4URVS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 178
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
478
structure length
450
Chain Sequence
RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords GTPASE HRAS
publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
total genus 178
structure length 450
sequence length 478
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4urvS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4urvS01
4NYIS 1XD2C 1NVUS 1NVVS 4URZS 1BKDS 1XD4A 1NVWS 4MH0E 4URXS 3QXLA 2IJES 4L9MA 4JGWA 3CF6E 4US1S 4URWS 4URYS 4US0S 3KSYA 4URVS 4NYJS 4MGIE 2II0A 4NYMS 3T6AA 4MGYE 4MGKE 4URUS 5CM9A 4US2S 1NVXS 3T6GA 5CM8A 4MGZE 4F7ZA 2BYVE
chains in the Genus database with same CATH superfamily
4NYIS 1XD2C 1NVUS 1NVVS 4URZS 1BKDS 1XD4A 1NVWS 4MH0E 4URXS 3QXLA 2IJES 4L9MA 4JGWA 3CF6E 4US1S 4URWS 4URYS 4US0S 3KSYA 4URVS 4NYJS 4MGIE 2II0A 4NYMS 3T6AA 4MGYE 4MGKE 4URUS 5CM9A 4US2S 1NVXS 3T6GA 5CM8A 4MGZE 4F7ZA 2BYVE
chains in the Genus database with same CATH topology
4NYIS 1XD2C 1NVUS 1NVVS 4URZS 1BKDS 1XD4A 1NVWS 4MH0E 4URXS 3QXLA 2IJES 4L9MA 4JGWA 3CF6E 4US1S 4URWS 4URYS 4US0S 3KSYA 4URVS 4NYJS 4MGIE 2II0A 4NYMS 3T6AA 4MGYE 4MGKE 4URUS 5CM9A 4US2S 1NVXS 3T6GA 5CM8A 4MGZE 4F7ZA 2BYVE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NYI S;  1XD2 C;  1NVU S;  1NVV S;  4URZ S;  1BKD S;  1XD4 A;  1NVW S;  4MH0 E;  4URX S;  3QXL A;  2IJE S;  4L9M A;  4JGW A;  3CF6 E;  4US1 S;  4URW S;  4URY S;  4US0 S;  3KSY A;  4URV S;  4NYJ S;  4MGI E;  2II0 A;  4NYM S;  3T6A A;  4MGY E;  4MGK E;  4URU S;  5CM9 A;  4US2 S;  1NVX S;  3T6G A;  5CM8 A;  4MGZ E;  4F7Z A;  2BYV E; 
#chains in the Genus database with same CATH topology
 4NYI S;  1XD2 C;  1NVU S;  1NVV S;  4URZ S;  1BKD S;  1XD4 A;  1NVW S;  4MH0 E;  4URX S;  3QXL A;  2IJE S;  4L9M A;  4JGW A;  3CF6 E;  4US1 S;  4URW S;  4URY S;  4US0 S;  3KSY A;  4URV S;  4NYJ S;  4MGI E;  2II0 A;  4NYM S;  3T6A A;  4MGY E;  4MGK E;  4URU S;  5CM9 A;  4US2 S;  1NVX S;  3T6G A;  5CM8 A;  4MGZ E;  4F7Z A;  2BYV E; 
#chains in the Genus database with same CATH homology
 4NYI S;  1XD2 C;  1NVU S;  1NVV S;  4URZ S;  1BKD S;  1XD4 A;  1NVW S;  4MH0 E;  4URX S;  3QXL A;  2IJE S;  4L9M A;  4JGW A;  3CF6 E;  4US1 S;  4URW S;  4URY S;  4US0 S;  3KSY A;  4URV S;  4NYJ S;  4MGI E;  2II0 A;  4NYM S;  3T6A A;  4MGY E;  4MGK E;  4URU S;  5CM9 A;  4US2 S;  1NVX S;  3T6G A;  5CM8 A;  4MGZ E;  4F7Z A;  2BYV E; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...