4V2ZA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords CEREBLON ISOFORM 4
publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
source organism Magnetospirillum gryphiswaldense
total genus 23
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2zA00
4V2ZA 3E0OA 4CI2B 4TZ4C 4CI1B 2KZNA 4V31A 3MAOA 3HCGA 3HCHA 2K8DA 3HCJA 3CXKA 2KV1A 3WX1A 3WX2A 4V2YA 4V30A 4CI3B 3CEZA 4TZCA 3E0MA 5AMHA 4TZUA 1L1DA 3HCIA
chains in the Genus database with same CATH superfamily
4AY2A 1H6QA 4V2ZA 3E0OA 4CI2B 1FWQA 4TZ4C 1TXJA 4BPBA 5F9HA 4CI1B 2KZNA 4V31A 3MAOA 3LRNA 2QFDA 3HCGA 3OG8A 2RQAA 3HCHA 2K8DA 3HCJA 3CXKA 5E3HA 2KV1A 2LVLA 1H7YA 3WX1A 2RMJA 4A2VA 2YKGA 3WX2A 4V2YA 3EQTA 2KWBA 3EBMA 4A2XA 4V30A 1YZ1A 2LOYA 3DJMA 3GA3A 4CI3B 2RQBA 3LRRA 2W4RA 3CEZA 3FACA 1HXRA 2QFBA 4TZCA 3E0MA 2HR9A 5AMHA 4TZUA 3ZD7A 3ZD6A 2FU5A 3NCUA 1L1DA 3HCIA 5F98A 5F9FA 3P3KA
chains in the Genus database with same CATH topology
4V2ZA 3E0OA 4CI2B 4TZ4C 4CI1B 2KZNA 4V31A 3MAOA 3HCGA 3HCHA 2K8DA 3HCJA 3CXKA 2KV1A 3WX1A 3WX2A 4V2YA 4V30A 4CI3B 3CEZA 4TZCA 3E0MA 5AMHA 4TZUA 1L1DA 3HCIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2Z A;  3E0O A;  4CI2 B;  4TZ4 C;  4CI1 B;  2KZN A;  4V31 A;  3MAO A;  3HCG A;  3HCH A;  2K8D A;  3HCJ A;  3CXK A;  2KV1 A;  3WX1 A;  3WX2 A;  4V2Y A;  4V30 A;  4CI3 B;  3CEZ A;  4TZC A;  3E0M A;  5AMH A;  4TZU A;  1L1D A;  3HCI A; 
#chains in the Genus database with same CATH topology
 4AY2 A;  1H6Q A;  4V2Z A;  3E0O A;  4CI2 B;  1FWQ A;  4TZ4 C;  1TXJ A;  4BPB A;  5F9H A;  4CI1 B;  2KZN A;  4V31 A;  3MAO A;  3LRN A;  2QFD A;  3HCG A;  3OG8 A;  2RQA A;  3HCH A;  2K8D A;  3HCJ A;  3CXK A;  5E3H A;  2KV1 A;  2LVL A;  1H7Y A;  3WX1 A;  2RMJ A;  4A2V A;  2YKG A;  3WX2 A;  4V2Y A;  3EQT A;  2KWB A;  3EBM A;  4A2X A;  4V30 A;  1YZ1 A;  2LOY A;  3DJM A;  3GA3 A;  4CI3 B;  2RQB A;  3LRR A;  2W4R A;  3CEZ A;  3FAC A;  1HXR A;  2QFB A;  4TZC A;  3E0M A;  2HR9 A;  5AMH A;  4TZU A;  3ZD7 A;  3ZD6 A;  2FU5 A;  3NCU A;  1L1D A;  3HCI A;  5F98 A;  5F9F A;  3P3K A; 
#chains in the Genus database with same CATH homology
 4V2Z A;  3E0O A;  4CI2 B;  4TZ4 C;  4CI1 B;  2KZN A;  4V31 A;  3MAO A;  3HCG A;  3HCH A;  2K8D A;  3HCJ A;  3CXK A;  2KV1 A;  3WX1 A;  3WX2 A;  4V2Y A;  4V30 A;  4CI3 B;  3CEZ A;  4TZC A;  3E0M A;  5AMH A;  4TZU A;  1L1D A;  3HCI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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