4V2RA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 250
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
250
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE (L-BETA-PHENYLALANINE FORMING)
publication title Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 250
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2rA02
1Q5NA 4NSLA 4BABA 1U16A 3E04A 1FUQA 4HGVA 1DOFA 2J91A 5HW2A 1U15A 1C3UA 1YFEA 5EYTA 2RJSA 1GKJA 3RRPA 3UNVA 1HY0A 3TV2A 2QGAB 1TJWA 1C3CA 3R6VA 5F91A 4MX2A 1GK3A 3RD8A 4CQ5A 1TJVA 2PTRA 2O7DA 4C5UA 1DCNA 2PTSA 4ADLA 3C8TA 1T6PA 3GTDA 2O6YA 4APBA 4C5SA 4APAA 1TJUA 3OCEA 4C6GA 3NO9A 2PTQA 1RE5A 2O7EA 4V2RA 3KDYA 3R6YA 1JSWA 5D6BA 1VDKA 2VD6A 1TJ7A 4FLCA 1FURA 3KDZA 5EYVA 1AUWA 1GK2A 1GKMA 3OCFA 1K62A 1YFMA 2PFMA 2E9FA 3CZOA 2NYFA 5F92A 2YIIA 1FUOA 1J3UA 4V2QA 1KQ7A 1XWOA 2O78A 4ADMA 4FFXA 1FUPA 2NYNA 1HY1A 3R6QA 2RJRA 1YISA 3QBPA 2HVGA 4NLEA 3GZHA 2FUSA 2QVEA 4BAAA 4EEIA 3BHGA 1Y2MA 2O7FA 1B8FA 1I0AA 4C5RA 1W27A 1EB4A 2O7BA 1K7WA 4EFCA 1T6JA 2OHYA 3NZ4A 2X75A
chains in the Genus database with same CATH superfamily
2Y0NA 1Q5NA 4NSLA 4BABA 2N3EA 1Y1WA 1U16A 3E04A 2EZAA 1FUQA 4HGVA 1K83A 1YNND 1DOFA 2J91A 5HW2A 4CEJA 1U15A 1C3UA 1R9TA 1XL7A 4WNLA 1ZYMA 1YFEA 5EYTA 2NVYA 2RJSA 1GKJA 2NVXA 3RRPA 1XLYA 3UNVA 1HY0A 3TV2A 2QGAB 1YNJD 1TJWA 2VL7A 1C3CA 1SMYD 3R6VA 5F91A 4MX2A 1GK3A 3RD8A 4CQ5A 1TJVA 2FENA 2PTRA 2JA6A 2K3QA 2O7DA 1HQMD 4C5UA 1WCMA 1DCNA 2PTSA 4ADLA 3GTQA 4CEHA 2O5JD 2E2IA 5IZ2A 3C8TA 2LTHA 1T6PA 3U44A 1XL8A 3GTOA 3CRVA 3GTDA 2O6YA 4APBA 4C5SA 1TWHA 4APAA 1TJUA 3OCEA 2MQAA 2BE5D 2R93A 3GTMA 2X0OA 4C6GA 3H0GA 3NO9A 2PTQA 1RE5A 2O7EA 4V2RA 2LPIA 3GTPA 2HWGA 1XMDA 3KDYA 3R6YA 1TWCA 1JSWA 2R92A 1Y1VA 4CEIA 5D6BA 2AQLA 1VDKA 2VD6A 1TJ7A 4QIWA 2LKMB 4FBSA 4FLCA 4C2MA 2LPJA 1FURA 2MX9A 2MX8A 3KDZA 4A15A 3LR6A 5EYVA 2HROA 1AUWA 1I50A 1XMCA 1GK2A 1SFOA 1GKMA 2JA7A 3OCFA 1TWFA 1K62A 2A6ED 2VK9A 1YFMA 2PFMA 2E9FA 2JA5A 2X0QA 1I3QA 2A6HD 1EZBA 3CZOA 3CQZA 3U4QA 2E2HA 2NYFA 2MP0A 2YIIA 1FUOA 5F92A 1ZYRD 3GTLA 3GTKA 1J3UA 4V2QA 3GTGA 2VUMA 1KQ7A 2K3OA 1XWOA 1TWGA 2FIOA 3EZBA 1I6VD 2CW0D 2O78A 4ADMA 4FFXA 2FELA 2X0PA 3LR2A 2A68D 1IW7D 2VSFA 1FUPA 2F5JA 2NYNA 2FIPA 3EZAA 1HY1A 3R6QA 5H8WA 1EZAA 3GTJA 2RJRA 1YISA 3QBPA 2HVGA 4NLEA 3GZHA 2FUSA 1TWAA 2QVEA 2EZCA 3FKIA 3LRDA 4BAAA 3EZEA 2R7ZA 3CRW1 4EEIA 2K3NA 2YU9A 2N1DB 3BHGA 2LYIA 1Y2MA 2O7FA 1B8FA 1I0AA 5M0IA 1W27A 4C5RA 1EB4A 2O7BA 1K7WA 4EFCA 1T6JA 2A69D 2OHYA 3NZ4A 5M0JA 3LR8A 2B63A 2X75A 2EZBA
chains in the Genus database with same CATH topology
