4W9JB

Pvhl:elob:eloc in complex with (2s,4r)-1-((s)-2-((s)-2-acetamido-4-methylpentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 13)
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
96
structure length
86
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription
molecule keywords Transcription elongation factor B polypeptide 2
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
source organism Homo sapiens
total genus 24
structure length 86
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9jB00
3WSOB 5A6RA 4U2NA 4W9FB 2P1PA 2E31B 1VCBB 4BKTB 1T1DA 3HTMA 4CP3A 4I6JC 1LDKD 4JTAB 5LLIB 3HVEA 4CRHA 3OHVA 2FNJC 2IF5A 3OGKA 2C9WC 4BGCA 2P1QA 3LNMB 3ZTDB 4JTCB 3MKSA 3HU6A 2OVQA 2VKPA 1FS1B 1EODA 3KVTA 5BXBA 5HYWB 1HV2A 2VPKA 5IBKA 2OVRA 4CXIA 3I3NA 3M8VA 2Q81A 4AJYC 4CXTA 2JZ3C 4U77A 3LUTB 3M52A 1R28A 5FTAA 1CS3A 3GA1A 1R2BA 3LBZA 2OVPA 4W9GB 5H7GA 1QDVA 1LQBB 5BO4C 4ZOUA 2YY9A 3E4UA 1BUOA 4B9KB 4AP2A 4U2MA 3FKCA 4CXJA 2E32B 1P22B 4EOZA 1EOEA 3C6PA 1A68A 2NZ0B 1LM8C 1NEXA 3ZUNB 5DADA 3DRZA 2ASSA 4HXIA 1R29A 4WQOC 4W9KB 3OGLA 1DSXA 4W9CB 5JH5B 4W9JB 4JGHC 2A79B 2IZVC 4W9HH 5H7HA 5DAFA 4AWJB 3ZRFB 3ZRCB 2R9RB 4B9KE 4APFA 5HZGC 2P1NA 3OGMA 4JTDB 4J8ZA 4W9EB 5EUPA 3V7DA 2NN2A 1S1GA 2I2RA 3OHUA 2ASTA 3C6NA 5BXDA 1EOFA 3M5BA 1FS2B 2PPIA 3M4TA 3ZTCB 1EXBE 3ZKJB 3ZNGB 4W9IB 2IHCA 2Z8HA 3C6OA 4UYIA 1QDWA 3BIMA 3L2OA 4W9DB 3B84A 3HQIA 4B95B 5BXHA 2MA9C 4N9F5 3DCGB 4UIJA 4W9LB 1NN7A 4W9HB 4BKSB 5A15A 2P1OA 1FQVB 2P1MA 3HVEB
chains in the Genus database with same CATH superfamily
3WSOB 5A6RA 4U2NA 4W9FB 2P1PA 2E31B 1VCBB 4BKTB 1T1DA 3HTMA 4CP3A 4I6JC 1LDKD 4JTAB 5LLIB 3HVEA 4CRHA 3OHVA 2FNJC 2IF5A 3OGKA 2C9WC 4BGCA 2P1QA 3LNMB 3ZTDB 4JTCB 3MKSA 3HU6A 2OVQA 2VKPA 1FS1B 1EODA 3KVTA 5BXBA 5HYWB 1HV2A 2VPKA 5IBKA 2OVRA 4CXIA 3I3NA 3M8VA 2Q81A 4AJYC 4CXTA 2JZ3C 4U77A 3LUTB 3M52A 1R28A 5FTAA 1CS3A 3GA1A 1R2BA 3LBZA 2OVPA 4W9GB 5H7GA 1QDVA 1LQBB 5BO4C 4ZOUA 2YY9A 4YY8A 3E4UA 1BUOA 4B9KB 4AP2A 4ZGCA 3DRYA 4U2MA 3FKCA 4CXJA 2E32B 1P22B 4EOZA 1EOEA 3C6PA 1A68A 2NZ0B 