4XS3A

Crystal structure of a metabolic reductase with (e)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
Total Genus 130
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
410
structure length
383
Chain Sequence
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRKPIIIGHHYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Isocitrate dehydrogenase [NADP] cytoplasmic
publication title Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.
pubmed doi rcsb
source organism Homo sapiens
total genus 130
structure length 383
sequence length 410
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2015-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4xs3A00
4F7IA 4HCXA 1XABA 2D4VA 3VL7A 5GRFA 3VKZA 2AYQA 4UMYA 2QFVA 5HN4A 1GC9A 1IPDA 4XRXA 5DE1A 3U1HA 1CW4A 1XGVA 1V53A 3VMKA 4AJ3A 3MAPA 1HEXA 2Y41A 4P69C 1PTMA 5GRLA 1V94A 2G4OA 5LGEA 1IDEA 3TNGA 1V5BA 4WUOA 2Y40A 1PS6A 5L57A 2QFXA 5GRHA 4ATYA 1T0LA 4I3KA 1P8FA 2Y42A 1WPWA 2QFWA 1ZORA 3BLXB 1VLCA 4XXVA 3UDOA 4IWHA 1T09A 4I3LA 3TY3A 4AJRA 2D1CA 4UMXA 2Y3ZA 3R8WA 1CW1A 1IDFA 2DHTA 4AJCA 5HN6A 2UXRA 1TYOA 2E0CA 1G2UA 4L03A 2ZTWA 3DMSA 5ICDA 3VL4A 1PB3A 5J34A 1PS7A 1OSIA 3VMLA 5GRIA 3VL2A 3MASA 5K11A 1AI3A 1X0LA 1LWDA 1ISOA 1CW7A 4KZOA 1CNZA 1PB1A 7ICDA 4YB4A 1IDDA 1AI2A 3MARA 4AOUA 5I95A 5I96A 5GREA 4AOYA 5L58A 3INMA 1YXOA 3BLVA 5GRLB 1GC8A 1YCOA 5K10A 3FMXX 3FLKA 5GRHB 4AJBA 4ICDA 1XAAA 1XACA 5GRFB 3VL6A 1CM7A 1DR0A 3WZVA 2UXQA 3ICDA 1IKAA 1VI1A 1DPZA 2IV0A 1GROA 3WZWA 1HQSA 4Y1PA 5HN3A 2QFYA 3TSNA 3LCBC 1GRPA 1OSJA 3TY4A 1DR8A 3ASJA 3US8A 3UDUA 5HN5A 3LXYA 3AH3A 5GRIB 1WALA 1R8KA 1BL5A 3MASB 3UF6A 5J33A 4JA8A 4XS3A 4AJAA 4AOVA 3U9EA 1HJ6A 2E5MA 9ICDA 4BNPA 1IDMA 4AJSA 3VMJA 1A05A 1IDCA 3WZXA 6ICDA 8ICDA 5GREB 1W0DA 3BLVB 3BLXA 4L04A 4L06A 5J32A 1XADA 4JQPA 2HI1A 3WZYA 1U7NA 3VL3A 1SJSA 1XKDA
chains in the Genus database with same CATH superfamily
4F7IA 4HCXA 1XABA 2D4VA 3VL7A 5GRFA 3VKZA 2AYQA 4UMYA 2QFVA 5HN4A 1GC9A 1IPDA 4XRXA 5DE1A 3U1HA 1CW4A 1XGVA 1V53A 3VMKA 4AJ3A 3MAPA 1HEXA 2Y41A 4P69C 1PTMA 5GRLA 1V94A 2G4OA 5LGEA 1IDEA 3TNGA 1V5BA 4WUOA 2Y40A 1PS6A 5L57A 2QFXA 5GRHA 4ATYA 1T0LA 4I3KA 1P8FA 2Y42A 1WPWA 2QFWA 1ZORA 3BLXB 1VLCA 4XXVA 3UDOA 4IWHA 1T09A 4I3LA 3TY3A 4AJRA 2D1CA 4UMXA 2Y3ZA 3R8WA 1CW1A 1IDFA 2DHTA 4AJCA 5HN6A 2UXRA 1TYOA 2E0CA 1G2UA 4L03A 2ZTWA 3DMSA 5ICDA 3VL4A 1PB3A 5J34A 1PS7A 1OSIA 3VMLA 5GRIA 3VL2A 