4UPHA

Crystal structure of phosphonate monoester hydrolase of agrobacterium radiobacter
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
sequence length
504
structure length
503
Chain Sequence
b'RPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPSPARATLYTGLYQMNHRVCRNGSPLDARFDNLALAARRGGYDPTLFGYTDTAPDPRGMDPNDPHLTTYEGVLPGFSARQLLPEHEKQWLSWLRSRGHPEATSRDIHIPVGATPGEISDVAPAYSKDETQTAFLAGEFIRWLGEQDAPWFAHVSFLRPHPPFSVPEPYNRMFTPSDGPAFARAANREAEQAVHPLLAFALPLIGKDSFIYGGEGSASDWTSEDLSAIRAIYYGMIAEVDTQLGRIWQALKNVGAWDDTLIIFTSDHAEMMGDHWMLGKGGFFDGSYHVPLVIRDPGHPGGAGRQVERFTSAADIFPTLCDRLGLVPDNHLDGGTLVPFLEGGEPEGWRDAAFWEFDFRDIAKGEAERHFGLKSNACNLAVIRDERFKYVHFAGLPPLLYDLAKDPMELTNVAADADYAAVRLGYAEKLLSLRAQHLDQTLAYTELTEKGPVSRRP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SULFATASE (SULFURIC ESTER HYDROLASE) PROTEIN
publication title Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
pubmed doi rcsb
source organism Agrobacterium radiobacter k84
molecule tags Hydrolase
total genus 169
structure length 503
sequence length 504
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
A PF16347 DUF4976 Domain of unknown function (DUF4976)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4uphA00
4KAVA 3BDHA 4UORA 4UPKA 1Y6VA 2G9YA 5EGEA 3M8YA 2W5RA 2VQRA 2W5XA 4KJGA 1ALHA 1ED8A 4KAYA 1N2LA 4ZG9A 4ZG7A 3B5QA 1ELXA 4CYSA 3MK2A 4FDJA 1ZEFA 5LRMA 1AJBA 1EJJA 2XRGA 1AJCA 5DLTA 3NKRA 3ED4A 2GLQA 5L0EA 2GSUA 1URBA 2XR9A 5KXAA 1AJDA 4LR9A 1ALJA 3OT9A 4N7TA 3WAWA 2ZKTA 3DPCA 5LRNA 2IUCA 1ANIA 4ZG6A 1HQAA 4QAXA 5K4PA 2W8SA 1EW8A 4GTWA 1B8JA 1K7HA 4LR8A 3SZZA 5LQQA 5IJSA 3MK1A 4NWJA 4ZGAA 1KHKA 5GOVA 1ED9A 1KH7A 3M7VA 4KJDA 3NKMA 3CMRA 1Y7AA 5IJQA 1E3CP 2GA3A 3BDGB 2X98A 4MIVA 1KHJA 4UOPA 1N2KA 4CYRA 5AJ9A 5GRRA 1SHNA 4LRDA 3T00A 4LREA 4GTXA 3T01A 4LQYA 1EW2A 1KH5A 3UN2A 4MY4A 1EI6A 4GTYA 4CXSA 1E33P 2ANHA 1E2SP 2GSOA 1ELZA 1ALKA 5TJ3A 3M8ZA 3M8WA 3DYCA 3UN5A 1EW9A 2RH6A 3UN3A 5L0BA 1ZEBA 1ALIA 4LR7A 1E1ZP 5L0KA 2W5TA 3Q3QA 3WAXA 4LRFA 1HJKA 2W5VA 4YR1A 3WAYA 3BDFA 5DLVA 4UPIA 3BDGA 1URAA 4UPLA 1KHLA 3NKNA 1ELYA 3IGZB 2W5SA 3WAVA 1SHQA 2W5WA 1AJAA 3MK0A 3T02A 3TX0A 2QZUA 5DLWA 1KH4A 4B56A 1KH9A 5LIAA 1AUKA 5HRTA 3NKOA 1FSUA 2W5QA 4LR2A 2D1GA 3UO0A 3A52A 1ANJA 2IFYA 4UPHA 1O99A 4UOOA 1EQJA 3LXQA 3TG0A 4CXKA 3TWZA 4CXUA 3NVLA 4KM4A 3SZYA 3KD8A 3E2DA 1O98A 3IGYB 4MHXA 4NWXA 5INHA 2W8DA 3IDDA 4LRAA 3NKPA 5EGHA 2GSNA 4TN0A 2IUCB 3WBHA 1HDHA 1KHNA 3NKQA 4LRCA 1P49A 4LRBA 4GTZA 4FDIA 5C66A 3UNYA 1ZEDA
