4URYS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
480
structure length
449
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 173
structure length 449
sequence length 480
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4uryS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4uryS01
2IJES 4JGWA 4L9MA 1XD4A 4NYIS 4MH0E 4F7ZA 1NVWS 1NVVS 2II0A 3T6GA 1BKDS 2BYVE 4MGYE 5CM8A 4NYMS 5CM9A 4URUS 1XD2C 1NVXS 3T6AA 4URZS 4URYS 4URWS 4US0S 4NYJS 1NVUS 4MGKE 4MGZE 3CF6E 4MGIE 4URVS 4US1S 3KSYA 3QXLA 4URXS 4US2S
chains in the Genus database with same CATH superfamily
2IJES 4JGWA 4L9MA 1XD4A 4NYIS 4MH0E 4F7ZA 1NVWS 1NVVS 2II0A 3T6GA 1BKDS 2BYVE 4MGYE 5CM8A 4NYMS 5CM9A 4URUS 1XD2C 1NVXS 3T6AA 4URZS 4URYS 4URWS 4US0S 4NYJS 1NVUS 4MGKE 4MGZE 3CF6E 4MGIE 4URVS 4US1S 3KSYA 3QXLA 4URXS 4US2S
chains in the Genus database with same CATH topology
2IJES 4JGWA 4L9MA 1XD4A 4NYIS 4MH0E 4F7ZA 1NVWS 1NVVS 2II0A 3T6GA 1BKDS 2BYVE 4MGYE 5CM8A 4NYMS 5CM9A 4URUS 1XD2C 1NVXS 3T6AA 4URZS 4URYS 4URWS 4US0S 4NYJS 1NVUS 4MGKE 4MGZE 3CF6E 4MGIE 4URVS 4US1S 3KSYA 3QXLA 4URXS 4US2S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IJE S;  4JGW A;  4L9M A;  1XD4 A;  4NYI S;  4MH0 E;  4F7Z A;  1NVW S;  1NVV S;  2II0 A;  3T6G A;  1BKD S;  2BYV E;  4MGY E;  5CM8 A;  4NYM S;  5CM9 A;  4URU S;  1XD2 C;  1NVX S;  3T6A A;  4URZ S;  4URY S;  4URW S;  4US0 S;  4NYJ S;  1NVU S;  4MGK E;  4MGZ E;  3CF6 E;  4MGI E;  4URV S;  4US1 S;  3KSY A;  3QXL A;  4URX S;  4US2 S; 
#chains in the Genus database with same CATH topology
 2IJE S;  4JGW A;  4L9M A;  1XD4 A;  4NYI S;  4MH0 E;  4F7Z A;  1NVW S;  1NVV S;  2II0 A;  3T6G A;  1BKD S;  2BYV E;  4MGY E;  5CM8 A;  4NYM S;  5CM9 A;  4URU S;  1XD2 C;  1NVX S;  3T6A A;  4URZ S;  4URY S;  4URW S;  4US0 S;  4NYJ S;  1NVU S;  4MGK E;  4MGZ E;  3CF6 E;  4MGI E;  4URV S;  4US1 S;  3KSY A;  3QXL A;  4URX S;  4US2 S; 
#chains in the Genus database with same CATH homology
 2IJE S;  4JGW A;  4L9M A;  1XD4 A;  4NYI S;  4MH0 E;  4F7Z A;  1NVW S;  1NVV S;  2II0 A;  3T6G A;  1BKD S;  2BYV E;  4MGY E;  5CM8 A;  4NYM S;  5CM9 A;  4URU S;  1XD2 C;  1NVX S;  3T6A A;  4URZ S;  4URY S;  4URW S;  4US0 S;  4NYJ S;  1NVU S;  4MGK E;  4MGZ E;  3CF6 E;  4MGI E;  4URV S;  4US1 S;  3KSY A;  3QXL A;  4URX S;  4US2 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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