4UPIA

Dimeric sulfatase spas1 from silicibacter pomeroyi
Total Genus 217
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
217
sequence length
548
structure length
547
Chain Sequence
b'NRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATVGPSRMSAYTGRYVRSHGSTQNGIPLRVGEPTLGDHLRDVGMRNVLIGKTHMRPDLDGMKRLGIDPDSEIGARVGEGGFDAFDRDDGVHPTGYRKKEPAYNDYLRHAGFQAENPWEFWANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFMEAAEKDGRPWCAHLSYIKPHWPYIVPAPYHDMFGPDDVKPAVRSDEELKAAHPLFKAMTEEVYSRNFARDEVREKVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYLGDHWMGEKYLFYEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAPTFVDYAGGVPPMHILEGKSLLPLLHDDDSSWDRQYVFSELDYSNLPARLKLGRDIQDCRATMVFDGRYKLVEVMGFAPILFDLEVDPDELKDLGRDPSAEEVRQRLTSALDAWHRNTRQRITKSDAAYRALDPVLRESDPDLMAGVIIGYWDEDEVEAEKRRIARILGEN'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SULFATASE FAMILY PROTEIN
publication title Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
pubmed doi rcsb
source organism Ruegeria pomeroyi
molecule tags Hydrolase
total genus 217
structure length 547
sequence length 548
ec nomenclature
pdb deposition date 2014-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4upiA01
3M8WA 4B56A 1EW9A 4ZG7A 3OT9A 5EGEA 5GOVA 2GSUA 2XRGA 2D1GA 4CYSA 4CYRA 1K7HA 5DLVA 4LRFA 3UO0A 4UPIA 2GLQA 4CXSA 1E1ZP 2W8SA 4UPLA 4GTWA 4LR7A 4TN0A 1B8JA 1AUKA 1KHKA 4LR9A 1ZEDA 1HJKA 3MK1A 4LR8A 3DPCA 1ANIA 4KJGA 5C66A 1N2LA 4YR1A 2W5RA 1KHLA 1KH7A 1O99A 2G9YA 4NWJA 3UN3A 4KAYA 2W5TA 3WAVA 3BDGB 1ZEBA 4LRBA 5DLWA 3T01A 2IUCA 3TWZA 4GTZA 1O98A 1EW2A 2W5XA 4LRAA 2X98A 5K4PA 3T00A 3TX0A 3SZZA 2W8DA 5TJ3A 1ALKA 2QZUA 2ZKTA 1EQJA 5L0EA 5L0BA 4GTYA 3M7VA 5AJ9A 1E33P 3NKOA 1AJDA 3BDGA 2IFYA 2GSOA 3WBHA 2GA3A 5LIAA 1EI6A 4UORA 4UOPA 1ALHA 3WAWA 1URAA 4FDIA 2VQRA 4LQYA 3M8YA 4MY4A 1FSUA 1E3CP 1N2KA 1HQAA 1SHNA 2W5SA 1AJBA 5KXAA 3LXQA 3NKPA 3MK2A 2W5WA 3KD8A 3NKMA 5LRMA 1ED9A 3ED4A 4N7TA 1KH5A 5INHA 1ZEFA 1ELZA 1EW8A 5IJSA 3IDDA 5IJQA 2W5VA 3CMRA 3DYCA 3BDFA 4KAVA 3UN2A 4ZG9A 3E2DA 5DLTA 5LQQA 4ZGAA 4LR2A 5L0KA 1ED8A 4CXKA 1KH4A 4LRDA 3MK0A 3M8ZA 3NVLA 3B5QA 1Y6VA 1AJCA 1HDHA 5LRNA 1EJJA 1P49A 1ALIA 4KM4A 4ZG6A 3IGYB 4NWXA 4LRCA 3WAYA 2RH6A 3NKQA 1AJAA 5HRTA 4FDJA 1Y7AA 4UOOA 1ELYA 1ALJA 2ANHA 1E2SP 4UPHA 1ELXA 3IGZB 3WAXA 3Q3QA 4UPKA 2IUCB 2W5QA 3BDHA 4MHXA 4CXUA 3NKRA 4MIVA 3UNYA 5EGHA 4LREA 2XR9A 1KH9A 3UN5A 3NKNA 3A52A 3SZYA 1URBA 1SHQA 4GTXA 1KHJA 3T02A 4QAXA 1ANJA 4KJDA 2GSNA 3TG0A 1KHNA 5GRRA