chains in the Genus database with same CATH superfamily
4KAVA 3BDHA 4UORA 4UPKA 1Y6VA 2G9YA 5EGEA 3M8YA 2W5RA 2VQRA 2W5XA 4KJGA 1ALHA 1ED8A 4KAYA 1N2LA 4ZG9A 4ZG7A 3B5QA 1ELXA 4CYSA 3MK2A 4FDJA 1ZEFA 5LRMA 1AJBA 1EJJA 2XRGA 1AJCA 5DLTA 3NKRA 3ED4A 2GLQA 5L0EA 2GSUA 1URBA 2XR9A 5KXAA 1AJDA 4LR9A 1ALJA 3OT9A 4N7TA 3WAWA 2ZKTA 3DPCA 5LRNA 2IUCA 1ANIA 4ZG6A 1HQAA 4QAXA 5K4PA 2W8SA 1EW8A 4GTWA 1B8JA 1K7HA 4LR8A 3SZZA 5LQQA 5IJSA 3MK1A 4NWJA 4ZGAA 1KHKA 5GOVA 1ED9A 1KH7A 3M7VA 4KJDA 3NKMA 3CMRA 1Y7AA 5IJQA 1E3CP 2GA3A 3BDGB 2X98A 4MIVA 1KHJA 4UOPA 1N2KA 4CYRA 5AJ9A 5GRRA 1SHNA 4LRDA 3T00A 4LREA 4GTXA 3T01A 4LQYA 1EW2A 1KH5A 3UN2A 4MY4A 1EI6A 4GTYA 4CXSA 1E33P 2ANHA 1E2SP 2GSOA 1ELZA 1ALKA 5TJ3A 3M8ZA 3M8WA 3DYCA 3UN5A 1EW9A 2RH6A 3UN3A 5L0BA 1ZEBA 1ALIA 4LR7A 1E1ZP 5L0KA 2W5TA 3Q3QA 3WAXA 4LRFA 1HJKA 2W5VA 4YR1A 3WAYA 3BDFA 5DLVA 4UPIA 3BDGA 1URAA 4UPLA 1KHLA 3NKNA 1ELYA 3IGZB 2W5SA 3WAVA 1SHQA 2W5WA 1AJAA 3MK0A 3T02A 3TX0A 2QZUA 5DLWA 1KH4A 4B56A 1KH9A 5LIAA 1AUKA 5HRTA 3NKOA 1FSUA 2W5QA 4LR2A 2D1GA 3UO0A 3A52A 1ANJA 2IFYA 4UPHA 1O99A 4UOOA 1EQJA 3LXQA 3TG0A 4CXKA 3TWZA 4CXUA 3NVLA 4KM4A 3SZYA 3KD8A 3E2DA 1O98A 3IGYB 4MHXA 4NWXA 5INHA 2W8DA 3IDDA 4LRAA 3NKPA 5EGHA 2GSNA 4TN0A 2IUCB 3WBHA 1HDHA 1KHNA 3NKQA 4LRCA 1P49A 4LRBA 4GTZA 4FDIA 5C66A 3UNYA 1ZEDA
chains in the Genus database with same CATH topology
4KAVA 3BDHA 4UORA 4UPKA 1Y6VA 2G9YA 5EGEA 3M8YA 2W5RA 2VQRA 2W5XA 4KJGA 1ALHA 1ED8A 4KAYA 1N2LA 4ZG9A 4ZG7A 3B5QA 1ELXA 4CYSA 3MK2A 4FDJA 1ZEFA 5LRMA 1AJBA 1EJJA 2XRGA 1AJCA 5DLTA 3NKRA 3ED4A 2GLQA 5L0EA 2GSUA 1URBA 2XR9A 5KXAA 1AJDA 4LR9A 1ALJA 3OT9A 4N7TA 3WAWA 2ZKTA 3DPCA 5LRNA 2IUCA 1ANIA 4ZG6A 1HQAA 4QAXA 5K4PA 2W8SA 1EW8A 4GTWA 1B8JA 1K7HA 4LR8A 3SZZA 5LQQA 5IJSA 3MK1A 4NWJA 4ZGAA 1KHKA 5GOVA 1ED9A 1KH7A 3M7VA 4KJDA 3NKMA 3CMRA 1Y7AA 5IJQA 1E3CP 2GA3A 3BDGB 2X98A 4MIVA 1KHJA 4UOPA 1N2KA 4CYRA 5AJ9A 5GRRA 1SHNA 4LRDA 3T00A 