4WKEA

Crystal structure of human adamts-4 in complex with inhibitor 5-chloro-n-{[(4r)-2,5-dioxo-4-(1,3-thiazol-2-yl)imidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 10)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
214
Chain Sequence
LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
pubmed doi rcsb
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 71
structure length 214
sequence length 220
ec nomenclature ec 3.4.24.82: ADAMTS-4 endopeptidase.
pdb deposition date 2014-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4wkeA00
3LJTA 1ZP5A 2Z2DA 5CXAA 5B5OA 4PKUA 1OS2A 1QIBA 1BKCI 1FBLA 3AYUA 4XBHA 1ZXVA 1UTZA 1DMTA 1CIZA 4G9LA 1JJ9A 3HBVP 2WO9A 1EAKA 4R3VA 1GO8P 1XFXA 2K2GA 5D3CA 4G0DA 1G49A 1K7IA 4WKEA 4H49A 3EHYA 4AYKA 3KEJA 2A8HA 4I35A 3WV1A 3DPFA 1DTHA 3LUMA 1K7QA 4WZVA 2MZHA 1MNCA 3EHXA 4A7BA 2X3CA 3B2ZA 3L0VA 4GUYA 1USNA 2ERQA 2XS3A 4HMAA 1RMZA 3OHOA 3ZVSA 1CK7A 4PKRA 2K9CA 1PWWA 1S4BP 1BIWA 3F19A 1IABA 2Y6DA 3SHIA 1R55A 1YP1A 3I7IA 4FVLA 5LABA 4QKZA 2W15A 4EFSA 3LIRA 1I1IP 4ON1A 1BQOA 3WV3A 3KWVC 3LILA 4AXQA 3B8ZA 2OVZA 2W12A 2X3AA 1R54A 2TCLA 2O3EA 1R1HA 1HY7A 2MLRA 3LEAA 4FU4A 1AKLA 4JIJA 3F18A 1XUDA 1PWPA 4I03A 1QJJA 3F1AA 4PKWA 5CUHA 2OI0A 1I73A 3CKIA 3HDAP 2HU6A 1G12A 5JMYA 2AIGP 2JT6A 1KUKA 5BOYA 1B3DA 4DD8A 3BA0A 4GR8A 3KMEA 1QICA 2RJQA 3LKAA 3OHLA 4IN9A 3P24A 1D5JA 4GQLA 5I43A 1CGFA 3DL1A 1ZTQA 1ASTA 2SRTA 4PKSA 4FXYP 3L0TA 3LMCA 1ZXCA 5I2ZA 2EROA 2OXWA 1BUVM 2E3XA 3LJGA 1O0QA 3LQ0A 1QJIA 1O0TA 2OZRA 1UMSA 1OM6A 2POJA 3DNGA 3N2UA 4IUWA 4H3XA 3HYGA 3ZUKA 3HY7A 1R1JA 3HY9A 2Y6CA 1UTTA 1CAQA 2OW9A 3RTSA 2OW2A 2OY4A 5D7WA 3ZXHA 4PKTA 1YQYA 2N8RA 3MA2A 3UVCA 1HOVA 5BOTA 1YOUA 3KECA 1HV5A 2D1NA 1HTDA 3KHIA 1C7KA 4GF1A 2V4BA 1OM8A 2DW0A 2YB9A 5CZMA 1SU3A 1HFSA 1MMBA 5I4OA 3TVCA 4JP4A 1D8MA 3F17A 5D1TA 1AF0A 2OVXA 1J7NA 1SRPA 1ND1A 4L6TA 1GO7P 2ERPA 1ZS0A 1PWQA 3KEKA 3KRYA 2O36A 4WF6A 1CQRA 1B8YA 1D8FA 3LJZA 1EB6A 1GXDA 2YIGA 3DWBA 1SATA 1GE7A 1JANA 3DPEA 1HFCA 2XS4A 5L7FA 2J0TA 2J83A 1D7XA 1BSWA 2CKIA 1JK3A 5L79A 4Q1LA 1IAGA 3LQBA 2D1OA 4PKVA 3VTGA 3P1VA 2OXZA 4JPAA 2CLTA 1SMPA 2DDFA 4HX3A 4WK7A 456CA 1L6JA 2AYKA 1Y0VA 2DW2A 5D1UA 3LUNA 1JAQA 5BPAA 830CA 1BKCE 2E2DA 4XCTA 4ILWD 1SLNA 3G5CA 1MMRA 1XUCA 4XM6A 1JIZA 1IACA 4DV8A 2DDYA 2L0RA 3ELMA 1CXVA 4H84A 4H1QA 3K7LA 4GWMA 3GBOA 2W14A 5D2BA 4WKIA 1OMJA 2OW0A 1WNIA 1AYKA 4GR0A 4XM7A 2I47A 3AYKA 1ROSA 4GR3A 5B5PA 4FXQA 3EDZA 1BKCA 1Y93A 4JA1A 5I12A 5I3MA 4H82A 1XFZA 2JNPA 3K7NA 3EDIA 1GE5A 2FV9A 1JIWP 3E8RA 1G9KA 2PJTA 3USNA 2W13A 1UEAA 1GKCA 4XM8A 1JAPA 1OS9A 1IAEA 1MMPA 1QIAA 1ATLA 2MZEA 3HBUP 2MZIA 1KUFA 1R1IA 1Y8JA 1XFVA 1OO9A 1Z3JA 1Q3AA 1SLMA 1XFWA 1KUHA 4DPEA 4L63A 2QPJA 2JT5A 4DF9A 1KAPP 1A86A 3O2XA 3LE9A 4H76A 1MMQA 3TS4A 3LK8A 