4W9IB

Pvhl:elob:eloc in complex with (2s,4r)-1-((2s,4r)-1-acetyl-4-hydroxypyrrolidine-2-carbonyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 10)
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
96
structure length
86
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Ligase
molecule keywords Transcription elongation factor B polypeptide 2
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
source organism Homo sapiens
total genus 23
structure length 86
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9iB00
2OVRA 2P1QA 4W9GB 4JTAB 3V7DA 3OHUA 2I2RA 2Q81A 5BXBA 1EODA 3ZTCB 2NZ0B 1NEXA 4WQOC 3DRZA 2JZ3C 1FS2B 4W9JB 3OGKA 4JTCB 2C9WC 2VKPA 2FNJC 4W9HH 4CRHA 3OGMA 1FS1B 3C6PA 5DADA 3LBZA 1R2BA 5LLIB 3M4TA 3MKSA 4W9DB 4ZOUA 2OVQA 2OVPA 2R9RB 4U2MA 3ZKJB 4EOZA 4UIJA 4JTDB 4B9KB 1P22B 3ZRCB 4BKSB 2IHCA 4CXTA 4I6JC 4BKTB 5HYWB 3B84A 1DSXA 3ZNGB 3C6OA 5BXHA 4W9CB 4CXJA 2P1PA 3LUTB 5H7GA 3ZUNB 2E31B 3LNMB 1R28A 2ASTA 4JGHC 1S1GA 3ZRFB 5DAFA 1EOFA 3HVEA 1HV2A 1LDKD 3C6NA 3E4UA 2A79B 1FQVB 4W9FB 2E32B 5BO4C 4CXIA 2P1MA 5A15A 4APFA 4U77A 4B9KE 4N9F5 3HTMA 4AJYC 1QDWA 1EXBE 4AP2A 1QDVA 5A6RA 1LQBB 1T1DA 2ASSA 3OHVA 4U2NA 4B95B 3FKCA 3L2OA 2NN2A 1VCBB 3M8VA 1CS3A 2P1OA 3HVEB 2IZVC 3ZTDB 1R29A 3HU6A 4W9HB 4W9LB 4J8ZA 4W9IB 1EOEA 1BUOA 4W9EB 3OGLA 3M5BA 4BGCA 3I3NA 3HQIA 5BXDA 2YY9A 3WSOB 2PPIA 4W9KB 3KVTA 4HXIA 5H7HA 2MA9C 3DCGB 5EUPA 4CP3A 3BIMA 1A68A 1LM8C 5IBKA 2IF5A 5FTAA 3GA1A 2Z8HA 5JH5B 4UYIA 3M52A 5HZGC 2P1NA 1NN7A 4AWJB 2VPKA
chains in the Genus database with same CATH superfamily
2OVRA 2P1QA 4W9GB 4JTAB 3V7DA 3OHUA 2I2RA 2Q81A 5BXBA 1EODA 3ZTCB 2NZ0B 1NEXA 4YY8A 4WQOC 3DRZA 2JZ3C 1FS2B 4W9JB 3OGKA 4JTCB 2C9WC 2VKPA 2FNJC 4W9HH 4CRHA 3DRYA 3OGMA 1FS1B 3C6PA 5DADA 3LBZA 1R2BA 5LLIB 3M4TA 3MKSA 4W9DB 4ZOUA 2OVQA 2OVPA 2R9RB 4U2MA 3ZKJB 4EOZA 4UIJA 4JTDB 4B9KB 1P22B 3ZRCB 4BKSB 2IHCA 4CXTA 4I6JC 4BKTB 5HYWB 3B84A 1DSXA 3ZNGB 3C6OA 5BXHA 4W9CB 4CXJA 2P1PA 3DRXA 3LUTB 5H7GA 3ZUNB 2E31B 3LNMB 1R28A 2ASTA 4JGHC 1S1GA 3ZRFB 5DAFA 1EOFA 3HVEA 1HV2A 1LDKD 3C6NA 