The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
192
|
sequence length |
658
|
structure length |
657
|
Chain Sequence |
ISPIFQGGSYQLNNKSIDISSLLLDKLSGESQTVVMKFKADKPNSLQALFGLSNSKAGFKNNYFSIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGKHKGQAVENTLVFVSDSKDKTYTMYVNGIEVFSETVDTFLPISNINGIDKATLGAVNREGKEHYLAKGSIDEISLFNKAISDQEVSTIPLSNPFQLIFQSGDSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKINIATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDKKSGKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVRENGVVYNETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLRERHNGKQVPMNVFYKDSLFKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHNGTYLCPGQGLALGSSNRLIFATYTSGELTYLISDDSGQTWKKSSASIPFKNATAEAQMVELRGVIRTFFRTTTGKIAYMTSRDSGETWSKVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQLVVGLVNKEDDSIDWKYHYGIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLSNVVQYIDLEINDLT
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
rcsb |
| molecule tags |
Hydrolase
|
| source organism |
Streptococcus pneumoniae serotype 4 (strain atcc baa-334 / tigr4)
|
| molecule keywords |
Sialidase B
|
| total genus |
192
|
| structure length |
657
|
| sequence length |
658
|
| ec nomenclature |
ec
3.2.1.18: Exo-alpha-sialidase. |
| pdb deposition date | 2015-01-14 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF02012 | BNR | BNR/Asp-box repeat |
| A | PF02973 | Sialidase | Sialidase, N-terminal domain |
| A | PF13088 | BNR_2 | BNR repeat-like domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Beta Barrel | Intramolecular trans-sialidase; domain 3 | Intramolecular Trans-sialidase; Domain 3 | ||
| Mainly Beta | Sandwich | Jelly Rolls | Jelly Rolls | ||
| Mainly Beta | 6 Propeller | Neuraminidase | Neuraminidase |