1CGLA 3VI1A 3EDHA 1IAAA 1C8TA 1A85A 4J4MA 1JKYA 1EUBA 1BQQM 1ZVXA 3U1RA 4AIGA 1JH1A 1GKDA 1JAOA 3HDBA 1PWVA 1QUAA 1CGEA 2RJPA 1I76A 1XFUA 2OW1A 1BUDA 3TT4A 4PKQA 1H71P 2JSDA 5D1SA 1FLSA 1G4KA 4CTHA 4ZR5A 4H30A 4JQGA 2W0DA 3HB2P 4A3WA 2X7MA 3RTTA 3LGPA 1KUIA 3DSLA 2KRJA 4IJOA 1K7GA 3TSKA 3V96B 3F16A 3G42A 1XFYA 2JIHA 3O64A 1RM8A 4AUOA 1UMTA 3I7GA 1BM6A 3LIKA 1IADA 1PWUA 3N2VA 2MLSA 2USNA 1FM1A 1C3IA 3F15A 3AIGA 966CA 1KUGA 4L19A 2X3BA 4GWNA 3Q2GA 5I0LA 3EDGA 2WOAA 3Q2HA 3B92A 3WV2A 1GE6A 3KMCA 1OM7A 5H8XA 2OY2A 2WO8A 2OXUA 3EWJA 1G05A 1XURA 2DW1A 2FV5A 4H2EA 1YCMA 1BZSA 3NX7A 1KBCA
chains in the Genus database with same CATH superfamily
3LJTA 1ZP5A 2Z2DA 5CXAA 5B5OA 4PKUA 1OS2A 1QIBA 1BKCI 1FBLA 3AYUA 4XBHA 1ZXVA 1UTZA 1DMTA 1CIZA 4G9LA 1JJ9A 3HBVP 2WO9A 1EAKA 4R3VA 1GO8P 1XFXA 2K2GA 5D3CA 4G0DA 1G49A 1K7IA 4WKEA 4H49A 3EHYA 4AYKA 3KEJA 2A8HA 4I35A 3WV1A 3DPFA 3DTEA 1DTHA 3LUMA 2YUFA 1K7QA 4WZVA 2MZHA 1MNCA 3EHXA 4A7BA 2X3CA 3B2ZA 3L0VA 4GUYA 1USNA 2ERQA 2XS3A 4HMAA 1RMZA 3OHOA 3ZVSA 1CK7A 4PKRA 2K9CA 1PWWA 1S4BP 1BIWA 1TVIA 3F19A 1IABA 2Y6DA 3SHIA 1R55A 1YP1A 3I7IA 4FVLA 5LABA 4QKZA 2W15A 4EFSA 3LIRA 1I1IP 4ON1A 1BQOA 3WV3A 3KWVC 3LILA 4AXQA 3B8ZA 2OVZA 2W12A 2X3AA 1R54A 2TCLA 2O3EA 1R1HA 1HY7A 2MLRA 3LEAA 4FU4A 1AKLA 3DTIA 3F18A 4JIJA 4L7AA 1XUDA 1PWPA 4I03A 1QJJA 3F1AA 4PKWA 5CUHA 2OI0A 1I73A 3CKIA 3HDAP 2HU6A 1G12A 5JMYA 2AIGP 2JT6A 1KUKA 5BOYA 1B3DA 4DD8A 3BA0A 4GR8A 3KMEA 1QICA 2RJQA 3LKAA 3OHLA 4IN9A 3P24A 1D5JA 4GQLA 5I43A 1CGFA 3DL1A 1ZTQA 1ASTA 2SRTA 4PKSA 4FXYP 3L0TA 3LMCA 1ZXCA 5I2ZA 2EROA 2OXWA 1BUVM 2E3XA 3LJGA 1O0QA 3LQ0A 1QJIA 1O0TA 2OZRA 1UMSA 1OM6A 2POJA 3DNGA 3N2UA 4IUWA 4H3XA 3HYGA 3ZUKA 3HY7A 1R1JA 3HY9A 2Y6CA 1UTTA 1CAQA 2OW9A 3RTSA 2OW2A 2OY4A 5D7WA 3ZXHA 4PKTA 1YQYA 2N8RA 3MA2A 3UVCA 1HOVA 5BOTA 1YOUA 3KECA 1HV5A 2D1NA 1HTDA 3KHIA 1C7KA 4GF1A 2V4BA 1OM8A 2DW0A 2YB9A 5CZMA 1SU3A 1HFSA 1MMBA 5I4OA 3TVCA 4JP4A 1D8MA 3F17A 5D1TA 1AF0A 2OVXA 1J7NA 1SRPA 1ND1A 4L6TA 1GO7P 2ERPA 1ZS0A 1PWQA 3KEKA 3KRYA 2O36A 4WF6A 1CQRA 1B8YA 1D8FA 3LJZA 1EB6A 1GXDA 2YIGA 3DWBA 1SATA 1GE7A 1JANA 3DPEA 1HFCA 2XS4A 5L7FA 2J0TA 2J83A 1D7XA 1BSWA 2CKIA 1JK3A 5L79A 4Q1LA 1IAGA 3LQBA 2D1OA 4PKVA 3VTGA 3P1VA 2OXZA 4JPAA 2CLTA 1SMPA 2DDFA 4HX3A 4WK7A 456CA 3DTKA 1L6JA 2AYKA 1Y0VA 2DW2A 5D1UA 3LUNA 1JAQA 5BPAA 830CA 1BKCE 2E2DA 4XCTA 4ILWD 1SLNA 3G5CA 1MMRA 1XUCA 4XM6A 1JIZA 1IACA 4DV8A 2DDYA 2L0RA 3ELMA 1CXVA 4H84A 4H1QA 3K7LA 4GWMA 3GBOA 2W14A 5D2BA 4WKIA 1OMJA 2OW0A 1WNIA 1AYKA 4GR0A 4XM7A 2I47A 3AYKA 1ROSA 4GR3A 5B5PA 4FXQA 3EDZA 1BKCA 1XAXA 1Y93A 4JA1A 5I12A 5I3MA 4H82A 1XFZA 2JNPA 3K7NA 3EDIA 1GE5A 2FV9A 1JIWP 3E8RA 1G9KA 2PJTA 3USNA 2W13A 1UEAA 1GKCA 4XM8A 1JAPA 1OS9A 1IAEA 1MMPA 1QIAA 1ATLA 2MZEA 3HBUP 2MZIA 1KUFA 1R1IA 1Y8JA 