2XQ3A 2XNUA 3JADA 3ZDHA 2X00D 5AFKA 2BJ0A 2XQ6A 4UM1A 5AINA 5L47A 2QC1B 4QH4A 4ILCA 2XZ5A 3EI0A 3TLTA 4HFDA 4LMJA 2BYNA 4UXUA 3WTJA 3WTKA 5HEHA 4XHEA 2YKSA 5L4EA 4AFTA 3U8LA 5CO5A 5SYOA 5L4HA 5AFJA 2XQ4A 3SIOA 2XQ8A 4TWHA 4ZRUA 4XK9A 3TLVA 1UV6A 4Z91A 3C79A 3PEOA 2PH9A 3U8JA 5FJVA 4DBMA 3WTNA 4AFHA 4ILAA 3WTOA 4TWFA 3IGQA 4LMKA 2XQ9A 4ZZBA 4A97A 2BG9E 2XQ7A 3JAEA 4NZBA 5BW2A 4PIRA 4EZ1A 2YMDA 4UM3P 3SQ6A 4BFQA 4HFIA 4ZZCA 4HFHA 4HFCA 3ZDGA 3PMZA 3SH1A 2YN6A 3T4MA 4ILBA 2BG9C 3EHZA 4ZR6A 2UZ6A 3UQ7A 2BR7A 4UM3A 3TLUA 5HEJA 2BYQA 1I9BA 4IREA 2XYSA 2YOEA 5TVCA 5LXBA 2PGZA 4UY2A 3RIAA 3UU5A 5KZUA 3RQUA 3EAMA 4Z90A 2W8FA 2BG9B 5J5FA 1UW6A 3WIPA 2XNTA 4FRRA 3RQWA 4COFA 4TNWA 2VL0A 2WNJA 5JMEA 5J5IA 2XQAA 3JAFA 3RI5A 3WTMA 4NPPA 5HEUA 4QAAA 4LMLA 4BQTA 5HEOA 2XQ5A 2X00A 2XZ6A 3RHWA 4ZJTA 5HEGA 3U8MA 4QH1A 5HCMA 2Y54A 4WV9A 3ZKRA 3TLWA 5J5GA 4ZJSA 5AFHA 3TLSA 4ZK1A 4AFGA 5AFLA 5BP0A 5IUXA 5BRXA 2Y56A 2BYSA 4HQPA 5J5HA 4IL9A 2BYPA 3SQ9A 5HCJA
chains in the Genus database with same CATH topology
2BR8A 3LSVA 5AFMB 3P50A 4HFBA 3U8NA 2YMEA 2Y58A 4ZK4A 3UQ4A 2C9TA 3GUAA 5AFMA 3P4WA 2BG9A 3WTIA 3RIFA 3UU4A 2BYRA 3UU8A 4HFEA 2XNVA 3C84A 5CFBA 3WTHA 5LG3A 3U8KA 2Y57A 2ZJVA 2W8GA 4X5TA 4QACA 4TWDA 2WNLA 4F8HA 2WN9A 4TNVA 3UU6A 5KE4A 1UX2A 5J0ZA 2WZYA 3UUBA 3WTLA 4QH5A 4IL4A 4A98A 2Y7YA 3UU3A 4QABA 4ALXA 4D01A 5AFNA 2ZJUA 4B5DA 4UM3S 2XYTA 2WNCA 2XQ3A 2XNUA 3JADA 3ZDHA 2X00D 5AFKA 2BJ0A 2XQ6A 4UM1A 5AINA 5L47A 2QC1B 4QH4A 4ILCA 2XZ5A 3EI0A 3TLTA 4HFDA 4LMJA 2BYNA 4UXUA 3WTJA 3WTKA 5HEHA 4XHEA 2YKSA 5L4EA 4AFTA 3U8LA 5CO5A 5SYOA 5L4HA 5AFJA 2XQ4A 3SIOA 2XQ8A 4TWHA 4ZRUA 4XK9A 3TLVA 1UV6A 4Z91A 3C79A 3PEOA 2PH9A 3U8JA 5FJVA 4DBMA 3WTNA 4AFHA 4ILAA 3WTOA 4TWFA 3IGQA 4LMKA 2XQ9A 4ZZBA 4A97A 2BG9E 2XQ7A 3JAEA 4NZBA 5BW2A 4PIRA 4EZ1A 2YMDA 4UM3P 3SQ6A 4BFQA 4HFIA 4ZZCA 4HFHA 4HFCA 3ZDGA 3PMZA 3SH1A 2YN6A 3T4MA 4ILBA 2BG9C 3EHZA 4ZR6A 2UZ6A 3UQ7A 2BR7A 4UM3A 3TLUA 5HEJA 2BYQA 1I9BA 4IREA 2XYSA 2YOEA 5TVCA 5LXBA 2PGZA 4UY2A 3RIAA 3UU5A 5KZUA 3RQUA 3EAMA 4Z90A 2W8FA 2BG9B 5J5FA 1UW6A 3WIPA 2XNTA 4FRRA 3RQWA 4COFA 4TNWA 2VL0A 2WNJA 5JMEA 5J5IA 2XQAA 3JAFA 3RI5A 3WTMA 4NPPA 5HEUA 4QAAA 4LMLA 