1LM8C 1NEXA 3ZUNB 5DADA 3DRZA 2ASSA 4HXIA 1R29A 4WQOC 4W9KB 3OGLA 1DSXA 4W9CB 5JH5B 4W9JB 4JGHC 2A79B 2IZVC 4W9HH 5H7HA 5DAFA 4AWJB 3ZRFB 3ZRCB 2R9RB 4B9KE 4APFA 5HZGC 2P1NA 3OGMA 4JTDB 4J8ZA 4W9EB 5EUPA 3V7DA 2NN2A 1S1GA 2I2RA 3OHUA 2ASTA 3C6NA 5BXDA 1EOFA 3DRXA 1FS2B 3M5BA 2PPIA 3M4TA 3ZTCB 1EXBE 3ZKJB 3ZNGB 4W9IB 2IHCA 2Z8HA 3C6OA 4UYIA 1QDWA 3BIMA 3L2OA 4W9DB 3B84A 3HQIA 4B95B 5BXHA 2MA9C 4N9F5 3DCGB 4UIJA 4W9LB 1NN7A 4W9HB 4BKSB 5A15A 2P1OA 1FQVB 2P1MA 3HVEB
chains in the Genus database with same CATH topology
3WSOB 5A6RA 4U2NA 4W9FB 2P1PA 2E31B 1VCBB 4BKTB 1T1DA 3HTMA 4CP3A 4I6JC 1LDKD 4JTAB 5LLIB 3HVEA 4CRHA 3OHVA 2FNJC 2IF5A 3OGKA 2C9WC 4BGCA 2P1QA 3LNMB 3ZTDB 4JTCB 3MKSA 3HU6A 2OVQA 2VKPA 1FS1B 1EODA 3KVTA 5BXBA 5HYWB 1HV2A 2VPKA 5IBKA 2OVRA 4CXIA 3I3NA 3M8VA 2Q81A 4AJYC 4CXTA 2JZ3C 4U77A 3LUTB 3M52A 1R28A 5FTAA 1CS3A 3GA1A 1R2BA 3LBZA 2OVPA 4W9GB 5H7GA 1QDVA 1LQBB 5BO4C 4ZOUA 2YY9A 4YY8A 3E4UA 1BUOA 4B9KB 4AP2A 4ZGCA 3DRYA 4U2MA 3FKCA 4CXJA 2E32B 1P22B 4EOZA 1EOEA 3C6PA 1A68A 2NZ0B 1LM8C 1NEXA 3ZUNB 5DADA 3DRZA 2ASSA 4HXIA 1R29A 4WQOC 4W9KB 3OGLA 1DSXA 4W9CB 5JH5B 4W9JB 4JGHC 2A79B 2IZVC 4W9HH 5H7HA 5DAFA 4AWJB 3ZRFB 3ZRCB 2R9RB 4B9KE 4APFA 5HZGC 2P1NA 3OGMA 4JTDB 4J8ZA 4W9EB 5EUPA 3V7DA 2NN2A 1S1GA 2I2RA 3OHUA 2ASTA 3C6NA 5BXDA 1EOFA 3DRXA 1FS2B 3M5BA 2PPIA 3M4TA 3ZTCB 1EXBE 3ZKJB 3ZNGB 4W9IB 2IHCA 2Z8HA 3C6OA 4UYIA 1QDWA 3BIMA 3L2OA 4W9DB 3B84A 3HQIA 4B95B 5BXHA 2MA9C 4N9F5 3DCGB 4UIJA 4W9LB 1NN7A 4W9HB 4BKSB 5A15A 2P1OA 1FQVB 2P1MA 3HVEB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WSO B;  5A6R A;  4U2N A;  4W9F B;  2P1P A;  2E31 B;  1VCB B;  4BKT B;  1T1D A;  3HTM A;  4CP3 A;  4I6J C;  1LDK D;  4JTA B;  5LLI B;  3HVE A;  4CRH A;  3OHV A;  2FNJ C;  2IF5 A;  3OGK A;  2C9W C;  4BGC A;  2P1Q A;  3LNM B;  3ZTD B;  4JTC B;  3MKS A;  3HU6 A;  2OVQ A;  2VKP A;  1FS1 B;  1EOD A;  3KVT A;  5BXB A;  5HYW B;  1HV2 A;  2VPK A;  5IBK A;  2OVR A;  4CXI A;  3I3N A;  3M8V A;  2Q81 A;  4AJY C;  4CXT A;  2JZ3 C;  4U77 A;  3LUT B;  3M52 A;  1R28 A;  5FTA A;  1CS3 