4URZS

The crystal structure of h-ras and sos in complex with ligands
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
479
structure length
454
Chain Sequence
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords GTPASE HRAS
total genus 176
structure length 454
sequence length 479
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4urzS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4urzS01
4US0S 4MGZE 3KSYA 4JGWA 5CM9A 1BKDS 1XD4A 4MGKE 4URUS 4URWS 4NYIS 2II0A 4URXS 2IJES 1NVVS 4MH0E 1NVUS 4URYS 5CM8A 4URZS 1NVWS 4US2S 4MGIE 4URVS 3CF6E 1XD2C 3QXLA 3T6GA 1NVXS 4NYJS 4F7ZA 4MGYE 4L9MA 4NYMS 3T6AA 2BYVE 4US1S
chains in the Genus database with same CATH superfamily
4US0S 4MGZE 3KSYA 4JGWA 5CM9A 1BKDS 1XD4A 4MGKE 4URUS 4URWS 4NYIS 2II0A 4URXS 2IJES 1NVVS 4MH0E 1NVUS 4URYS 5CM8A 4URZS 1NVWS 4US2S 4MGIE 4URVS 3CF6E 1XD2C 3QXLA 3T6GA 1NVXS 4NYJS 4F7ZA 4MGYE 4L9MA 4NYMS 3T6AA 2BYVE 4US1S
chains in the Genus database with same CATH topology
4US0S 4MGZE 3KSYA 4JGWA 5CM9A 1BKDS 1XD4A 4MGKE 4URUS 4URWS 4NYIS 2II0A 4URXS 2IJES 1NVVS 4MH0E 1NVUS 4URYS 5CM8A 4URZS 1NVWS 4US2S 4MGIE 4URVS 3CF6E 1XD2C 3QXLA 3T6GA 1NVXS 4NYJS 4F7ZA 4MGYE 4L9MA 4NYMS 3T6AA 2BYVE 4US1S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4US0 S;  4MGZ E;  3KSY A;  4JGW A;  5CM9 A;  1BKD S;  1XD4 A;  4MGK E;  4URU S;  4URW S;  4NYI S;  2II0 A;  4URX S;  2IJE S;  1NVV S;  4MH0 E;  1NVU S;  4URY S;  5CM8 A;  4URZ S;  1NVW S;  4US2 S;  4MGI E;  4URV S;  3CF6 E;  1XD2 C;  3QXL A;  3T6G A;  1NVX S;  4NYJ S;  4F7Z A;  4MGY E;  4L9M A;  4NYM S;  3T6A A;  2BYV E;  4US1 S; 
#chains in the Genus database with same CATH topology
 4US0 S;  4MGZ E;  3KSY A;  4JGW A;  5CM9 A;  1BKD S;  1XD4 A;  4MGK E;  4URU S;  4URW S;  4NYI S;  2II0 A;  4URX S;  2IJE S;  1NVV S;  4MH0 E;  1NVU S;  4URY S;  5CM8 A;  4URZ S;  1NVW S;  4US2 S;  4MGI E;  4URV S;  3CF6 E;  1XD2 C;  3QXL A;  3T6G A;  1NVX S;  4NYJ S;  4F7Z A;  4MGY E;  4L9M A;  4NYM S;  3T6A A;  2BYV E;  4US1 S; 
#chains in the Genus database with same CATH homology
 4US0 S;  4MGZ E;  3KSY A;  4JGW A;  5CM9 A;  1BKD S;  1XD4 A;  4MGK E;  4URU S;  4URW S;  4NYI S;  2II0 A;  4URX S;  2IJE S;  1NVV S;  4MH0 E;  1NVU S;  4URY S;  5CM8 A;  4URZ S;  1NVW S;  4US2 S;  4MGI E;  4URV S;  3CF6 E;  1XD2 C;  3QXL A;  3T6G A;  1NVX S;  4NYJ S;  4F7Z A;  4MGY E;  4L9M A;  4NYM S;  3T6A A;  2BYV E;  4US1 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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