4URVS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
478
structure length
450
Chain Sequence
RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 178
structure length 450
sequence length 478
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4urvS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4urvS01
4US2S 3T6AA 4MGKE 3T6GA 5CM9A 4NYJS 4MGYE 4URWS 1NVXS 4NYMS 4US1S 1XD2C 3CF6E 4US0S 4URXS 4URVS 3QXLA 1NVUS 2BYVE 2IJES 4JGWA 4MGZE 3KSYA 1NVVS 1XD4A 4URYS 4URZS 5CM8A 4F7ZA 4L9MA 1NVWS 1BKDS 2II0A 4URUS 4NYIS 4MH0E 4MGIE
chains in the Genus database with same CATH superfamily
4US2S 3T6AA 4MGKE 3T6GA 5CM9A 4NYJS 4MGYE 4URWS 1NVXS 4NYMS 4US1S 1XD2C 3CF6E 4US0S 4URXS 4URVS 3QXLA 1NVUS 2BYVE 2IJES 4JGWA 4MGZE 3KSYA 1NVVS 1XD4A 4URYS 4URZS 5CM8A 4F7ZA 4L9MA 1NVWS 1BKDS 2II0A 4URUS 4NYIS 4MH0E 4MGIE
chains in the Genus database with same CATH topology
4US2S 3T6AA 4MGKE 3T6GA 5CM9A 4NYJS 4MGYE 4URWS 1NVXS 4NYMS 4US1S 1XD2C 3CF6E 4US0S 4URXS 4URVS 3QXLA 1NVUS 2BYVE 2IJES 4JGWA 4MGZE 3KSYA 1NVVS 1XD4A 4URYS 4URZS 5CM8A 4F7ZA 4L9MA 1NVWS 1BKDS 2II0A 4URUS 4NYIS 4MH0E 4MGIE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4US2 S;  3T6A A;  4MGK E;  3T6G A;  5CM9 A;  4NYJ S;  4MGY E;  4URW S;  1NVX S;  4NYM S;  4US1 S;  1XD2 C;  3CF6 E;  4US0 S;  4URX S;  4URV S;  3QXL A;  1NVU S;  2BYV E;  2IJE S;  4JGW A;  4MGZ E;  3KSY A;  1NVV S;  1XD4 A;  4URY S;  4URZ S;  5CM8 A;  4F7Z A;  4L9M A;  1NVW S;  1BKD S;  2II0 A;  4URU S;  4NYI S;  4MH0 E;  4MGI E; 
#chains in the Genus database with same CATH topology
 4US2 S;  3T6A A;  4MGK E;  3T6G A;  5CM9 A;  4NYJ S;  4MGY E;  4URW S;  1NVX S;  4NYM S;  4US1 S;  1XD2 C;  3CF6 E;  4US0 S;  4URX S;  4URV S;  3QXL A;  1NVU S;  2BYV E;  2IJE S;  4JGW A;  4MGZ E;  3KSY A;  1NVV S;  1XD4 A;  4URY S;  4URZ S;  5CM8 A;  4F7Z A;  4L9M A;  1NVW S;  1BKD S;  2II0 A;  4URU S;  4NYI S;  4MH0 E;  4MGI E; 
#chains in the Genus database with same CATH homology
 4US2 S;  3T6A A;  4MGK E;  3T6G A;  5CM9 A;  4NYJ S;  4MGY E;  4URW S;  1NVX S;  4NYM S;  4US1 S;  1XD2 C;  3CF6 E;  4US0 S;  4URX S;  4URV S;  3QXL A;  1NVU S;  2BYV E;  2IJE S;  4JGW A;  4MGZ E;  3KSY A;  1NVV S;  1XD4 A;  4URY S;  4URZ S;  5CM8 A;  4F7Z A;  4L9M A;  1NVW S;  1BKD S;  2II0 A;  4URU S;  4NYI S;  4MH0 E;  4MGI E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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