4UU9C

Crystal structure of the human c5a in complex with medi7814 a neutralising antibody
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
65
structure length
65
Chain Sequence
STLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords MEDI7814
publication title Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
pubmed doi rcsb
source organism Homo sapiens
total genus 24
structure length 65
sequence length 65
chains with identical sequence D
ec nomenclature
pdb deposition date 2014-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 4uu9C00
5B4PB 1KJSA 4FXKB 4P3AA 4P39A 2B39A 3CU7A 3HQBA 1C5AA 3HQAA 2A73B 4WB3A 4I6OA 3KLSA 1CFAA 4WB2A 5JPNB 4UU9C 4P3BA 4HW5A 4HWJA
chains in the Genus database with same CATH superfamily
4FXGB 5B4PB 1KJSA 4FXKB 4D9JA 4P3AA 4P39A 3MD2A 2B39A 3CU7A 4ITVA 4IQ4A 4PUSA 1EA3A 3HQBA 1C5AA 3HQAA 2A73B 4WB3A 2Z16A 3VDXA 4I6OA 5JPMB 3KLSA 1CFAA 4WB2A 1AA7A 5JPNB 4UU9C 4P3BA 4HW5A 5CQEA 4HWJA
chains in the Genus database with same CATH topology
5B4PB 1KJSA 4FXKB 4P3AA 4P39A 2B39A 3CU7A 3HQBA 1C5AA 3HQAA 2A73B 4WB3A 4I6OA 3KLSA 1CFAA 4WB2A 5JPNB 4UU9C 4P3BA 4HW5A 4HWJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5B4P B;  1KJS A;  4FXK B;  4P3A A;  4P39 A;  2B39 A;  3CU7 A;  3HQB A;  1C5A A;  3HQA A;  2A73 B;  4WB3 A;  4I6O A;  3KLS A;  1CFA A;  4WB2 A;  5JPN B;  4UU9 C;  4P3B A;  4HW5 A;  4HWJ A; 
#chains in the Genus database with same CATH topology
 4FXG B;  5B4P B;  1KJS A;  4FXK B;  4D9J A;  4P3A A;  4P39 A;  3MD2 A;  2B39 A;  3CU7 A;  4ITV A;  4IQ4 A;  4PUS A;  1EA3 A;  3HQB A;  1C5A A;  3HQA A;  2A73 B;  4WB3 A;  2Z16 A;  3VDX A;  4I6O A;  5JPM B;  3KLS A;  1CFA A;  4WB2 A;  1AA7 A;  5JPN B;  4UU9 C;  4P3B A;  4HW5 A;  5CQE A;  4HWJ A; 
#chains in the Genus database with same CATH homology
 5B4P B;  1KJS A;  4FXK B;  4P3A A;  4P39 A;  2B39 A;  3CU7 A;  3HQB A;  1C5A A;  3HQA A;  2A73 B;  4WB3 A;  4I6O A;  3KLS A;  1CFA A;  4WB2 A;  5JPN B;  4UU9 C;  4P3B A;  4HW5 A;  4HWJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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