4XRXA

Crystal structure of a metabolic reductase with (e)-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
411
structure length
390
Chain Sequence
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Isocitrate dehydrogenase [NADP] cytoplasmic
publication title Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.
pubmed doi rcsb
source organism Homo sapiens
total genus 133
structure length 390
sequence length 411
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2015-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4xrxA00
4HCXA 1GC9A 4AJAA 4AJCA 3MASA 1HJ6A 3DMSA 3TY3A 1DR0A 3TSNA 1DR8A 4AJBA 8ICDA 4F7IA 1PS6A 4KZOA 3WZXA 5L58A 1WALA 1CW7A 3R8WA 1W0DA 1IDCA 1PS7A 2QFYA 3AH3A 3FLKA 1ZORA 2D4VA 3VKZA 4L04A 3MASB 2Y42A 1G2UA 1IPDA 3WZWA 2E0CA 7ICDA 1CW1A 1HQSA 2UXQA 5GRLA 5L57A 4UMXA 5J32A 2G4OA 5J33A 3FMXX 2QFVA 2QFWA 4P69C 4Y1PA 4AJ3A 2IV0A 1OSIA 3U9EA 4UMYA 2UXRA 4AJRA 3BLXA 5GRFA 2ZTWA 4I3LA 3VL3A 4ICDA 1IKAA 5J34A 5K10A 1IDFA 1V5BA 2Y41A 5DE1A 1GC8A 9ICDA 1BL5A 3MAPA 5I96A 5GRHA 5HN5A 3UDOA 3VMKA 1SJSA 1R8KA 3VL2A 1PB3A 3BLVA 1AI3A 3VL4A 1DPZA 1YCOA 4L06A 1IDEA 3WZYA 5GREA 3VL7A 3BLXB 5GRFB 2Y3ZA 4JQPA 4WUOA 4ATYA 1A05A 4IWHA 3LXYA 1XADA 5K11A 4AOUA 3UF6A 2QFXA 1IDDA 1XACA 1XAAA 1XKDA 2Y40A 5ICDA 5GRIA 2AYQA 4XS3A 1XABA 3BLVB 1TYOA 3TY4A 4XRXA 6ICDA 1CW4A 1YXOA 5GRLB 1T0LA 3ICDA 4AOYA 2HI1A 3U1HA 1V53A 1VLCA 1AI2A 2D1CA 5HN3A 1P8FA 1WPWA 5GRIB 4AJSA 1OSJA 4XXVA 3UDUA 4YB4A 2DHTA 3US8A 3VL6A 1IDMA 4I3KA 5I95A 1ISOA 1HEXA 1VI1A 1U7NA 1GRPA 3TNGA 1PB1A 1T09A 4L03A 5GRHB 1XGVA 1LWDA 1PTMA 3LCBC 3WZVA 3ASJA 3MARA 2E5MA 5HN6A 1X0LA 3INMA 1CM7A 1GROA 4JA8A 5GREB 4BNPA 3VMJA 5LGEA 4AOVA 3VMLA 1CNZA 1V94A 5HN4A
chains in the Genus database with same CATH superfamily
4HCXA 1GC9A 4AJAA 4AJCA 3MASA 1HJ6A 3DMSA 3TY3A 1DR0A 3TSNA 1DR8A 4AJBA 8ICDA 4F7IA 1PS6A 4KZOA 3WZXA 5L58A 1WALA 1CW7A 3R8WA 1W0DA 1IDCA 1PS7A 2QFYA 3AH3A 3FLKA 1ZORA 2D4VA 3VKZA 4L04A 3MASB 2Y42A 1G2UA 1IPDA 3WZWA 2E0CA 7ICDA 1CW1A 1HQSA 2UXQA 5GRLA 5L57A 4UMXA 5J32A 2G4OA 5J33A 3FMXX 2QFVA 2QFWA 4P69C 4Y1PA 4AJ3A 2IV0A 1OSIA 3U9EA 4UMYA 2UXRA 4AJRA 3BLXA 5GRFA 2ZTWA 4I3LA 3VL3A 4ICDA 1IKAA 5J34A 5K10A 1IDFA 1V5BA 2Y41A 5DE1A 1GC8A 9ICDA 1BL5A 3MAPA 5I96A 5GRHA 5HN5A 3UDOA 3VMKA 1SJSA 1R8KA 3VL2A 1PB3A 3BLVA 1AI3A 3VL4A 1DPZA 1YCOA 4L06A 1IDEA 3WZYA 5GREA 3VL7A 3BLXB 5GRFB 2Y3ZA 4JQPA 