4WVTA

Crystal structure of xiap-bir2 domain complexed with ligand bound
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
79
structure length
79
Chain Sequence
GHMRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Apoptosis
molecule keywords E3 ubiquitin-protein ligase XIAP
publication title The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
pubmed doi rcsb
source organism Homo sapiens
total genus 19
structure length 79
sequence length 79
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2014-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 4wvtA00
4WVTA 3UIJA 3UW5A 1M4MA 4HY5A 2I3HA 1SE0A 3F7HA 3M0AD 3UEDA 3UW4A 2OPZA 4A0JA 1I3OE 3G76A 5C84A 4MTZA 3UIKA 4J44A 4J3YA 4WVSA 1F3HA 4HY0A 3MUPA 3UIGA 3CM2A 4EC4A 2JK7A 4EB9A 2QFAA 1XB1A 5C7BA 5C0LA 1XOXA 5C7CA 2QRAA 3CLXA 1OXQA 4KJUA 3SIPE 4KMPA 5C3KA 3UEGA 3F7IA 3CM7A 3EYLA 1E31A 4J47A 4J48A 4WVUA 3HL5A 1C9QA 1G73C 2RAWA 1XB0A 1OY7A 2VSLA 1TFQA 2POPB 3T6PA 2RAXA 2VM5A 4A0NA 3D9TA 3M0DD 4J45A 4J46A 3UIHA 3GTAA 3D9UA 4MTIA 1JD6A 4A0IA 3UEFA 1QBHA 1OXNA 4LGUA 5C83A 4LGEA 1NW9A 4HY4A 2I3IA 3F7GA 2POIA 3OZ1A 1G3FA 1TFTA 5C7DA 5C7AA 1TW6A 2OPYA 3UECA 3UIIA 4OXCA 3GT9A 3UEHA 1F9XA 1JD4A 5C0KA 1SDZA 3SIQA 4MU7A 2UVLA 3UEIA 1Q4QA 1JD5A 4KMNA 3M1DA 4KJVA 3UEEA 5C3HA
chains in the Genus database with same CATH superfamily
4WVTA 3UIJA 3UW5A 1M4MA 4HY5A 2I3HA 1SE0A 3F7HA 3M0AD 3UEDA 3UW4A 2OPZA 4A0JA 1I3OE 3G76A 5C84A 4MTZA 3UIKA 4J44A 4J3YA 4WVSA 1F3HA 4HY0A 3MUPA 3UIGA 3CM2A 4EC4A 2JK7A 4EB9A 2QFAA 1XB1A 5C7BA 5C0LA 1XOXA 5C7CA 2QRAA 3CLXA 1OXQA 4KJUA 3SIPE 4KMPA 5C3KA 3UEGA 3F7IA 3CM7A 3EYLA 1E31A 4J47A 4J48A 4WVUA 3HL5A 1C9QA 1G73C 2RAWA 1XB0A 1OY7A 2VSLA 1TFQA 2POPB 3T6PA 2RAXA 2VM5A 4A0NA 3D9TA 3M0DD 4J45A 4J46A 3UIHA 3GTAA 3D9UA 4MTIA 1JD6A 4A0IA 3UEFA 1QBHA 1OXNA 4LGUA 5C83A 4LGEA 1NW9A 4HY4A 2I3IA 3F7GA 2POIA 3OZ1A 1G3FA 1TFTA 5C7DA 5C7AA 1TW6A 2OPYA 3UECA 3UIIA 4OXCA 3GT9A 3UEHA 1F9XA 1JD4A 5C0KA 1SDZA 3SIQA 4MU7A 2UVLA 3UEIA 1Q4QA 1JD5A 4KMNA 3M1DA 4KJVA 3UEEA 5C3HA