1XFVA 1OO9A 1Z3JA 1Q3AA 1SLMA 1XFWA 1KUHA 4DPEA 4L63A 2QPJA 2JT5A 4DF9A 1KAPP 1A86A 3O2XA 3LE9A 4H76A 1MMQA 3TS4A 3LK8A 1CGLA 3VI1A 1XM5A 3EDHA 1IAAA 1C8TA 1A85A 4J4MA 1JKYA 1EUBA 1BQQM 1ZVXA 3U1RA 4AIGA 1JH1A 1GKDA 1JAOA 3HDBA 1PWVA 1QUAA 1CGEA 2RJPA 1I76A 1XFUA 2OW1A 1BUDA 3TT4A 4PKQA 1H71P 2JSDA 5D1SA 1FLSA 1G4KA 4CTHA 4ZR5A 4H30A 4JQGA 2W0DA 3HB2P 4A3WA 2X7MA 3RTTA 3LGPA 1KUIA 3DSLA 1OZ9A 2KRJA 4IJOA 1K7GA 3TSKA 3V96B 3F16A 3G42A 1XFYA 2JIHA 3O64A 1RM8A 4AUOA 1UMTA 3I7GA 1BM6A 3LIKA 1IADA 1PWUA 3N2VA 2MLSA 2USNA 1FM1A 1C3IA 3F15A 3AIGA 966CA 1KUGA 4L19A 2X3BA 4GWNA 3Q2GA 5I0LA 3EDGA 2WOAA 3Q2HA 3B92A 3WV2A 1GE6A 3KMCA 1OM7A 5H8XA 2OY2A 2WO8A 2OXUA 3EWJA 1G05A 1XURA 2DW1A 2FV5A 4H2EA 1YCMA 1BZSA 3NX7A 1KBCA
chains in the Genus database with same CATH topology
3LJTA 1ZP5A 2Z2DA 5CXAA 5B5OA 4PKUA 1OS2A 1QIBA 1BKCI 1FBLA 3AYUA 4XBHA 1ZXVA 1UTZA 1DMTA 1CIZA 4G9LA 1JJ9A 3HBVP 2WO9A 1EAKA 4R3VA 1GO8P 1XFXA 2K2GA 5D3CA 4G0DA 1G49A 1K7IA 4WKEA 4H49A 3EHYA 4AYKA 3KEJA 2A8HA 4I35A 3WV1A 3DPFA 3DTEA 1DTHA 3LUMA 2YUFA 1K7QA 4WZVA 2MZHA 1MNCA 3EHXA 4A7BA 2X3CA 3B2ZA 3L0VA 4GUYA 1USNA 2ERQA 2XS3A 4HMAA 1RMZA 3OHOA 3ZVSA 1CK7A 4PKRA 2K9CA 1PWWA 1S4BP 1BIWA 3F19A 1IABA 2Y6DA 3SHIA 1R55A 1YP1A 3I7IA 4FVLA 5LABA 4QKZA 2W15A 4EFSA 3LIRA 1I1IP 4ON1A 1BQOA 3WV3A 3KWVC 3LILA 4AXQA 3B8ZA 2OVZA 2W12A 2X3AA 1R54A 2TCLA 2O3EA 1R1HA 1HY7A 2MLRA 3LEAA 4FU4A 1AKLA 3DTIA 3F18A 4JIJA 4L7AA 1XUDA 1PWPA 4I03A 1QJJA 3F1AA 4PKWA 5CUHA 2OI0A 1I73A 3CKIA 3HDAP 2HU6A 1G12A 5JMYA 2AIGP 2JT6A 1KUKA 5BOYA 1B3DA 4DD8A 3BA0A 4GR8A 3KMEA 1QICA 2RJQA 3LKAA 3OHLA 4IN9A 3P24A 1D5JA 4GQLA 5I43A 1CGFA 3DL1A 1ZTQA 1ASTA 2SRTA 4PKSA 4FXYP 3L0TA 3LMCA 1ZXCA 5I2ZA 2EROA 2OXWA 1BUVM 2E3XA 3LJGA 1O0QA 3LQ0A 1QJIA 1O0TA 2OZRA 1UMSA 1OM6A 2POJA 3DNGA 3N2UA 4IUWA 4H3XA 3HYGA 3ZUKA 3HY7A 1R1JA 3HY9A 2Y6CA 1UTTA 1CAQA 2OW9A 3RTSA 2OW2A 2OY4A 5D7WA 3ZXHA 4PKTA 1YQYA 2N8RA 3MA2A 3UVCA 1HOVA 5BOTA 1YOUA 3KECA 1HV5A 2D1NA 1HTDA 3KHIA 1C7KA 4GF1A 2V4BA 1OM8A 2DW0A 2YB9A 5CZMA 1SU3A 1HFSA 1MMBA 5I4OA 3TVCA 4JP4A 1D8MA 3F17A 5D1TA 1AF0A 2OVXA 1J7NA 1SRPA 1ND1A 4L6TA 1GO7P 2ERPA 1ZS0A 1PWQA 3KEKA 3KRYA 2O36A 4WF6A 1CQRA 1B8YA 1D8FA 3LJZA 1EB6A 1GXDA 2YIGA 3DWBA 1SATA 1GE7A 1JANA 3DPEA 1HFCA 2XS4A 5L7FA 2J0TA 2J83A 1D7XA 1BSWA 2CKIA 1JK3A 5L79A 4Q1LA 1IAGA 3LQBA 2D1OA 4PKVA 3VTGA 3P1VA 2OXZA 4JPAA 2CLTA 1SMPA 2DDFA 4HX3A 4WK7A 456CA 3DTKA 1L6JA 2AYKA 1Y0VA 2DW2A 5D1UA 3LUNA 1JAQA 5BPAA 830CA 1BKCE 2E2DA 4XCTA 4ILWD 1SLNA 3G5CA 1MMRA 1XUCA 4XM6A 1JIZA 1IACA 4DV8A 2DDYA 2L0RA 3ELMA 1CXVA 4H84A 4H1QA 3K7LA 4GWMA 3GBOA 2W14A 5D2BA 4WKIA 1OMJA 2OW0A 1WNIA 1AYKA 4GR0A 4XM7A 2I47A 3AYKA 1ROSA 4GR3A 5B5PA 4FXQA 3EDZA 1BKCA 1Y93A 4JA1A 5I12A 5I3MA 4H82A 1XFZA 2JNPA 3K7NA 3EDIA 1GE5A 2FV9A 1JIWP 