4XSSB

Insulin-like growth factor i in complex with site 1 of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
61
structure length
47
Chain Sequence
ETLCGAELVDALQFVCGDRGFYFNTGIVDECCFRSCDLRRLEMYCAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/hormone receptor
molecule keywords Insulin-like growth factor I
publication title Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
pubmed doi rcsb
source organism Homo sapiens
total genus 12
structure length 47
sequence length 61
ec nomenclature
pdb deposition date 2015-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 4xssB00
1ZEIA 2DSRI 2LWZA 1TGRA 3LRIA 6INSE 1GZYB 1EFEA 2KJIA 2JZQA 1WQJI 1BQTA 2DSPI 2KQPA 2GF1A 1H02B 5L3MA 5L3NA 2L29B 4XSSB 2DSQC 1GZRB 1SJUA 5L3LA 1PMXA 1IMXA 3GF1A 1B9GA 3KR3D 1IGLA 1H59A 1GZZB
chains in the Genus database with same CATH superfamily
1ZEIA 2DSRI 3F2CA 2LWZA 1TGRA 2L14B 3LRIA 6INSE 1GZYB 1EFEA 2KJIA 2JZQA 1WQJI 1BQTA 2DSPI 2KQPA 2GF1A 1H02B 3F2DA 5L3MA 5L3NA 2L29B 4XSSB 2DSQC 1GZRB 1SJUA 3F2BA 5L3LA 1PMXA 1IMXA 3GF1A 1B9GA 3KR3D 1IGLA 1H59A 1GZZB
chains in the Genus database with same CATH topology
1ZEIA 2DSRI 2LWZA 1TGRA 3LRIA 6INSE 1GZYB 1EFEA 2KJIA 2JZQA 1WQJI 1BQTA 2DSPI 2KQPA 2GF1A 1H02B 5L3MA 5L3NA 2L29B 4XSSB 2DSQC 1GZRB 1SJUA 5L3LA 1PMXA 1IMXA 3GF1A 1B9GA 3KR3D 1IGLA 1H59A 1GZZB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEI A;  2DSR I;  2LWZ A;  1TGR A;  3LRI A;  6INS E;  1GZY B;  1EFE A;  2KJI A;  2JZQ A;  1WQJ I;  1BQT A;  2DSP I;  2KQP A;  2GF1 A;  1H02 B;  5L3M A;  5L3N A;  2L29 B;  4XSS B;  2DSQ C;  1GZR B;  1SJU A;  5L3L A;  1PMX A;  1IMX A;  3GF1 A;  1B9G A;  3KR3 D;  1IGL A;  1H59 A;  1GZZ B; 
#chains in the Genus database with same CATH topology
 1ZEI A;  2DSR I;  3F2C A;  2LWZ A;  1TGR A;  2L14 B;  3LRI A;  6INS E;  1GZY B;  1EFE A;  2KJI A;  2JZQ A;  1WQJ I;  1BQT A;  2DSP I;  2KQP A;  2GF1 A;  1H02 B;  3F2D A;  5L3M A;  5L3N A;  2L29 B;  4XSS B;  2DSQ C;  1GZR B;  1SJU A;  3F2B A;  5L3L A;  1PMX A;  1IMX A;  3GF1 A;  1B9G A;  3KR3 D;  1IGL A;  1H59 A;  1GZZ B; 
#chains in the Genus database with same CATH homology
 1ZEI A;  2DSR I;  2LWZ A;  1TGR A;  3LRI A;  6INS E;  1GZY B;  1EFE A;  2KJI A;  2JZQ A;  1WQJ I;  1BQT A;  2DSP I;  2KQP A;  2GF1 A;  1H02 B;  5L3M A;  5L3N A;  2L29 B;  4XSS B;  2DSQ C;  1GZR B;  1SJU A;  5L3L A;  1PMX A;  1IMX A;  3GF1 A;  1B9G A;  3KR3 D;  1IGL A;  1H59 A;  1GZZ B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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