4WUOA 4ATYA 1A05A 4IWHA 3LXYA 1XADA 5K11A 4AOUA 3UF6A 2QFXA 1IDDA 1XACA 1XAAA 1XKDA 2Y40A 5ICDA 5GRIA 2AYQA 4XS3A 1XABA 3BLVB 1TYOA 3TY4A 4XRXA 6ICDA 1CW4A 1YXOA 5GRLB 1T0LA 3ICDA 4AOYA 2HI1A 3U1HA 1V53A 1VLCA 1AI2A 2D1CA 5HN3A 1P8FA 1WPWA 5GRIB 4AJSA 1OSJA 4XXVA 3UDUA 4YB4A 2DHTA 3US8A 3VL6A 1IDMA 4I3KA 5I95A 1ISOA 1HEXA 1VI1A 1U7NA 1GRPA 3TNGA 1PB1A 1T09A 4L03A 5GRHB 1XGVA 1LWDA 1PTMA 3LCBC 3WZVA 3ASJA 3MARA 2E5MA 5HN6A 1X0LA 3INMA 1CM7A 1GROA 4JA8A 5GREB 4BNPA 3VMJA 5LGEA 4AOVA 3VMLA 1CNZA 1V94A 5HN4A
chains in the Genus database with same CATH topology
4HCXA 1GC9A 4AJAA 4AJCA 3MASA 1HJ6A 3DMSA 3TY3A 1DR0A 3TSNA 1DR8A 4AJBA 8ICDA 4F7IA 1PS6A 4KZOA 3WZXA 5L58A 1WALA 1CW7A 3R8WA 1W0DA 1IDCA 1PS7A 2QFYA 3AH3A 3FLKA 1ZORA 2D4VA 3VKZA 4L04A 3MASB 2Y42A 1G2UA 1IPDA 3WZWA 2E0CA 7ICDA 1CW1A 1HQSA 2UXQA 5GRLA 5L57A 4UMXA 5J32A 2G4OA 5J33A 3FMXX 2QFVA 2QFWA 4P69C 4Y1PA 4AJ3A 2IV0A 1OSIA 3U9EA 4UMYA 2UXRA 4AJRA 3BLXA 5GRFA 2ZTWA 4I3LA 3VL3A 4ICDA 1IKAA 5J34A 5K10A 1IDFA 1V5BA 2Y41A 5DE1A 1GC8A 9ICDA 1BL5A 3MAPA 5I96A 5GRHA 5HN5A 3UDOA 3VMKA 1SJSA 1R8KA 3VL2A 1PB3A 3BLVA 1AI3A 3VL4A 1DPZA 1YCOA 4L06A 1IDEA 3WZYA 5GREA 3VL7A 3BLXB 5GRFB 2Y3ZA 4JQPA 4WUOA 4ATYA 1A05A 4IWHA 3LXYA 1XADA 5K11A 4AOUA 3UF6A 2QFXA 1IDDA 1XACA 1XAAA 1XKDA 2Y40A 5ICDA 5GRIA 2AYQA 4XS3A 1XABA 3BLVB 1TYOA 3TY4A 4XRXA 6ICDA 1CW4A 1YXOA 5GRLB 1T0LA 3ICDA 4AOYA 2HI1A 3U1HA 1V53A 1VLCA 1AI2A 2D1CA 5HN3A 1P8FA 1WPWA 5GRIB 4AJSA 1OSJA 4XXVA 3UDUA 4YB4A 2DHTA 3US8A 3VL6A 1IDMA 4I3KA 5I95A 1ISOA 1HEXA 1VI1A 1U7NA 1GRPA 3TNGA 1PB1A 1T09A 4L03A 5GRHB 1XGVA 1LWDA 1PTMA 3LCBC 3WZVA 3ASJA 3MARA 2E5MA 5HN6A 1X0LA 3INMA 1CM7A 1GROA 4JA8A 5GREB 4BNPA 3VMJA 5LGEA 4AOVA 3VMLA 1CNZA 1V94A 5HN4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HCX A;  1GC9 A;  4AJA A;  4AJC A;  3MAS A;  1HJ6 A;  3DMS A;  3TY3 A;  1DR0 A;  3TSN A;  1DR8 A;  4AJB A;  8ICD A;  4F7I A;  1PS6 A;  4KZO A;  3WZX A;  5L58 A;  1WAL A;  1CW7 A;  3R8W A;  1W0D A;  1IDC A;  1PS7 A;  2QFY A;  3AH3 A;  3FLK A;  1ZOR A;  2D4V A;  3VKZ A;  4L04 A;  3MAS B;  2Y42 A;  1G2U A;  1IPD A;  3WZW A;  2E0C A;  7ICD A;  1CW1 A;  1HQS A;  2UXQ A;  5GRL A;  5L57 A;  4UMX A;  5J32 A;  2G4O A;  5J33 A;  3FMX X;  2QFV A;  2QFW A;  4P69 C;  4Y1P A;  4AJ3 A;  2IV0 A;  1OSI A;  3U9E A;  4UMY A;  2UXR A;  4AJR A;  3BLX A;  5GRF A;  2ZTW A;  4I3L A;  3VL3 A;  4ICD