chains in the Genus database with same CATH superfamily
3M8WA 4B56A 1EW9A 4ZG7A 3OT9A 5EGEA 5GOVA 2GSUA 2XRGA 2D1GA 4CYSA 4CYRA 1K7HA 5DLVA 4LRFA 3UO0A 4UPIA 2GLQA 4CXSA 1E1ZP 2W8SA 4UPLA 4GTWA 4LR7A 4TN0A 1B8JA 1AUKA 1KHKA 4LR9A 1ZEDA 1HJKA 3MK1A 4LR8A 3DPCA 1ANIA 4KJGA 5C66A 1N2LA 4YR1A 2W5RA 1KHLA 1KH7A 1O99A 2G9YA 4NWJA 3UN3A 4KAYA 2W5TA 3WAVA 3BDGB 1ZEBA 4LRBA 5DLWA 3T01A 2IUCA 3TWZA 4GTZA 1O98A 1EW2A 2W5XA 4LRAA 2X98A 5K4PA 3T00A 3TX0A 3SZZA 2W8DA 5TJ3A 1ALKA 2QZUA 2ZKTA 1EQJA 5L0EA 5L0BA 4GTYA 3M7VA 5AJ9A 1E33P 3NKOA 1AJDA 3BDGA 2IFYA 2GSOA 3WBHA 2GA3A 5LIAA 1EI6A 4UORA 4UOPA 1ALHA 3WAWA 1URAA 4FDIA 2VQRA 4LQYA 3M8YA 4MY4A 1FSUA 1E3CP 1N2KA 1HQAA 1SHNA 2W5SA 1AJBA 5KXAA 3LXQA 3NKPA 3MK2A 2W5WA 3KD8A 3NKMA 5LRMA 1ED9A 3ED4A 4N7TA 1KH5A 5INHA 1ZEFA 1ELZA 1EW8A 5IJSA 3IDDA 5IJQA 2W5VA 3CMRA 3DYCA 3BDFA 4KAVA 3UN2A 4ZG9A 3E2DA 5DLTA 5LQQA 4ZGAA 4LR2A 5L0KA 1ED8A 4CXKA 1KH4A 4LRDA 3MK0A 3M8ZA 3NVLA 3B5QA 1Y6VA 1AJCA 1HDHA 5LRNA 1EJJA 1P49A 1ALIA 4KM4A 4ZG6A 3IGYB 4NWXA 4LRCA 3WAYA 2RH6A 3NKQA 1AJAA 5HRTA 4FDJA 1Y7AA 4UOOA 1ELYA 1ALJA 2ANHA 1E2SP 4UPHA 1ELXA 3IGZB 3WAXA 3Q3QA 4UPKA 2IUCB 2W5QA 3BDHA 4MHXA 4CXUA 3NKRA 4MIVA 3UNYA 5EGHA 4LREA 2XR9A 1KH9A 3UN5A 3NKNA 3A52A 3SZYA 1URBA 1SHQA 4GTXA 1KHJA 3T02A 4QAXA 1ANJA 4KJDA 2GSNA 3TG0A 1KHNA 5GRRA
chains in the Genus database with same CATH topology
3M8WA 4B56A 1EW9A 4ZG7A 3OT9A 5EGEA 5GOVA 2GSUA 2XRGA 2D1GA 4CYSA 4CYRA 1K7HA 5DLVA 4LRFA 3UO0A 4UPIA 2GLQA 4CXSA 1E1ZP 2W8SA 4UPLA 4GTWA 4LR7A 4TN0A 1B8JA 1AUKA 1KHKA 4LR9A 1ZEDA 1HJKA 3MK1A 4LR8A 3DPCA 1ANIA 4KJGA 5C66A 1N2LA 4YR1A 2W5RA 1KHLA 1KH7A 1O99A 2G9YA 4NWJA 3UN3A 4KAYA 2W5TA 3WAVA 3BDGB 1ZEBA 4LRBA 5DLWA 3T01A 2IUCA 3TWZA 4GTZA 1O98A 1EW2A 2W5XA 4LRAA 2X98A 5K4PA 3T00A 3TX0A 3SZZA 2W8DA 5TJ3A 1ALKA 2QZUA 2ZKTA 1EQJA 5L0EA 5L0BA 4GTYA 3M7VA 5AJ9A 1E33P 3NKOA 1AJDA 3BDGA 2IFYA 2GSOA 3WBHA 2GA3A 5LIAA 1EI6A 4UORA 4UOPA 1ALHA 3WAWA 