4V2RA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 250
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
250
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMINOMUTASE (L-BETA-PHENYLALANINE FORMING)
total genus 250
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2rA02
3OCFA 4FLCA 5EYTA 2HVGA 1KQ7A 1FUOA 1T6PA 4C5RA 3UNVA 2E9FA 2YIIA 2PTSA 3RRPA 1Y2MA 1Q5NA 1TJ7A 2RJSA 2X75A 1FURA 1GK2A 4APBA 4C5UA 5F92A 1JSWA 2RJRA 3BHGA 2O7DA 2PTQA 3GTDA 3KDYA 1K62A 1C3CA 3KDZA 4APAA 5D6BA 4EEIA 4BABA 1K7WA 1DOFA 4V2QA 2VD6A 1EB4A 2O78A 3NZ4A 3OCEA 3RD8A 1FUPA 2QVEA 2NYNA 4BAAA 1C3UA 2NYFA 1I0AA 4EFCA 1HY0A 1B8FA 4C5SA 2FUSA 1AUWA 3C8TA 1U15A 2J91A 1DCNA 4V2RA 4C6GA 1RE5A 2O6YA 4NLEA 3CZOA 2QGAB 5EYVA 1YISA 2O7FA 1GKJA 1TJUA 1XWOA 3QBPA 1TJWA 1YFMA 3R6VA 1W27A 3GZHA 3R6YA 1GKMA 4ADLA 3E04A 1HY1A 2O7EA 1U16A 2OHYA 1VDKA 4HGVA 1FUQA 5F91A 4CQ5A 1TJVA 1T6JA 5HW2A 4NSLA 3TV2A 2PFMA 1GK3A 4FFXA 4ADMA 3R6QA 2PTRA 3NO9A 2O7BA 1J3UA 4MX2A 1YFEA
chains in the Genus database with same CATH superfamily
1XMDA 2VUMA 1XLYA 3LR2A 3OCFA 4FLCA 2EZBA 1I50A 5EYTA 2HVGA 2X0OA 3LRDA 1FUOA 3GTPA 1KQ7A 2CW0D 1T6PA 2JA7A 2MP0A 3U4QA 4C5RA 1TWAA 2E9FA 3UNVA 2YIIA 2PTSA 2NVYA 3RRPA 1Y2MA 1Q5NA 1TJ7A 2RJSA 3CRW1 2VK9A 2E2HA 1SFOA 3H0GA 2X75A 2AQLA 3FKIA 1FURA 4C5UA 1GK2A 4APBA 5F92A 1JSWA 2RJRA 2HROA 2K3NA 2MX8A 2VL7A 2LPIA 3BHGA 2O7DA 1YNND 2PTQA 3GTDA 3KDYA 2O5JD 4A15A 2E2IA 3LR8A 3GTMA 1XL7A 1K62A 3GTQA 1C3CA 2MQAA 3KDZA 4APAA 5D6BA 4EEIA 5M0JA 4BABA 2A69D 2K3QA 1YNJD 2R7ZA 1K7WA 2NVXA 1DOFA 5H8WA 4V2QA 2VD6A 2A6HD 2Y0NA 2EZAA 1EB4A 2LKMB 2X0PA 1XMCA 3NZ4A 2O78A 3CQZA 2A6ED 3U44A 3GTOA 3GTJA 3GTKA 3EZAA 2VSFA 5M0IA 3OCEA 3RD8A 2LTHA 1FUPA 2FENA 2K3OA 2QVEA 1IW7D 2B63A 2NYNA 1TWFA 4BAAA 1Y1WA 1TWCA 1C3UA 2NYFA 1I0AA 4EFCA 4WNLA 2LYIA 2JA5A 1XL8A 2N3EA 1HY0A 2LPJA 1B8FA 1TWGA 4FBSA 4C5SA 2FIOA 2A68D 2FUSA 2YU9A 2R93A 1AUWA 3C8TA 1U15A 2J91A 2BE5D 2F5JA 1DCNA 4V2RA 4C6GA 1RE5A 2O6YA 4NLEA 1ZYMA 3CZOA 1TWHA 2QGAB 4CEJA 5EYVA 1I3QA 1YISA 2O7FA 4QIWA 2JA6A 1K83A 3EZBA 1GKJA 1TJUA 1XWOA 2FELA 1Y1VA 3QBPA 1WCMA 3GTGA 3EZEA 4CEHA 2EZCA 1TJWA 1YFMA 3R6VA 1W27A 3GZHA 3R6YA 2X0QA 1GKMA 1EZAA 4ADLA 3E04A 2N1DB 1HY1A 2O7EA 1EZBA 1U16A 3LR6A 1VDKA 2OHYA 4C2MA 2R92A 4CEIA 4HGVA 1FUQA 2HWGA 1I6VD 5F91A 1R9TA 4CQ5A 1TJVA 1T6JA 5HW2A 4NSLA 3TV2A 2PFMA 1GK3A 4FFXA 1ZYRD 2MX9A 4ADMA 2FIPA 1HQMD 5IZ2A 3R6QA 1SMYD 2PTRA 3CRVA 3NO9A 2O7BA 1J3UA 3GTLA 4MX2A 1YFEA
chains in the Genus database with same CATH topology