A;  3GA1 A;  1R2B A;  3LBZ A;  2OVP A;  4W9G B;  5H7G A;  1QDV A;  1LQB B;  5BO4 C;  4ZOU A;  2YY9 A;  3E4U A;  1BUO A;  4B9K B;  4AP2 A;  4U2M A;  3FKC A;  4CXJ A;  2E32 B;  1P22 B;  4EOZ A;  1EOE A;  3C6P A;  1A68 A;  2NZ0 B;  1LM8 C;  1NEX A;  3ZUN B;  5DAD A;  3DRZ A;  2ASS A;  4HXI A;  1R29 A;  4WQO C;  4W9K B;  3OGL A;  1DSX A;  4W9C B;  5JH5 B;  4W9J B;  4JGH C;  2A79 B;  2IZV C;  4W9H H;  5H7H A;  5DAF A;  4AWJ B;  3ZRF B;  3ZRC B;  2R9R B;  4B9K E;  4APF A;  5HZG C;  2P1N A;  3OGM A;  4JTD B;  4J8Z A;  4W9E B;  5EUP A;  3V7D A;  2NN2 A;  1S1G A;  2I2R A;  3OHU A;  2AST A;  3C6N A;  5BXD A;  1EOF A;  3M5B A;  1FS2 B;  2PPI A;  3M4T A;  3ZTC B;  1EXB E;  3ZKJ B;  3ZNG B;  4W9I B;  2IHC A;  2Z8H A;  3C6O A;  4UYI A;  1QDW A;  3BIM A;  3L2O A;  4W9D B;  3B84 A;  3HQI A;  4B95 B;  5BXH A;  2MA9 C;  4N9F 5;  3DCG B;  4UIJ A;  4W9L B;  1NN7 A;  4W9H B;  4BKS B;  5A15 A;  2P1O A;  1FQV B;  2P1M A;  3HVE B; 
#chains in the Genus database with same CATH topology
 3WSO B;  5A6R A;  4U2N A;  4W9F B;  2P1P A;  2E31 B;  1VCB B;  4BKT B;  1T1D A;  3HTM A;  4CP3 A;  4I6J C;  1LDK D;  4JTA B;  5LLI B;  3HVE A;  4CRH A;  3OHV A;  2FNJ C;  2IF5 A;  3OGK A;  2C9W C;  4BGC A;  2P1Q A;  3LNM B;  3ZTD B;  4JTC B;  3MKS A;  3HU6 A;  2OVQ A;  2VKP A;  1FS1 B;  1EOD A;  3KVT A;  5BXB A;  5HYW B;  1HV2 A;  2VPK A;  5IBK A;  2OVR A;  4CXI A;  3I3N A;  3M8V A;  2Q81 A;  4AJY C;  4CXT A;  2JZ3 C;  4U77 A;  3LUT B;  3M52 A;  1R28 A;  5FTA A;  1CS3 A;  3GA1 A;  1R2B A;  3LBZ A;  2OVP A;  4W9G B;  5H7G A;  1QDV A;  1LQB B;  5BO4 C;  4ZOU A;  2YY9 A;  4YY8 A;  3E4U A;  1BUO A;  4B9K B;  4AP2 A;  4ZGC A;  3DRY A;  4U2M A;  3FKC A;  4CXJ A;  2E32 B;  1P22 B;  4EOZ A;  1EOE A;  3C6P A;  1A68 A;  2NZ0 B;  1LM8 C;  1NEX A;  3ZUN B;  5DAD A;  3DRZ A;  2ASS A;  4HXI A;  1R29 A;  4WQO C;  4W9K B;  3OGL A;  1DSX A;  4W9C B;  5JH5 B;  4W9J B;  4JGH C;  2A79 B;  2IZV C;  4W9H H;  5H7H A;  5DAF A;  4AWJ B;  3ZRF B;  3ZRC B;  2R9R B;  4B9K E;  4APF A;  5HZG C;  2P1N A;  3OGM A;  4JTD B;  4J8Z A;  4W9E