3E8RA 1G9KA 2PJTA 3USNA 2W13A 1UEAA 1GKCA 4XM8A 1JAPA 1OS9A 1IAEA 1MMPA 1QIAA 1ATLA 2MZEA 3HBUP 2MZIA 1KUFA 1R1IA 1Y8JA 1XFVA 1OO9A 1Z3JA 1Q3AA 1SLMA 1XFWA 1KUHA 4DPEA 4L63A 2QPJA 2JT5A 4DF9A 1KAPP 1A86A 3O2XA 3LE9A 4H76A 1MMQA 3TS4A 3LK8A 1CGLA 3VI1A 3EDHA 1IAAA 1C8TA 1A85A 4J4MA 1JKYA 1EUBA 1BQQM 1ZVXA 3U1RA 4AIGA 1JH1A 1GKDA 1JAOA 3HDBA 1PWVA 1QUAA 1CGEA 2RJPA 1I76A 1XFUA 2OW1A 1BUDA 3TT4A 4PKQA 1H71P 2JSDA 5D1SA 1FLSA 1G4KA 4CTHA 4ZR5A 4H30A 4JQGA 2W0DA 3HB2P 4A3WA 2X7MA 3RTTA 3LGPA 1KUIA 3DSLA 2KRJA 4IJOA 1K7GA 3TSKA 3V96B 3F16A 3G42A 1XFYA 2JIHA 3O64A 1RM8A 4AUOA 1UMTA 3I7GA 1BM6A 3LIKA 1IADA 1PWUA 3N2VA 2MLSA 2USNA 1FM1A 1C3IA 3F15A 3AIGA 966CA 1KUGA 4L19A 2X3BA 4GWNA 3Q2GA 5I0LA 3EDGA 2WOAA 3Q2HA 3B92A 3WV2A 1GE6A 3KMCA 1OM7A 5H8XA 2OY2A 2WO8A 2OXUA 3EWJA 1G05A 1XURA 2DW1A 2FV5A 4H2EA 1YCMA 1BZSA 3NX7A 1KBCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LJT A;  1ZP5 A;  2Z2D A;  5CXA A;  5B5O A;  4PKU A;  1OS2 A;  1QIB A;  1BKC I;  1FBL A;  3AYU A;  4XBH A;  1ZXV A;  1UTZ A;  1DMT A;  1CIZ A;  4G9L A;  1JJ9 A;  3HBV P;  2WO9 A;  1EAK A;  4R3V A;  1GO8 P;  1XFX A;  2K2G A;  5D3C A;  4G0D A;  1G49 A;  1K7I A;  4WKE A;  4H49 A;  3EHY A;  4AYK A;  3KEJ A;  2A8H A;  4I35 A;  3WV1 A;  3DPF A;  1DTH A;  3LUM A;  1K7Q A;  4WZV A;  2MZH A;  1MNC A;  3EHX A;  4A7B A;  2X3C A;  3B2Z A;  3L0V A;  4GUY A;  1USN A;  2ERQ A;  2XS3 A;  4HMA A;  1RMZ A;  3OHO A;  3ZVS A;  1CK7 A;  4PKR A;  2K9C A;  1PWW A;  1S4B P;  1BIW A;  3F19 A;  1IAB A;  2Y6D A;  3SHI A;  1R55 A;  1YP1 A;  3I7I A;  4FVL A;  5LAB A;  4QKZ A;  2W15 A;  4EFS A;  3LIR A;  1I1I P;  4ON1 A;  1BQO A;  3WV3 A;  3KWV C;  3LIL A;  4AXQ A;  3B8Z A;  2OVZ A;  2W12 A;  2X3A A;  1R54 A;  2TCL A;  2O3E A;  1R1H A;  1HY7 A;  2MLR A;  3LEA A;  4FU4 A;  1AKL A;  4JIJ A;  3F18 A;  1XUD A;  1PWP A;  4I03 A;  1QJJ A;  3F1A A;  4PKW A;  5CUH A;  2OI0 A;  1I73 A;  3CKI A;  3HDA P;  2HU6 A;  1G12 A;  5JMY A;  2AIG P;  2JT6 A;  1KUK A;  5BOY A;  1B3D A;  4DD8 A;  3BA0 A;  4GR8 A;  3KME A;  1QIC A;  2RJQ A;  3LKA A;  3OHL A;  4IN9 A;  3P24 A;  1D5J A;  4GQL A;  5I43 A;  1CGF A;  3DL1 A;  1ZTQ A;  1AST A;  2SRT A;  4PKS A;  4FXY P;  3L0T A;  3LMC A;  1ZXC A;  5I2Z A;  2ERO A;  2OXW A;  1BUV M;  2E3X A;  3LJG A;  1O0Q A;  3LQ0 A;  1QJI A;  1O0T A;  2OZR A;  1UMS A;  1OM6 A;  2POJ A;  3DNG A;  3N2U A;  4IUW A;  4H3X A;  3HYG A;  3ZUK A;  3HY7 A;  1R1J A;  3HY9 A;  2Y6C A;  1UTT A;  1CAQ A;  2OW9 A;  3RTS A;  2OW2 A;  2OY4 A;  5D7W A;  3ZXH A;  4PKT A;  1YQY A;  2N8R A;  3MA2 A;  3UVC A;  1HOV A;  5BOT A;  1YOU A;  3KEC A;  1HV5 A;  2D1N A;  1HTD A;  3KHI A;  1C7K A;  4GF1 A;  2V4B A;  1OM8 A;  2DW0 A;  2YB9 A;  5CZM A;  1SU3 A;  1HFS A;  1MMB A;  5I4O A;  3TVC A;  4JP4 A;  1D8M