3MASA 5K11A 1AI3A 1X0LA 1LWDA 1ISOA 1CW7A 4KZOA 1CNZA 1PB1A 7ICDA 4YB4A 1IDDA 1AI2A 3MARA 4AOUA 5I95A 5I96A 5GREA 4AOYA 5L58A 3INMA 1YXOA 3BLVA 5GRLB 1GC8A 1YCOA 5K10A 3FMXX 3FLKA 5GRHB 4AJBA 4ICDA 1XAAA 1XACA 5GRFB 3VL6A 1CM7A 1DR0A 3WZVA 2UXQA 3ICDA 1IKAA 1VI1A 1DPZA 2IV0A 1GROA 3WZWA 1HQSA 4Y1PA 5HN3A 2QFYA 3TSNA 3LCBC 1GRPA 1OSJA 3TY4A 1DR8A 3ASJA 3US8A 3UDUA 5HN5A 3LXYA 3AH3A 5GRIB 1WALA 1R8KA 1BL5A 3MASB 3UF6A 5J33A 4JA8A 4XS3A 4AJAA 4AOVA 3U9EA 1HJ6A 2E5MA 9ICDA 4BNPA 1IDMA 4AJSA 3VMJA 1A05A 1IDCA 3WZXA 6ICDA 8ICDA 5GREB 1W0DA 3BLVB 3BLXA 4L04A 4L06A 5J32A 1XADA 4JQPA 2HI1A 3WZYA 1U7NA 3VL3A 1SJSA 1XKDA
chains in the Genus database with same CATH topology
4F7IA 4HCXA 1XABA 2D4VA 3VL7A 5GRFA 3VKZA 2AYQA 4UMYA 2QFVA 5HN4A 1GC9A 1IPDA 4XRXA 5DE1A 3U1HA 1CW4A 1XGVA 1V53A 3VMKA 4AJ3A 3MAPA 1HEXA 2Y41A 4P69C 1PTMA 5GRLA 1V94A 2G4OA 5LGEA 1IDEA 3TNGA 1V5BA 4WUOA 2Y40A 1PS6A 5L57A 2QFXA 5GRHA 4ATYA 1T0LA 4I3KA 1P8FA 2Y42A 1WPWA 2QFWA 1ZORA 3BLXB 1VLCA 4XXVA 3UDOA 4IWHA 1T09A 4I3LA 3TY3A 4AJRA 2D1CA 4UMXA 2Y3ZA 3R8WA 1CW1A 1IDFA 2DHTA 4AJCA 5HN6A 2UXRA 1TYOA 2E0CA 1G2UA 4L03A 2ZTWA 3DMSA 5ICDA 3VL4A 1PB3A 5J34A 1PS7A 1OSIA 3VMLA 5GRIA 3VL2A 3MASA 5K11A 1AI3A 1X0LA 1LWDA 1ISOA 1CW7A 4KZOA 1CNZA 1PB1A 7ICDA 4YB4A 1IDDA 1AI2A 3MARA 4AOUA 5I95A 5I96A 5GREA 4AOYA 5L58A 3INMA 1YXOA 3BLVA 5GRLB 1GC8A 1YCOA 5K10A 3FMXX 3FLKA 5GRHB 4AJBA 4ICDA 1XAAA 1XACA 5GRFB 3VL6A 1CM7A 1DR0A 3WZVA 2UXQA 3ICDA 1IKAA 1VI1A 1DPZA 2IV0A 1GROA 3WZWA 1HQSA 4Y1PA 5HN3A 2QFYA 3TSNA 3LCBC 1GRPA 1OSJA 3TY4A 1DR8A 3ASJA 3US8A 3UDUA 5HN5A 3LXYA 3AH3A 5GRIB 1WALA 1R8KA 1BL5A 3MASB 3UF6A 5J33A 4JA8A 4XS3A 4AJAA 4AOVA 3U9EA 1HJ6A 2E5MA 9ICDA 4BNPA 1IDMA 4AJSA 3VMJA 1A05A 1IDCA 3WZXA 6ICDA 8ICDA 5GREB 1W0DA 3BLVB 3BLXA 4L04A 4L06A 5J32A 1XADA 4JQPA 2HI1A 3WZYA 1U7NA 3VL3A 1SJSA 1XKDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F7I A;  4HCX A;  1XAB A;  2D4V A;  3VL7 A;  5GRF A;  3VKZ A;  2AYQ A;  4UMY A;  2QFV A;  5HN4 A;  1GC9 A;  1IPD A;  4XRX A;  5DE1 A;  3U1H A;  1CW4 A;  1XGV A;  1V53 A;  3VMK A;  4AJ3 A;  3MAP A;  1HEX A;  2Y41 A;  4P69 C;  1PTM A;  5GRL A;  1V94 A;  2G4O A;  5LGE A;  1IDE A;  3TNG A;  1V5B A;  4WUO A;  2Y40 A;  1PS6 A;  5L57 A;  2QFX A;  5GRH A;  4ATY A;  1T0L A;  4I3K A;  1P8F A;  2Y42 A;  1WPW A;  2QFW A;  1ZOR A;  3BLX B;  1VLC A;  4XXV A;  3UDO A;  4IWH A;  1T09 A;  4I3L A;  3TY3 