4V2RA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 250
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
250
sequence length
666
structure length
612
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE (L-BETA-PHENYLALANINE FORMING)
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
publication title Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.
pubmed doi rcsb
total genus 250
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2rA02
4ADMA 3KDYA 1C3CA 2PTSA 3RRPA 1TJVA 3OCFA 4EEIA 4C5UA 1EB4A 1GKMA 5HW2A 2RJRA 3NO9A 2O7FA 5EYTA 2O7BA 2PTRA 2J91A 1GK2A 1GKJA 5EYVA 2X75A 3TV2A 3GTDA 1J3UA 1I0AA 4V2QA 3UNVA 1VDKA 2OHYA 2HVGA 3BHGA 1W27A 5D6BA 1K62A 1XWOA 3KDZA 1YFEA 1Q5NA 2FUSA 1TJUA 2PTQA 5F91A 1C3UA 2QGAB 2YIIA 2O7DA 4C5RA 5F92A 1T6PA 4BAAA 4FLCA 1JSWA 3R6YA 1HY1A 2RJSA 3R6QA 3E04A 4CQ5A 4APAA 1T6JA 4APBA 4MX2A 3OCEA 2NYNA 1U16A 1TJWA 1B8FA 4C6GA 4BABA 4V2RA 3CZOA 1FURA 1RE5A 1KQ7A 1FUOA 2O7EA 1YFMA 2O78A 2E9FA 1U15A 1DCNA 4NLEA 2QVEA 1GK3A 3QBPA 1HY0A 1FUQA 4EFCA 1DOFA 1K7WA 1TJ7A 2VD6A 4FFXA 4NSLA 2PFMA 3R6VA 1YISA 1FUPA 3GZHA 1Y2MA 4ADLA 3RD8A 2NYFA 3NZ4A 2O6YA 4C5SA 3C8TA 1AUWA 4HGVA
chains in the Genus database with same CATH superfamily
2F5JA 1HQMD 3EZAA 3GTLA 3KDYA 4ADMA 4A15A 1C3CA 2N3EA 2PTSA 3RRPA 1TJVA 4FBSA 4C2MA 2HROA 3LRDA 1I50A 3OCFA 4EEIA 2FELA 4C5UA 1EB4A 2MX8A 3U44A 2JA6A 1Y1WA 2A6ED 1GKMA 3GTOA 1XMCA 4CEJA 3CQZA 2R92A 5HW2A 2RJRA 3NO9A 2O7FA 5EYTA 2O7BA 2LTHA 3EZEA 2J91A 2PTRA 1TWHA 2E2HA 1GK2A 1GKJA 5EYVA 3LR2A 2X75A 3TV2A 3GTDA 2EZBA 1J3UA 1I0AA 1EZAA 4V2QA 2JA5A 3UNVA 4WNLA 2EZCA 1VDKA 2OHYA 2HVGA 3BHGA 1W27A 2VUMA 5H8WA 3LR6A 5D6BA 1K62A 1XWOA 2MX9A 3LR8A 3KDZA 2K3NA 1YFEA 1XLYA 1Q5NA 2FUSA 1TJUA 2PTQA 1TWGA 2K3OA 5F91A 4CEIA 1C3UA 3EZBA 2QGAB 2YIIA 3GTJA 2O7DA 4C5RA 5F92A 1T6PA 1ZYRD 4BAAA 2LYIA 2FENA 4FLCA 1JSWA 1TWAA 1HY1A 3R6YA 2FIPA 2RJSA 3R6QA 2VK9A 3CRVA 2A68D 1YNJD 3GTQA 1EZBA 3E04A 2HWGA 2CW0D 4CQ5A 4APAA 1T6JA 2O5JD 4APBA 2A69D 4MX2A 3OCEA 2NYNA 4QIWA 1R9TA 1U16A 2R93A 2N1DB 1TJWA 1B8FA 2X0PA 2X0OA 3H0GA 3FKIA 4C6GA 1TWCA 2AQLA 1I3QA 4BABA 4V2RA 5M0JA 2NVYA 3GTKA 2E2IA 1XL7A 3CZOA 1FURA 1RE5A 2A6HD 1KQ7A 3GTMA 1FUOA 2MQAA 1XMDA 1YFMA 2O7EA 2E9FA 2O78A 1U15A 1YNND 2LKMB 5IZ2A 2FIOA 3GTGA 1DCNA 2VSFA 4NLEA 1Y1VA 3U4QA 2QVEA 1GK3A 2X0QA 3QBPA 1TWFA 1HY0A 1FUQA 4EFCA 1DOFA 2LPJA 1K7WA 1TJ7A 2VD6A 4FFXA 5M0IA 4CEHA 1WCMA 1I6VD 4NSLA 2PFMA 2R7ZA 1YISA 3R6VA 1K83A 1SFOA 2MP0A 1FUPA 3GZHA 1SMYD 1Y2MA 4ADLA 3RD8A 2LPIA 2NVXA 2NYFA 3CRW1 2BE5D 3GTPA 2EZAA 2VL7A 3NZ4A 2O6YA 1XL8A 2B63A 2YU9A 1IW7D 4C5SA 2JA7A 1ZYMA 2K3QA 3C8TA 1AUWA 4HGVA 2Y0NA
