4V2RA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 250
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
250
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMINOMUTASE (L-BETA-PHENYLALANINE FORMING)
total genus 250
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2rA02
1C3CA 5EYVA 2HVGA 2PTQA 3KDZA 2QGAB 5F91A 3BHGA 3R6YA 2O78A 2O7DA 2VD6A 4APAA 1B8FA 1T6PA 4C5RA 3OCFA 4V2RA 1GKMA 3R6VA 1TJ7A 1FURA 3KDYA 1C3UA 2E9FA 3C8TA 1FUQA 3R6QA 3CZOA 2PFMA 1FUPA 2NYFA 2PTRA 1KQ7A 3RD8A 3TV2A 2X75A 1AUWA 1Q5NA 4EFCA 4NSLA 1GKJA 3E04A 1FUOA 4EEIA 5F92A 1YISA 4ADLA 3OCEA 2RJRA 1VDKA 1DOFA 3QBPA 1Y2MA 4C6GA 1DCNA 1EB4A 2FUSA 1W27A 4V2QA 4APBA 1HY1A 2O7FA 4ADMA 1JSWA 2O7BA 1YFEA 2NYNA 3NO9A 2O6YA 4C5UA 5D6BA 2PTSA 1TJVA 1J3UA 1GK2A 1GK3A 3UNVA 1I0AA 2RJSA 5HW2A 1T6JA 4CQ5A 2YIIA 2J91A 4C5SA 4BABA 4BAAA 1TJUA 1K7WA 3RRPA 1RE5A 3NZ4A 1HY0A 4NLEA 1U15A 1U16A 1TJWA 3GTDA 4FFXA 5EYTA 2O7EA 1XWOA 3GZHA 4FLCA 2OHYA 1K62A 2QVEA 1YFMA 4HGVA 4MX2A
chains in the Genus database with same CATH superfamily
2FENA 1R9TA 2Y0NA 3U44A 1C3CA 5EYVA 1XL7A 2R93A 4CEJA 2HVGA 2K3QA 2A69D 2CW0D 2PTQA 3KDZA 2QGAB 4WNLA 4FBSA 5F91A 3BHGA 3R6YA 2O78A 2JA6A 2YU9A 1TWCA 2O7DA 2VD6A 2VSFA 1Y1VA 2LPJA 4APAA 1B8FA 2LKMB 2N3EA 2EZCA 1T6PA 1TWFA 4C5RA 2E2HA 2AQLA 2O5JD 1YNND 2EZBA 2BE5D 3CRW1 2HWGA 4V2RA 1GKMA 3OCFA 5IZ2A 3R6VA 2R7ZA 1TJ7A 1FURA 3KDYA 3LR2A 2VUMA 1C3UA 2LYIA 2E9FA 3C8TA 1FUQA 3R6QA 3EZAA 1I3QA 3LR6A 2JA5A 3CZOA 2K3NA 2PFMA 1FUPA 1XLYA 3GTLA 2NYFA 2PTRA 1KQ7A 3RD8A 3TV2A 1YNJD 2X75A 3GTJA 1AUWA 2NVXA 1Q5NA 4EFCA 4NSLA 1GKJA 2MX9A 3E04A 1FUOA 4EEIA 3GTOA 5M0IA 5F92A 1YISA 1XMCA 3GTKA 4C2MA 4ADLA 3OCEA 2RJRA 2X0QA 3LR8A 1VDKA 1DOFA 4A15A 2MX8A 3QBPA 4CEIA 1Y2MA 4C6GA 3GTQA 2FIPA 1DCNA 1EB4A 2FUSA 1IW7D 4MX2A 1W27A 1TWAA 4CEHA 1SFOA 3GTPA 4V2QA 4APBA 1HY1A 3U4QA 5M0JA 3EZEA 3GTMA 2R92A 1WCMA 2VL7A 2O7FA 1TWGA 2A68D 2JA7A 1ZYRD 2LPIA 4ADMA 1JSWA 2O7BA 2FELA 1YFEA 3FKIA 2NYNA 4QIWA 2MP0A 3NO9A 2O6YA 4C5UA 1HQMD 5D6BA 2PTSA 1TJVA 1J3UA 2A6ED 2EZAA 1GK2A 1GK3A 3UNVA 3CQZA 2X0PA 1I0AA 2RJSA 5HW2A 1T6JA 4CQ5A 2F5JA 2YIIA 3H0GA 2A6HD 1K83A 1EZBA 2J91A 1Y1WA 1ZYMA 2X0OA 4BABA 4BAAA 4C5SA 2FIOA 2E2IA 1TJUA 1K7WA 1XL8A 1TWHA 2NVYA 3RRPA 3GTGA 1RE5A 1I6VD 3NZ4A 2N1DB 1EZAA 1HY0A 4NLEA 1U15A 2LTHA 1TJWA 1U16A 3GTDA 4FFXA 5EYTA 2O7EA 2K3OA 3EZBA 5H8WA 1XWOA 3GZHA 4FLCA 2VK9A 2OHYA 1SMYD 3CRVA 2MQAA 1K62A 2QVEA 1XMDA 1YFMA 3LRDA 2B63A 2HROA 4HGVA 1I50A
chains in the Genus database with same CATH topology
1C3CA 5EYVA 2HVGA 2PTQA 3KDZA 2QGAB 5F91A 3BHGA 3R6YA 2O78A 2O7DA 2VD6A 4APAA 1B8FA 1T6PA 4C5RA 3OCFA 4V2RA 1GKMA 3R6VA 1TJ7A 1FURA 3KDYA 1C3UA 2E9FA 3C8TA 1FUQA 3R6QA 3CZOA 2PFMA 1FUPA 2NYFA 2PTRA 1KQ7A 3RD8A 3TV2A 2X75A 1AUWA 1Q5NA 4EFCA 4NSLA 1GKJA 3E04A 1FUOA 4EEIA 5F92A 1YISA 4ADLA 3OCEA 2RJRA 1VDKA 1DOFA 3QBPA 1Y2MA 4C6GA 1DCNA 1EB4A 2FUSA 1W27A 4V2QA 4APBA 1HY1A 2O7FA 4ADMA 1JSWA 2O7BA 1YFEA 2NYNA 3NO9A 2O6YA 4C5UA 5D6BA 2PTSA 1TJVA 1J3UA 1GK2A 1GK3A 3UNVA 1I0AA 2RJSA 5HW2A 1T6JA 4CQ5A 2YIIA 2J91A 4C5SA 4BABA 4BAAA 1TJUA 1K7WA 3RRPA 1RE5A 3NZ4A 1HY0A 4NLEA 1U15A 1U16A 1TJWA 3GTDA 4FFXA 5EYTA 2O7EA 1XWOA 3GZHA 4FLCA 2OHYA 1K62A 2QVEA 1YFMA 4HGVA 4MX2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3C A;  5EYV A;  2HVG A;  2PTQ A;  3KDZ A;  2QGA B;  5F91 A;  3BHG A;  3R6Y A;  2O78 A;  2O7D A;  2VD6 A;  4APA A;  1B8F A;  1T6P A;  4C5R A;  3OCF A;  4V2R A;  1GKM A;  3R6V A;  1TJ7 A;  1FUR A;  3KDY A;  1C3U A;  2E9F A;  3C8T A;  1FUQ A;  3R6Q A;  3CZO A;  2PFM A;  1FUP A;  2NYF A;  2PTR A;  1KQ7 A;  3RD8 A;  3TV2 A;  2X75 A;  1AUW A;  1Q5N A;  4EFC A;  4NSL A;  1GKJ A;  3E04 A;  1FUO A;  4EEI A;  5F92 A;  1YIS A;  4ADL A;  3OCE A;  2RJR A;  1VDK A;  1DOF A;  3QBP A;  1Y2M A;  4C6G A;  1DCN A;  1EB4 A;  2FUS A;  1W27 A;  4V2Q A;  4APB A;  1HY1 A;  2O7F A;  4ADM A;  1JSW A;  2O7B A;  1YFE A;  2NYN A;  3NO9 A;  2O6Y A;  4C5U A;  5D6B A;  2PTS A;  1TJV A;  1J3U A;  1GK2 A;  1GK3 A;  3UNV A;  1I0A A;  2RJS A;  5HW2 A;  1T6J A;  4CQ5 A;  2YII A;  2J91 A;  4C5S A;  4BAB A;  4BAA A;  1TJU A;  1K7W A;  3RRP A;  1RE5 A;  3NZ4 A;  1HY0 A;  4NLE A;  1U15 A;  1U16 A;  1TJW A;  3GTD A;  4FFX A;  5EYT A;  2O7E A;  1XWO A;  3GZH A;  4FLC A;  2OHY A;  1K62 A;  2QVE A;  1YFM A;  4HGV A;  4MX2 A; 
#chains in the Genus database with same CATH topology
 2FEN A;  1R9T A;  2Y0N A;  3U44 A;  1C3C A;  5EYV A;  1XL7 A;  2R93 A;  4CEJ A;  2HVG A;  2K3Q A;  2A69 D;  2CW0 D;  2PTQ A;  3KDZ A;  2QGA B;  4WNL A;  4FBS A;  5F91 A;  3BHG A;  3R6Y A;  2O78 A;  2JA6 A;  2YU9 A;  1TWC A;  2O7D A;  2VD6 A;  2VSF A;  1Y1V A;  2LPJ A;  4APA A;  1B8F A;  2LKM B;  2N3E A;  2EZC A;  1T6P A;  1TWF A;  4C5R A;  2E2H A;  2AQL A;  2O5J D;  1YNN D;  2EZB A;  2BE5 D;  3CRW 1;  2HWG A;  4V2R A;  1GKM A;  3OCF A;  5IZ2 A;  3R6V A;  2R7Z A;  1TJ7 A;  1FUR A;  3KDY A;  3LR2 A;  2VUM A;  1C3U A;  2LYI A;  2E9F A;  3C8T A;  1FUQ A;  3R6Q A;  3EZA A;  1I3Q A;  3LR6 A;  2JA5 A;  3CZO A;  2K3N A;  2PFM A;  1FUP A;  1XLY A;  3GTL A;  2NYF A;  2PTR A;  1KQ7 A;  3RD8 A;  3TV2 A;  1YNJ D;  2X75 A;  3GTJ A;  1AUW A;  2NVX A;  1Q5N A;  4EFC A;  4NSL A;  1GKJ A;  2MX9 A;  3E04 A;  1FUO A;  4EEI A;  3GTO A;  5M0I A;  5F92 A;  1YIS A;  1XMC A;  3GTK A;  4C2M A;  4ADL A;  3OCE A;  2RJR A;  2X0Q A;  3LR8 A;  1VDK A;  1DOF A;  4A15 A;  2MX8 A;  3QBP A;  4CEI A;  1Y2M A;  4C6G A;  3GTQ A;  2FIP A;  1DCN A;  1EB4 A;  2FUS A;  1IW7 D;  4MX2 A;  1W27 A;  1TWA A;  4CEH A;  1SFO A;  3GTP A;  4V2Q A;  4APB A;  1HY1 A;  3U4Q A;  5M0J A;  3EZE A;  3GTM A;  2R92 A;  1WCM A;  2VL7 A;  2O7F A;  1TWG A;  2A68 D;  2JA7 A;  1ZYR D;  2LPI A;  4ADM A;  1JSW A;  2O7B A;  2FEL A;  1YFE A;  3FKI A;  2NYN A;  4QIW A;  2MP0 A;  3NO9 A;  2O6Y A;  4C5U A;  1HQM D;  5D6B A;  2PTS A;  1TJV A;  1J3U A;  2A6E D;  2EZA A;  1GK2 A;  1GK3 A;  3UNV A;  3CQZ A;  2X0P A;  1I0A A;  2RJS A;  5HW2 A;  1T6J A;  4CQ5 A;  2F5J A;  2YII A;  3H0G A;  2A6H D;  1K83 A;  1EZB A;  2J91 A;  1Y1W A;  1ZYM A;  2X0O A;  4BAB A;  4BAA A;  4C5S A;  2FIO A;  2E2I A;  1TJU A;  1K7W A;  1XL8 A;  1TWH A;  2NVY A;  3RRP A;  3GTG A;  1RE5 A;  1I6V D;  3NZ4 A;  2N1D B;  1EZA A;  1HY0 A;  4NLE A;  1U15 A;  2LTH A;  1TJW A;  1U16 A;  3GTD A;  4FFX A;  5EYT A;  2O7E A;  2K3O A;  3EZB A;  5H8W A;  1XWO A;  3GZH A;  4FLC A;  2VK9 A;  2OHY A;  1SMY D;  3CRV A;  2MQA A;  1K62 A;  2QVE A;  1XMD A;  1YFM A;  3LRD A;  2B63 A;  2HRO A;  4HGV A;  1I50 A; 
#chains in the Genus database with same CATH homology
 1C3C A;  5EYV A;  2HVG A;  2PTQ A;  3KDZ A;  2QGA B;  5F91 A;  3BHG A;  3R6Y A;  2O78 A;  2O7D A;  2VD6 A;  4APA A;  1B8F A;  1T6P A;  4C5R A;  3OCF A;  4V2R A;  1GKM A;  3R6V A;  1TJ7 A;  1FUR A;  3KDY A;  1C3U A;  2E9F A;  3C8T A;  1FUQ A;  3R6Q A;  3CZO A;  2PFM A;  1FUP A;  2NYF A;  2PTR A;  1KQ7 A;  3RD8 A;  3TV2 A;  2X75 A;  1AUW A;  1Q5N A;  4EFC A;  4NSL A;  1GKJ A;  3E04 A;  1FUO A;  4EEI A;  5F92 A;  1YIS A;  4ADL A;  3OCE A;  2RJR A;  1VDK A;  1DOF A;  3QBP A;  1Y2M A;  4C6G A;  1DCN A;  1EB4 A;  2FUS A;  1W27 A;  4V2Q A;  4APB A;  1HY1 A;  2O7F A;  4ADM A;  1JSW A;  2O7B A;  1YFE A;  2NYN A;  3NO9 A;  2O6Y A;  4C5U A;  5D6B A;  2PTS A;  1TJV A;  1J3U A;  1GK2 A;  1GK3 A;  3UNV A;  1I0A A;  2RJS A;  5HW2 A;  1T6J A;  4CQ5 A;  2YII A;  2J91 A;  4C5S A;  4BAB A;  4BAA A;  1TJU A;  1K7W A;  3RRP A;  1RE5 A;  3NZ4 A;  1HY0 A;  4NLE A;  1U15 A;  1U16 A;  1TJW A;  3GTD A;  4FFX A;  5EYT A;  2O7E A;  1XWO A;  3GZH A;  4FLC A;  2OHY A;  1K62 A;  2QVE A;  1YFM A;  4HGV A;  4MX2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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