1Q5NA 4NSLA 4BABA 1U16A 3E04A 1FUQA 4HGVA 1DOFA 2J91A 5HW2A 1U15A 1C3UA 1YFEA 5EYTA 2RJSA 1GKJA 3RRPA 3UNVA 1HY0A 3TV2A 2QGAB 1TJWA 1C3CA 3R6VA 5F91A 4MX2A 1GK3A 3RD8A 4CQ5A 1TJVA 2PTRA 2O7DA 4C5UA 1DCNA 2PTSA 4ADLA 3C8TA 1T6PA 3GTDA 2O6YA 4APBA 4C5SA 4APAA 1TJUA 3OCEA 4C6GA 3NO9A 2PTQA 1RE5A 2O7EA 4V2RA 3KDYA 3R6YA 1JSWA 5D6BA 1VDKA 2VD6A 1TJ7A 4FLCA 1FURA 3KDZA 5EYVA 1AUWA 1GK2A 1GKMA 3OCFA 1K62A 1YFMA 2PFMA 2E9FA 3CZOA 2NYFA 5F92A 2YIIA 1FUOA 1J3UA 4V2QA 1KQ7A 1XWOA 2O78A 4ADMA 4FFXA 1FUPA 2NYNA 1HY1A 3R6QA 2RJRA 1YISA 3QBPA 2HVGA 4NLEA 3GZHA 2FUSA 2QVEA 4BAAA 4EEIA 3BHGA 1Y2MA 2O7FA 1B8FA 1I0AA 4C5RA 1W27A 1EB4A 2O7BA 1K7WA 4EFCA 1T6JA 2OHYA 3NZ4A 2X75A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q5N A;  4NSL A;  4BAB A;  1U16 A;  3E04 A;  1FUQ A;  4HGV A;  1DOF A;  2J91 A;  5HW2 A;  1U15 A;  1C3U A;  1YFE A;  5EYT A;  2RJS A;  1GKJ A;  3RRP A;  3UNV A;  1HY0 A;  3TV2 A;  2QGA B;  1TJW A;  1C3C A;  3R6V A;  5F91 A;  4MX2 A;  1GK3 A;  3RD8 A;  4CQ5 A;  1TJV A;  2PTR A;  2O7D A;  4C5U A;  1DCN A;  2PTS A;  4ADL A;  3C8T A;  1T6P A;  3GTD A;  2O6Y A;  4APB A;  4C5S A;  4APA A;  1TJU A;  3OCE A;  4C6G A;  3NO9 A;  2PTQ A;  1RE5 A;  2O7E A;  4V2R A;  3KDY A;  3R6Y A;  1JSW A;  5D6B A;  1VDK A;  2VD6 A;  1TJ7 A;  4FLC A;  1FUR A;  3KDZ A;  5EYV A;  1AUW A;  1GK2 A;  1GKM A;  3OCF A;  1K62 A;  1YFM A;  2PFM A;  2E9F A;  3CZO A;  2NYF A;  5F92 A;  2YII A;  1FUO A;  1J3U A;  4V2Q A;  1KQ7 A;  1XWO A;  2O78 A;  4ADM A;  4FFX A;  1FUP A;  2NYN A;  1HY1 A;  3R6Q A;  2RJR A;  1YIS A;  3QBP A;  2HVG A;  4NLE A;  3GZH A;  2FUS A;  2QVE A;  4BAA A;  4EEI A;  3BHG A;  1Y2M A;  2O7F A;  1B8F A;  1I0A A;  4C5R A;  1W27 A;  1EB4 A;  2O7B A;  1K7W A;  4EFC A;  1T6J A;  2OHY A;  3NZ4 A;  2X75 A; 
#chains in the Genus database with same CATH topology
 2Y0N A;  1Q5N A;  4NSL A;  4BAB A;  2N3E A;  1Y1W A;  1U16 A;  3E04 A;  2EZA A;  1FUQ A;  4HGV A;  1K83 A;  1YNN D;  1DOF A;  2J91 A;  5HW2 A;  4CEJ A;  1U15 A;  1C3U A;  1R9T A;  1XL7 A;  4WNL A;  1ZYM A;  1YFE A;  5EYT A;  2NVY A;  2RJS A;  1GKJ A;  2NVX A;  3RRP A;  1XLY A;  3UNV A;  1HY0 A;  3TV2 A;  2QGA B;  1YNJ D;  1TJW A;  2VL7 A;  1C3C A;  1SMY D;  3R6V A;  5F91 A;  4MX2 A;  1GK3 A;  3RD8 A;  4CQ5 A;  1TJV A;  2FEN A;  2PTR A;  2JA6 A;  2K3Q A;  2O7D A;  1HQM D;  4C5U A;  1WCM A;  1DCN A;  2PTS A;  4ADL A;  3GTQ A;  4CEH A;  2O5J D;  2E2I A;  5IZ2 A;  3C8T A;  2LTH A;  1T6P A;  3U44 A;  1XL8 A;  3GTO A;  3CRV A;  3GTD A;  2O6Y A;  4APB A;  4C5S A;  1TWH A;  4APA A;  1TJU A;  3OCE A;  2MQA