chains in the Genus database with same CATH topology
4WVTA 3UIJA 3UW5A 1M4MA 4HY5A 2I3HA 1SE0A 3F7HA 3M0AD 3UEDA 3UW4A 2OPZA 4A0JA 1I3OE 3G76A 5C84A 4MTZA 3UIKA 4J44A 4J3YA 4WVSA 1F3HA 4HY0A 3MUPA 3UIGA 3CM2A 4EC4A 2JK7A 4EB9A 2QFAA 1XB1A 5C7BA 5C0LA 1XOXA 5C7CA 2QRAA 3CLXA 1OXQA 4KJUA 3SIPE 4KMPA 5C3KA 3UEGA 3F7IA 3CM7A 3EYLA 1E31A 4J47A 4J48A 4WVUA 3HL5A 1C9QA 1G73C 2RAWA 1XB0A 1OY7A 2VSLA 1TFQA 2POPB 3T6PA 2RAXA 2VM5A 4A0NA 3D9TA 3M0DD 4J45A 4J46A 3UIHA 3GTAA 3D9UA 4MTIA 1JD6A 4A0IA 3UEFA 1QBHA 1OXNA 4LGUA 5C83A 4LGEA 1NW9A 4HY4A 2I3IA 3F7GA 2POIA 3OZ1A 1G3FA 1TFTA 5C7DA 5C7AA 1TW6A 2OPYA 3UECA 3UIIA 4OXCA 3GT9A 3UEHA 1F9XA 1JD4A 5C0KA 1SDZA 3SIQA 4MU7A 2UVLA 3UEIA 1Q4QA 1JD5A 4KMNA 3M1DA 4KJVA 3UEEA 5C3HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WVT A;  3UIJ A;  3UW5 A;  1M4M A;  4HY5 A;  2I3H A;  1SE0 A;  3F7H A;  3M0A D;  3UED A;  3UW4 A;  2OPZ A;  4A0J A;  1I3O E;  3G76 A;  5C84 A;  4MTZ A;  3UIK A;  4J44 A;  4J3Y A;  4WVS A;  1F3H A;  4HY0 A;  3MUP A;  3UIG A;  3CM2 A;  4EC4 A;  2JK7 A;  4EB9 A;  2QFA A;  1XB1 A;  5C7B A;  5C0L A;  1XOX A;  5C7C A;  2QRA A;  3CLX A;  1OXQ A;  4KJU A;  3SIP E;  4KMP A;  5C3K A;  3UEG A;  3F7I A;  3CM7 A;  3EYL A;  1E31 A;  4J47 A;  4J48 A;  4WVU A;  3HL5 A;  1C9Q A;  1G73 C;  2RAW A;  1XB0 A;  1OY7 A;  2VSL A;  1TFQ A;  2POP B;  3T6P A;  2RAX A;  2VM5 A;  4A0N A;  3D9T A;  3M0D D;  4J45 A;  4J46 A;  3UIH A;  3GTA A;  3D9U A;  4MTI A;  1JD6 A;  4A0I A;  3UEF A;  1QBH A;  1OXN A;  4LGU A;  5C83 A;  4LGE A;  1NW9 A;  4HY4 A;  2I3I A;  3F7G A;  2POI A;  3OZ1 A;  1G3F A;  1TFT A;  5C7D A;  5C7A A;  1TW6 A;  2OPY A;  3UEC A;  3UII A;  4OXC A;  3GT9 A;  3UEH A;  1F9X A;  1JD4 A;  5C0K A;  1SDZ A;  3SIQ A;  4MU7 A;  2UVL A;  3UEI A;  1Q4Q A;  1JD5 A;  4KMN A;  3M1D A;  4KJV A;  3UEE A;  5C3H A; 
#chains in the Genus database with same CATH topology