4BQTA 5HEOA 2XQ5A 2X00A 2XZ6A 3RHWA 4ZJTA 5HEGA 3U8MA 4QH1A 5HCMA 2Y54A 4WV9A 3ZKRA 3TLWA 5J5GA 4ZJSA 5AFHA 3TLSA 4ZK1A 4AFGA 5AFLA 5BP0A 5IUXA 5BRXA 2Y56A 2BYSA 4HQPA 5J5HA 4IL9A 2BYPA 3SQ9A 5HCJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BR8 A;  3LSV A;  5AFM B;  3P50 A;  4HFB A;  3U8N A;  2YME A;  2Y58 A;  4ZK4 A;  3UQ4 A;  2C9T A;  3GUA A;  5AFM A;  3P4W A;  2BG9 A;  3WTI A;  3RIF A;  3UU4 A;  2BYR A;  3UU8 A;  4HFE A;  2XNV A;  3C84 A;  5CFB A;  3WTH A;  5LG3 A;  3U8K A;  2Y57 A;  2ZJV A;  2W8G A;  4X5T A;  4QAC A;  4TWD A;  2WNL A;  4F8H A;  2WN9 A;  4TNV A;  3UU6 A;  5KE4 A;  1UX2 A;  5J0Z A;  2WZY A;  3UUB A;  3WTL A;  4QH5 A;  4IL4 A;  4A98 A;  2Y7Y A;  3UU3 A;  4QAB A;  4ALX A;  4D01 A;  5AFN A;  2ZJU A;  4B5D A;  4UM3 S;  2XYT A;  2WNC A;  2XQ3 A;  2XNU A;  3JAD A;  3ZDH A;  2X00 D;  5AFK A;  2BJ0 A;  2XQ6 A;  4UM1 A;  5AIN A;  5L47 A;  2QC1 B;  4QH4 A;  4ILC A;  2XZ5 A;  3EI0 A;  3TLT A;  4HFD A;  4LMJ A;  2BYN A;  4UXU A;  3WTJ A;  3WTK A;  5HEH A;  4XHE A;  2YKS A;  5L4E A;  4AFT A;  3U8L A;  5CO5 A;  5SYO A;  5L4H A;  5AFJ A;  2XQ4 A;  3SIO A;  2XQ8 A;  4TWH A;  4ZRU A;  4XK9 A;  3TLV A;  1UV6 A;  4Z91 A;  3C79 A;  3PEO A;  2PH9 A;  3U8J A;  5FJV A;  4DBM A;  3WTN A;  4AFH A;  4ILA A;  3WTO A;  4TWF A;  3IGQ A;  4LMK A;  2XQ9 A;  4ZZB A;  4A97 A;  2BG9 E;  2XQ7 A;  3JAE A;  4NZB A;  5BW2 A;  4PIR A;  4EZ1 A;  2YMD A;  4UM3 P;  3SQ6 A;  4BFQ A;  4HFI A;  4ZZC A;  4HFH A;  4HFC A;  3ZDG A;  3PMZ A;  3SH1 A;  2YN6 A;  3T4M A;  4ILB A;  2BG9 C;  3EHZ A;  4ZR6 A;  2UZ6 A;  3UQ7 A;  2BR7 A;  4UM3 A;  3TLU A;  5HEJ A;  2BYQ A;  1I9B A;  4IRE A;  2XYS A;  2YOE A;  5TVC A;  5LXB A;  2PGZ A;  4UY2 A;  3RIA A;  3UU5 A;  5KZU A;  3RQU A;  3EAM A;  4Z90 A;  2W8F A;  2BG9 B;  5J5F A;  1UW6 A;  3WIP A;  2XNT A;  4FRR A;  3RQW A;  4COF A;  4TNW A;  2VL0 A;  2WNJ A;  5JME A;  5J5I A;  2XQA A;  3JAF A;  3RI5 A;  3WTM A;  4NPP A;  5HEU A;  4QAA A;  4LML A;  4BQT A;  5HEO A;  2XQ5 A;  2X00 A;  2XZ6 A;  3RHW A;  4ZJT A;  5HEG A;  3U8M A;  4QH1 A;  5HCM A;  2Y54 A;  4WV9 A;  3ZKR A;  3TLW A;  5J5G A;  4ZJS A;  5AFH A;  3TLS A;  4ZK1 A;  4AFG A;  5AFL A;  5BP0 A;  5IUX A;  5BRX A;  2Y56 A;  2BYS A;  4HQP A;  5J5H A;  4IL9 A;  2BYP A;  3SQ9 A;  5HCJ A; 