4LREA 4GTXA 3T01A 4LQYA 1EW2A 1KH5A 3UN2A 4MY4A 1EI6A 4GTYA 4CXSA 1E33P 2ANHA 1E2SP 2GSOA 1ELZA 1ALKA 5TJ3A 3M8ZA 3M8WA 3DYCA 3UN5A 1EW9A 2RH6A 3UN3A 5L0BA 1ZEBA 1ALIA 4LR7A 1E1ZP 5L0KA 2W5TA 3Q3QA 3WAXA 4LRFA 1HJKA 2W5VA 4YR1A 3WAYA 3BDFA 5DLVA 4UPIA 3BDGA 1URAA 4UPLA 1KHLA 3NKNA 1ELYA 3IGZB 2W5SA 3WAVA 1SHQA 2W5WA 1AJAA 3MK0A 3T02A 3TX0A 2QZUA 5DLWA 1KH4A 4B56A 1KH9A 5LIAA 1AUKA 5HRTA 3NKOA 1FSUA 2W5QA 4LR2A 2D1GA 3UO0A 3A52A 1ANJA 2IFYA 4UPHA 1O99A 4UOOA 1EQJA 3LXQA 3TG0A 4CXKA 3TWZA 4CXUA 3NVLA 4KM4A 3SZYA 3KD8A 3E2DA 1O98A 3IGYB 4MHXA 4NWXA 5INHA 2W8DA 3IDDA 4LRAA 3NKPA 5EGHA 2GSNA 4TN0A 2IUCB 3WBHA 1HDHA 1KHNA 3NKQA 4LRCA 1P49A 4LRBA 4GTZA 4FDIA 5C66A 3UNYA 1ZEDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KAV A;  3BDH A;  4UOR A;  4UPK A;  1Y6V A;  2G9Y A;  5EGE A;  3M8Y A;  2W5R A;  2VQR A;  2W5X A;  4KJG A;  1ALH A;  1ED8 A;  4KAY A;  1N2L A;  4ZG9 A;  4ZG7 A;  3B5Q A;  1ELX A;  4CYS A;  3MK2 A;  4FDJ A;  1ZEF A;  5LRM A;  1AJB A;  1EJJ A;  2XRG A;  1AJC A;  5DLT A;  3NKR A;  3ED4 A;  2GLQ A;  5L0E A;  2GSU A;  1URB A;  2XR9 A;  5KXA A;  1AJD A;  4LR9 A;  1ALJ A;  3OT9 A;  4N7T A;  3WAW A;  2ZKT A;  3DPC A;  5LRN A;  2IUC A;  1ANI A;  4ZG6 A;  1HQA A;  4QAX A;  5K4P A;  2W8S A;  1EW8 A;  4GTW A;  1B8J A;  1K7H A;  4LR8 A;  3SZZ A;  5LQQ A;  5IJS A;  3MK1 A;  4NWJ A;  4ZGA A;  1KHK A;  5GOV A;  1ED9 A;  1KH7 A;  3M7V A;  4KJD A;  3NKM A;  3CMR A;  1Y7A A;  5IJQ A;  1E3C P;  2GA3 A;  3BDG B;  2X98 A;  4MIV A;  1KHJ A;  4UOP A;  1N2K A;  4CYR A;  5AJ9 A;  5GRR A;  1SHN A;  4LRD A;  3T00 A;  4LRE A;  4GTX A;  3T01 A;  4LQY A;  1EW2 A;  1KH5 A;  3UN2 A;  4MY4 A;  1EI6 A;  4GTY A;  4CXS A;  1E33 P;  2ANH A;  1E2S P;  2GSO A;  1ELZ A;  1ALK A;  5TJ3 A;  3M8Z A;  3M8W A;  3DYC A;  3UN5 A;  1EW9 A;  2RH6 A;  3UN3 A;  5L0B A;  1ZEB A;  1ALI A;  4LR7 A;  1E1Z P;  5L0K A;  2W5T A;  3Q3Q A;  3WAX A;  4LRF A;  1HJK A;  2W5V A;  4YR1 A;  3WAY A;  3BDF A;  5DLV A;  4UPI A;  3BDG A;  1URA A;  4UPL A;  1KHL A;  3NKN A;  1ELY A;  3IGZ B;  2W5S A;  3WAV A;  1SHQ A;  2W5W A;  1AJA A;  3MK0 A;  3T02 A;  3TX0 A;  2QZU A;  5DLW A;  1KH4 A;  4B56 A;  1KH9 A;  5LIA A;  1AUK A;  5HRT A;  3NKO A;  1FSU A;  