 4WVT A;  3UIJ A;  3UW5 A;  1M4M A;  4HY5 A;  2I3H A;  1SE0 A;  3F7H A;  3M0A D;  3UED A;  3UW4 A;  2OPZ A;  4A0J A;  1I3O E;  3G76 A;  5C84 A;  4MTZ A;  3UIK A;  4J44 A;  4J3Y A;  4WVS A;  1F3H A;  4HY0 A;  3MUP A;  3UIG A;  3CM2 A;  4EC4 A;  2JK7 A;  4EB9 A;  2QFA A;  1XB1 A;  5C7B A;  5C0L A;  1XOX A;  5C7C A;  2QRA A;  3CLX A;  1OXQ A;  4KJU A;  3SIP E;  4KMP A;  5C3K A;  3UEG A;  3F7I A;  3CM7 A;  3EYL A;  1E31 A;  4J47 A;  4J48 A;  4WVU A;  3HL5 A;  1C9Q A;  1G73 C;  2RAW A;  1XB0 A;  1OY7 A;  2VSL A;  1TFQ A;  2POP B;  3T6P A;  2RAX A;  2VM5 A;  4A0N A;  3D9T A;  3M0D D;  4J45 A;  4J46 A;  3UIH A;  3GTA A;  3D9U A;  4MTI A;  1JD6 A;  4A0I A;  3UEF A;  1QBH A;  1OXN A;  4LGU A;  5C83 A;  4LGE A;  1NW9 A;  4HY4 A;  2I3I A;  3F7G A;  2POI A;  3OZ1 A;  1G3F A;  1TFT A;  5C7D A;  5C7A A;  1TW6 A;  2OPY A;  3UEC A;  3UII A;  4OXC A;  3GT9 A;  3UEH A;  1F9X A;  1JD4 A;  5C0K A;  1SDZ A;  3SIQ A;  4MU7 A;  2UVL A;  3UEI A;  1Q4Q A;  1JD5 A;  4KMN A;  3M1D A;  4KJV A;  3UEE A;  5C3H A; 
#chains in the Genus database with same CATH homology
 4WVT A;  3UIJ A;  3UW5 A;  1M4M A;  4HY5 A;  2I3H A;  1SE0 A;  3F7H A;  3M0A D;  3UED A;  3UW4 A;  2OPZ A;  4A0J A;  1I3O E;  3G76 A;  5C84 A;  4MTZ A;  3UIK A;  4J44 A;  4J3Y A;  4WVS A;  1F3H A;  4HY0 A;  3MUP A;  3UIG A;  3CM2 A;  4EC4 A;  2JK7 A;  4EB9 A;  2QFA A;  1XB1 A;  5C7B A;  5C0L A;  1XOX A;  5C7C A;  2QRA A;  3CLX A;  1OXQ A;  4KJU A;  3SIP E;  4KMP A;  5C3K A;  3UEG A;  3F7I A;  3CM7 A;  3EYL A;  1E31 A;  4J47 A;  4J48 A;  4WVU A;  3HL5 A;  1C9Q A;  1G73 C;  2RAW A;  1XB0 A;  1OY7 A;  2VSL A;  1TFQ A;  2POP B;  3T6P A;  2RAX A;  2VM5 A;  4A0N A;  3D9T A;  3M0D D;  4J45 A;  4J46 A;  3UIH A;  3GTA A;  3D9U A;  4MTI A;  1JD6 A;  4A0I A;  3UEF A;  1QBH A;  1OXN A;  4LGU A;  5C83 A;  4LGE A;  1NW9 A;  4HY4 A;  2I3I A;  3F7G A;  2POI A;  3OZ1 A;  1G3F A;  1TFT A;  5C7D A;  5C7A A;  1TW6 A;  2OPY A;  3UEC A;  3UII A;  4OXC A;  3GT9 A;  3UEH A;  1F9X A;  1JD4 A;  5C0K A;  1SDZ A;  3SIQ A;  4MU7 A;  2UVL A;  3UEI A;  1Q4Q A;  1JD5 A;  4KMN A;  3M1D A;  4KJV A;  3UEE A;  5C3H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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