4X9RA

Plk-1 polo-box domain in complex with bioactive imidazolium-containing phosphopeptide macrocycle 3b
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
total genus 71
structure length 220
sequence length 220
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9rA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9rA01
4O56A 3P35A 4YYPA 4LKMA 4O6WA 3BZIA 4LKLA 4WHHA 4O9WA 1Q4KA 2OGQA 5LHZA 4E67A 1Q4OA 1UMWA 3P2ZA 3FVHA 4J7BB 2OJXA 4RCPA 4HABA 3HIKA 3C5LA 4HCOA 3RQ7A 3P2WA 3Q1IA 3HIHA 4E9DA 4H5XA 4DFWA 4X9WA 4RS6A 3P36A 5J19A 4WHLA 3P37A 4X9VA 5DMVC 5DMSA 4WHKA 4XB0A 3P34A 4X9RA 4H71A 4E9CA 2N19A 5DNJA 4HY2A
chains in the Genus database with same CATH superfamily
4FDJA 4O6WA 3BZIA 1A87A 1HDHA 4N9JA 3KDRA 2I9ZA 1E2SP 2OJXA 2QZUA 3HMJG 4H5XA 4CYSA 4N7VA 3FS3A 3P37A 4CXSA 4X9VA 1N2LA 3P34A 4H71A 4FDIA 5DNJA 5AJ9A 2IA9A 3GYVA 4WHHA 4O9WA 1Q4KA 2OGQA 5LHZA 1FSUA 3HFDA 4CYRA 3ED4A 4HABA 2E50A 3C5LA 4HCOA 3RQ7A 3Q1IA 3HIHA 4E9DA 5J19A 3LXQA 4WHKA 4XB0A 4X9RA 3LM3A 4NKBA 4CXUA 1E2TA 2N19A 4O56A 3P35A 4YYPA 4LKLA 1E33P 4E67A 1UMWA 1Q4OA 3P2ZA 4J7BB 4RCPA 2I9XA 3P2WA 1E1ZP 4DFWA 4G7NA 4X9WA 4WHLA 5DMVC 3GYWA 4E9CA 4CXKA 4HY2A 1E3CP 1F32A 4LKMA 4N7ZA 5DAYA 3FVHA 2VKZG 1F34B 2UV8G 1N2KA 3HIKA 4RS6A 3P36A 4NK7A 5DMSA 1AUKA 1P49A
chains in the Genus database with same CATH topology
4O56A 3P35A 4YYPA 4LKMA 4O6WA 3BZIA 4LKLA 4WHHA 4O9WA 1Q4KA 2OGQA 5LHZA 4E67A 1Q4OA 1UMWA 3P2ZA 3FVHA 4J7BB 2OJXA 4RCPA 4HABA 3HIKA 3C5LA 4HCOA 3RQ7A 3P2WA 3Q1IA 3HIHA 4E9DA 4H5XA 4DFWA 4X9WA 4RS6A 3P36A 5J19A 4WHLA 3P37A 4X9VA 5DMVC 5DMSA 4WHKA 4XB0A 3P34A 4X9RA 4H71A 4E9CA 2N19A 5DNJA 4HY2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O56 A;  3P35 A;  4YYP A;  4LKM A;  4O6W A;  3BZI A;  4LKL A;  4WHH A;  4O9W A;  1Q4K A;  2OGQ A;  5LHZ A;  4E67 A;  1Q4O A;  1UMW A;  3P2Z A;  3FVH A;  4J7B B;  2OJX A;  4RCP A;  4HAB A;  3HIK A;  3C5L A;  4HCO A;  3RQ7 A;  3P2W A;  3Q1I A;  3HIH A;  4E9D A;  4H5X A;  4DFW A;  4X9W A;  4RS6 A;  3P36 A;  5J19 A;  4WHL A;  3P37 A;  4X9V A;  5DMV C;  5DMS A;  4WHK A;  4XB0 A;  3P34 A;  4X9R A;  4H71 A;  4E9C A;  2N19 A;  5DNJ A;  4HY2 A; 
#chains in the Genus database with same CATH topology
 4FDJ A;  4O6W A;  3BZI A;  1A87 A;  1HDH A;  4N9J A;  3KDR A;  2I9Z A;  1E2S P;  2OJX A;  2QZU A;  3HMJ G;  4H5X A;  4CYS A;  4N7V A;  3FS3 A;  3P37 A;  4CXS A;  4X9V A;  1N2L A;  3P34 A;  4H71 A;  4FDI A;  5DNJ A;  5AJ9 A;  2IA9 A;  3GYV A;  4WHH A;  4O9W A;  1Q4K A;  2OGQ A;  5LHZ A;  1FSU A;  3HFD A;  4CYR A;  3ED4 A;  4HAB A;  2E50 A;  3C5L A;  4HCO A;  3RQ7 A;  3Q1I A;  3HIH A;  4E9D A;  5J19 A;  3LXQ A;  4WHK A;  4XB0 A;  4X9R A;  3LM3 A;  4NKB A;  4CXU A;  1E2T A;  2N19 A;  4O56 A;  3P35 A;  4YYP A;  4LKL A;  1E33 P;  4E67 A;  1UMW A;  1Q4O A;  3P2Z A;  4J7B B;  4RCP A;  2I9X A;  3P2W A;  1E1Z P;  4DFW A;  4G7N A;  4X9W A;  4WHL A;  5DMV C;  3GYW A;  4E9C A;  4CXK A;  4HY2 A;  1E3C P;  1F32 A;  4LKM A;  4N7Z A;  5DAY A;  3FVH A;  2VKZ G;  1F34 B;  2UV8 G;  1N2K A;  3HIK A;  4RS6 A;  3P36 A;  4NK7 A;  5DMS A;  1AUK A;  1P49 A; 
#chains in the Genus database with same CATH homology
 4O56 A;  3P35 A;  4YYP A;  4LKM A;  4O6W A;  3BZI A;  4LKL A;  4WHH A;  4O9W A;  1Q4K A;  2OGQ A;  5LHZ A;  4E67 A;  1Q4O A;  1UMW A;  3P2Z A;  3FVH A;  4J7B B;  2OJX A;  4RCP A;  4HAB A;  3HIK A;  3C5L A;  4HCO A;  3RQ7 A;  3P2W A;  3Q1I A;  3HIH A;  4E9D A;  4H5X A;  4DFW A;  4X9W A;  4RS6 A;  3P36 A;  5J19 A;  4WHL A;  3P37 A;  4X9V A;  5DMV C;  5DMS A;  4WHK A;  4XB0 A;  3P34 A;  4X9R A;  4H71 A;  4E9C A;  2N19 A;  5DNJ A;  4HY2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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