A;  3F17 A;  5D1T A;  1AF0 A;  2OVX A;  1J7N A;  1SRP A;  1ND1 A;  4L6T A;  1GO7 P;  2ERP A;  1ZS0 A;  1PWQ A;  3KEK A;  3KRY A;  2O36 A;  4WF6 A;  1CQR A;  1B8Y A;  1D8F A;  3LJZ A;  1EB6 A;  1GXD A;  2YIG A;  3DWB A;  1SAT A;  1GE7 A;  1JAN A;  3DPE A;  1HFC A;  2XS4 A;  5L7F A;  2J0T A;  2J83 A;  1D7X A;  1BSW A;  2CKI A;  1JK3 A;  5L79 A;  4Q1L A;  1IAG A;  3LQB A;  2D1O A;  4PKV A;  3VTG A;  3P1V A;  2OXZ A;  4JPA A;  2CLT A;  1SMP A;  2DDF A;  4HX3 A;  4WK7 A;  456C A;  1L6J A;  2AYK A;  1Y0V A;  2DW2 A;  5D1U A;  3LUN A;  1JAQ A;  5BPA A;  830C A;  1BKC E;  2E2D A;  4XCT A;  4ILW D;  1SLN A;  3G5C A;  1MMR A;  1XUC A;  4XM6 A;  1JIZ A;  1IAC A;  4DV8 A;  2DDY A;  2L0R A;  3ELM A;  1CXV A;  4H84 A;  4H1Q A;  3K7L A;  4GWM A;  3GBO A;  2W14 A;  5D2B A;  4WKI A;  1OMJ A;  2OW0 A;  1WNI A;  1AYK A;  4GR0 A;  4XM7 A;  2I47 A;  3AYK A;  1ROS A;  4GR3 A;  5B5P A;  4FXQ A;  3EDZ A;  1BKC A;  1Y93 A;  4JA1 A;  5I12 A;  5I3M A;  4H82 A;  1XFZ A;  2JNP A;  3K7N A;  3EDI A;  1GE5 A;  2FV9 A;  1JIW P;  3E8R A;  1G9K A;  2PJT A;  3USN A;  2W13 A;  1UEA A;  1GKC A;  4XM8 A;  1JAP A;  1OS9 A;  1IAE A;  1MMP A;  1QIA A;  1ATL A;  2MZE A;  3HBU P;  2MZI A;  1KUF A;  1R1I A;  1Y8J A;  1XFV A;  1OO9 A;  1Z3J A;  1Q3A A;  1SLM A;  1XFW A;  1KUH A;  4DPE A;  4L63 A;  2QPJ A;  2JT5 A;  4DF9 A;  1KAP P;  1A86 A;  3O2X A;  3LE9 A;  4H76 A;  1MMQ A;  3TS4 A;  3LK8 A;  1CGL A;  3VI1 A;  3EDH A;  1IAA A;  1C8T A;  1A85 A;  4J4M A;  1JKY A;  1EUB A;  1BQQ M;  1ZVX A;  3U1R A;  4AIG A;  1JH1 A;  1GKD A;  1JAO A;  3HDB A;  1PWV A;  1QUA A;  1CGE A;  2RJP A;  1I76 A;  1XFU A;  2OW1 A;  1BUD A;  3TT4 A;  4PKQ A;  1H71 P;  2JSD A;  5D1S A;  1FLS A;  1G4K A;  4CTH A;  4ZR5 A;  4H30 A;  4JQG A;  2W0D A;  3HB2 P;  4A3W A;  2X7M A;  3RTT A;  3LGP A;  1KUI A;  3DSL A;  2KRJ A;  4IJO A;  1K7G A;  3TSK A;  3V96 B;  3F16 A;  3G42 A;  1XFY A;  2JIH A;  3O64 A;  1RM8 A;  4AUO A;  1UMT A;  3I7G A;  1BM6 A;  3LIK A;  1IAD A;  1PWU A;  3N2V A;  2MLS A;  2USN A;  1FM1 A;  1C3I A;  3F15 A;  3AIG A;  966C A;  1KUG A;  4L19 A;  2X3B A;  4GWN A;  3Q2G A;  5I0L A;  3EDG A;  2WOA A;  3Q2H A;  3B92 A;  3WV2 A;  1GE6 A;  3KMC A;  1OM7 A;  5H8X A;  2OY2 A;  2WO8 A;  2OXU A;  3EWJ A;  1G05 A;  1XUR A;  2DW1 A;  2FV5 A;  4H2E A;  1YCM A;  1BZS A;  3NX7 A;  1KBC A; 
#chains in the Genus database with same CATH topology