1URAA 4FDIA 2VQRA 4LQYA 3M8YA 4MY4A 1FSUA 1E3CP 1N2KA 1HQAA 1SHNA 2W5SA 1AJBA 5KXAA 3LXQA 3NKPA 3MK2A 2W5WA 3KD8A 3NKMA 5LRMA 1ED9A 3ED4A 4N7TA 1KH5A 5INHA 1ZEFA 1ELZA 1EW8A 5IJSA 3IDDA 5IJQA 2W5VA 3CMRA 3DYCA 3BDFA 4KAVA 3UN2A 4ZG9A 3E2DA 5DLTA 5LQQA 4ZGAA 4LR2A 5L0KA 1ED8A 4CXKA 1KH4A 4LRDA 3MK0A 3M8ZA 3NVLA 3B5QA 1Y6VA 1AJCA 1HDHA 5LRNA 1EJJA 1P49A 1ALIA 4KM4A 4ZG6A 3IGYB 4NWXA 4LRCA 3WAYA 2RH6A 3NKQA 1AJAA 5HRTA 4FDJA 1Y7AA 4UOOA 1ELYA 1ALJA 2ANHA 1E2SP 4UPHA 1ELXA 3IGZB 3WAXA 3Q3QA 4UPKA 2IUCB 2W5QA 3BDHA 4MHXA 4CXUA 3NKRA 4MIVA 3UNYA 5EGHA 4LREA 2XR9A 1KH9A 3UN5A 3NKNA 3A52A 3SZYA 1URBA 1SHQA 4GTXA 1KHJA 3T02A 4QAXA 1ANJA 4KJDA 2GSNA 3TG0A 1KHNA 5GRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M8W A;  4B56 A;  1EW9 A;  4ZG7 A;  3OT9 A;  5EGE A;  5GOV A;  2GSU A;  2XRG A;  2D1G A;  4CYS A;  4CYR A;  1K7H A;  5DLV A;  4LRF A;  3UO0 A;  4UPI A;  2GLQ A;  4CXS A;  1E1Z P;  2W8S A;  4UPL A;  4GTW A;  4LR7 A;  4TN0 A;  1B8J A;  1AUK A;  1KHK A;  4LR9 A;  1ZED A;  1HJK A;  3MK1 A;  4LR8 A;  3DPC A;  1ANI A;  4KJG A;  5C66 A;  1N2L A;  4YR1 A;  2W5R A;  1KHL A;  1KH7 A;  1O99 A;  2G9Y A;  4NWJ A;  3UN3 A;  4KAY A;  2W5T A;  3WAV A;  3BDG B;  1ZEB A;  4LRB A;  5DLW A;  3T01 A;  2IUC A;  3TWZ A;  4GTZ A;  1O98 A;  1EW2 A;  2W5X A;  4LRA A;  2X98 A;  5K4P A;  3T00 A;  3TX0 A;  3SZZ A;  2W8D A;  5TJ3 A;  1ALK A;  2QZU A;  2ZKT A;  1EQJ A;  5L0E A;  5L0B A;  4GTY A;  3M7V A;  5AJ9 A;  1E33 P;  3NKO A;  1AJD A;  3BDG A;  2IFY A;  2GSO A;  3WBH A;  2GA3 A;  5LIA A;  1EI6 A;  4UOR A;  4UOP A;  1ALH A;  3WAW A;  1URA A;  4FDI A;  2VQR A;  4LQY A;  3M8Y A;  4MY4 A;  1FSU A;  1E3C P;  1N2K A;  1HQA A;  1SHN A;  2W5S A;  1AJB A;  5KXA A;  3LXQ A;  3NKP A;  3MK2 A;  2W5W A;  3KD8 A;  3NKM A;  5LRM A;  1ED9 A;  3ED4 A;  4N7T A;  1KH5 A;  5INH A;  1ZEF A;  1ELZ A;  1EW8 A;  5IJS A;  3IDD A;  5IJQ A;  2W5V A;  3CMR A;  3DYC A;  3BDF A;  4KAV A;  3UN2 A;  4ZG9 A;  3E2D A;  5DLT A;  5LQQ A;  4ZGA A;  4LR2 A;  5L0K A;  1ED8 A;  4CXK A;  1KH4 A;  4LRD A;  3MK0 A;  3M8Z A;  3NVL A;  3B5Q A;  1Y6V A;  1AJC A;  1HDH A;  5LRN A;  1EJJ A;  1P49 A;  1ALI A;  4KM4 A;  4ZG6 A;  3IGY B;  4NWX A;  4LRC A;  3WAY A;  