4WLSA

Crystal structure of the metal-free (repressor) form of e. coli cuer, a copper efflux regulator, bound to copa promoter dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
111
structure length
111
Chain Sequence
MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription regulator/dna
molecule keywords HTH-type transcriptional regulator CueR
publication title Allosteric transcriptional regulation via changes in the overall topology of the core promoter.
pubmed doi rcsb
source organism Escherichia coli dh5[alpha]
total genus 43
structure length 111
sequence length 111
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00376 MerR MerR family regulatory protein
A PF09278 MerR-DNA-bind MerR, DNA binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1660.10 Mainly Alpha Orthogonal Bundle Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 4wlsA00
3GP4A 5D90A 2ZHGA 2DG6A 3D71A 3D70A 2JMLA 3D6YA 1Q05A 4R22B 4R4EA 3Q1MA 1Q06A 3HH0A 3D6ZA 1JBGA 1Q09A 1Q0AA 5E01A 5I41B 3GPVA 3Q2YA 3QAOA 1R8EA 4J2NA 3UCSA 1Q07A 3Q5RA 1EXJA 3IAOA 4WLSA 2VZ4A 4R24B 5D8CA 5I44A 3Q5SA 1EXIA 4WLWA 1R8DA 3Q5PA 3Q3DA 2ZHHA 1Q08A
chains in the Genus database with same CATH superfamily
3GP4A 5D90A 2ZHGA 2DG6A 3D71A 3D70A 1Y6UA 2JMLA 3D6YA 3EZ2A 1Q05A 4R22B 4R4EA 2KVVA 4LHFA 1Q06A 3Q1MA 3HH0A 3D6ZA 1JBGA 1Q09A 1Q0AA 5E01A 5I41B 3EZ7A 3GPVA 1LX8A 3Q2YA 3QAOA 1R8EA 4J2NA 3UCSA 1Q07A 3Q5RA 4DCZA 3EZ9A 1EXJA 3IAOA 2IEFA 4WLSA 2VZ4A 4R24B 2OG0A 5D8CA 5I44A 3Q5SA 1EXIA 1PM6A 4WLWA 1R8DA 3EZFA 3Q5PA 3Q3DA 1RH6A 2ZHHA 1Q08A 3EZ6A
chains in the Genus database with same CATH topology
3GP4A 5D90A 2ZHGA 2DG6A 3D71A 3D70A 1Y6UA 2JMLA 3D6YA 3EZ2A 1Q05A 4R22B 4R4EA 2KVVA 4LHFA 1Q06A 3Q1MA 3HH0A 3D6ZA 1JBGA 1Q09A 1Q0AA 5E01A 5I41B 3EZ7A 3GPVA 1LX8A 3Q2YA 3QAOA 1R8EA 4J2NA 3UCSA 1Q07A 3Q5RA 4DCZA 3EZ9A 1EXJA 3IAOA 2IEFA 4WLSA 2VZ4A 4R24B 2OG0A 5D8CA 5I44A 3Q5SA 1EXIA 1PM6A 4WLWA 1R8DA 3EZFA 3Q5PA 3Q3DA 1RH6A 2ZHHA 1Q08A 3EZ6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GP4 A;  5D90 A;  2ZHG A;  2DG6 A;  3D71 A;  3D70 A;  2JML A;  3D6Y A;  1Q05 A;  4R22 B;  4R4E A;  3Q1M A;  1Q06 A;  3HH0 A;  3D6Z A;  1JBG A;  1Q09 A;  1Q0A A;  5E01 A;  5I41 B;  3GPV A;  3Q2Y A;  3QAO A;  1R8E A;  4J2N A;  3UCS A;  1Q07 A;  3Q5R A;  1EXJ A;  3IAO A;  4WLS A;  2VZ4 A;  4R24 B;  5D8C A;  5I44 A;  3Q5S A;  1EXI A;  4WLW A;  1R8D A;  3Q5P A;  3Q3D A;  2ZHH A;  1Q08 A; 
#chains in the Genus database with same CATH topology
 3GP4 A;  5D90 A;  2ZHG A;  2DG6 A;  3D71 A;  3D70 A;  1Y6U A;  2JML A;  3D6Y A;  3EZ2 A;  1Q05 A;  4R22 B;  4R4E A;  2KVV A;  4LHF A;  1Q06 A;  3Q1M A;  3HH0 A;  3D6Z A;  1JBG A;  1Q09 A;  1Q0A A;  5E01 A;  5I41 B;  3EZ7 A;  3GPV A;  1LX8 A;  3Q2Y A;  3QAO A;  1R8E A;  4J2N A;  3UCS A;  1Q07 A;  3Q5R A;  4DCZ A;  3EZ9 A;  1EXJ A;  3IAO A;  2IEF A;  4WLS A;  2VZ4 A;  4R24 B;  2OG0 A;  5D8C A;  5I44 A;  3Q5S A;  1EXI A;  1PM6 A;  4WLW A;  1R8D A;  3EZF A;  3Q5P A;  3Q3D A;  1RH6 A;  2ZHH A;  1Q08 A;  3EZ6 A; 
#chains in the Genus database with same CATH homology
 3GP4 A;  5D90 A;  2ZHG A;  2DG6 A;  3D71 A;  3D70 A;  1Y6U A;  2JML A;  3D6Y A;  3EZ2 A;  1Q05 A;  4R22 B;  4R4E A;  2KVV A;  4LHF A;  1Q06 A;  3Q1M A;  3HH0 A;  3D6Z A;  1JBG A;  1Q09 A;  1Q0A A;  5E01 A;  5I41 B;  3EZ7 A;  3GPV A;  1LX8 A;  3Q2Y A;  3QAO A;  1R8E A;  4J2N A;  3UCS A;  1Q07 A;  3Q5R A;  4DCZ A;  3EZ9 A;  1EXJ A;  3IAO A;  2IEF A;  4WLS A;  2VZ4 A;  4R24 B;  2OG0 A;  5D8C A;  5I44 A;  3Q5S A;  1EXI A;  1PM6 A;  4WLW A;  1R8D A;  3EZF A;  3Q5P A;  3Q3D A;  1RH6 A;  2ZHH A;  1Q08 A;  3EZ6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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