4XR8F

Crystal structure of the hpv16 e6/e6ap/p53 ternary complex at 2.25 a resolution
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
143
structure length
143
Chain Sequence
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYSYSLYGTTLEQQYNKPLSDLLIRCINCQKPLSPEEKQRHLDKKQRFHNIRGRWTGRCMSCSRSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Viral protein/ antitumor protein
molecule keywords Maltose-binding periplasmic protein, ubiquitin ligase E6AP
publication title Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
pubmed doi rcsb
source organism Escherichia coli
total genus 43
structure length 143
sequence length 143
chains with identical sequence H
ec nomenclature
pdb deposition date 2015-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00518 E6 Early Protein (E6)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.240.40 Alpha Beta 2-Layer Sandwich CRO Repressor CRO Repressor 4xr8F01
3.30.240.40 Alpha Beta 2-Layer Sandwich CRO Repressor CRO Repressor 4xr8F02
2LJYA 2M3LA 4XR8F 2FK4A 2LJZA 2LJXA 4GIZC
chains in the Genus database with same CATH superfamily
2A63A 1D1LA 3ORCA 1COPD 4XR8F 2LJXA 2ORCA 2CW1A 2LJYA 2LJZA 1D1MA 2ECSA 6CROA 1WU7A 1ORCA 2FK4A 5CROA 2M3LA 2OVGA 3C6FA 4GIZC
chains in the Genus database with same CATH topology
2A63A 1D1LA 3ORCA 1COPD 4XR8F 2LJXA 2ORCA 2CW1A 2LJYA 2LJZA 1D1MA 2ECSA 6CROA 1WU7A 1ORCA 2FK4A 5CROA 2M3LA 2OVGA 4GIZC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LJY A;  2M3L A;  4XR8 F;  2FK4 A;  2LJZ A;  2LJX A;  4GIZ C; 
#chains in the Genus database with same CATH topology
 2A63 A;  1D1L A;  3ORC A;  1COP D;  4XR8 F;  2LJX A;  2ORC A;  2CW1 A;  2LJY A;  2LJZ A;  1D1M A;  2ECS A;  6CRO A;  1WU7 A;  1ORC A;  2FK4 A;  5CRO A;  2M3L A;  2OVG A;  3C6F A;  4GIZ C; 
#chains in the Genus database with same CATH homology
 2A63 A;  1D1L A;  3ORC A;  1COP D;  4XR8 F;  2LJX A;  2ORC A;  2CW1 A;  2LJY A;  2LJZ A;  1D1M A;  2ECS A;  6CRO A;  1WU7 A;  1ORC A;  2FK4 A;  5CRO A;  2M3L A;  2OVG A;  4GIZ C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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