A;  4AJR A;  2D1C A;  4UMX A;  2Y3Z A;  3R8W A;  1CW1 A;  1IDF A;  2DHT A;  4AJC A;  5HN6 A;  2UXR A;  1TYO A;  2E0C A;  1G2U A;  4L03 A;  2ZTW A;  3DMS A;  5ICD A;  3VL4 A;  1PB3 A;  5J34 A;  1PS7 A;  1OSI A;  3VML A;  5GRI A;  3VL2 A;  3MAS A;  5K11 A;  1AI3 A;  1X0L A;  1LWD A;  1ISO A;  1CW7 A;  4KZO A;  1CNZ A;  1PB1 A;  7ICD A;  4YB4 A;  1IDD A;  1AI2 A;  3MAR A;  4AOU A;  5I95 A;  5I96 A;  5GRE A;  4AOY A;  5L58 A;  3INM A;  1YXO A;  3BLV A;  5GRL B;  1GC8 A;  1YCO A;  5K10 A;  3FMX X;  3FLK A;  5GRH B;  4AJB A;  4ICD A;  1XAA A;  1XAC A;  5GRF B;  3VL6 A;  1CM7 A;  1DR0 A;  3WZV A;  2UXQ A;  3ICD A;  1IKA A;  1VI1 A;  1DPZ A;  2IV0 A;  1GRO A;  3WZW A;  1HQS A;  4Y1P A;  5HN3 A;  2QFY A;  3TSN A;  3LCB C;  1GRP A;  1OSJ A;  3TY4 A;  1DR8 A;  3ASJ A;  3US8 A;  3UDU A;  5HN5 A;  3LXY A;  3AH3 A;  5GRI B;  1WAL A;  1R8K A;  1BL5 A;  3MAS B;  3UF6 A;  5J33 A;  4JA8 A;  4XS3 A;  4AJA A;  4AOV A;  3U9E A;  1HJ6 A;  2E5M A;  9ICD A;  4BNP A;  1IDM A;  4AJS A;  3VMJ A;  1A05 A;  1IDC A;  3WZX A;  6ICD A;  8ICD A;  5GRE B;  1W0D A;  3BLV B;  3BLX A;  4L04 A;  4L06 A;  5J32 A;  1XAD A;  4JQP A;  2HI1 A;  3WZY A;  1U7N A;  3VL3 A;  1SJS A;  1XKD A; 
#chains in the Genus database with same CATH topology
 4F7I A;  4HCX A;  1XAB A;  2D4V A;  3VL7 A;  5GRF A;  3VKZ A;  2AYQ A;  4UMY A;  2QFV A;  5HN4 A;  1GC9 A;  1IPD A;  4XRX A;  5DE1 A;  3U1H A;  1CW4 A;  1XGV A;  1V53 A;  3VMK A;  4AJ3 A;  3MAP A;  1HEX A;  2Y41 A;  4P69 C;  1PTM A;  5GRL A;  1V94 A;  2G4O A;  5LGE A;  1IDE A;  3TNG A;  1V5B A;  4WUO A;  2Y40 A;  1PS6 A;  5L57 A;  2QFX A;  5GRH A;  4ATY A;  1T0L A;  4I3K A;  1P8F A;  2Y42 A;  1WPW A;  2QFW A;  1ZOR A;  3BLX B;  1VLC A;  4XXV A;  3UDO A;  4IWH A;  1T09 A;  4I3L A;  3TY3 A;  4AJR A;  2D1C A;  4UMX A;  2Y3Z A;  3R8W A;  1CW1 A;  1IDF A;  2DHT A;  4AJC A;  5HN6 A;  2UXR A;  1TYO A;  2E0C A;  1G2U A;  4L03 A;  2ZTW A;  3DMS A;  5ICD A;  3VL4 A;  1PB3 A;  5J34 A;  1PS7 A;  1OSI A;  3VML A;  5GRI A;  3VL2 A;  3MAS A;  5K11 A;  1AI3 A;  1X0L A;  1LWD A;  1ISO A;  1CW7 A;  4KZO A;  1CNZ A;  1PB1 A;  7ICD A;  4YB4 A;  1IDD A;  1AI2 A;  3MAR A;  4AOU A;  5I95 A;  5I96 A;  5GRE A;  4AOY A;  5L58 A;  3INM A;  1YXO A;  3BLV A;  5GRL B;  1GC8 A;  1YCO A;  5K10 A;  3FMX X;  3FLK A;  5GRH B;  4AJB A;  4ICD A;  1XAA A;  1XAC A;  5GRF B;  3VL6 A;  1CM7 A;  1DR0 A;  3WZV A;  2UXQ A;  3ICD