4V2RA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 250
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
250
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE (L-BETA-PHENYLALANINE FORMING)
publication title Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 250
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2rA02
1K7WA 1W27A 3GTDA 4BABA 4APBA 1C3UA 4V2RA 1FUQA 3RRPA 1Y2MA 1GKMA 1XWOA 1HY1A 2O7FA 2X75A 3C8TA 3UNVA 4NSLA 1VDKA 4V2QA 1TJWA 4C5SA 5EYTA 1KQ7A 2OHYA 2HVGA 1DCNA 3QBPA 1TJUA 5HW2A 1EB4A 1GKJA 1Q5NA 3RD8A 5D6BA 1J3UA 3E04A 1DOFA 2O6YA 3BHGA 3NZ4A 1GK3A 1U15A 1U16A 1AUWA 3R6VA 2QVEA 5F91A 2J91A 2PFMA 4BAAA 4C6GA 3NO9A 3OCEA 4MX2A 4APAA 4HGVA 4ADLA 2FUSA 3KDZA 4FLCA 3CZOA 1JSWA 1RE5A 5EYVA 2PTSA 3KDYA 2NYFA 1GK2A 1YISA 4NLEA 1T6JA 3OCFA 4ADMA 1FUPA 2O7BA 4EFCA 2O78A 3TV2A 1B8FA 3R6QA 2QGAB 1I0AA 1YFMA 2RJSA 1HY0A 4FFXA 1TJVA 4EEIA 1TJ7A 2YIIA 2NYNA 2PTQA 2O7EA 4C5UA 1C3CA 3R6YA 1FUOA 1FURA 4C5RA 4CQ5A 2RJRA 1T6PA 1YFEA 2O7DA 2PTRA 1K62A 5F92A 2E9FA 3GZHA 2VD6A
chains in the Genus database with same CATH superfamily
1ZYMA 2MX9A 2EZBA 1TWAA 3H0GA 1I50A 4CEIA 3GTQA 2A69D 1K7WA 2LPIA 1W27A 2AQLA 3LR8A 3GTDA 4BABA 3CRW1 3U4QA 4CEHA 1C3UA 3EZEA 4APBA 2EZCA 1HQMD 4V2RA 3CQZA 1FUQA 3RRPA 1Y2MA 1GKMA 1XWOA 1HY1A 3EZBA 2K3NA 1ZYRD 1TWCA 2O7FA 2X75A 3C8TA 2A6ED 3UNVA 4NSLA 4QIWA 2R7ZA 2JA7A 4V2QA 4CEJA 1VDKA 1TJWA 3LR2A 1TWFA 4C5SA 2JA6A 2NVXA 1KQ7A 5EYTA 2OHYA 1XMDA 2HWGA 2HVGA 1EZAA 1SFOA 1DCNA 2YU9A 2HROA 3QBPA 2R92A 1XL7A 1EZBA 1IW7D 1TJUA 5HW2A 1Y1WA 2N1DB 2FIOA 5M0IA 1EB4A 2VK9A 1GKJA 1Q5NA 3RD8A 5D6BA 1J3UA 3GTLA 3E04A 1DOFA 2O6YA 2CW0D 3BHGA 3NZ4A 1GK3A 1U15A 2FENA 1U16A 2LYIA 3LRDA 2VUMA 3U44A 2BE5D 3GTMA 1AUWA 2B63A 3GTOA 5M0JA 3R6VA 4FBSA 2F5JA 5IZ2A 2QVEA 5F91A 1YNND 2J91A 2MQAA 2X0OA 2PFMA 4BAAA 2MX8A 4C6GA 4C2MA 3NO9A 2MP0A 2NVYA 3OCEA 2FIPA 4MX2A 4APAA 4HGVA 1WCMA 2A68D 4ADLA 4A15A 2FUSA 2E2IA 3KDZA 1XMCA 1YNJD 2O5JD 4FLCA 3CZOA 1JSWA 2EZAA 1Y1VA 2N3EA 3EZAA 3GTKA 1RE5A 2VSFA 5EYVA 1K83A 2PTSA 3KDYA 2NYFA 1SMYD 1GK2A 1YISA 3GTPA 1XL8A 1TWHA 4NLEA 2X0QA 1T6JA 2LTHA 3OCFA 4ADMA 2Y0NA 1FUPA 2R93A 2O7BA 4EFCA 2O78A 2VL7A 3TV2A 1B8FA 3R6QA 2QGAB 1I0AA 2A6HD 1YFMA 5H8WA 3GTJA 2RJSA 1HY0A 1I3QA 2K3OA 4FFXA 1TJVA 3GTGA 3CRVA 1R9TA 4EEIA 1TJ7A 2YIIA 2K3QA 2LKMB 1XLYA 3FKIA 2NYNA 2PTQA 1I6VD 2O7EA 2FELA 4C5UA 1C3CA 3R6YA 1FUOA 1FURA 4C5RA 4CQ5A 2RJRA 4WNLA 1T6PA 1YFEA 3LR6A 2O7DA 2LPJA 1K62A 2PTRA 2E2HA 2X0PA 1TWGA 2JA5A 5F92A 2E9FA 3GZHA 2VD6A
chains in the Genus database with same CATH topology