chains in the Genus database with same CATH topology
4ADMA 3KDYA 1C3CA 2PTSA 3RRPA 1TJVA 3OCFA 4EEIA 4C5UA 1EB4A 1GKMA 5HW2A 2RJRA 3NO9A 2O7FA 5EYTA 2O7BA 2PTRA 2J91A 1GK2A 1GKJA 5EYVA 2X75A 3TV2A 3GTDA 1J3UA 1I0AA 4V2QA 3UNVA 1VDKA 2OHYA 2HVGA 3BHGA 1W27A 5D6BA 1K62A 1XWOA 3KDZA 1YFEA 1Q5NA 2FUSA 1TJUA 2PTQA 5F91A 1C3UA 2QGAB 2YIIA 2O7DA 4C5RA 5F92A 1T6PA 4BAAA 4FLCA 1JSWA 3R6YA 1HY1A 2RJSA 3R6QA 3E04A 4CQ5A 4APAA 1T6JA 4APBA 4MX2A 3OCEA 2NYNA 1U16A 1TJWA 1B8FA 4C6GA 4BABA 4V2RA 3CZOA 1FURA 1RE5A 1KQ7A 1FUOA 2O7EA 1YFMA 2O78A 2E9FA 1U15A 1DCNA 4NLEA 2QVEA 1GK3A 3QBPA 1HY0A 1FUQA 4EFCA 1DOFA 1K7WA 1TJ7A 2VD6A 4FFXA 4NSLA 2PFMA 3R6VA 1YISA 1FUPA 3GZHA 1Y2MA 4ADLA 3RD8A 2NYFA 3NZ4A 2O6YA 4C5SA 3C8TA 1AUWA 4HGVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ADM A;  3KDY A;  1C3C A;  2PTS A;  3RRP A;  1TJV A;  3OCF A;  4EEI A;  4C5U A;  1EB4 A;  1GKM A;  5HW2 A;  2RJR A;  3NO9 A;  2O7F A;  5EYT A;  2O7B A;  2PTR A;  2J91 A;  1GK2 A;  1GKJ A;  5EYV A;  2X75 A;  3TV2 A;  3GTD A;  1J3U A;  1I0A A;  4V2Q A;  3UNV A;  1VDK A;  2OHY A;  2HVG A;  3BHG A;  1W27 A;  5D6B A;  1K62 A;  1XWO A;  3KDZ A;  1YFE A;  1Q5N A;  2FUS A;  1TJU A;  2PTQ A;  5F91 A;  1C3U A;  2QGA B;  2YII A;  2O7D A;  4C5R A;  5F92 A;  1T6P A;  4BAA A;  4FLC A;  1JSW A;  3R6Y A;  1HY1 A;  2RJS A;  3R6Q A;  3E04 A;  4CQ5 A;  4APA A;  1T6J A;  4APB A;  4MX2 A;  3OCE A;  2NYN A;  1U16 A;  1TJW A;  1B8F A;  4C6G A;  4BAB A;  4V2R A;  3CZO A;  1FUR A;  1RE5 A;  1KQ7 A;  1FUO A;  2O7E A;  1YFM A;  2O78 A;  2E9F A;  1U15 A;  1DCN A;  4NLE A;  2QVE A;  1GK3 A;  3QBP A;  1HY0 A;  1FUQ A;  4EFC A;  1DOF A;  1K7W A;  1TJ7 A;  2VD6 A;  4FFX A;  4NSL A;  2PFM A;  3R6V A;  1YIS A;  1FUP A;  3GZH A;  1Y2M A;  4ADL A;  3RD8 A;  2NYF A;  3NZ4 A;  2O6Y A;  4C5S A;  3C8T A;  1AUW A;  4HGV A; 
#chains in the Genus database with same CATH topology
 2F5J A;  1HQM D;  3EZA A;  3GTL A;  3KDY A;  4ADM A;  4A15 A;  1C3C A;  2N3E A;  2PTS A;  3RRP A;  1TJV A;  4FBS A;  4C2M A;  2HRO A;  3LRD A;  1I50 A;  3OCF A;  4EEI A;  2FEL A;  4C5U A;  1EB4 A;  2MX8 A;  3U44 A;  2JA6 A;  1Y1W A;  2A6E D;  1GKM A;  3GTO A;  1XMC A;  4CEJ A;  3CQZ A;  2R92 A;  5HW2 A;  2RJR A;  3NO9 A;  2O7F A;  5EYT A;  2O7B A;  2LTH A;  3EZE A;  2J91 A;  2PTR A;  1TWH A;  2E2H A;  1GK2 A;  1GKJ A;  5EYV A;  3LR2 A;  2X75 A;  3TV2 A;  3GTD A;  2EZB A;  1J3U A;  1I0A A;  1EZA A;  4V2Q A;  2JA5 A;  3UNV A;  4WNL A;  2EZC A;  1VDK A;  2OHY A;  2HVG A;  3BHG A;  1W27 A;  2VUM A;  5H8W A;  3LR6 A;  5D6B A;  1K62 A;  1XWO A;  2MX9 A;  3LR8 A;  