4URVS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
478
structure length
450
Chain Sequence
RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords GTPASE HRAS
total genus 178
structure length 450
sequence length 478
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4urvS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4urvS01
3T6AA 4JGWA 1XD4A 2IJES 1NVVS 3KSYA 4MH0E 4URXS 4MGYE 1NVWS 4NYIS 4F7ZA 4US1S 3T6GA 5CM8A 4US2S 2BYVE 4URWS 3CF6E 4URVS 1XD2C 4URYS 4L9MA 5CM9A 4MGKE 4NYMS 1NVUS 4NYJS 1NVXS 4URUS 4MGIE 4MGZE 4US0S 1BKDS 4URZS 2II0A 3QXLA
chains in the Genus database with same CATH superfamily
3T6AA 4JGWA 1XD4A 2IJES 1NVVS 3KSYA 4MH0E 4URXS 4MGYE 1NVWS 4NYIS 4F7ZA 4US1S 3T6GA 5CM8A 4US2S 2BYVE 4URWS 3CF6E 4URVS 1XD2C 4URYS 4L9MA 5CM9A 4MGKE 4NYMS 1NVUS 4NYJS 1NVXS 4URUS 4MGIE 4MGZE 4US0S 1BKDS 4URZS 2II0A 3QXLA
chains in the Genus database with same CATH topology
3T6AA 4JGWA 1XD4A 2IJES 1NVVS 3KSYA 4MH0E 4URXS 4MGYE 1NVWS 4NYIS 4F7ZA 4US1S 3T6GA 5CM8A 4US2S 2BYVE 4URWS 3CF6E 4URVS 1XD2C 4URYS 4L9MA 5CM9A 4MGKE 4NYMS 1NVUS 4NYJS 1NVXS 4URUS 4MGIE 4MGZE 4US0S 1BKDS 4URZS 2II0A 3QXLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T6A A;  4JGW A;  1XD4 A;  2IJE S;  1NVV S;  3KSY A;  4MH0 E;  4URX S;  4MGY E;  1NVW S;  4NYI S;  4F7Z A;  4US1 S;  3T6G A;  5CM8 A;  4US2 S;  2BYV E;  4URW S;  3CF6 E;  4URV S;  1XD2 C;  4URY S;  4L9M A;  5CM9 A;  4MGK E;  4NYM S;  1NVU S;  4NYJ S;  1NVX S;  4URU S;  4MGI E;  4MGZ E;  4US0 S;  1BKD S;  4URZ S;  2II0 A;  3QXL A; 
#chains in the Genus database with same CATH topology
 3T6A A;  4JGW A;  1XD4 A;  2IJE S;  1NVV S;  3KSY A;  4MH0 E;  4URX S;  4MGY E;  1NVW S;  4NYI S;  4F7Z A;  4US1 S;  3T6G A;  5CM8 A;  4US2 S;  2BYV E;  4URW S;  3CF6 E;  4URV S;  1XD2 C;  4URY S;  4L9M A;  5CM9 A;  4MGK E;  4NYM S;  1NVU S;  4NYJ S;  1NVX S;  4URU S;  4MGI E;  4MGZ E;  4US0 S;  1BKD S;  4URZ S;  2II0 A;  3QXL A; 
#chains in the Genus database with same CATH homology
 3T6A A;  4JGW A;  1XD4 A;  2IJE S;  1NVV S;  3KSY A;  4MH0 E;  4URX S;  4MGY E;  1NVW S;  4NYI S;  4F7Z A;  4US1 S;  3T6G A;  5CM8 A;  4US2 S;  2BYV E;  4URW S;  3CF6 E;  4URV S;  1XD2 C;  4URY S;  4L9M A;  5CM9 A;  4MGK E;  4NYM S;  1NVU S;  4NYJ S;  1NVX S;  4URU S;  4MGI E;  4MGZ E;  4US0 S;  1BKD S;  4URZ S;  2II0 A;  3QXL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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