3E4UA 2A79B 1FQVB 4W9FB 2E32B 5BO4C 4CXIA 2P1MA 5A15A 4APFA 4U77A 4B9KE 4N9F5 3HTMA 4AJYC 4ZGCA 1QDWA 1EXBE 4AP2A 1QDVA 5A6RA 1LQBB 1T1DA 2ASSA 3OHVA 4U2NA 4B95B 3FKCA 3L2OA 2NN2A 1VCBB 3M8VA 1CS3A 2P1OA 3HVEB 2IZVC 3ZTDB 1R29A 3HU6A 4W9HB 4W9LB 4J8ZA 4W9IB 1EOEA 1BUOA 4W9EB 3OGLA 3M5BA 4BGCA 3I3NA 3HQIA 5BXDA 2YY9A 3WSOB 2PPIA 4W9KB 3KVTA 4HXIA 5H7HA 2MA9C 3DCGB 5EUPA 4CP3A 3BIMA 1A68A 1LM8C 5IBKA 2IF5A 5FTAA 3GA1A 2Z8HA 5JH5B 4UYIA 3M52A 5HZGC 2P1NA 1NN7A 4AWJB 2VPKA
chains in the Genus database with same CATH topology
2OVRA 2P1QA 4W9GB 4JTAB 3V7DA 3OHUA 2I2RA 2Q81A 5BXBA 1EODA 3ZTCB 2NZ0B 1NEXA 4YY8A 4WQOC 3DRZA 2JZ3C 1FS2B 4W9JB 3OGKA 4JTCB 2C9WC 2VKPA 2FNJC 4W9HH 4CRHA 3DRYA 3OGMA 1FS1B 3C6PA 5DADA 3LBZA 1R2BA 5LLIB 3M4TA 3MKSA 4W9DB 4ZOUA 2OVQA 2OVPA 2R9RB 4U2MA 3ZKJB 4EOZA 4UIJA 4JTDB 4B9KB 1P22B 3ZRCB 4BKSB 2IHCA 4CXTA 4I6JC 4BKTB 5HYWB 3B84A 1DSXA 3ZNGB 3C6OA 5BXHA 4W9CB 4CXJA 2P1PA 3DRXA 3LUTB 5H7GA 3ZUNB 2E31B 3LNMB 1R28A 2ASTA 4JGHC 1S1GA 3ZRFB 5DAFA 1EOFA 3HVEA 1HV2A 1LDKD 3C6NA 3E4UA 2A79B 1FQVB 4W9FB 2E32B 5BO4C 4CXIA 2P1MA 5A15A 4APFA 4U77A 4B9KE 4N9F5 3HTMA 4AJYC 4ZGCA 1QDWA 1EXBE 4AP2A 1QDVA 5A6RA 1LQBB 1T1DA 2ASSA 3OHVA 4U2NA 4B95B 3FKCA 3L2OA 2NN2A 1VCBB 3M8VA 1CS3A 2P1OA 3HVEB 2IZVC 3ZTDB 1R29A 3HU6A 4W9HB 4W9LB 4J8ZA 4W9IB 1EOEA 1BUOA 4W9EB 3OGLA 3M5BA 4BGCA 3I3NA 3HQIA 5BXDA 2YY9A 3WSOB 2PPIA 4W9KB 3KVTA 4HXIA 5H7HA 2MA9C 3DCGB 5EUPA 4CP3A 3BIMA 1A68A 1LM8C 5IBKA 2IF5A 5FTAA 3GA1A 2Z8HA 5JH5B 4UYIA 3M52A 5HZGC 2P1NA 1NN7A 4AWJB 2VPKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OVR A;  2P1Q A;  4W9G B;  4JTA B;  3V7D A;  3OHU A;  2I2R A;  2Q81 A;  5BXB A;  1EOD A;  3ZTC B;  2NZ0 B;  1NEX A;  4WQO C;  3DRZ A;  2JZ3 C;  1FS2 B;  4W9J B;  3OGK A;  4JTC B;  2C9W C;  2VKP A;  2FNJ C;  4W9H H;  4CRH A;  3OGM A;  1FS1 B;  3C6P A;  5DAD A;  3LBZ A;  1R2B A;  5LLI B;  3M4T A;  3MKS A;  4W9D B;  4ZOU A;  2OVQ A;  2OVP A;  2R9R B;  4U2M A;  3ZKJ B;  4EOZ A;  4UIJ A;  4JTD B;  4B9K B;  1P22 B;  3ZRC B;  4BKS B;  2IHC A;  4CXT A;  4I6J C;  4BKT B;  