B;  5EUP A;  3V7D A;  2NN2 A;  1S1G A;  2I2R A;  3OHU A;  2AST A;  3C6N A;  5BXD A;  1EOF A;  3DRX A;  1FS2 B;  3M5B A;  2PPI A;  3M4T A;  3ZTC B;  1EXB E;  3ZKJ B;  3ZNG B;  4W9I B;  2IHC A;  2Z8H A;  3C6O A;  4UYI A;  1QDW A;  3BIM A;  3L2O A;  4W9D B;  3B84 A;  3HQI A;  4B95 B;  5BXH A;  2MA9 C;  4N9F 5;  3DCG B;  4UIJ A;  4W9L B;  1NN7 A;  4W9H B;  4BKS B;  5A15 A;  2P1O A;  1FQV B;  2P1M A;  3HVE B; 
#chains in the Genus database with same CATH homology
 3WSO B;  5A6R A;  4U2N A;  4W9F B;  2P1P A;  2E31 B;  1VCB B;  4BKT B;  1T1D A;  3HTM A;  4CP3 A;  4I6J C;  1LDK D;  4JTA B;  5LLI B;  3HVE A;  4CRH A;  3OHV A;  2FNJ C;  2IF5 A;  3OGK A;  2C9W C;  4BGC A;  2P1Q A;  3LNM B;  3ZTD B;  4JTC B;  3MKS A;  3HU6 A;  2OVQ A;  2VKP A;  1FS1 B;  1EOD A;  3KVT A;  5BXB A;  5HYW B;  1HV2 A;  2VPK A;  5IBK A;  2OVR A;  4CXI A;  3I3N A;  3M8V A;  2Q81 A;  4AJY C;  4CXT A;  2JZ3 C;  4U77 A;  3LUT B;  3M52 A;  1R28 A;  5FTA A;  1CS3 A;  3GA1 A;  1R2B A;  3LBZ A;  2OVP A;  4W9G B;  5H7G A;  1QDV A;  1LQB B;  5BO4 C;  4ZOU A;  2YY9 A;  4YY8 A;  3E4U A;  1BUO A;  4B9K B;  4AP2 A;  4ZGC A;  3DRY A;  4U2M A;  3FKC A;  4CXJ A;  2E32 B;  1P22 B;  4EOZ A;  1EOE A;  3C6P A;  1A68 A;  2NZ0 B;  1LM8 C;  1NEX A;  3ZUN B;  5DAD A;  3DRZ A;  2ASS A;  4HXI A;  1R29 A;  4WQO C;  4W9K B;  3OGL A;  1DSX A;  4W9C B;  5JH5 B;  4W9J B;  4JGH C;  2A79 B;  2IZV C;  4W9H H;  5H7H A;  5DAF A;  4AWJ B;  3ZRF B;  3ZRC B;  2R9R B;  4B9K E;  4APF A;  5HZG C;  2P1N A;  3OGM A;  4JTD B;  4J8Z A;  4W9E B;  5EUP A;  3V7D A;  2NN2 A;  1S1G A;  2I2R A;  3OHU A;  2AST A;  3C6N A;  5BXD A;  1EOF A;  3DRX A;  1FS2 B;  3M5B A;  2PPI A;  3M4T A;  3ZTC B;  1EXB E;  3ZKJ B;  3ZNG B;  4W9I B;  2IHC A;  2Z8H A;  3C6O A;  4UYI A;  1QDW A;  3BIM A;  3L2O A;  4W9D B;  3B84 A;  3HQI A;  4B95 B;  5BXH A;  2MA9 C;  4N9F 5;  3DCG B;  4UIJ A;  4W9L B;  1NN7 A;  4W9H B;  4BKS B;  5A15 A;  2P1O A;  1FQV B;  2P1M A;  3HVE B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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