 3LJT A;  1ZP5 A;  2Z2D A;  5CXA A;  5B5O A;  4PKU A;  1OS2 A;  1QIB A;  1BKC I;  1FBL A;  3AYU A;  4XBH A;  1ZXV A;  1UTZ A;  1DMT A;  1CIZ A;  4G9L A;  1JJ9 A;  3HBV P;  2WO9 A;  1EAK A;  4R3V A;  1GO8 P;  1XFX A;  2K2G A;  5D3C A;  4G0D A;  1G49 A;  1K7I A;  4WKE A;  4H49 A;  3EHY A;  4AYK A;  3KEJ A;  2A8H A;  4I35 A;  3WV1 A;  3DPF A;  3DTE A;  1DTH A;  3LUM A;  2YUF A;  1K7Q A;  4WZV A;  2MZH A;  1MNC A;  3EHX A;  4A7B A;  2X3C A;  3B2Z A;  3L0V A;  4GUY A;  1USN A;  2ERQ A;  2XS3 A;  4HMA A;  1RMZ A;  3OHO A;  3ZVS A;  1CK7 A;  4PKR A;  2K9C A;  1PWW A;  1S4B P;  1BIW A;  1TVI A;  3F19 A;  1IAB A;  2Y6D A;  3SHI A;  1R55 A;  1YP1 A;  3I7I A;  4FVL A;  5LAB A;  4QKZ A;  2W15 A;  4EFS A;  3LIR A;  1I1I P;  4ON1 A;  1BQO A;  3WV3 A;  3KWV C;  3LIL A;  4AXQ A;  3B8Z A;  2OVZ A;  2W12 A;  2X3A A;  1R54 A;  2TCL A;  2O3E A;  1R1H A;  1HY7 A;  2MLR A;  3LEA A;  4FU4 A;  1AKL A;  3DTI A;  3F18 A;  4JIJ A;  4L7A A;  1XUD A;  1PWP A;  4I03 A;  1QJJ A;  3F1A A;  4PKW A;  5CUH A;  2OI0 A;  1I73 A;  3CKI A;  3HDA P;  2HU6 A;  1G12 A;  5JMY A;  2AIG P;  2JT6 A;  1KUK A;  5BOY A;  1B3D A;  4DD8 A;  3BA0 A;  4GR8 A;  3KME A;  1QIC A;  2RJQ A;  3LKA A;  3OHL A;  4IN9 A;  3P24 A;  1D5J A;  4GQL A;  5I43 A;  1CGF A;  3DL1 A;  1ZTQ A;  1AST A;  2SRT A;  4PKS A;  4FXY P;  3L0T A;  3LMC A;  1ZXC A;  5I2Z A;  2ERO A;  2OXW A;  1BUV M;  2E3X A;  3LJG A;  1O0Q A;  3LQ0 A;  1QJI A;  1O0T A;  2OZR A;  1UMS A;  1OM6 A;  2POJ A;  3DNG A;  3N2U A;  4IUW A;  4H3X A;  3HYG A;  3ZUK A;  3HY7 A;  1R1J A;  3HY9 A;  2Y6C A;  1UTT A;  1CAQ A;  2OW9 A;  3RTS A;  2OW2 A;  2OY4 A;  5D7W A;  3ZXH A;  4PKT A;  1YQY A;  2N8R A;  3MA2 A;  3UVC A;  1HOV A;  5BOT A;  1YOU A;  3KEC A;  1HV5 A;  2D1N A;  1HTD A;  3KHI A;  1C7K A;  4GF1 A;  2V4B A;  1OM8 A;  2DW0 A;  2YB9 A;  5CZM A;  1SU3 A;  1HFS A;  1MMB A;  5I4O A;  3TVC A;  4JP4 A;  1D8M A;  3F17 A;  5D1T A;  1AF0 A;  2OVX A;  1J7N A;  1SRP A;  1ND1 A;  4L6T A;  1GO7 P;  2ERP A;  1ZS0 A;  1PWQ A;  3KEK A;  3KRY A;  2O36 A;  4WF6 A;  1CQR A;  1B8Y A;  1D8F A;  3LJZ A;  1EB6 A;  1GXD A;  2YIG A;  3DWB A;  1SAT A;  1GE7 A;  1JAN A;  3DPE A;  1HFC A;  2XS4 A;  5L7F A;  2J0T A;  2J83 A;  1D7X A;  1BSW A;  2CKI A;  1JK3 A;  5L79 A;  4Q1L A;  1IAG A;  3LQB A;  2D1O A;  4PKV A;  3VTG A;  3P1V A;  2OXZ A;  4JPA A;  2CLT A;  1SMP A;  2DDF A;  4HX3 A;  4WK7 A;  456C A;  3DTK A;  1L6J A;  2AYK A;  1Y0V A;  2DW2 A;  5D1U A;  3LUN A;  1JAQ A;  5BPA A;  830C A;  1BKC E;  2E2D A;  4XCT A;  4ILW D;  1SLN A;  3G5C A;  1MMR A;  1XUC A;  4XM6 A;  1JIZ A;  1IAC A;  4DV8 A;  2DDY A;  2L0R A;  3ELM A;  1CXV A;  4H84 A;  4H1Q A;  3K7L A;  4GWM A;  3GBO A;  2W14 A;  5D2B A;  4WKI A;  1OMJ A;  2OW0 A;  1WNI A;  1AYK A;  4GR0 A;  4XM7 A;  2I47 A;  3AYK A;  1ROS A;  4GR3 A;  5B5P A;  4FXQ A;  3EDZ A;  1BKC A;  1XAX A;  1Y93 A;  4JA1 A;  5I12 A;  5I3M A;  4H82 A;  1XFZ A;  2JNP A;  3K7N A;  3EDI A;  1GE5 A;  2FV9 A;  1JIW P;  3E8R A;  1G9K A;  2PJT A;  3USN A;  2W13 A;  1UEA A;  1GKC A;  4XM8 A;  1JAP A;  1OS9 A;  1IAE A;  1MMP A;  1QIA A;  1ATL A;  2MZE A;  3HBU P;  2MZI A;  1KUF A;  1R1I