4X9RA

Plk-1 polo-box domain in complex with bioactive imidazolium-containing phosphopeptide macrocycle 3b
Total Genus 71
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
220
Chain Sequence
b'HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 71
structure length 220
sequence length 220
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9rA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9rA01
4E67A 3P36A 3P34A 3P2WA 5DNJA 1Q4OA 4RS6A 4O9WA 5LHZA 4RCPA 4LKLA 3HIHA 4HCOA 5DMSA 4X9RA 4HABA 5DMVC 4WHKA 3P37A 4E9DA 3HIKA 3RQ7A 4O56A 4H5XA 4HY2A 3P35A 1Q4KA 4WHLA 5J19A 2N19A 2OGQA 4J7BB 3FVHA 4XB0A 4WHHA 4YYPA 3BZIA 4X9WA 3Q1IA 4DFWA 3P2ZA 4E9CA 1UMWA 4H71A 4X9VA 4LKMA 3C5LA 2OJXA 4O6WA
chains in the Genus database with same CATH superfamily
4G7NA 3P2WA 4RCPA 4X9RA 4O56A 1Q4KA 3FVHA 4XB0A 4WHHA 1HDHA 1A87A 3FS3A 1P49A 3LXQA 4N9JA 4E67A 3P34A 5DAYA 5DNJA 4HABA 4CYSA 1FSUA 3RQ7A 4H5XA 5J19A 1E3CP 4J7BB 2I9XA 3LM3A 4H71A 4LKMA 4NK7A 1AUKA 1E1ZP 2UV8G 1Q4OA 4RS6A 2QZUA 4HCOA 5DMVC 4CXUA 4HY2A 3P35A 4N7VA 2N19A 1E2TA 4YYPA 3BZIA 3Q1IA 4DFWA 2E50A 1UMWA 4X9VA 4CXSA 3C5LA 4O6WA 1N2KA 4FDJA 3P36A 5AJ9A 5LHZA 4O9WA 4LKLA 3HIHA 5DMSA 3ED4A 4FDIA 4N7ZA 4WHKA 3P37A 4E9DA 4CXKA 3HMJG 3HIKA 3KDRA 4NKBA 4WHLA 2OGQA 2I9ZA 1N2LA 2VKZG 3GYWA 1F34B 4X9WA 3GYVA 3P2ZA 1F32A 4E9CA 3HFDA 4CYRA 1E2SP 2OJXA 2IA9A 1E33P
chains in the Genus database with same CATH topology
4E67A 3P36A 3P34A 3P2WA 5DNJA 1Q4OA 4RS6A 4O9WA 5LHZA 4RCPA 4LKLA 3HIHA 4HCOA 5DMSA 4X9RA 4HABA 5DMVC 4WHKA 3P37A 4E9DA 3HIKA 3RQ7A 4O56A 4H5XA 4HY2A 3P35A 1Q4KA 4WHLA 5J19A 2N19A 2OGQA 4J7BB 3FVHA 4XB0A 4WHHA 4YYPA 3BZIA 4X9WA 3Q1IA 4DFWA 3P2ZA 4E9CA 1UMWA 4H71A 4X9VA 4LKMA 3C5LA 2OJXA 4O6WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E67 A;  3P36 A;  3P34 A;  3P2W A;  5DNJ A;  1Q4O A;  4RS6 A;  4O9W A;  5LHZ A;  4RCP A;  4LKL A;  3HIH A;  4HCO A;  5DMS A;  4X9R A;  4HAB A;  5DMV C;  4WHK A;  3P37 A;  4E9D A;  3HIK A;  3RQ7 A;  4O56 A;  4H5X A;  4HY2 A;  3P35 A;  1Q4K A;  4WHL A;  5J19 A;  2N19 A;  2OGQ A;  4J7B B;  3FVH A;  4XB0 A;  4WHH A;  4YYP A;  3BZI A;  4X9W A;  3Q1I A;  4DFW A;  3P2Z A;  4E9C A;  1UMW A;  4H71 A;  4X9V A;  4LKM A;  3C5L A;  2OJX A;  4O6W A; 
#chains in the Genus database with same CATH topology
 4G7N A;  3P2W A;  4RCP A;  4X9R A;  4O56 A;  1Q4K A;  3FVH A;  4XB0 A;  4WHH A;  1HDH A;  1A87 A;  3FS3 A;  1P49 A;  3LXQ A;  4N9J A;  4E67 A;  3P34 A;  5DAY A;  5DNJ A;  4HAB A;  4CYS A;  1FSU A;  3RQ7 A;  4H5X A;  5J19 A;  1E3C P;  4J7B B;  2I9X A;  3LM3 A;  4H71 A;  4LKM A;  4NK7 A;  1AUK A;  1E1Z P;  2UV8 G;  1Q4O A;  4RS6 A;  2QZU A;  4HCO A;  5DMV C;  4CXU A;  4HY2 A;  3P35 A;  4N7V A;  2N19 A;  1E2T A;  4YYP A;  3BZI A;  3Q1I A;  4DFW A;  2E50 A;  1UMW A;  4X9V A;  4CXS A;  3C5L A;  4O6W A;  1N2K A;  4FDJ A;  3P36 A;  5AJ9 A;  5LHZ A;  4O9W A;  4LKL A;  3HIH A;  5DMS A;  3ED4 A;  4FDI A;  4N7Z A;  4WHK A;  3P37 A;  4E9D A;  4CXK A;  3HMJ G;  3HIK A;  3KDR A;  4NKB A;  4WHL A;  2OGQ A;  2I9Z A;  1N2L A;  2VKZ G;  3GYW A;  1F34 B;  4X9W A;  3GYV A;  3P2Z A;  1F32 A;  4E9C A;  3HFD A;  4CYR A;  1E2S P;  2OJX A;  2IA9 A;  1E33 P; 
#chains in the Genus database with same CATH homology
 4E67 A;  3P36 A;  3P34 A;  3P2W A;  5DNJ A;  1Q4O A;  4RS6 A;  4O9W A;  5LHZ A;  4RCP A;  4LKL A;  3HIH A;  4HCO A;  5DMS A;  4X9R A;  4HAB A;  5DMV C;  4WHK A;  3P37 A;  4E9D A;  3HIK A;  3RQ7 A;  4O56 A;  4H5X A;  4HY2 A;  3P35 A;  1Q4K A;  4WHL A;  5J19 A;  2N19 A;  2OGQ A;  4J7B B;  3FVH A;  4XB0 A;  4WHH A;  4YYP A;  3BZI A;  4X9W A;  3Q1I A;  4DFW A;  3P2Z A;  4E9C A;  1UMW A;  4H71 A;  4X9V A;  4LKM A;  3C5L A;  2OJX A;  4O6W A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...