4V2YA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords CEREBLON ISOFORM 4
publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
source organism Magnetospirillum gryphiswaldense
total genus 25
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2yA00
4TZ4C 1L1DA 3HCHA 5AMHA 4V2ZA 4V31A 4V2YA 4CI2B 2K8DA 3MAOA 4TZCA 3WX1A 3HCJA 3E0OA 4TZUA 3CXKA 2KV1A 3WX2A 3HCIA 3HCGA 2KZNA 3E0MA 4CI1B 4CI3B 4V30A 3CEZA
chains in the Genus database with same CATH superfamily
1HXRA 4TZ4C 2HR9A 1L1DA 4A2VA 1H6QA 5F9FA 2RQAA 3ZD7A 3HCHA 5AMHA 3DJMA 4V31A 4V2YA 4V2ZA 4CI2B 3LRRA 2K8DA 3MAOA 3FACA 5F9HA 4AY2A 4TZCA 2LVLA 3HCJA 3WX1A 1YZ1A 3ZD6A 2W4RA 3E0OA 4TZUA 2QFBA 1H7YA 3CXKA 2FU5A 2KV1A 2KWBA 1FWQA 3GA3A 3P3KA 5F98A 4A2XA 3EBMA 2RMJA 3WX2A 3HCIA 3OG8A 3EQTA 3HCGA 2LOYA 2KZNA 3E0MA 4CI1B 3NCUA 4CI3B 3LRNA 2YKGA 4V30A 2RQBA 5E3HA 1TXJA 3CEZA 2QFDA 4BPBA
chains in the Genus database with same CATH topology
4TZ4C 1L1DA 3HCHA 5AMHA 4V2ZA 4V31A 4V2YA 4CI2B 2K8DA 3MAOA 4TZCA 3WX1A 3HCJA 3E0OA 4TZUA 3CXKA 2KV1A 3WX2A 3HCIA 3HCGA 2KZNA 3E0MA 4CI1B 4CI3B 4V30A 3CEZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZ4 C;  1L1D A;  3HCH A;  5AMH A;  4V2Z A;  4V31 A;  4V2Y A;  4CI2 B;  2K8D A;  3MAO A;  4TZC A;  3WX1 A;  3HCJ A;  3E0O A;  4TZU A;  3CXK A;  2KV1 A;  3WX2 A;  3HCI A;  3HCG A;  2KZN A;  3E0M A;  4CI1 B;  4CI3 B;  4V30 A;  3CEZ A; 
#chains in the Genus database with same CATH topology
 1HXR A;  4TZ4 C;  2HR9 A;  1L1D A;  4A2V A;  1H6Q A;  5F9F A;  2RQA A;  3ZD7 A;  3HCH A;  5AMH A;  3DJM A;  4V31 A;  4V2Y A;  4V2Z A;  4CI2 B;  3LRR A;  2K8D A;  3MAO A;  3FAC A;  5F9H A;  4AY2 A;  4TZC A;  2LVL A;  3HCJ A;  3WX1 A;  1YZ1 A;  3ZD6 A;  2W4R A;  3E0O A;  4TZU A;  2QFB A;  1H7Y A;  3CXK A;  2FU5 A;  2KV1 A;  2KWB A;  1FWQ A;  3GA3 A;  3P3K A;  5F98 A;  4A2X A;  3EBM A;  2RMJ A;  3WX2 A;  3HCI A;  3OG8 A;  3EQT A;  3HCG A;  2LOY A;  2KZN A;  3E0M A;  4CI1 B;  3NCU A;  4CI3 B;  3LRN A;  2YKG A;  4V30 A;  2RQB A;  5E3H A;  1TXJ A;  3CEZ A;  2QFD A;  4BPB A; 
#chains in the Genus database with same CATH homology
 4TZ4 C;  1L1D A;  3HCH A;  5AMH A;  4V2Z A;  4V31 A;  4V2Y A;  4CI2 B;  2K8D A;  3MAO A;  4TZC A;  3WX1 A;  3HCJ A;  3E0O A;  4TZU A;  3CXK A;  2KV1 A;  3WX2 A;  3HCI A;  3HCG A;  2KZN A;  3E0M A;  4CI1 B;  4CI3 B;  4V30 A;  3CEZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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