A;  1Y8J A;  1XFV A;  1OO9 A;  1Z3J A;  1Q3A A;  1SLM A;  1XFW A;  1KUH A;  4DPE A;  4L63 A;  2QPJ A;  2JT5 A;  4DF9 A;  1KAP P;  1A86 A;  3O2X A;  3LE9 A;  4H76 A;  1MMQ A;  3TS4 A;  3LK8 A;  1CGL A;  3VI1 A;  1XM5 A;  3EDH A;  1IAA A;  1C8T A;  1A85 A;  4J4M A;  1JKY A;  1EUB A;  1BQQ M;  1ZVX A;  3U1R A;  4AIG A;  1JH1 A;  1GKD A;  1JAO A;  3HDB A;  1PWV A;  1QUA A;  1CGE A;  2RJP A;  1I76 A;  1XFU A;  2OW1 A;  1BUD A;  3TT4 A;  4PKQ A;  1H71 P;  2JSD A;  5D1S A;  1FLS A;  1G4K A;  4CTH A;  4ZR5 A;  4H30 A;  4JQG A;  2W0D A;  3HB2 P;  4A3W A;  2X7M A;  3RTT A;  3LGP A;  1KUI A;  3DSL A;  1OZ9 A;  2KRJ A;  4IJO A;  1K7G A;  3TSK A;  3V96 B;  3F16 A;  3G42 A;  1XFY A;  2JIH A;  3O64 A;  1RM8 A;  4AUO A;  1UMT A;  3I7G A;  1BM6 A;  3LIK A;  1IAD A;  1PWU A;  3N2V A;  2MLS A;  2USN A;  1FM1 A;  1C3I A;  3F15 A;  3AIG A;  966C A;  1KUG A;  4L19 A;  2X3B A;  4GWN A;  3Q2G A;  5I0L A;  3EDG A;  2WOA A;  3Q2H A;  3B92 A;  3WV2 A;  1GE6 A;  3KMC A;  1OM7 A;  5H8X A;  2OY2 A;  2WO8 A;  2OXU A;  3EWJ A;  1G05 A;  1XUR A;  2DW1 A;  2FV5 A;  4H2E A;  1YCM A;  1BZS A;  3NX7 A;  1KBC A; 
#chains in the Genus database with same CATH homology
 3LJT A;  1ZP5 A;  2Z2D A;  5CXA A;  5B5O A;  4PKU A;  1OS2 A;  1QIB A;  1BKC I;  1FBL A;  3AYU A;  4XBH A;  1ZXV A;  1UTZ A;  1DMT A;  1CIZ A;  4G9L A;  1JJ9 A;  3HBV P;  2WO9 A;  1EAK A;  4R3V A;  1GO8 P;  1XFX A;  2K2G A;  5D3C A;  4G0D A;  1G49 A;  1K7I A;  4WKE A;  4H49 A;  3EHY A;  4AYK A;  3KEJ A;  2A8H A;  4I35 A;  3WV1 A;  3DPF A;  3DTE A;  1DTH A;  3LUM A;  2YUF A;  1K7Q A;  4WZV A;  2MZH A;  1MNC A;  3EHX A;  4A7B A;  2X3C A;  3B2Z A;  3L0V A;  4GUY A;  1USN A;  2ERQ A;  2XS3 A;  4HMA A;  1RMZ A;  3OHO A;  3ZVS A;  1CK7 A;  4PKR A;  2K9C A;  1PWW A;  1S4B P;  1BIW A;  3F19 A;  1IAB A;  2Y6D A;  3SHI A;  1R55 A;  1YP1 A;  3I7I A;  4FVL A;  5LAB A;  4QKZ A;  2W15 A;  4EFS A;  3LIR A;  1I1I P;  4ON1 A;  1BQO A;  3WV3 A;  3KWV C;  3LIL A;  4AXQ A;  3B8Z A;  2OVZ A;  2W12 A;  2X3A A;  1R54 A;  2TCL A;  2O3E A;  1R1H A;  1HY7 A;  2MLR A;  3LEA A;  4FU4 A;  1AKL A;  3DTI A;  3F18 A;  4JIJ A;  4L7A A;  1XUD A;  1PWP A;  4I03 A;  1QJJ A;  3F1A A;  4PKW A;  5CUH A;  2OI0 A;  1I73 A;  3CKI A;  3HDA P;  2HU6 A;  1G12 A;  5JMY A;  2AIG P;  2JT6 A;  1KUK A;  5BOY A;  1B3D A;  4DD8 A;  3BA0 A;  4GR8 A;  3KME A;  1QIC A;  2RJQ A;  3LKA A;  3OHL A;  4IN9 A;  3P24 A;  1D5J A;  4GQL A;  5I43 A;  1CGF A;  3DL1 A;  1ZTQ A;  1AST A;  2SRT A;  4PKS A;  4FXY P;  3L0T A;  3LMC A;  1ZXC A;  5I2Z A;  2ERO A;  2OXW A;  1BUV M;  2E3X A;  3LJG A;  1O0Q A;  3LQ0 A;  1QJI A;  1O0T A;  2OZR A;  1UMS A;  1OM6 A;  2POJ A;  3DNG A;  3N2U A;  4IUW A;  4H3X A;  3HYG A;  3ZUK A;  3HY7 A;  1R1J A;  3HY9 A;  2Y6C A;  1UTT