A;  1IKA A;  1VI1 A;  1DPZ A;  2IV0 A;  1GRO A;  3WZW A;  1HQS A;  4Y1P A;  5HN3 A;  2QFY A;  3TSN A;  3LCB C;  1GRP A;  1OSJ A;  3TY4 A;  1DR8 A;  3ASJ A;  3US8 A;  3UDU A;  5HN5 A;  3LXY A;  3AH3 A;  5GRI B;  1WAL A;  1R8K A;  1BL5 A;  3MAS B;  3UF6 A;  5J33 A;  4JA8 A;  4XS3 A;  4AJA A;  4AOV A;  3U9E A;  1HJ6 A;  2E5M A;  9ICD A;  4BNP A;  1IDM A;  4AJS A;  3VMJ A;  1A05 A;  1IDC A;  3WZX A;  6ICD A;  8ICD A;  5GRE B;  1W0D A;  3BLV B;  3BLX A;  4L04 A;  4L06 A;  5J32 A;  1XAD A;  4JQP A;  2HI1 A;  3WZY A;  1U7N A;  3VL3 A;  1SJS A;  1XKD A; 
#chains in the Genus database with same CATH homology
 4F7I A;  4HCX A;  1XAB A;  2D4V A;  3VL7 A;  5GRF A;  3VKZ A;  2AYQ A;  4UMY A;  2QFV A;  5HN4 A;  1GC9 A;  1IPD A;  4XRX A;  5DE1 A;  3U1H A;  1CW4 A;  1XGV A;  1V53 A;  3VMK A;  4AJ3 A;  3MAP A;  1HEX A;  2Y41 A;  4P69 C;  1PTM A;  5GRL A;  1V94 A;  2G4O A;  5LGE A;  1IDE A;  3TNG A;  1V5B A;  4WUO A;  2Y40 A;  1PS6 A;  5L57 A;  2QFX A;  5GRH A;  4ATY A;  1T0L A;  4I3K A;  1P8F A;  2Y42 A;  1WPW A;  2QFW A;  1ZOR A;  3BLX B;  1VLC A;  4XXV A;  3UDO A;  4IWH A;  1T09 A;  4I3L A;  3TY3 A;  4AJR A;  2D1C A;  4UMX A;  2Y3Z A;  3R8W A;  1CW1 A;  1IDF A;  2DHT A;  4AJC A;  5HN6 A;  2UXR A;  1TYO A;  2E0C A;  1G2U A;  4L03 A;  2ZTW A;  3DMS A;  5ICD A;  3VL4 A;  1PB3 A;  5J34 A;  1PS7 A;  1OSI A;  3VML A;  5GRI A;  3VL2 A;  3MAS A;  5K11 A;  1AI3 A;  1X0L A;  1LWD A;  1ISO A;  1CW7 A;  4KZO A;  1CNZ A;  1PB1 A;  7ICD A;  4YB4 A;  1IDD A;  1AI2 A;  3MAR A;  4AOU A;  5I95 A;  5I96 A;  5GRE A;  4AOY A;  5L58 A;  3INM A;  1YXO A;  3BLV A;  5GRL B;  1GC8 A;  1YCO A;  5K10 A;  3FMX X;  3FLK A;  5GRH B;  4AJB A;  4ICD A;  1XAA A;  1XAC A;  5GRF B;  3VL6 A;  1CM7 A;  1DR0 A;  3WZV A;  2UXQ A;  3ICD A;  1IKA A;  1VI1 A;  1DPZ A;  2IV0 A;  1GRO A;  3WZW A;  1HQS A;  4Y1P A;  5HN3 A;  2QFY A;  3TSN A;  3LCB C;  1GRP A;  1OSJ A;  3TY4 A;  1DR8 A;  3ASJ A;  3US8 A;  3UDU A;  5HN5 A;  3LXY A;  3AH3 A;  5GRI B;  1WAL A;  1R8K A;  1BL5 A;  3MAS B;  3UF6 A;  5J33 A;  4JA8 A;  4XS3 A;  4AJA A;  4AOV A;  3U9E A;  1HJ6 A;  2E5M A;  9ICD A;  4BNP A;  1IDM A;  4AJS A;  3VMJ A;  1A05 A;  1IDC A;  3WZX A;  6ICD A;  8ICD A;  5GRE B;  1W0D A;  3BLV B;  3BLX A;  4L04 A;  4L06 A;  5J32 A;  1XAD A;  4JQP A;  2HI1 A;  3WZY A;  1U7N A;  3VL3 A;  1SJS A;  1XKD A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...