2RH6 A;  3NKQ A;  1AJA A;  5HRT A;  4FDJ A;  1Y7A A;  4UOO A;  1ELY A;  1ALJ A;  2ANH A;  1E2S P;  4UPH A;  1ELX A;  3IGZ B;  3WAX A;  3Q3Q A;  4UPK A;  2IUC B;  2W5Q A;  3BDH A;  4MHX A;  4CXU A;  3NKR A;  4MIV A;  3UNY A;  5EGH A;  4LRE A;  2XR9 A;  1KH9 A;  3UN5 A;  3NKN A;  3A52 A;  3SZY A;  1URB A;  1SHQ A;  4GTX A;  1KHJ A;  3T02 A;  4QAX A;  1ANJ A;  4KJD A;  2GSN A;  3TG0 A;  1KHN A;  5GRR A; 
#chains in the Genus database with same CATH topology
 3M8W A;  4B56 A;  1EW9 A;  4ZG7 A;  3OT9 A;  5EGE A;  5GOV A;  2GSU A;  2XRG A;  2D1G A;  4CYS A;  4CYR A;  1K7H A;  5DLV A;  4LRF A;  3UO0 A;  4UPI A;  2GLQ A;  4CXS A;  1E1Z P;  2W8S A;  4UPL A;  4GTW A;  4LR7 A;  4TN0 A;  1B8J A;  1AUK A;  1KHK A;  4LR9 A;  1ZED A;  1HJK A;  3MK1 A;  4LR8 A;  3DPC A;  1ANI A;  4KJG A;  5C66 A;  1N2L A;  4YR1 A;  2W5R A;  1KHL A;  1KH7 A;  1O99 A;  2G9Y A;  4NWJ A;  3UN3 A;  4KAY A;  2W5T A;  3WAV A;  3BDG B;  1ZEB A;  4LRB A;  5DLW A;  3T01 A;  2IUC A;  3TWZ A;  4GTZ A;  1O98 A;  1EW2 A;  2W5X A;  4LRA A;  2X98 A;  5K4P A;  3T00 A;  3TX0 A;  3SZZ A;  2W8D A;  5TJ3 A;  1ALK A;  2QZU A;  2ZKT A;  1EQJ A;  5L0E A;  5L0B A;  4GTY A;  3M7V A;  5AJ9 A;  1E33 P;  3NKO A;  1AJD A;  3BDG A;  2IFY A;  2GSO A;  3WBH A;  2GA3 A;  5LIA A;  1EI6 A;  4UOR A;  4UOP A;  1ALH A;  3WAW A;  1URA A;  4FDI A;  2VQR A;  4LQY A;  3M8Y A;  4MY4 A;  1FSU A;  1E3C P;  1N2K A;  1HQA A;  1SHN A;  2W5S A;  1AJB A;  5KXA A;  3LXQ A;  3NKP A;  3MK2 A;  2W5W A;  3KD8 A;  3NKM A;  5LRM A;  1ED9 A;  3ED4 A;  4N7T A;  1KH5 A;  5INH A;  1ZEF A;  1ELZ A;  1EW8 A;  5IJS A;  3IDD A;  5IJQ A;  2W5V A;  3CMR A;  3DYC A;  3BDF A;  4KAV A;  3UN2 A;  4ZG9 A;  3E2D A;  5DLT A;  5LQQ A;  4ZGA A;  4LR2 A;  5L0K A;  1ED8 A;  4CXK A;  1KH4 A;  4LRD A;  3MK0 A;  3M8Z A;  3NVL A;  3B5Q A;  1Y6V A;  1AJC A;  1HDH A;  5LRN A;  1EJJ A;  1P49 A;  1ALI A;  4KM4 A;  4ZG6 A;  3IGY B;  4NWX A;  4LRC A;  3WAY A;  2RH6 A;  3NKQ A;  1AJA A;  5HRT A;  4FDJ A;  1Y7A A;  4UOO A;  1ELY A;  1ALJ A;  2ANH A;  1E2S P;  4UPH A;  1ELX A;  3IGZ B;  3WAX A;  3Q3Q A;  4UPK A;  2IUC B;  2W5Q A;  3BDH A;  4MHX A;  4CXU A;  3NKR A;  4MIV A;  3UNY A;  5EGH A;  4LRE A;  2XR9 A;  1KH9 A;  3UN5 A;  3NKN A;  3A52 A;  3SZY A;  1URB A;  1SHQ A;  4GTX A;  1KHJ A;  3T02 A;  4QAX A;  1ANJ A;  4KJD A;  2GSN A;  3TG0 A;  1KHN A;  5GRR A; 
