4URYS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
480
structure length
449
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords GTPASE HRAS
publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
total genus 173
structure length 449
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4uryS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4uryS01
4MGYE 4MH0E 5CM9A 2II0A 3CF6E 1XD2C 4MGZE 4US0S 1XD4A 5CM8A 1NVUS 4MGKE 4URVS 4JGWA 4L9MA 4URUS 4URYS 1NVVS 4URZS 4NYMS 4US1S 2BYVE 4F7ZA 1NVXS 4URWS 3T6GA 1NVWS 3QXLA 4NYJS 1BKDS 4US2S 4MGIE 3KSYA 3T6AA 4NYIS 4URXS 2IJES
chains in the Genus database with same CATH superfamily
4MGYE 4MH0E 5CM9A 2II0A 3CF6E 1XD2C 4MGZE 4US0S 1XD4A 5CM8A 1NVUS 4MGKE 4URVS 4JGWA 4L9MA 4URUS 4URYS 1NVVS 4URZS 4NYMS 4US1S 2BYVE 4F7ZA 1NVXS 4URWS 3T6GA 1NVWS 3QXLA 4NYJS 1BKDS 4US2S 4MGIE 3KSYA 3T6AA 4NYIS 4URXS 2IJES
chains in the Genus database with same CATH topology
4MGYE 4MH0E 5CM9A 2II0A 3CF6E 1XD2C 4MGZE 4US0S 1XD4A 5CM8A 1NVUS 4MGKE 4URVS 4JGWA 4L9MA 4URUS 4URYS 1NVVS 4URZS 4NYMS 4US1S 2BYVE 4F7ZA 1NVXS 4URWS 3T6GA 1NVWS 3QXLA 4NYJS 1BKDS 4US2S 4MGIE 3KSYA 3T6AA 4NYIS 4URXS 2IJES
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MGY E;  4MH0 E;  5CM9 A;  2II0 A;  3CF6 E;  1XD2 C;  4MGZ E;  4US0 S;  1XD4 A;  5CM8 A;  1NVU S;  4MGK E;  4URV S;  4JGW A;  4L9M A;  4URU S;  4URY S;  1NVV S;  4URZ S;  4NYM S;  4US1 S;  2BYV E;  4F7Z A;  1NVX S;  4URW S;  3T6G A;  1NVW S;  3QXL A;  4NYJ S;  1BKD S;  4US2 S;  4MGI E;  3KSY A;  3T6A A;  4NYI S;  4URX S;  2IJE S; 
#chains in the Genus database with same CATH topology
 4MGY E;  4MH0 E;  5CM9 A;  2II0 A;  3CF6 E;  1XD2 C;  4MGZ E;  4US0 S;  1XD4 A;  5CM8 A;  1NVU S;  4MGK E;  4URV S;  4JGW A;  4L9M A;  4URU S;  4URY S;  1NVV S;  4URZ S;  4NYM S;  4US1 S;  2BYV E;  4F7Z A;  1NVX S;  4URW S;  3T6G A;  1NVW S;  3QXL A;  4NYJ S;  1BKD S;  4US2 S;  4MGI E;  3KSY A;  3T6A A;  4NYI S;  4URX S;  2IJE S; 
#chains in the Genus database with same CATH homology
 4MGY E;  4MH0 E;  5CM9 A;  2II0 A;  3CF6 E;  1XD2 C;  4MGZ E;  4US0 S;  1XD4 A;  5CM8 A;  1NVU S;  4MGK E;  4URV S;  4JGW A;  4L9M A;  4URU S;  4URY S;  1NVV S;  4URZ S;  4NYM S;  4US1 S;  2BYV E;  4F7Z A;  1NVX S;  4URW S;  3T6G A;  1NVW S;  3QXL A;  4NYJ S;  1BKD S;  4US2 S;  4MGI E;  3KSY A;  3T6A A;  4NYI S;  4URX S;  2IJE S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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