3OCFA 4FLCA 5EYTA 2HVGA 1KQ7A 1FUOA 1T6PA 4C5RA 3UNVA 2E9FA 2YIIA 2PTSA 3RRPA 1Y2MA 1Q5NA 1TJ7A 2RJSA 2X75A 1FURA 1GK2A 4APBA 4C5UA 5F92A 1JSWA 2RJRA 3BHGA 2O7DA 2PTQA 3GTDA 3KDYA 1K62A 1C3CA 3KDZA 4APAA 5D6BA 4EEIA 4BABA 1K7WA 1DOFA 4V2QA 2VD6A 1EB4A 2O78A 3NZ4A 3OCEA 3RD8A 1FUPA 2QVEA 2NYNA 4BAAA 1C3UA 2NYFA 1I0AA 4EFCA 1HY0A 1B8FA 4C5SA 2FUSA 1AUWA 3C8TA 1U15A 2J91A 1DCNA 4V2RA 4C6GA 1RE5A 2O6YA 4NLEA 3CZOA 2QGAB 5EYVA 1YISA 2O7FA 1GKJA 1TJUA 1XWOA 3QBPA 1TJWA 1YFMA 3R6VA 1W27A 3GZHA 3R6YA 1GKMA 4ADLA 3E04A 1HY1A 2O7EA 1U16A 2OHYA 1VDKA 4HGVA 1FUQA 5F91A 4CQ5A 1TJVA 1T6JA 5HW2A 4NSLA 3TV2A 2PFMA 1GK3A 4FFXA 4ADMA 3R6QA 2PTRA 3NO9A 2O7BA 1J3UA 4MX2A 1YFEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OCF A;  4FLC A;  5EYT A;  2HVG A;  1KQ7 A;  1FUO A;  1T6P A;  4C5R A;  3UNV A;  2E9F A;  2YII A;  2PTS A;  3RRP A;  1Y2M A;  1Q5N A;  1TJ7 A;  2RJS A;  2X75 A;  1FUR A;  1GK2 A;  4APB A;  4C5U A;  5F92 A;  1JSW A;  2RJR A;  3BHG A;  2O7D A;  2PTQ A;  3GTD A;  3KDY A;  1K62 A;  1C3C A;  3KDZ A;  4APA A;  5D6B A;  4EEI A;  4BAB A;  1K7W A;  1DOF A;  4V2Q A;  2VD6 A;  1EB4 A;  2O78 A;  3NZ4 A;  3OCE A;  3RD8 A;  1FUP A;  2QVE A;  2NYN A;  4BAA A;  1C3U A;  2NYF A;  1I0A A;  4EFC A;  1HY0 A;  1B8F A;  4C5S A;  2FUS A;  1AUW A;  3C8T A;  1U15 A;  2J91 A;  1DCN A;  4V2R A;  4C6G A;  1RE5 A;  2O6Y A;  4NLE A;  3CZO A;  2QGA B;  5EYV A;  1YIS A;  2O7F A;  1GKJ A;  1TJU A;  1XWO A;  3QBP A;  1TJW A;  1YFM A;  3R6V A;  1W27 A;  3GZH A;  3R6Y A;  1GKM A;  4ADL A;  3E04 A;  1HY1 A;  2O7E A;  1U16 A;  2OHY A;  1VDK A;  4HGV A;  1FUQ A;  5F91 A;  4CQ5 A;  1TJV A;  1T6J A;  5HW2 A;  4NSL A;  3TV2 A;  2PFM A;  1GK3 A;  4FFX A;  4ADM A;  3R6Q A;  2PTR A;  3NO9 A;  2O7B A;  1J3U A;  4MX2 A;  1YFE A; 
#chains in the Genus database with same CATH topology
 1XMD A;  2VUM A;  1XLY A;  3LR2 A;  3OCF A;  4FLC A;  2EZB A;  1I50 A;  5EYT A;  2HVG A;  2X0O A;  3LRD A;  1FUO A;  3GTP A;  1KQ7 A;  2CW0 D;  1T6P A;  2JA7 A;  2MP0 A;  3U4Q A;  4C5R A;  1TWA A;  2E9F A;  3UNV A;  2YII A;  2PTS A;  2NVY A;  3RRP A;  1Y2M A;  1Q5N A;  1TJ7 A;  2RJS A;  3CRW 1;  2VK9 A;  2E2H A;  1SFO A;  3H0G A;  2X75 A;  2AQL A;  3FKI A;  1FUR A;  4C5U A;  1GK2 A;  4APB A;  5F92 A;  1JSW A;  2RJR A;  2HRO A;  2K3N A;  2MX8 A;  2VL7 A;  2LPI A;  3BHG A;  2O7D A;  1YNN D;  2PTQ A;  3GTD A;  3KDY A;  2O5J D;  4A15 A;  2E2I A;  3LR8 A;  3GTM A;  1XL7 A;  1K62 A;  3GTQ A;  1C3C A;  2MQA A;  3KDZ A;  4APA A;  5D6B A;  4EEI A;  5M0J A;  4BAB A;  2A69 D;  2K3Q A;  1YNJ D;  