3KDZ A;  2K3N A;  1YFE A;  1XLY A;  1Q5N A;  2FUS A;  1TJU A;  2PTQ A;  1TWG A;  2K3O A;  5F91 A;  4CEI A;  1C3U A;  3EZB A;  2QGA B;  2YII A;  3GTJ A;  2O7D A;  4C5R A;  5F92 A;  1T6P A;  1ZYR D;  4BAA A;  2LYI A;  2FEN A;  4FLC A;  1JSW A;  1TWA A;  1HY1 A;  3R6Y A;  2FIP A;  2RJS A;  3R6Q A;  2VK9 A;  3CRV A;  2A68 D;  1YNJ D;  3GTQ A;  1EZB A;  3E04 A;  2HWG A;  2CW0 D;  4CQ5 A;  4APA A;  1T6J A;  2O5J D;  4APB A;  2A69 D;  4MX2 A;  3OCE A;  2NYN A;  4QIW A;  1R9T A;  1U16 A;  2R93 A;  2N1D B;  1TJW A;  1B8F A;  2X0P A;  2X0O A;  3H0G A;  3FKI A;  4C6G A;  1TWC A;  2AQL A;  1I3Q A;  4BAB A;  4V2R A;  5M0J A;  2NVY A;  3GTK A;  2E2I A;  1XL7 A;  3CZO A;  1FUR A;  1RE5 A;  2A6H D;  1KQ7 A;  3GTM A;  1FUO A;  2MQA A;  1XMD A;  1YFM A;  2O7E A;  2E9F A;  2O78 A;  1U15 A;  1YNN D;  2LKM B;  5IZ2 A;  2FIO A;  3GTG A;  1DCN A;  2VSF A;  4NLE A;  1Y1V A;  3U4Q A;  2QVE A;  1GK3 A;  2X0Q A;  3QBP A;  1TWF A;  1HY0 A;  1FUQ A;  4EFC A;  1DOF A;  2LPJ A;  1K7W A;  1TJ7 A;  2VD6 A;  4FFX A;  5M0I A;  4CEH A;  1WCM A;  1I6V D;  4NSL A;  2PFM A;  2R7Z A;  1YIS A;  3R6V A;  1K83 A;  1SFO A;  2MP0 A;  1FUP A;  3GZH A;  1SMY D;  1Y2M A;  4ADL A;  3RD8 A;  2LPI A;  2NVX A;  2NYF A;  3CRW 1;  2BE5 D;  3GTP A;  2EZA A;  2VL7 A;  3NZ4 A;  2O6Y A;  1XL8 A;  2B63 A;  2YU9 A;  1IW7 D;  4C5S A;  2JA7 A;  1ZYM A;  2K3Q A;  3C8T A;  1AUW A;  4HGV A;  2Y0N A; 
#chains in the Genus database with same CATH homology
 4ADM A;  3KDY A;  1C3C A;  2PTS A;  3RRP A;  1TJV A;  3OCF A;  4EEI A;  4C5U A;  1EB4 A;  1GKM A;  5HW2 A;  2RJR A;  3NO9 A;  2O7F A;  5EYT A;  2O7B A;  2PTR A;  2J91 A;  1GK2 A;  1GKJ A;  5EYV A;  2X75 A;  3TV2 A;  3GTD A;  1J3U A;  1I0A A;  4V2Q A;  3UNV A;  1VDK A;  2OHY A;  2HVG A;  3BHG A;  1W27 A;  5D6B A;  1K62 A;  1XWO A;  3KDZ A;  1YFE A;  1Q5N A;  2FUS A;  1TJU A;  2PTQ A;  5F91 A;  1C3U A;  2QGA B;  2YII A;  2O7D A;  4C5R A;  5F92 A;  1T6P A;  4BAA A;  4FLC A;  1JSW A;  3R6Y A;  1HY1 A;  2RJS A;  3R6Q A;  3E04 A;  4CQ5 A;  4APA A;  1T6J A;  4APB A;  4MX2 A;  3OCE A;  2NYN A;  1U16 A;  1TJW A;  1B8F A;  4C6G A;  4BAB A;  4V2R A;  3CZO A;  1FUR A;  1RE5 A;  1KQ7 A;  1FUO A;  2O7E A;  1YFM A;  2O78 A;  2E9F A;  1U15 A;  1DCN A;  4NLE A;  2QVE A;  1GK3 A;  3QBP A;  1HY0 A;  1FUQ A;  4EFC A;  1DOF A;  1K7W A;  1TJ7 A;  2VD6 A;  4FFX A;  4NSL A;  2PFM A;  3R6V A;  1YIS A;  1FUP A;  3GZH A;  1Y2M A;  4ADL A;  3RD8 A;  2NYF A;  3NZ4 A;  2O6Y A;  4C5S A;  3C8T A;  1AUW A;  4HGV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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