2W5Q A;  4LR2 A;  2D1G A;  3UO0 A;  3A52 A;  1ANJ A;  2IFY A;  4UPH A;  1O99 A;  4UOO A;  1EQJ A;  3LXQ A;  3TG0 A;  4CXK A;  3TWZ A;  4CXU A;  3NVL A;  4KM4 A;  3SZY A;  3KD8 A;  3E2D A;  1O98 A;  3IGY B;  4MHX A;  4NWX A;  5INH A;  2W8D A;  3IDD A;  4LRA A;  3NKP A;  5EGH A;  2GSN A;  4TN0 A;  2IUC B;  3WBH A;  1HDH A;  1KHN A;  3NKQ A;  4LRC A;  1P49 A;  4LRB A;  4GTZ A;  4FDI A;  5C66 A;  3UNY A;  1ZED A; 
#chains in the Genus database with same CATH topology
 4KAV A;  3BDH A;  4UOR A;  4UPK A;  1Y6V A;  2G9Y A;  5EGE A;  3M8Y A;  2W5R A;  2VQR A;  2W5X A;  4KJG A;  1ALH A;  1ED8 A;  4KAY A;  1N2L A;  4ZG9 A;  4ZG7 A;  3B5Q A;  1ELX A;  4CYS A;  3MK2 A;  4FDJ A;  1ZEF A;  5LRM A;  1AJB A;  1EJJ A;  2XRG A;  1AJC A;  5DLT A;  3NKR A;  3ED4 A;  2GLQ A;  5L0E A;  2GSU A;  1URB A;  2XR9 A;  5KXA A;  1AJD A;  4LR9 A;  1ALJ A;  3OT9 A;  4N7T A;  3WAW A;  2ZKT A;  3DPC A;  5LRN A;  2IUC A;  1ANI A;  4ZG6 A;  1HQA A;  4QAX A;  5K4P A;  2W8S A;  1EW8 A;  4GTW A;  1B8J A;  1K7H A;  4LR8 A;  3SZZ A;  5LQQ A;  5IJS A;  3MK1 A;  4NWJ A;  4ZGA A;  1KHK A;  5GOV A;  1ED9 A;  1KH7 A;  3M7V A;  4KJD A;  3NKM A;  3CMR A;  1Y7A A;  5IJQ A;  1E3C P;  2GA3 A;  3BDG B;  2X98 A;  4MIV A;  1KHJ A;  4UOP A;  1N2K A;  4CYR A;  5AJ9 A;  5GRR A;  1SHN A;  4LRD A;  3T00 A;  4LRE A;  4GTX A;  3T01 A;  4LQY A;  1EW2 A;  1KH5 A;  3UN2 A;  4MY4 A;  1EI6 A;  4GTY A;  4CXS A;  1E33 P;  2ANH A;  1E2S P;  2GSO A;  1ELZ A;  1ALK A;  5TJ3 A;  3M8Z A;  3M8W A;  3DYC A;  3UN5 A;  1EW9 A;  2RH6 A;  3UN3 A;  5L0B A;  1ZEB A;  1ALI A;  4LR7 A;  1E1Z P;  5L0K A;  2W5T A;  3Q3Q A;  3WAX A;  4LRF A;  1HJK A;  2W5V A;  4YR1 A;  3WAY A;  3BDF A;  5DLV A;  4UPI A;  3BDG A;  1URA A;  4UPL A;  1KHL A;  3NKN A;  1ELY A;  3IGZ B;  2W5S A;  3WAV A;  1SHQ A;  2W5W A;  1AJA A;  3MK0 A;  3T02 A;  3TX0 A;  2QZU A;  5DLW A;  1KH4 A;  4B56 A;  1KH9 A;  5LIA A;  1AUK A;  5HRT A;  3NKO A;  1FSU A;  2W5Q A;  4LR2 A;  2D1G A;  3UO0 A;  3A52 A;  1ANJ A;  2IFY A;  4UPH A;  1O99 A;  4UOO A;  1EQJ A;  3LXQ A;  3TG0 A;  4CXK A;  3TWZ A;  4CXU A;  3NVL A;  4KM4 A;  3SZY A;  3KD8 A;  3E2D A;  1O98 A;  3IGY B;  4MHX A;  4NWX A;  5INH A;  2W8D A;  3IDD A;  4LRA A;  3NKP A;  5EGH A;  2GSN A;  4TN0 A;  2IUC B;  3WBH A;  1HDH A;  1KHN A;  3NKQ A;  4LRC A;  1P49 A;  4LRB A;  4GTZ A;  4FDI A;  5C66 A;  3UNY A;  1ZED A; 