5HYW B;  3B84 A;  1DSX A;  3ZNG B;  3C6O A;  5BXH A;  4W9C B;  4CXJ A;  2P1P A;  3LUT B;  5H7G A;  3ZUN B;  2E31 B;  3LNM B;  1R28 A;  2AST A;  4JGH C;  1S1G A;  3ZRF B;  5DAF A;  1EOF A;  3HVE A;  1HV2 A;  1LDK D;  3C6N A;  3E4U A;  2A79 B;  1FQV B;  4W9F B;  2E32 B;  5BO4 C;  4CXI A;  2P1M A;  5A15 A;  4APF A;  4U77 A;  4B9K E;  4N9F 5;  3HTM A;  4AJY C;  1QDW A;  1EXB E;  4AP2 A;  1QDV A;  5A6R A;  1LQB B;  1T1D A;  2ASS A;  3OHV A;  4U2N A;  4B95 B;  3FKC A;  3L2O A;  2NN2 A;  1VCB B;  3M8V A;  1CS3 A;  2P1O A;  3HVE B;  2IZV C;  3ZTD B;  1R29 A;  3HU6 A;  4W9H B;  4W9L B;  4J8Z A;  4W9I B;  1EOE A;  1BUO A;  4W9E B;  3OGL A;  3M5B A;  4BGC A;  3I3N A;  3HQI A;  5BXD A;  2YY9 A;  3WSO B;  2PPI A;  4W9K B;  3KVT A;  4HXI A;  5H7H A;  2MA9 C;  3DCG B;  5EUP A;  4CP3 A;  3BIM A;  1A68 A;  1LM8 C;  5IBK A;  2IF5 A;  5FTA A;  3GA1 A;  2Z8H A;  5JH5 B;  4UYI A;  3M52 A;  5HZG C;  2P1N A;  1NN7 A;  4AWJ B;  2VPK A; 
#chains in the Genus database with same CATH topology
 2OVR A;  2P1Q A;  4W9G B;  4JTA B;  3V7D A;  3OHU A;  2I2R A;  2Q81 A;  5BXB A;  1EOD A;  3ZTC B;  2NZ0 B;  1NEX A;  4YY8 A;  4WQO C;  3DRZ A;  2JZ3 C;  1FS2 B;  4W9J B;  3OGK A;  4JTC B;  2C9W C;  2VKP A;  2FNJ C;  4W9H H;  4CRH A;  3DRY A;  3OGM A;  1FS1 B;  3C6P A;  5DAD A;  3LBZ A;  1R2B A;  5LLI B;  3M4T A;  3MKS A;  4W9D B;  4ZOU A;  2OVQ A;  2OVP A;  2R9R B;  4U2M A;  3ZKJ B;  4EOZ A;  4UIJ A;  4JTD B;  4B9K B;  1P22 B;  3ZRC B;  4BKS B;  2IHC A;  4CXT A;  4I6J C;  4BKT B;  5HYW B;  3B84 A;  1DSX A;  3ZNG B;  3C6O A;  5BXH A;  4W9C B;  4CXJ A;  2P1P A;  3DRX A;  3LUT B;  5H7G A;  3ZUN B;  2E31 B;  3LNM B;  1R28 A;  2AST A;  4JGH C;  1S1G A;  3ZRF B;  5DAF A;  1EOF A;  3HVE A;  1HV2 A;  1LDK D;  3C6N A;  3E4U A;  2A79 B;  1FQV B;  4W9F B;  2E32 B;  5BO4 C;  4CXI A;  2P1M A;  5A15 A;  4APF A;  4U77 A;  4B9K E;  4N9F 5;  3HTM A;  4AJY C;  4ZGC A;  1QDW A;  1EXB E;  4AP2 A;  1QDV A;  5A6R A;  1LQB B;  1T1D A;  2ASS A;  3OHV A;  4U2N A;  4B95 B;  3FKC A;  3L2O A;  2NN2 A;  1VCB B;  3M8V A;  1CS3 A;  