A;  2BE5 D;  2R93 A;  3GTM A;  2X0O A;  4C6G A;  3H0G A;  3NO9 A;  2PTQ A;  1RE5 A;  2O7E A;  4V2R A;  2LPI A;  3GTP A;  2HWG A;  1XMD A;  3KDY A;  3R6Y A;  1TWC A;  1JSW A;  2R92 A;  1Y1V A;  4CEI A;  5D6B A;  2AQL A;  1VDK A;  2VD6 A;  1TJ7 A;  4QIW A;  2LKM B;  4FBS A;  4FLC A;  4C2M A;  2LPJ A;  1FUR A;  2MX9 A;  2MX8 A;  3KDZ A;  4A15 A;  3LR6 A;  5EYV A;  2HRO A;  1AUW A;  1I50 A;  1XMC A;  1GK2 A;  1SFO A;  1GKM A;  2JA7 A;  3OCF A;  1TWF A;  1K62 A;  2A6E D;  2VK9 A;  1YFM A;  2PFM A;  2E9F A;  2JA5 A;  2X0Q A;  1I3Q A;  2A6H D;  1EZB A;  3CZO A;  3CQZ A;  3U4Q A;  2E2H A;  2NYF A;  2MP0 A;  2YII A;  1FUO A;  5F92 A;  1ZYR D;  3GTL A;  3GTK A;  1J3U A;  4V2Q A;  3GTG A;  2VUM A;  1KQ7 A;  2K3O A;  1XWO A;  1TWG A;  2FIO A;  3EZB A;  1I6V D;  2CW0 D;  2O78 A;  4ADM A;  4FFX A;  2FEL A;  2X0P A;  3LR2 A;  2A68 D;  1IW7 D;  2VSF A;  1FUP A;  2F5J A;  2NYN A;  2FIP A;  3EZA A;  1HY1 A;  3R6Q A;  5H8W A;  1EZA A;  3GTJ A;  2RJR A;  1YIS A;  3QBP A;  2HVG A;  4NLE A;  3GZH A;  2FUS A;  1TWA A;  2QVE A;  2EZC A;  3FKI A;  3LRD A;  4BAA A;  3EZE A;  2R7Z A;  3CRW 1;  4EEI A;  2K3N A;  2YU9 A;  2N1D B;  3BHG A;  2LYI A;  1Y2M A;  2O7F A;  1B8F A;  1I0A A;  5M0I A;  1W27 A;  4C5R A;  1EB4 A;  2O7B A;  1K7W A;  4EFC A;  1T6J A;  2A69 D;  2OHY A;  3NZ4 A;  5M0J A;  3LR8 A;  2B63 A;  2X75 A;  2EZB A; 
#chains in the Genus database with same CATH homology
 1Q5N A;  4NSL A;  4BAB A;  1U16 A;  3E04 A;  1FUQ A;  4HGV A;  1DOF A;  2J91 A;  5HW2 A;  1U15 A;  1C3U A;  1YFE A;  5EYT A;  2RJS A;  1GKJ A;  3RRP A;  3UNV A;  1HY0 A;  3TV2 A;  2QGA B;  1TJW A;  1C3C A;  3R6V A;  5F91 A;  4MX2 A;  1GK3 A;  3RD8 A;  4CQ5 A;  1TJV A;  2PTR A;  2O7D A;  4C5U A;  1DCN A;  2PTS A;  4ADL A;  3C8T A;  1T6P A;  3GTD A;  2O6Y A;  4APB A;  4C5S A;  4APA A;  1TJU A;  3OCE A;  4C6G A;  3NO9 A;  2PTQ A;  1RE5 A;  2O7E A;  4V2R A;  3KDY A;  3R6Y A;  1JSW A;  5D6B A;  1VDK A;  2VD6 A;  1TJ7 A;  4FLC A;  1FUR A;  3KDZ A;  5EYV A;  1AUW A;  1GK2 A;  1GKM A;  3OCF A;  1K62 A;  1YFM A;  2PFM A;  2E9F A;  3CZO A;  2NYF A;  5F92 A;  2YII A;  1FUO A;  1J3U A;  4V2Q A;  1KQ7 A;  1XWO A;  2O78 A;  4ADM A;  4FFX A;  1FUP A;  2NYN A;  1HY1 A;  3R6Q A;  2RJR A;  1YIS A;  3QBP A;  2HVG A;  4NLE A;  3GZH A;  2FUS A;  2QVE A;  4BAA A;  4EEI A;  3BHG A;  1Y2M A;  2O7F A;  1B8F A;  1I0A A;  4C5R A;  1W27 A;  1EB4 A;  2O7B A;  1K7W A;  4EFC A;  1T6J A;  2OHY A;  3NZ4 A;  2X75 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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