2R7Z A;  1K7W A;  2NVX A;  1DOF A;  5H8W A;  4V2Q A;  2VD6 A;  2A6H D;  2Y0N A;  2EZA A;  1EB4 A;  2LKM B;  2X0P A;  1XMC A;  3NZ4 A;  2O78 A;  3CQZ A;  2A6E D;  3U44 A;  3GTO A;  3GTJ A;  3GTK A;  3EZA A;  2VSF A;  5M0I A;  3OCE A;  3RD8 A;  2LTH A;  1FUP A;  2FEN A;  2K3O A;  2QVE A;  1IW7 D;  2B63 A;  2NYN A;  1TWF A;  4BAA A;  1Y1W A;  1TWC A;  1C3U A;  2NYF A;  1I0A A;  4EFC A;  4WNL A;  2LYI A;  2JA5 A;  1XL8 A;  2N3E A;  1HY0 A;  2LPJ A;  1B8F A;  1TWG A;  4FBS A;  4C5S A;  2FIO A;  2A68 D;  2FUS A;  2YU9 A;  2R93 A;  1AUW A;  3C8T A;  1U15 A;  2J91 A;  2BE5 D;  2F5J A;  1DCN A;  4V2R A;  4C6G A;  1RE5 A;  2O6Y A;  4NLE A;  1ZYM A;  3CZO A;  1TWH A;  2QGA B;  4CEJ A;  5EYV A;  1I3Q A;  1YIS A;  2O7F A;  4QIW A;  2JA6 A;  1K83 A;  3EZB A;  1GKJ A;  1TJU A;  1XWO A;  2FEL A;  1Y1V A;  3QBP A;  1WCM A;  3GTG A;  3EZE A;  4CEH A;  2EZC A;  1TJW A;  1YFM A;  3R6V A;  1W27 A;  3GZH A;  3R6Y A;  2X0Q A;  1GKM A;  1EZA A;  4ADL A;  3E04 A;  2N1D B;  1HY1 A;  2O7E A;  1EZB A;  1U16 A;  3LR6 A;  1VDK A;  2OHY A;  4C2M A;  2R92 A;  4CEI A;  4HGV A;  1FUQ A;  2HWG A;  1I6V D;  5F91 A;  1R9T A;  4CQ5 A;  1TJV A;  1T6J A;  5HW2 A;  4NSL A;  3TV2 A;  2PFM A;  1GK3 A;  4FFX A;  1ZYR D;  2MX9 A;  4ADM A;  2FIP A;  1HQM D;  5IZ2 A;  3R6Q A;  1SMY D;  2PTR A;  3CRV A;  3NO9 A;  2O7B A;  1J3U A;  3GTL A;  4MX2 A;  1YFE A; 
#chains in the Genus database with same CATH homology
 3OCF A;  4FLC A;  5EYT A;  2HVG A;  1KQ7 A;  1FUO A;  1T6P A;  4C5R A;  3UNV A;  2E9F A;  2YII A;  2PTS A;  3RRP A;  1Y2M A;  1Q5N A;  1TJ7 A;  2RJS A;  2X75 A;  1FUR A;  1GK2 A;  4APB A;  4C5U A;  5F92 A;  1JSW A;  2RJR A;  3BHG A;  2O7D A;  2PTQ A;  3GTD A;  3KDY A;  1K62 A;  1C3C A;  3KDZ A;  4APA A;  5D6B A;  4EEI A;  4BAB A;  1K7W A;  1DOF A;  4V2Q A;  2VD6 A;  1EB4 A;  2O78 A;  3NZ4 A;  3OCE A;  3RD8 A;  1FUP A;  2QVE A;  2NYN A;  4BAA A;  1C3U A;  2NYF A;  1I0A A;  4EFC A;  1HY0 A;  1B8F A;  4C5S A;  2FUS A;  1AUW A;  3C8T A;  1U15 A;  2J91 A;  1DCN A;  4V2R A;  4C6G A;  1RE5 A;  2O6Y A;  4NLE A;  3CZO A;  2QGA B;  5EYV A;  1YIS A;  2O7F A;  1GKJ A;  1TJU A;  1XWO A;  3QBP A;  1TJW A;  1YFM A;  3R6V A;  1W27 A;  3GZH A;  3R6Y A;  1GKM A;  4ADL A;  3E04 A;  1HY1 A;  2O7E A;  1U16 A;  2OHY A;  1VDK A;  4HGV A;  1FUQ A;  5F91 A;  4CQ5 A;  1TJV A;  1T6J A;  5HW2 A;  4NSL A;  3TV2 A;  2PFM A;  1GK3 A;  4FFX A;  4ADM A;  3R6Q A;  2PTR A;  3NO9 A;  2O7B A;  1J3U A;  4MX2 A;  1YFE A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...