2P1O A;  3HVE B;  2IZV C;  3ZTD B;  1R29 A;  3HU6 A;  4W9H B;  4W9L B;  4J8Z A;  4W9I B;  1EOE A;  1BUO A;  4W9E B;  3OGL A;  3M5B A;  4BGC A;  3I3N A;  3HQI A;  5BXD A;  2YY9 A;  3WSO B;  2PPI A;  4W9K B;  3KVT A;  4HXI A;  5H7H A;  2MA9 C;  3DCG B;  5EUP A;  4CP3 A;  3BIM A;  1A68 A;  1LM8 C;  5IBK A;  2IF5 A;  5FTA A;  3GA1 A;  2Z8H A;  5JH5 B;  4UYI A;  3M52 A;  5HZG C;  2P1N A;  1NN7 A;  4AWJ B;  2VPK A; 
#chains in the Genus database with same CATH homology
 2OVR A;  2P1Q A;  4W9G B;  4JTA B;  3V7D A;  3OHU A;  2I2R A;  2Q81 A;  5BXB A;  1EOD A;  3ZTC B;  2NZ0 B;  1NEX A;  4YY8 A;  4WQO C;  3DRZ A;  2JZ3 C;  1FS2 B;  4W9J B;  3OGK A;  4JTC B;  2C9W C;  2VKP A;  2FNJ C;  4W9H H;  4CRH A;  3DRY A;  3OGM A;  1FS1 B;  3C6P A;  5DAD A;  3LBZ A;  1R2B A;  5LLI B;  3M4T A;  3MKS A;  4W9D B;  4ZOU A;  2OVQ A;  2OVP A;  2R9R B;  4U2M A;  3ZKJ B;  4EOZ A;  4UIJ A;  4JTD B;  4B9K B;  1P22 B;  3ZRC B;  4BKS B;  2IHC A;  4CXT A;  4I6J C;  4BKT B;  5HYW B;  3B84 A;  1DSX A;  3ZNG B;  3C6O A;  5BXH A;  4W9C B;  4CXJ A;  2P1P A;  3DRX A;  3LUT B;  5H7G A;  3ZUN B;  2E31 B;  3LNM B;  1R28 A;  2AST A;  4JGH C;  1S1G A;  3ZRF B;  5DAF A;  1EOF A;  3HVE A;  1HV2 A;  1LDK D;  3C6N A;  3E4U A;  2A79 B;  1FQV B;  4W9F B;  2E32 B;  5BO4 C;  4CXI A;  2P1M A;  5A15 A;  4APF A;  4U77 A;  4B9K E;  4N9F 5;  3HTM A;  4AJY C;  4ZGC A;  1QDW A;  1EXB E;  4AP2 A;  1QDV A;  5A6R A;  1LQB B;  1T1D A;  2ASS A;  3OHV A;  4U2N A;  4B95 B;  3FKC A;  3L2O A;  2NN2 A;  1VCB B;  3M8V A;  1CS3 A;  2P1O A;  3HVE B;  2IZV C;  3ZTD B;  1R29 A;  3HU6 A;  4W9H B;  4W9L B;  4J8Z A;  4W9I B;  1EOE A;  1BUO A;  4W9E B;  3OGL A;  3M5B A;  4BGC A;  3I3N A;  3HQI A;  5BXD A;  2YY9 A;  3WSO B;  2PPI A;  4W9K B;  3KVT A;  4HXI A;  5H7H A;  2MA9 C;  3DCG B;  5EUP A;  4CP3 A;  3BIM A;  1A68 A;  1LM8 C;  5IBK A;  2IF5 A;  5FTA A;  3GA1 A;  2Z8H A;  5JH5 B;  4UYI A;  3M52 A;  5HZG C;  2P1N A;  1NN7 A;  4AWJ B;  2VPK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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