#chains in the Genus database with same CATH topology
 2BR8 A;  3LSV A;  5AFM B;  3P50 A;  4HFB A;  3U8N A;  2YME A;  2Y58 A;  4ZK4 A;  3UQ4 A;  2C9T A;  3GUA A;  5AFM A;  3P4W A;  2BG9 A;  3WTI A;  3RIF A;  3UU4 A;  2BYR A;  3UU8 A;  4HFE A;  2XNV A;  3C84 A;  5CFB A;  3WTH A;  5LG3 A;  3U8K A;  2Y57 A;  2ZJV A;  2W8G A;  4X5T A;  4QAC A;  4TWD A;  2WNL A;  4F8H A;  2WN9 A;  4TNV A;  3UU6 A;  5KE4 A;  1UX2 A;  5J0Z A;  2WZY A;  3UUB A;  3WTL A;  4QH5 A;  4IL4 A;  4A98 A;  2Y7Y A;  3UU3 A;  4QAB A;  4ALX A;  4D01 A;  5AFN A;  2ZJU A;  4B5D A;  4UM3 S;  2XYT A;  2WNC A;  2XQ3 A;  2XNU A;  3JAD A;  3ZDH A;  2X00 D;  5AFK A;  2BJ0 A;  2XQ6 A;  4UM1 A;  5AIN A;  5L47 A;  2QC1 B;  4QH4 A;  4ILC A;  2XZ5 A;  3EI0 A;  3TLT A;  4HFD A;  4LMJ A;  2BYN A;  4UXU A;  3WTJ A;  3WTK A;  5HEH A;  4XHE A;  2YKS A;  5L4E A;  4AFT A;  3U8L A;  5CO5 A;  5SYO A;  5L4H A;  5AFJ A;  2XQ4 A;  3SIO A;  2XQ8 A;  4TWH A;  4ZRU A;  4XK9 A;  3TLV A;  1UV6 A;  4Z91 A;  3C79 A;  3PEO A;  2PH9 A;  3U8J A;  5FJV A;  4DBM A;  3WTN A;  4AFH A;  4ILA A;  3WTO A;  4TWF A;  3IGQ A;  4LMK A;  2XQ9 A;  4ZZB A;  4A97 A;  2BG9 E;  2XQ7 A;  3JAE A;  4NZB A;  5BW2 A;  4PIR A;  4EZ1 A;  2YMD A;  4UM3 P;  3SQ6 A;  4BFQ A;  4HFI A;  4ZZC A;  4HFH A;  4HFC A;  3ZDG A;  3PMZ A;  3SH1 A;  2YN6 A;  3T4M A;  4ILB A;  2BG9 C;  3EHZ A;  4ZR6 A;  2UZ6 A;  3UQ7 A;  2BR7 A;  4UM3 A;  3TLU A;  5HEJ A;  2BYQ A;  1I9B A;  4IRE A;  2XYS A;  2YOE A;  5TVC A;  5LXB A;  2PGZ A;  4UY2 A;  3RIA A;  3UU5 A;  5KZU A;  3RQU A;  3EAM A;  4Z90 A;  2W8F A;  2BG9 B;  5J5F A;  1UW6 A;  3WIP A;  2XNT A;  4FRR A;  3RQW A;  4COF A;  4TNW A;  2VL0 A;  2WNJ A;  5JME A;  5J5I A;  2XQA A;  3JAF A;  3RI5 A;  3WTM A;  4NPP A;  5HEU A;  4QAA A;  4LML A;  4BQT A;  5HEO A;  2XQ5 A;  2X00 A;  2XZ6 A;  3RHW A;  4ZJT A;  5HEG A;  3U8M A;  4QH1 A;  5HCM A;  2Y54 A;  4WV9 A;  3ZKR A;  3TLW A;  5J5G A;  4ZJS A;  5AFH A;  3TLS A;  4ZK1 A;  4AFG A;  5AFL A;  5BP0 A;  5IUX A;  5BRX A;  2Y56 A;  2BYS A;  4HQP A;  5J5H A;  4IL9 A;  2BYP A;  3SQ9 A;  5HCJ A; 