A;  1IKA A;  5J34 A;  5K10 A;  1IDF A;  1V5B A;  2Y41 A;  5DE1 A;  1GC8 A;  9ICD A;  1BL5 A;  3MAP A;  5I96 A;  5GRH A;  5HN5 A;  3UDO A;  3VMK A;  1SJS A;  1R8K A;  3VL2 A;  1PB3 A;  3BLV A;  1AI3 A;  3VL4 A;  1DPZ A;  1YCO A;  4L06 A;  1IDE A;  3WZY A;  5GRE A;  3VL7 A;  3BLX B;  5GRF B;  2Y3Z A;  4JQP A;  4WUO A;  4ATY A;  1A05 A;  4IWH A;  3LXY A;  1XAD A;  5K11 A;  4AOU A;  3UF6 A;  2QFX A;  1IDD A;  1XAC A;  1XAA A;  1XKD A;  2Y40 A;  5ICD A;  5GRI A;  2AYQ A;  4XS3 A;  1XAB A;  3BLV B;  1TYO A;  3TY4 A;  4XRX A;  6ICD A;  1CW4 A;  1YXO A;  5GRL B;  1T0L A;  3ICD A;  4AOY A;  2HI1 A;  3U1H A;  1V53 A;  1VLC A;  1AI2 A;  2D1C A;  5HN3 A;  1P8F A;  1WPW A;  5GRI B;  4AJS A;  1OSJ A;  4XXV A;  3UDU A;  4YB4 A;  2DHT A;  3US8 A;  3VL6 A;  1IDM A;  4I3K A;  5I95 A;  1ISO A;  1HEX A;  1VI1 A;  1U7N A;  1GRP A;  3TNG A;  1PB1 A;  1T09 A;  4L03 A;  5GRH B;  1XGV A;  1LWD A;  1PTM A;  3LCB C;  3WZV A;  3ASJ A;  3MAR A;  2E5M A;  5HN6 A;  1X0L A;  3INM A;  1CM7 A;  1GRO A;  4JA8 A;  5GRE B;  4BNP A;  3VMJ A;  5LGE A;  4AOV A;  3VML A;  1CNZ A;  1V94 A;  5HN4 A; 
#chains in the Genus database with same CATH topology
 4HCX A;  1GC9 A;  4AJA A;  4AJC A;  3MAS A;  1HJ6 A;  3DMS A;  3TY3 A;  1DR0 A;  3TSN A;  1DR8 A;  4AJB A;  8ICD A;  4F7I A;  1PS6 A;  4KZO A;  3WZX A;  5L58 A;  1WAL A;  1CW7 A;  3R8W A;  1W0D A;  1IDC A;  1PS7 A;  2QFY A;  3AH3 A;  3FLK A;  1ZOR A;  2D4V A;  3VKZ A;  4L04 A;  3MAS B;  2Y42 A;  1G2U A;  1IPD A;  3WZW A;  2E0C A;  7ICD A;  1CW1 A;  1HQS A;  2UXQ A;  5GRL A;  5L57 A;  4UMX A;  5J32 A;  2G4O A;  5J33 A;  3FMX X;  2QFV A;  2QFW A;  4P69 C;  4Y1P A;  4AJ3 A;  2IV0 A;  1OSI A;  3U9E A;  4UMY A;  2UXR A;  4AJR A;  3BLX A;  5GRF A;  2ZTW A;  4I3L A;  3VL3 A;  4ICD A;  1IKA A;  5J34 A;  5K10 A;  1IDF A;  1V5B A;  2Y41 A;  5DE1 A;  1GC8 A;  9ICD A;  1BL5 A;  3MAP A;  5I96 A;  5GRH A;  5HN5 A;  3UDO A;  3VMK A;  1SJS A;  1R8K A;  3VL2 A;  1PB3 A;  3BLV A;  1AI3 A;  3VL4 A;  1DPZ A;  1YCO A;  4L06 A;  1IDE A;  3WZY A;  5GRE A;  3VL7 A;  3BLX B;  5GRF B;  2Y3Z A;  4JQP A;  4WUO A;  4ATY A;  1A05 A;  4IWH A;  3LXY A;  1XAD A;  5K11 A;  4AOU A;  3UF6 A;  2QFX A;  1IDD A;  1XAC A;  1XAA A;  1XKD A;  2Y40 A;  5ICD A;  5GRI A;  2AYQ A;  4XS3 A;  1XAB A;  3BLV B;  1TYO A;  3TY4 A;  4XRX A;  6ICD A;  1CW4 A;  1YXO A;  5GRL B;  1T0L A;  3ICD A;  4AOY A;  