A;  1CAQ A;  2OW9 A;  3RTS A;  2OW2 A;  2OY4 A;  5D7W A;  3ZXH A;  4PKT A;  1YQY A;  2N8R A;  3MA2 A;  3UVC A;  1HOV A;  5BOT A;  1YOU A;  3KEC A;  1HV5 A;  2D1N A;  1HTD A;  3KHI A;  1C7K A;  4GF1 A;  2V4B A;  1OM8 A;  2DW0 A;  2YB9 A;  5CZM A;  1SU3 A;  1HFS A;  1MMB A;  5I4O A;  3TVC A;  4JP4 A;  1D8M A;  3F17 A;  5D1T A;  1AF0 A;  2OVX A;  1J7N A;  1SRP A;  1ND1 A;  4L6T A;  1GO7 P;  2ERP A;  1ZS0 A;  1PWQ A;  3KEK A;  3KRY A;  2O36 A;  4WF6 A;  1CQR A;  1B8Y A;  1D8F A;  3LJZ A;  1EB6 A;  1GXD A;  2YIG A;  3DWB A;  1SAT A;  1GE7 A;  1JAN A;  3DPE A;  1HFC A;  2XS4 A;  5L7F A;  2J0T A;  2J83 A;  1D7X A;  1BSW A;  2CKI A;  1JK3 A;  5L79 A;  4Q1L A;  1IAG A;  3LQB A;  2D1O A;  4PKV A;  3VTG A;  3P1V A;  2OXZ A;  4JPA A;  2CLT A;  1SMP A;  2DDF A;  4HX3 A;  4WK7 A;  456C A;  3DTK A;  1L6J A;  2AYK A;  1Y0V A;  2DW2 A;  5D1U A;  3LUN A;  1JAQ A;  5BPA A;  830C A;  1BKC E;  2E2D A;  4XCT A;  4ILW D;  1SLN A;  3G5C A;  1MMR A;  1XUC A;  4XM6 A;  1JIZ A;  1IAC A;  4DV8 A;  2DDY A;  2L0R A;  3ELM A;  1CXV A;  4H84 A;  4H1Q A;  3K7L A;  4GWM A;  3GBO A;  2W14 A;  5D2B A;  4WKI A;  1OMJ A;  2OW0 A;  1WNI A;  1AYK A;  4GR0 A;  4XM7 A;  2I47 A;  3AYK A;  1ROS A;  4GR3 A;  5B5P A;  4FXQ A;  3EDZ A;  1BKC A;  1Y93 A;  4JA1 A;  5I12 A;  5I3M A;  4H82 A;  1XFZ A;  2JNP A;  3K7N A;  3EDI A;  1GE5 A;  2FV9 A;  1JIW P;  3E8R A;  1G9K A;  2PJT A;  3USN A;  2W13 A;  1UEA A;  1GKC A;  4XM8 A;  1JAP A;  1OS9 A;  1IAE A;  1MMP A;  1QIA A;  1ATL A;  2MZE A;  3HBU P;  2MZI A;  1KUF A;  1R1I A;  1Y8J A;  1XFV A;  1OO9 A;  1Z3J A;  1Q3A A;  1SLM A;  1XFW A;  1KUH A;  4DPE A;  4L63 A;  2QPJ A;  2JT5 A;  4DF9 A;  1KAP P;  1A86 A;  3O2X A;  3LE9 A;  4H76 A;  1MMQ A;  3TS4 A;  3LK8 A;  1CGL A;  3VI1 A;  3EDH A;  1IAA A;  1C8T A;  1A85 A;  4J4M A;  1JKY A;  1EUB A;  1BQQ M;  1ZVX A;  3U1R A;  4AIG A;  1JH1 A;  1GKD A;  1JAO A;  3HDB A;  1PWV A;  1QUA A;  1CGE A;  2RJP A;  1I76 A;  1XFU A;  2OW1 A;  1BUD A;  3TT4 A;  4PKQ A;  1H71 P;  2JSD A;  5D1S A;  1FLS A;  1G4K A;  4CTH A;  4ZR5 A;  4H30 A;  4JQG A;  2W0D A;  3HB2 P;  4A3W A;  2X7M A;  3RTT A;  3LGP A;  1KUI A;  3DSL A;  2KRJ A;  4IJO A;  1K7G A;  3TSK A;  3V96 B;  3F16 A;  3G42 A;  1XFY A;  2JIH A;  3O64 A;  1RM8 A;  4AUO A;  1UMT A;  3I7G A;  1BM6 A;  3LIK A;  1IAD A;  1PWU A;  3N2V A;  2MLS A;  2USN A;  1FM1 A;  1C3I A;  3F15 A;  3AIG A;  966C A;  1KUG A;  4L19 A;  2X3B A;  4GWN A;  3Q2G A;  5I0L A;  3EDG A;  2WOA A;  3Q2H A;  3B92 A;  3WV2 A;  1GE6 A;  3KMC A;  1OM7 A;  5H8X A;  2OY2 A;  2WO8 A;  2OXU A;  3EWJ A;  1G05 A;  1XUR A;  2DW1 A;  2FV5 A;  4H2E A;  1YCM A;  1BZS A;  3NX7 A;  1KBC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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