#chains in the Genus database with same CATH homology
 2BR8 A;  3LSV A;  5AFM B;  3P50 A;  4HFB A;  3U8N A;  2YME A;  2Y58 A;  4ZK4 A;  3UQ4 A;  2C9T A;  3GUA A;  5AFM A;  3P4W A;  2BG9 A;  3WTI A;  3RIF A;  3UU4 A;  2BYR A;  3UU8 A;  4HFE A;  2XNV A;  3C84 A;  5CFB A;  3WTH A;  5LG3 A;  3U8K A;  2Y57 A;  2ZJV A;  2W8G A;  4X5T A;  4QAC A;  4TWD A;  2WNL A;  4F8H A;  2WN9 A;  4TNV A;  3UU6 A;  5KE4 A;  1UX2 A;  5J0Z A;  2WZY A;  3UUB A;  3WTL A;  4QH5 A;  4IL4 A;  4A98 A;  2Y7Y A;  3UU3 A;  4QAB A;  4ALX A;  4D01 A;  5AFN A;  2ZJU A;  4B5D A;  4UM3 S;  2XYT A;  2WNC A;  2XQ3 A;  2XNU A;  3JAD A;  3ZDH A;  2X00 D;  5AFK A;  2BJ0 A;  2XQ6 A;  4UM1 A;  5AIN A;  5L47 A;  2QC1 B;  4QH4 A;  4ILC A;  2XZ5 A;  3EI0 A;  3TLT A;  4HFD A;  4LMJ A;  2BYN A;  4UXU A;  3WTJ A;  3WTK A;  5HEH A;  4XHE A;  2YKS A;  5L4E A;  4AFT A;  3U8L A;  5CO5 A;  5SYO A;  5L4H A;  5AFJ A;  2XQ4 A;  3SIO A;  2XQ8 A;  4TWH A;  4ZRU A;  4XK9 A;  3TLV A;  1UV6 A;  4Z91 A;  3C79 A;  3PEO A;  2PH9 A;  3U8J A;  5FJV A;  4DBM A;  3WTN A;  4AFH A;  4ILA A;  3WTO A;  4TWF A;  3IGQ A;  4LMK A;  2XQ9 A;  4ZZB A;  4A97 A;  2BG9 E;  2XQ7 A;  3JAE A;  4NZB A;  5BW2 A;  4PIR A;  4EZ1 A;  2YMD A;  4UM3 P;  3SQ6 A;  4BFQ A;  4HFI A;  4ZZC A;  4HFH A;  4HFC A;  3ZDG A;  3PMZ A;  3SH1 A;  2YN6 A;  3T4M A;  4ILB A;  2BG9 C;  3EHZ A;  4ZR6 A;  2UZ6 A;  3UQ7 A;  2BR7 A;  4UM3 A;  3TLU A;  5HEJ A;  2BYQ A;  1I9B A;  4IRE A;  2XYS A;  2YOE A;  5TVC A;  5LXB A;  2PGZ A;  4UY2 A;  3RIA A;  3UU5 A;  5KZU A;  3RQU A;  3EAM A;  4Z90 A;  2W8F A;  2BG9 B;  5J5F A;  1UW6 A;  3WIP A;  2XNT A;  4FRR A;  3RQW A;  4COF A;  4TNW A;  2VL0 A;  2WNJ A;  5JME A;  5J5I A;  2XQA A;  3JAF A;  3RI5 A;  3WTM A;  4NPP A;  5HEU A;  4QAA A;  4LML A;  4BQT A;  5HEO A;  2XQ5 A;  2X00 A;  2XZ6 A;  3RHW A;  4ZJT A;  5HEG A;  3U8M A;  4QH1 A;  5HCM A;  2Y54 A;  4WV9 A;  3ZKR A;  3TLW A;  5J5G A;  4ZJS A;  5AFH A;  3TLS A;  4ZK1 A;  4AFG A;  5AFL A;  5BP0 A;  5IUX A;  5BRX A;  2Y56 A;  2BYS A;  4HQP A;  5J5H A;  4IL9 A;  2BYP A;  3SQ9 A;  5HCJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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