#chains in the Genus database with same CATH homology
 3M8W A;  4B56 A;  1EW9 A;  4ZG7 A;  3OT9 A;  5EGE A;  5GOV A;  2GSU A;  2XRG A;  2D1G A;  4CYS A;  4CYR A;  1K7H A;  5DLV A;  4LRF A;  3UO0 A;  4UPI A;  2GLQ A;  4CXS A;  1E1Z P;  2W8S A;  4UPL A;  4GTW A;  4LR7 A;  4TN0 A;  1B8J A;  1AUK A;  1KHK A;  4LR9 A;  1ZED A;  1HJK A;  3MK1 A;  4LR8 A;  3DPC A;  1ANI A;  4KJG A;  5C66 A;  1N2L A;  4YR1 A;  2W5R A;  1KHL A;  1KH7 A;  1O99 A;  2G9Y A;  4NWJ A;  3UN3 A;  4KAY A;  2W5T A;  3WAV A;  3BDG B;  1ZEB A;  4LRB A;  5DLW A;  3T01 A;  2IUC A;  3TWZ A;  4GTZ A;  1O98 A;  1EW2 A;  2W5X A;  4LRA A;  2X98 A;  5K4P A;  3T00 A;  3TX0 A;  3SZZ A;  2W8D A;  5TJ3 A;  1ALK A;  2QZU A;  2ZKT A;  1EQJ A;  5L0E A;  5L0B A;  4GTY A;  3M7V A;  5AJ9 A;  1E33 P;  3NKO A;  1AJD A;  3BDG A;  2IFY A;  2GSO A;  3WBH A;  2GA3 A;  5LIA A;  1EI6 A;  4UOR A;  4UOP A;  1ALH A;  3WAW A;  1URA A;  4FDI A;  2VQR A;  4LQY A;  3M8Y A;  4MY4 A;  1FSU A;  1E3C P;  1N2K A;  1HQA A;  1SHN A;  2W5S A;  1AJB A;  5KXA A;  3LXQ A;  3NKP A;  3MK2 A;  2W5W A;  3KD8 A;  3NKM A;  5LRM A;  1ED9 A;  3ED4 A;  4N7T A;  1KH5 A;  5INH A;  1ZEF A;  1ELZ A;  1EW8 A;  5IJS A;  3IDD A;  5IJQ A;  2W5V A;  3CMR A;  3DYC A;  3BDF A;  4KAV A;  3UN2 A;  4ZG9 A;  3E2D A;  5DLT A;  5LQQ A;  4ZGA A;  4LR2 A;  5L0K A;  1ED8 A;  4CXK A;  1KH4 A;  4LRD A;  3MK0 A;  3M8Z A;  3NVL A;  3B5Q A;  1Y6V A;  1AJC A;  1HDH A;  5LRN A;  1EJJ A;  1P49 A;  1ALI A;  4KM4 A;  4ZG6 A;  3IGY B;  4NWX A;  4LRC A;  3WAY A;  2RH6 A;  3NKQ A;  1AJA A;  5HRT A;  4FDJ A;  1Y7A A;  4UOO A;  1ELY A;  1ALJ A;  2ANH A;  1E2S P;  4UPH A;  1ELX A;  3IGZ B;  3WAX A;  3Q3Q A;  4UPK A;  2IUC B;  2W5Q A;  3BDH A;  4MHX A;  4CXU A;  3NKR A;  4MIV A;  3UNY A;  5EGH A;  4LRE A;  2XR9 A;  1KH9 A;  3UN5 A;  3NKN A;  3A52 A;  3SZY A;  1URB A;  1SHQ A;  4GTX A;  1KHJ A;  3T02 A;  4QAX A;  1ANJ A;  4KJD A;  2GSN A;  3TG0 A;  1KHN A;  5GRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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