1K7WA 1W27A 3GTDA 4BABA 4APBA 1C3UA 4V2RA 1FUQA 3RRPA 1Y2MA 1GKMA 1XWOA 1HY1A 2O7FA 2X75A 3C8TA 3UNVA 4NSLA 1VDKA 4V2QA 1TJWA 4C5SA 5EYTA 1KQ7A 2OHYA 2HVGA 1DCNA 3QBPA 1TJUA 5HW2A 1EB4A 1GKJA 1Q5NA 3RD8A 5D6BA 1J3UA 3E04A 1DOFA 2O6YA 3BHGA 3NZ4A 1GK3A 1U15A 1U16A 1AUWA 3R6VA 2QVEA 5F91A 2J91A 2PFMA 4BAAA 4C6GA 3NO9A 3OCEA 4MX2A 4APAA 4HGVA 4ADLA 2FUSA 3KDZA 4FLCA 3CZOA 1JSWA 1RE5A 5EYVA 2PTSA 3KDYA 2NYFA 1GK2A 1YISA 4NLEA 1T6JA 3OCFA 4ADMA 1FUPA 2O7BA 4EFCA 2O78A 3TV2A 1B8FA 3R6QA 2QGAB 1I0AA 1YFMA 2RJSA 1HY0A 4FFXA 1TJVA 4EEIA 1TJ7A 2YIIA 2NYNA 2PTQA 2O7EA 4C5UA 1C3CA 3R6YA 1FUOA 1FURA 4C5RA 4CQ5A 2RJRA 1T6PA 1YFEA 2O7DA 2PTRA 1K62A 5F92A 2E9FA 3GZHA 2VD6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K7W A;  1W27 A;  3GTD A;  4BAB A;  4APB A;  1C3U A;  4V2R A;  1FUQ A;  3RRP A;  1Y2M A;  1GKM A;  1XWO A;  1HY1 A;  2O7F A;  2X75 A;  3C8T A;  3UNV A;  4NSL A;  1VDK A;  4V2Q A;  1TJW A;  4C5S A;  5EYT A;  1KQ7 A;  2OHY A;  2HVG A;  1DCN A;  3QBP A;  1TJU A;  5HW2 A;  1EB4 A;  1GKJ A;  1Q5N A;  3RD8 A;  5D6B A;  1J3U A;  3E04 A;  1DOF A;  2O6Y A;  3BHG A;  3NZ4 A;  1GK3 A;  1U15 A;  1U16 A;  1AUW A;  3R6V A;  2QVE A;  5F91 A;  2J91 A;  2PFM A;  4BAA A;  4C6G A;  3NO9 A;  3OCE A;  4MX2 A;  4APA A;  4HGV A;  4ADL A;  2FUS A;  3KDZ A;  4FLC A;  3CZO A;  1JSW A;  1RE5 A;  5EYV A;  2PTS A;  3KDY A;  2NYF A;  1GK2 A;  1YIS A;  4NLE A;  1T6J A;  3OCF A;  4ADM A;  1FUP A;  2O7B A;  4EFC A;  2O78 A;  3TV2 A;  1B8F A;  3R6Q A;  2QGA B;  1I0A A;  1YFM A;  2RJS A;  1HY0 A;  4FFX A;  1TJV A;  4EEI A;  1TJ7 A;  2YII A;  2NYN A;  2PTQ A;  2O7E A;  4C5U A;  1C3C A;  3R6Y A;  1FUO A;  1FUR A;  4C5R A;  4CQ5 A;  2RJR A;  1T6P A;  1YFE A;  2O7D A;  2PTR A;  1K62 A;  5F92 A;  2E9F A;  3GZH A;  2VD6 A; 
#chains in the Genus database with same CATH topology
 1ZYM A;  2MX9 A;  2EZB A;  1TWA A;  3H0G A;  1I50 A;  4CEI A;  3GTQ A;  2A69 D;  1K7W A;  2LPI A;  1W27 A;  2AQL A;  3LR8 A;  3GTD A;  4BAB A;  3CRW 1;  3U4Q A;  4CEH A;  1C3U A;  3EZE A;  4APB A;  2EZC A;  1HQM D;  4V2R A;  3CQZ A;  1FUQ A;  3RRP A;  1Y2M A;  1GKM A;  1XWO A;  1HY1 A;  3EZB A;  2K3N A;  1ZYR D;  1TWC A;  2O7F A;  2X75 A;  3C8T A;  2A6E D;  3UNV A;  4NSL A;  4QIW A;  2R7Z A;  2JA7 A;  4V2Q A;  4CEJ A;  1VDK A;  1TJW A;  3LR2 A;  1TWF A;  4C5S A;  2JA6 A;  2NVX A;  1KQ7 A;  5EYT A;  2OHY A;  1XMD A;  2HWG A;  2HVG A;  1EZA A;  1SFO A;  1DCN A;  2YU9 A;  2HRO A;  3QBP A;  2R92 A;  1XL7 A;  1EZB A;  1IW7 D;  1TJU A;  5HW2 A;  1Y1W A;  2N1D B;  2FIO A;  5M0I A;  1EB4 A;  2VK9 A;  1GKJ A;  1Q5N A;  3RD8 A;  5D6B A;  1J3U A;  3GTL A;  3E04 A;  1DOF A;  2O6Y A;  2CW0 D;  3BHG A;  3NZ4 A;  1GK3 A;  1U15 A;  2FEN A;  1U16 A;  2LYI A;  3LRD A;  2VUM A;  3U44 A;  2BE5 D;  3GTM A;  1AUW A;  2B63 A;  3GTO A;  5M0J A;  3R6V A;  4FBS A;  2F5J A;  5IZ2 A;  2QVE A;  5F91 A;  1YNN D;  2J91 A;  2MQA A;  2X0O A;  2PFM A;  4BAA A;  2MX8 A;  4C6G A;  4C2M A;  3NO9 A;  2MP0 A;  2NVY A;  3OCE A;  2FIP A;  4MX2 A;  4APA A;  4HGV A;  1WCM A;  2A68 D;  4ADL A;  4A15 A;  2FUS A;  2E2I A;  3KDZ A;  1XMC A;  1YNJ D;  2O5J D;  4FLC A;  3CZO A;  1JSW A;  2EZA A;  1Y1V A;  2N3E A;  3EZA A;  3GTK A;  1RE5 A;  2VSF A;  5EYV A;  1K83 A;  2PTS A;  3KDY A;  2NYF A;  1SMY D;  1GK2 A;  1YIS A;  3GTP A;  1XL8 A;  1TWH A;  4NLE A;  2X0Q A;  1T6J A;  2LTH A;  3OCF A;  4ADM A;  2Y0N A;  1FUP A;  2R93 A;  2O7B A;  4EFC A;  2O78 A;  2VL7 A;  3TV2 A;  1B8F A;  3R6Q A;  2QGA B;  1I0A A;  2A6H D;  1YFM A;  5H8W A;  3GTJ A;  2RJS A;  1HY0 A;  1I3Q A;  2K3O A;  4FFX A;  1TJV A;  3GTG A;  3CRV A;  1R9T A;  4EEI A;  1TJ7 A;  2YII A;  2K3Q A;  2LKM B;  1XLY A;  3FKI A;  2NYN A;  2PTQ A;  1I6V D;  2O7E A;  2FEL A;  4C5U A;  1C3C A;  3R6Y A;  1FUO A;  1FUR A;  4C5R A;  4CQ5 A;  2RJR A;  4WNL A;  1T6P A;  1YFE A;  3LR6 A;  2O7D A;  2LPJ A;  1K62 A;  2PTR A;  2E2H A;  2X0P A;  1TWG A;  2JA5 A;  5F92 A;  2E9F A;  3GZH A;  2VD6 A; 
#chains in the Genus database with same CATH homology
 1K7W A;  1W27 A;  3GTD A;  4BAB A;  4APB A;  1C3U A;  4V2R A;  1FUQ A;  3RRP A;  1Y2M A;  1GKM A;  1XWO A;  1HY1 A;  2O7F A;  2X75 A;  3C8T A;  3UNV A;  4NSL A;  1VDK A;  4V2Q A;  1TJW A;  4C5S A;  5EYT A;  1KQ7 A;  2OHY A;  2HVG A;  1DCN A;  3QBP A;  1TJU A;  5HW2 A;  1EB4 A;  1GKJ A;  1Q5N A;  3RD8 A;  5D6B A;  1J3U A;  3E04 A;  1DOF A;  2O6Y A;  3BHG A;  3NZ4 A;  1GK3 A;  1U15 A;  1U16 A;  1AUW A;  3R6V A;  2QVE A;  5F91 A;  2J91 A;  2PFM A;  4BAA A;  4C6G A;  3NO9 A;  3OCE A;  4MX2 A;  4APA A;  4HGV A;  4ADL A;  2FUS A;  3KDZ A;  4FLC A;  3CZO A;  1JSW A;  1RE5 A;  5EYV A;  2PTS A;  3KDY A;  2NYF A;  1GK2 A;  1YIS A;  4NLE A;  1T6J A;  3OCF A;  4ADM A;  1FUP A;  2O7B A;  4EFC A;  2O78 A;  3TV2 A;  1B8F A;  3R6Q A;  2QGA B;  1I0A A;  1YFM A;  2RJS A;  1HY0 A;  4FFX A;  1TJV A;  4EEI A;  1TJ7 A;  2YII A;  2NYN A;  2PTQ A;  2O7E A;  4C5U A;  1C3C A;  3R6Y A;  1FUO A;  1FUR A;  4C5R A;  4CQ5 A;  2RJR A;  1T6P A;  1YFE A;  2O7D A;  2PTR A;  1K62 A;  5F92 A;  2E9F A;  3GZH A;  2VD6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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