4US1S

The crystal structure of h-ras and sos in complex with ligands
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
481
structure length
455
Chain Sequence
EQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPESAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords GTPASE HRAS
publication title Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
pubmed doi rcsb
source organism Homo sapiens
total genus 174
structure length 455
sequence length 481
ec nomenclature
pdb deposition date 2014-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4us1S02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4us1S01
4MGKE 4URZS 4MGIE 1XD4A 1BKDS 4URYS 1NVUS 1XD2C 4NYIS 2IJES 4MGYE 3KSYA 4US2S 5CM8A 3QXLA 1NVXS 4NYJS 4F7ZA 4URWS 1NVWS 3CF6E 4URUS 5CM9A 4MH0E 4JGWA 4NYMS 1NVVS 4URXS 4L9MA 4URVS 3T6GA 4US1S 4MGZE 2BYVE 3T6AA 2II0A 4US0S
chains in the Genus database with same CATH superfamily
4MGKE 4URZS 4MGIE 1XD4A 1BKDS 4URYS 1NVUS 1XD2C 4NYIS 2IJES 4MGYE 3KSYA 4US2S 5CM8A 3QXLA 1NVXS 4NYJS 4F7ZA 4URWS 1NVWS 3CF6E 4URUS 5CM9A 4MH0E 4JGWA 4NYMS 1NVVS 4URXS 4L9MA 4URVS 3T6GA 4US1S 4MGZE 2BYVE 3T6AA 2II0A 4US0S
chains in the Genus database with same CATH topology
4MGKE 4URZS 4MGIE 1XD4A 1BKDS 4URYS 1NVUS 1XD2C 4NYIS 2IJES 4MGYE 3KSYA 4US2S 5CM8A 3QXLA 1NVXS 4NYJS 4F7ZA 4URWS 1NVWS 3CF6E 4URUS 5CM9A 4MH0E 4JGWA 4NYMS 1NVVS 4URXS 4L9MA 4URVS 3T6GA 4US1S 4MGZE 2BYVE 3T6AA 2II0A 4US0S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MGK E;  4URZ S;  4MGI E;  1XD4 A;  1BKD S;  4URY S;  1NVU S;  1XD2 C;  4NYI S;  2IJE S;  4MGY E;  3KSY A;  4US2 S;  5CM8 A;  3QXL A;  1NVX S;  4NYJ S;  4F7Z A;  4URW S;  1NVW S;  3CF6 E;  4URU S;  5CM9 A;  4MH0 E;  4JGW A;  4NYM S;  1NVV S;  4URX S;  4L9M A;  4URV S;  3T6G A;  4US1 S;  4MGZ E;  2BYV E;  3T6A A;  2II0 A;  4US0 S; 
#chains in the Genus database with same CATH topology
 4MGK E;  4URZ S;  4MGI E;  1XD4 A;  1BKD S;  4URY S;  1NVU S;  1XD2 C;  4NYI S;  2IJE S;  4MGY E;  3KSY A;  4US2 S;  5CM8 A;  3QXL A;  1NVX S;  4NYJ S;  4F7Z A;  4URW S;  1NVW S;  3CF6 E;  4URU S;  5CM9 A;  4MH0 E;  4JGW A;  4NYM S;  1NVV S;  4URX S;  4L9M A;  4URV S;  3T6G A;  4US1 S;  4MGZ E;  2BYV E;  3T6A A;  2II0 A;  4US0 S; 
#chains in the Genus database with same CATH homology
 4MGK E;  4URZ S;  4MGI E;  1XD4 A;  1BKD S;  4URY S;  1NVU S;  1XD2 C;  4NYI S;  2IJE S;  4MGY E;  3KSY A;  4US2 S;  5CM8 A;  3QXL A;  1NVX S;  4NYJ S;  4F7Z A;  4URW S;  1NVW S;  3CF6 E;  4URU S;  5CM9 A;  4MH0 E;  4JGW A;  4NYM S;  1NVV S;  4URX S;  4L9M A;  4URV S;  3T6G A;  4US1 S;  4MGZ E;  2BYV E;  3T6A A;  2II0 A;  4US0 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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