2HI1 A;  3U1H A;  1V53 A;  1VLC A;  1AI2 A;  2D1C A;  5HN3 A;  1P8F A;  1WPW A;  5GRI B;  4AJS A;  1OSJ A;  4XXV A;  3UDU A;  4YB4 A;  2DHT A;  3US8 A;  3VL6 A;  1IDM A;  4I3K A;  5I95 A;  1ISO A;  1HEX A;  1VI1 A;  1U7N A;  1GRP A;  3TNG A;  1PB1 A;  1T09 A;  4L03 A;  5GRH B;  1XGV A;  1LWD A;  1PTM A;  3LCB C;  3WZV A;  3ASJ A;  3MAR A;  2E5M A;  5HN6 A;  1X0L A;  3INM A;  1CM7 A;  1GRO A;  4JA8 A;  5GRE B;  4BNP A;  3VMJ A;  5LGE A;  4AOV A;  3VML A;  1CNZ A;  1V94 A;  5HN4 A; 
#chains in the Genus database with same CATH homology
 4HCX A;  1GC9 A;  4AJA A;  4AJC A;  3MAS A;  1HJ6 A;  3DMS A;  3TY3 A;  1DR0 A;  3TSN A;  1DR8 A;  4AJB A;  8ICD A;  4F7I A;  1PS6 A;  4KZO A;  3WZX A;  5L58 A;  1WAL A;  1CW7 A;  3R8W A;  1W0D A;  1IDC A;  1PS7 A;  2QFY A;  3AH3 A;  3FLK A;  1ZOR A;  2D4V A;  3VKZ A;  4L04 A;  3MAS B;  2Y42 A;  1G2U A;  1IPD A;  3WZW A;  2E0C A;  7ICD A;  1CW1 A;  1HQS A;  2UXQ A;  5GRL A;  5L57 A;  4UMX A;  5J32 A;  2G4O A;  5J33 A;  3FMX X;  2QFV A;  2QFW A;  4P69 C;  4Y1P A;  4AJ3 A;  2IV0 A;  1OSI A;  3U9E A;  4UMY A;  2UXR A;  4AJR A;  3BLX A;  5GRF A;  2ZTW A;  4I3L A;  3VL3 A;  4ICD A;  1IKA A;  5J34 A;  5K10 A;  1IDF A;  1V5B A;  2Y41 A;  5DE1 A;  1GC8 A;  9ICD A;  1BL5 A;  3MAP A;  5I96 A;  5GRH A;  5HN5 A;  3UDO A;  3VMK A;  1SJS A;  1R8K A;  3VL2 A;  1PB3 A;  3BLV A;  1AI3 A;  3VL4 A;  1DPZ A;  1YCO A;  4L06 A;  1IDE A;  3WZY A;  5GRE A;  3VL7 A;  3BLX B;  5GRF B;  2Y3Z A;  4JQP A;  4WUO A;  4ATY A;  1A05 A;  4IWH A;  3LXY A;  1XAD A;  5K11 A;  4AOU A;  3UF6 A;  2QFX A;  1IDD A;  1XAC A;  1XAA A;  1XKD A;  2Y40 A;  5ICD A;  5GRI A;  2AYQ A;  4XS3 A;  1XAB A;  3BLV B;  1TYO A;  3TY4 A;  4XRX A;  6ICD A;  1CW4 A;  1YXO A;  5GRL B;  1T0L A;  3ICD A;  4AOY A;  2HI1 A;  3U1H A;  1V53 A;  1VLC A;  1AI2 A;  2D1C A;  5HN3 A;  1P8F A;  1WPW A;  5GRI B;  4AJS A;  1OSJ A;  4XXV A;  3UDU A;  4YB4 A;  2DHT A;  3US8 A;  3VL6 A;  1IDM A;  4I3K A;  5I95 A;  1ISO A;  1HEX A;  1VI1 A;  1U7N A;  1GRP A;  3TNG A;  1PB1 A;  1T09 A;  4L03 A;  5GRH B;  1XGV A;  1LWD A;  1PTM A;  3LCB C;  3WZV A;  3ASJ A;  3MAR A;  2E5M A;  5HN6 A;  1X0L A;  3INM A;  1CM7 A;  1GRO A;  4JA8 A;  5GRE B;  4BNP A;  3VMJ A;  5LGE A;  4AOV A;  3VML A;  1CNZ A;  1V94 A;  5HN4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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