#chains in the Genus database with same CATH homology
 4KAV A;  3BDH A;  4UOR A;  4UPK A;  1Y6V A;  2G9Y A;  5EGE A;  3M8Y A;  2W5R A;  2VQR A;  2W5X A;  4KJG A;  1ALH A;  1ED8 A;  4KAY A;  1N2L A;  4ZG9 A;  4ZG7 A;  3B5Q A;  1ELX A;  4CYS A;  3MK2 A;  4FDJ A;  1ZEF A;  5LRM A;  1AJB A;  1EJJ A;  2XRG A;  1AJC A;  5DLT A;  3NKR A;  3ED4 A;  2GLQ A;  5L0E A;  2GSU A;  1URB A;  2XR9 A;  5KXA A;  1AJD A;  4LR9 A;  1ALJ A;  3OT9 A;  4N7T A;  3WAW A;  2ZKT A;  3DPC A;  5LRN A;  2IUC A;  1ANI A;  4ZG6 A;  1HQA A;  4QAX A;  5K4P A;  2W8S A;  1EW8 A;  4GTW A;  1B8J A;  1K7H A;  4LR8 A;  3SZZ A;  5LQQ A;  5IJS A;  3MK1 A;  4NWJ A;  4ZGA A;  1KHK A;  5GOV A;  1ED9 A;  1KH7 A;  3M7V A;  4KJD A;  3NKM A;  3CMR A;  1Y7A A;  5IJQ A;  1E3C P;  2GA3 A;  3BDG B;  2X98 A;  4MIV A;  1KHJ A;  4UOP A;  1N2K A;  4CYR A;  5AJ9 A;  5GRR A;  1SHN A;  4LRD A;  3T00 A;  4LRE A;  4GTX A;  3T01 A;  4LQY A;  1EW2 A;  1KH5 A;  3UN2 A;  4MY4 A;  1EI6 A;  4GTY A;  4CXS A;  1E33 P;  2ANH A;  1E2S P;  2GSO A;  1ELZ A;  1ALK A;  5TJ3 A;  3M8Z A;  3M8W A;  3DYC A;  3UN5 A;  1EW9 A;  2RH6 A;  3UN3 A;  5L0B A;  1ZEB A;  1ALI A;  4LR7 A;  1E1Z P;  5L0K A;  2W5T A;  3Q3Q A;  3WAX A;  4LRF A;  1HJK A;  2W5V A;  4YR1 A;  3WAY A;  3BDF A;  5DLV A;  4UPI A;  3BDG A;  1URA A;  4UPL A;  1KHL A;  3NKN A;  1ELY A;  3IGZ B;  2W5S A;  3WAV A;  1SHQ A;  2W5W A;  1AJA A;  3MK0 A;  3T02 A;  3TX0 A;  2QZU A;  5DLW A;  1KH4 A;  4B56 A;  1KH9 A;  5LIA A;  1AUK A;  5HRT A;  3NKO A;  1FSU A;  2W5Q A;  4LR2 A;  2D1G A;  3UO0 A;  3A52 A;  1ANJ A;  2IFY A;  4UPH A;  1O99 A;  4UOO A;  1EQJ A;  3LXQ A;  3TG0 A;  4CXK A;  3TWZ A;  4CXU A;  3NVL A;  4KM4 A;  3SZY A;  3KD8 A;  3E2D A;  1O98 A;  3IGY B;  4MHX A;  4NWX A;  5INH A;  2W8D A;  3IDD A;  4LRA A;  3NKP A;  5EGH A;  2GSN A;  4TN0 A;  2IUC B;  3WBH A;  1HDH A;  1KHN A;  3NKQ A;  4LRC A;  1P49 A;  4LRB A;  4GTZ A;  4FDI A;  5C66 A;  3UNY A;  1ZED A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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